Longitudinal Trends in Illness Perception and Depression during Adjuvant Breast Cancer Endocrine Therapy: A Prospective Observational Study

This study aimed to identify the changes in the illness perceptions and depression of women with breast cancer, undergoing AET, at three time points (i.e., before initiating AET, 3 months follow-up, and 12 months follow-up). We investigated the interaction effects of their demographic and clinical characteristics on illness perception changes over time. Furthermore, factors including the patient’s characteristics and illness perceptions associated with depressive symptoms 1 year after starting AET were explored. Illness perception and depressive symptoms were assessed with the brief illness perception questionnaire and the Center for Epidemiologic Studies Depression Scale, in a prospective study of 150 women. The changes in illness perceptions and depression between the three time points were analyzed using repeated measures ANOVA. The factors associated with depressive symptoms were identified using regression analysis. Illness perception improved overall over the 12 months. However, more patients perceived their illness as chronic, experienced more symptoms, and developed negative beliefs that treatment could not control their disease. Patients’ depressive symptoms decreased significantly. Depression at the baseline, cancer stage, and the perception of personal control were highly associated with depression after 12 months. These findings suggest that healthcare providers should offer appropriate interventions to patients, for managing symptoms, having a positive belief that treatment can control their disease, and preventing long-term depressive symptoms.

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Psychological Outcomes in Children and Early Adolescents With Type 1 Diabetes Following Pediatric Diabetes Summer Camp: A 3-Month Follow-Up Study

Frontiers in Pediatrics ◽

10.3389/fped.2021.650201 ◽

2021 ◽

Vol 9 ◽

Author(s):

Alda Troncone ◽

Antonietta Chianese ◽

Crescenzo Cascella ◽

Angela Zanfardino ◽

Dario Iafusco

Keyword(s):

Type 1 Diabetes ◽

Glycemic Control ◽

Psychosocial Adjustment ◽

Repeated Measures ◽

Summer Camp ◽

Illness Perception ◽

Healthcare Providers ◽

Follow Up Study

Objective: The aim of this study was to assess general psychosocial adjustment to diabetes and perceived disease management among patients with type 1 diabetes (T1D) and their parents before and after patients' participation in a diabetes summer camp.Methods: In this follow-up study, 20 children and adolescents with T1D (eight boys; mean age = 11.01 ± 0.94 years; mean diabetes duration = 3.02 ± 2.27) attending a southern Italian diabetic center, along with their parents, were assessed prior to and 3 months after the youths participated in a 1 week camp-based intervention involving didactic and interactive child-centered education and recreational activities. Patients and their parents completed measures assessing patients' quality of life and strategies employed by patients to cope with pain. Patients also completed measures evaluating their diabetes psychosocial adjustment, diabetes self-efficacy management, and illness perception; also, their parents completed measures of caregivers' perceived diabetes burden and treatment satisfaction. Youths' glycated hemoglobin (HbA1c) and standardized body mass index (z-BMI) values were also assessed. Within-subjects repeated-measures analyses of variance evaluated pre- and post-camp changes.Results: Camp attendance showed no beneficial effects on glycemic control, as indicated by HbA1c values both before (7.02%) and after (7.28%) camp being lower than 7.5%. HbA1c values were found to have increased after camp (pre-camp = 7.02%, post-camp = 7.28%; p = 0.010), but since they still fell within an acceptable range, they did not reveal clinically relevant changes in glycemic control. No substantial significant improvement in psychosocial measures was observed in children or parents (all p > 0.05). According to the parents' evaluation, social support-seeking as a patient pain-coping strategy was slightly increased (p = 0.044) after attending the camp.Conclusions: This study does not provide empirical evidence of benefits of participating in a diabetes camp for either patients or their parents. These findings suggest that healthcare providers rethink such camps as an experience for youths with T1D that actively involves parents and that includes both youth- and parent-focused psychological interventions.

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Newborn Behavioral Observation, maternal stress, depressive symptoms and the mother-infant relationship: Results from the Northern Babies Longitudinal Study (NorBaby).

10.21203/rs.3.rs-15813/v2 ◽

2020 ◽

Author(s):

Ragnhild Sørensen Høifødt ◽

Dag Nordahl ◽

Inger Pauline Landsem ◽

Gábor Csifcsák ◽

Agnes Bohne ◽

...

