scholarly journals Development of Polymer-Assisted Nanoparticles and Nanogels for Cancer Therapy: An Update

Gels ◽  
2021 ◽  
Vol 7 (2) ◽  
pp. 60
Author(s):  
Bibi Noorheen Haleema Mooneerah Neerooa ◽  
Li-Ting Ooi ◽  
Kamyar Shameli ◽  
Nuraina Anisa Dahlan ◽  
Jahid M. M. Islam ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Anticancer Drug ◽  
Polymer Network ◽  
Review Article ◽  
Environment Friendly ◽  
Physiochemical Properties ◽  
Drug Nanoparticles ◽  
Toxic Environment ◽  
High Flexibility ◽  
Causes Of Deaths

With cancer remaining as one of the main causes of deaths worldwide, many studies are undergoing the effort to look for a novel and potent anticancer drug. Nanoparticles (NPs) are one of the rising fields in research for anticancer drug development. One of the key advantages of using NPs for cancer therapy is its high flexibility for modification, hence additional properties can be added to the NPs in order to improve its anticancer action. Polymer has attracted considerable attention to be used as a material to enhance the bioactivity of the NPs. Nanogels, which are NPs cross-linked with hydrophilic polymer network have also exhibited benefits in anticancer application. The characteristics of these nanomaterials include non-toxic, environment-friendly, and variable physiochemical properties. Some other unique properties of polymers are also attributed by diverse methods of polymer synthesis. This then contributes to the unique properties of the nanodrugs. This review article provides an in-depth update on the development of polymer-assisted NPs and nanogels for cancer therapy. Topics such as the synthesis, usage, and properties of the nanomaterials are discussed along with their mechanisms and functions in anticancer application. The advantages and limitations are also discussed in this article.

Anticancer Drug Prescription Patterns in Japan: Future Directions in Cancer Therapy

2018 ◽  
Vol 52 (6) ◽  
pp. 718-723 ◽  
Author(s):  
Shoyo Shibata ◽  
Maiko Matsushita ◽  
Yoshimasa Saito ◽  
Takeshi Suzuki
Keyword(s):  
Cancer Therapy ◽  
Anticancer Drug ◽  
Drug Prescription ◽  
Future Directions ◽  
Prescription Patterns

scholarly journals Vitamin-anticancer drug conjugates: a new era for cancer therapy

2020 ◽  
Vol 50 (3) ◽  
Author(s):  
Ritesh Bhole ◽  
Shradha Jadhav ◽  
Yogesh B. Zambare ◽  
Rupesh V. Chikhale ◽  
Chandrakant Bonde
Keyword(s):  
Cancer Therapy ◽  
Anticancer Drug ◽  
New Era ◽  
Drug Conjugates

Availability of pharmacogenetic and pharmacogenomic information in anticancer drug monographs in France: personalized cancer therapy

2011 ◽  
Vol 12 (5) ◽  
pp. 681-691 ◽  
Author(s):  
Laetitia Albertini ◽  
Gérard Siest ◽  
Elise Jeannesson ◽  
Sophie Visvikis-Siest
Keyword(s):  
Cancer Therapy ◽  
Anticancer Drug ◽  
Personalized Cancer Therapy ◽  
Personalized Cancer

Micro/nanomachines: what is needed for them to become a real force in cancer therapy?

Nanoscale ◽  
2019 ◽  
Vol 11 (14) ◽  
pp. 6519-6532 ◽  
Author(s):  
Lucie Reinišová ◽  
Soňa Hermanová ◽  
Martin Pumera
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Anticancer Drug ◽  
Future Development ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Anticancer Drug Delivery

A biomedical perspective is used to assess micro/nanomotor-based anticancer drug delivery systems with recommendations for their effective future development.

scholarly journals Controlled delivery of a protein tyrosine phosphatase inhibitor, SHP099, using cyclodextrin-mediated host–guest interactions in polyelectrolyte multilayer films for cancer therapy