Keyword(s):

Depressive Symptoms ◽

Longitudinal Study ◽

Parental Stress ◽

Repeated Measures ◽

Comparison Group ◽

Depression Scale ◽

Behavioral Observation ◽

Stress Index ◽

Maternal Depressive Symptoms

Abstract Background: Families can experience the postpartum period as overwhelming and many report a special need for support. The Newborn Behavioral Observation (NBO) aims to promote a positive parent-infant relationship by sensitising parents to the infant’s signals. This article evaluates the NBO as a universal preventive intervention within the regular well-baby clinic service on measures of maternal depressive symptoms, parental stress, the mother-infant relationship and satisfaction/benefit of the postpartum follow-up.Methods : This investigation is part of a larger longitudinal study comprising 220 women and 130 of their partners recruited between 2015 and 2017. The study had a non-randomised cluster-controlled design with 6 measurement points. This article is based on a sample of 196 women using data from T1 (gestational weeks 13-39), T4 (5-15 weeks postpartum) and T5 (3-9 months postpartum). Participants were allocated to a group receiving the NBO (n=82) and a care as usual comparison group (n=114). We measured maternal depressive symptoms and parental stress using the Edinburgh Postnatal Depression Scale (EPDS) and the Parenting Stress Index (PSI). The mother-infant relationship was assessed with the Parental Reflective Functioning Questionnaire (PRFQ), the Maternal Postnatal Attachment Scale (MPAS) and the Maternal Confidence Questionnaire (MCQ). Participants also answered questions about satisfaction/benefit of the postpartum follow-up. Results: A Mann-Whitney U test indicated that participants in the NBO-group learned significantly more than the comparison group from the follow-up about the baby’s signals in relation to sleep/sleep patterns, social interaction and crying/fuzziness. Multivariate analyses of covariance (MANCOVA) and repeated measures ANCOVA found no significant differences between the groups for the mother-infant relationship domains and few differences in depressive symptoms and parental stress. The repeated measures ANCOVA found that participants in the NBO-group scored slightly higher on parental stress, although the difference was small. Conclusions: The results indicate that the NBO-group learned more than the comparison group about reading their child’s signals in important everyday situations. However, the benefits of the NBO were limited for depressive symptoms, parental stress and self-reported mother-infant relationship. The study sample was generally well-functioning, and the results indicate that the benefits of the NBO may be limited within a well-functioning sample.

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Targeting Depressive Symptoms in Younger Breast Cancer Survivors: The Pathways to Wellness Randomized Controlled Trial of Mindfulness Meditation and Survivorship Education

Journal of Clinical Oncology ◽

10.1200/jco.21.00279 ◽

2021 ◽

pp. JCO.21.00279

Author(s):

Julienne E. Bower ◽

Ann H. Partridge ◽

Antonio C. Wolff ◽

Elissa D. Thorner ◽

Michael R. Irwin ◽

...

Keyword(s):

Breast Cancer ◽

Depressive Symptoms ◽

Cancer Survivors ◽

Behavioral Interventions ◽

Breast Cancer Survivors ◽

Mindfulness Meditation ◽

Controlled Trial ◽

Depression Scale ◽

Vasomotor Symptoms

PURPOSE Younger women are at risk for depression and related symptoms following breast cancer. The Pathways to Wellness study, a randomized, multi-institution, three-arm trial, tested the efficacy of two behavioral interventions for younger breast cancer survivors with elevated depressive symptoms: mindful awareness practices (MAPs) and survivorship education (SE) (Clincaltrials.gov identifier: NCT03025139 ). METHODS Women diagnosed with breast cancer at or before 50 years of age who had completed treatment and had elevated depressive symptoms were randomly assigned to 6 weeks of MAPs, SE, or wait-list control (WLC). Assessments were conducted preintervention and postintervention and at 3-month and 6-month postintervention follow-ups. Analyses compared each intervention to WLC using linear mixed models. The primary outcome was change in depressive symptoms from preintervention to postintervention on the Center for Epidemiologic Studies-Depression Scale; secondary outcomes included change in fatigue, insomnia, and vasomotor symptoms. RESULTS Two hundred forty-seven women (median age = 46 years) were randomly assigned to MAPs (n = 85), SE (n = 81), or WLC (n = 81). MAPs and SE led to significant decreases in depressive symptoms from preintervention to postintervention relative to WLC (mean change relative to WLC [95% CI]: MAPs, –4.7 [–7.5 to –1.9]; SE, –4.0 [–6.9 to –1.1]), which persisted at 6-month follow-up for MAPs (mean change relative to WLC [95% CI]: MAPs, –3.7 [–6.6 to –0.8]; SE, –2.8 [–5.9 to 0.2]). MAPs, but not SE, also had beneficial effects on fatigue, insomnia, and vasomotor symptoms that persisted at 6-month follow-up ( P < .05). CONCLUSION Mindfulness meditation and SE reduced depressive symptoms in younger breast cancer survivors. These interventions can be widely disseminated over virtual platforms and have significant potential benefit for quality of life and overall survivorship in this vulnerable group.

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Depression and Its Relationship with Coping Strategies and Illness Perceptions during the COVID-19 Lockdown in Greece: A Cross-Sectional Survey of the Population

Depression Research and Treatment ◽

10.1155/2020/3158954 ◽

2020 ◽

Vol 2020 ◽

pp. 1-11 ◽

Cited By ~ 2

Author(s):

Petros Skapinakis ◽

Stefanos Bellos ◽

Achilleas Oikonomou ◽

Georgios Dimitriadis ◽

Paschalis Gkikas ◽

...

Keyword(s):

Mental Health ◽

Depressive Symptoms ◽

Coping Strategies ◽

Illness Perceptions ◽

Illness Perception ◽

Personal Control ◽

Anxiety Symptoms ◽

Emotional Impact ◽

Cross Sectional Survey ◽

Brief Cope

Objective. The COVID-19 epidemic has shown a more benign course in Greece possibly due to the early lockdown measures. Mental health consequences of the lockdown however are unknown. In addition, illness perceptions and relevant strategies to cope with the stress of the epidemic may have played a role in complying with the restrictions. We conducted a survey of the Greek population with the aim to investigate the prevalence of anxiety and depression during the lockdown, the emotional impact of the epidemic, and the effect of coping strategies and illness perceptions in mental health. Methods. Adult persons were invited during the peak of the lockdown period through social media. Depressive and anxiety symptoms were assessed with the PHQ-9 and GAD-2 scales, respectively. Coping strategies were assessed with selected items of the Brief COPE questionnaire, while illness beliefs were assessed with items from the revised Illness Perception Questionnaire (IPQ-R). Results. A total of 3379 individuals took part. A strong emotional impact of the epidemic was more often in women and in those with severe financial difficulties. Levels of depressive and anxiety symptoms were high but similar to past assessments. Participants showed high levels of personal control and used more often positive strategies to cope with the stress of the epidemic. Depressive symptoms were higher in the younger, in students, in those with a stronger emotional impact, in those isolated due to symptoms, and those overexposed to media for COVID-19-related news. Lower levels of depression were seen in those using positive coping strategies and showing high levels of personal and treatment control. Conclusions. The study shows that certain psychological and social determinants were associated with increased depressive symptoms during the lockdown warranting the development of public health guidelines to mitigate the effects of the epidemic to the mental health of the population.

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Change and Impact of Illness Perceptions among Patients with Non-cardiac Chest Pain or Benign Palpitations Following Three Sessions of CBT

Behavioural and Cognitive Psychotherapy ◽

10.1017/s1352465813000179 ◽

2013 ◽

Vol 41 (4) ◽

pp. 398-407 ◽

Cited By ~ 22

Author(s):

Egil Jonsbu ◽

Egil W. Martinsen ◽

Gunnar Morken ◽

Torbjørn Moum ◽

Toril Dammen

Keyword(s):

Chest Pain ◽

Illness Perceptions ◽

Controlled Trial ◽

Illness Perception ◽

Intervention Group ◽

Personal Control ◽

Behavioural Therapy ◽

Control Group ◽

Long Term Treatment

Background: Many patients with non-cardiac chest pain or benign palpitations have poor prognosis in terms of symptom persistence, limitations in everyday activities, and reduced health-related quality of life (HRQOL). Aims: The aims of the study were to evaluate the changes and impact of illness perceptions during a three-session cognitive behavioural therapy (CBT) intervention for patients with non-cardiac chest pain or benign palpitations. Method: Patients with persistent complaints 6 months after a negative cardiac evaluation were invited to participate in a randomized controlled trial. Patients in the intervention group (n = 21) received three manualized sessions with CBT, including one physical activity exposure session; the control group (n = 19) received usual care from their general practitioner. Brief Illness Perception Questionnaire (BIPQ) was used to measure illness perceptions. Patients were assessed at start and end of the intervention and at 3- and 12-month follow-up. Results: The intervention and control group differed significantly on five of the eight items of BIPQ at least at one follow-up assessment. At end of treatment and at 3-month follow-up change in illness concern (Item 6 in BIPQ) mediated about 40% of the change in depression from baseline, and at 12-month follow-up about 50% of the change in depression was mediated by change in personal control (Item 3 in BIPQ). Conclusion: Illness perceptions measured with BIPQ may mediate the short and long term treatment effects of a three-session CBT-programme for patients with non-cardiac chest pain and benign palpitations.