RSC Advances ◽  
2020 ◽  
Vol 10 (34) ◽  
pp. 20073-20082 ◽  
Author(s):  
Soobin Wang ◽  
Alessia Battigelli ◽  
Dahlia Alkekhia ◽  
Alexis Fairman ◽  
Valentin Antoci ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Anticancer Drug ◽  
Protein Tyrosine Phosphatase ◽  
Multilayer Film ◽  
Tyrosine Phosphatase ◽  
Multilayer Films ◽  
Controlled Delivery ◽  
Polyelectrolyte Multilayer ◽  
Supramolecular Complexation ◽  
Protein Tyrosine Phosphatase Inhibitor

Controlled delivery of a potent anticancer drug, SHP099, after supramolecular complexation into a versatile multilayer film.

scholarly journals Pharmacophore hybridisation and nanoscale assembly to discover self-delivering lysosomotropic new-chemical entities for cancer therapy

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Zhao Ma ◽  
Jin Li ◽  
Kai Lin ◽  
Mythili Ramachandran ◽  
Dalin Zhang ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Cancer Therapy ◽  
Self Assembly ◽  
The Self ◽  
Single Drug ◽  
Drug Nanoparticles ◽  
Lysosomal Dysfunction ◽  
New Chemical Entities ◽  
Autophagy Inhibition

Abstract Integration of the unique advantages of the fields of drug discovery and drug delivery is invaluable for the advancement of drug development. Here we propose a self-delivering one-component new-chemical-entity nanomedicine (ONN) strategy to improve cancer therapy through incorporation of the self-assembly principle into drug design. A lysosomotropic detergent (MSDH) and an autophagy inhibitor (Lys05) are hybridised to develop bisaminoquinoline derivatives that can intrinsically form nanoassemblies. The selected BAQ12 and BAQ13 ONNs are highly effective in inducing lysosomal disruption, lysosomal dysfunction and autophagy blockade and exhibit 30-fold higher antiproliferative activity than hydroxychloroquine used in clinical trials. These single-drug nanoparticles demonstrate excellent pharmacokinetic and toxicological profiles and dramatic antitumour efficacy in vivo. In addition, they are able to encapsulate and deliver additional drugs to tumour sites and are thus promising agents for autophagy inhibition-based combination therapy. Given their transdisciplinary advantages, these BAQ ONNs have enormous potential to improve cancer therapy.

A synergistic polyphosphoester-based co-delivery system of the anticancer drug doxorubicin and the tumor suppressor gene p53 for lung cancer therapy

2018 ◽  
Vol 6 (20) ◽  
pp. 3262-3273 ◽  
Author(s):  
Jie Liu ◽  
Jinlin He ◽  
Mingzu Zhang ◽  
Guoqiang Xu ◽  
Peihong Ni
Keyword(s):  
Lung Cancer ◽  
Cancer Therapy ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Anticancer Drug ◽  
Delivery System ◽  
Suppressor Gene ◽  
Polymeric Prodrug ◽  
Lung Cancer Therapy ◽  
Tumor Suppressor Gene P53

Hybrid micelles composed of polymeric prodrug and gene carrier were constructed by polyphosphoester-based co-delivery system for lung cancer therapy.

Green HRM

2020 ◽  
Vol 10 (3) ◽  
pp. 1-8
Author(s):  
Anupama Lakhera ◽  
Pooja Sharma
Keyword(s):  
Sustainable Development ◽  
Carbon Footprint ◽  
Environmental Issues ◽  
Review Article ◽  
Sustainable Growth ◽  
Research Papers ◽  
Environment Friendly ◽  
Secondary Sources ◽  
Hr Practices ◽  
Social Wellbeing

Green HRM is a concept that is fast gaining prominence in the field of management. This review article discusses Green HRM for implementing best HR practices for reducing employees' carbon footprint and thus leading to sustainable growth within the organization. It explores how Green HRM can achieve the integration of environment-friendly HR practices and activities in order to achieve long-lasting sustainable development and a reduction of the employee carbon footprint. The data is collected on the basis of secondary sources such as articles, research papers, case studies, and internet websites. Green HRM does not only imply awareness and concern towards environmental issues, it favors the economic as well as social wellbeing of the employees and organization. This article deliberates on the Green HRM approach and the prominent part it can play in integrating and merging the HR practices within the organization in favour of the environment.

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