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Illness Perceptions; Mediators and/or Moderators in Disabling Persistent Low Back Pain? A Multiple Baseline Single-Case Experimental Design

10.21203/rs.3.rs-145891/v1 ◽

2021 ◽

Author(s):

Edwin Raaij ◽

Harriet Wittink ◽

Francois maissan ◽

Jos Twisk ◽

Raymond Ostelo

Keyword(s):

Low Back Pain ◽

Back Pain ◽

Experimental Design ◽

Repeated Measures ◽

Illness Perceptions ◽

Single Case ◽

Personal Control ◽

Low Back ◽

Physiotherapy Treatment

Abstract IntroductionIllness Perceptions (IPs) may be important in the management of persistent low back pain. The mediation and/or moderation effect of IPs on primary outcomes in physiotherapy treatment is unknown. MethodsA multiple single-case experimental design, using a matched care physiothetapy intervention, with 3 phases (phases A-B-A’) was used including a 3-month follow up (phase A’). Primary outcomes: pain intensity, physical functioning and pain interference in daily life. Analyzes: linear mixed models, adjusted for fear of movement, catastrophizing, avoidance, sombreness and sleep. ResultsNine patients were included by six different primary care physiotherapists. Repeated measures on 196 data points showed that IPs Consequences, Personal control, Identity, Concern and Emotional response had a mediation effect on all three primary outcomes. The IP Personal control acted as a moderator for all primary outcomes, with clinically relevant improvements at 3-month follow up.ConclusionThis is the first study to shed some light in the mediating effects of IPs on the outcome of a matched care physiotherapy treatment. At baseline, assessing Personal control is relevant to determine the outcome prognosis of successful physiotherapy management of persistent low back pain.

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Does transcranial direct current stimulation affect selective visual attention in children with left-sided infantile hemiplegia? A randomized, controlled pilot study

Brain Impairment ◽

10.1017/brimp.2020.20 ◽

2020 ◽

pp. 1-13

Author(s):

Raed A. Alharbi ◽

Saleh A. Aloyuni ◽

Faizan Kashoo ◽

Mohamed I. Waly ◽

Harpreet Singh ◽

...

Keyword(s):

Pilot Study ◽

Direct Current ◽

Transcranial Direct Current Stimulation ◽

Repeated Measures ◽

Sham Group ◽

Time Points ◽

Selective Visual Attention ◽

Subject Factor ◽

And Control

Abstract Objective: Infantile hemiplegia due to brain injury is associated with poor attention span, which critically affects the learning and acquisition of new skills, especially among children with left-sided infantile hemiplegia (LSIH). This study aimed to improve the selective visual attention (SVA) of children with LSIH through transcranial direct current stimulation (tDCS). Methods: A total of 15 children participated in this randomized, double-blinded, pilot study; of them, 10 experienced LSIH, and the remaining 5 were healthy age-matched controls. All the children performed the Computerized Stroop Color-Word Test (CSCWT) at baseline, during the 5th and 10th treatment sessions, and at follow-up. The experimental (n = 5) and control groups (n = 5) received tDCS, while the sham group (n = 5) received placebo tDCS. All three groups received cognitive training on alternate days, for 3 weeks, with the aim to improve SVA. Results: Two-way repeated measures analysis of variance (ANOVA) showed a statistically significant change in the mean scores of CSCWT between time points (baseline, 5th and 10th sessions, and follow-up) within-subject factor, group (experimental, sham) between-subject factor and interaction (time points X group) (p < 0.005). Furthermore, a one-way repeated measures ANOVA showed significant differences between time point (p < 0.005) for the experimental and control group but not the sham group. Conclusion: These pilot results suggest that future research should be conducted with adequate samples to enable conclusions to be drawn.

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Association of FKBP5 genotype with depressive symptoms in patients with coronary heart disease: a prospective study

Journal of Neural Transmission ◽

10.1007/s00702-020-02243-6 ◽

2020 ◽

Vol 127 (12) ◽

pp. 1651-1662

Author(s):

Julia Brandt ◽

Katharina Warnke ◽

Silke Jörgens ◽

Volker Arolt ◽

Katja Beer ◽

...

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Depressive Symptoms ◽

Coronary Revascularization ◽

Central Element ◽

Depression Scale ◽

Stress System ◽

Linear Regression Models ◽

A Prospective Study

AbstractDepression and coronary heart disease (CHD) are prevalent and often co-occurring disorders. Both have been associated with a dysregulated stress system. As a central element of the stress system, the FKBP5 gene has been shown to be associated with depression. In a prospective design, this study aims to investigate the association of FKBP5 with depressive symptoms in CHD patients. N = 268 hospitalized CHD patients were included. Depressive symptoms were measured using the Hospital Anxiety and Depression Scale (HADS-D) at four time points (baseline, and after 1 month, 6 months, and 12 months). The functional FKBP5 single-nucleotide polymorphism (SNP) rs1360780 was selected for genotyping. Linear regression models showed that a higher number of FKBP5 C alleles was associated with more depressive symptoms in CHD patients both at baseline (p = 0.015) and at 12-months follow-up (p = 0.025) after adjustment for confounders. Further analyses revealed that this effect was driven by an interaction of FKBP5 genotype with patients’ prior CHD course. Specifically, only in patients with a prior myocardial infarction or coronary revascularization, more depressive symptoms were associated with a higher number of C alleles (baseline: p = 0.046; 1-month: p = 0.026; 6-months: p = 0.028). Moreover, a higher number of C alleles was significantly related to a greater risk for dyslipidemia (p = .016). Our results point to a relevance of FKBP5 in the association of the two stress-related diseases depression and CHD.

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Post-surgical depressive symptoms and long-term survival in non-metastatic breast cancer patients at 11-year follow-up

General Hospital Psychiatry ◽

10.1016/j.genhosppsych.2016.10.002 ◽

2017 ◽

Vol 44 ◽

pp. 16-21 ◽

Cited By ~ 16

Author(s):

Michael H. Antoni ◽

Jamie M. Jacobs ◽

Laura C. Bouchard ◽

Suzanne C. Lechner ◽

Devika R. Jutagir ◽

...

Keyword(s):

Breast Cancer ◽

Metastatic Breast Cancer ◽

Depressive Symptoms ◽

Cancer Patients ◽

Metastatic Breast ◽

Breast Cancer Patients ◽

Term Survival ◽

Long Term Survival

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Prospective association between adherence to dietary recommendations and incident depressive symptoms in the French NutriNet-Santé cohort

British Journal Of Nutrition ◽

10.1017/s0007114518000910 ◽

2018 ◽

Vol 120 (3) ◽

pp. 290-300 ◽

Cited By ~ 6

Author(s):

Moufidath Adjibade ◽

Cédric Lemogne ◽

Chantal Julia ◽

Serge Hercberg ◽

Pilar Galan ◽

...

Keyword(s):

Depressive Symptoms ◽

Depression Scale ◽

Healthy Eating Index ◽

Continuous Variables ◽

Dietary Recommendations ◽

Nutritional Recommendations ◽

Dietary Record ◽

Prospective Association ◽

Incident Cases

AbstractA posteriorihealthier dietary patterns and several nutrients have been associated with lower risks of depression in various studies; however, evidence is lacking with regard to the prospective association between adherence to nutritional recommendations (food-based and nutrient-based recommendations) and incident depression or depressive symptoms. In this study, we investigate such associations in the NutriNet Santé cohort. The study sample included 26 225 participants (aged 18–86 years) who were initially free of depressive symptoms. Adherence to nutritional recommendations was measured by four scores namely modified French Programme National Nutrition Santé-Guideline Score (mPNNS-GS), Alternative Healthy Eating Index-2010 (AHEI-2010), Probability of Adequate Nutrient Intake Dietary Score (PANDiet) and Diet Quality Index-International (DQI-I), using non-consecutive dietary record data during the first 2 years of follow-up (mean number of recording days=8,sd2). Depressive symptoms were defined by a Center for Epidemiologic Studies Depression Scale (CES-D) score ≥17 for men and ≥23 for women. We used Cox proportional hazards models to estimate hazard ratios and 95 % CI, modelling the dietary scores as standardised continuous variables and as tertiles. Over a mean follow-up of 6 years, we identified 2166 incident cases of depressive symptoms. All dietary scores with the exception of the AHEI-2010 were significantly inversely associated with incident depressive symptoms. In the fully adjusted model, an increase of 1sdin the mPNNS-GS, PANDiet and DQI-I was, respectively, associated with an 8 % (95 % CI 4, 13), 5 % (95 % CI 1, 9) and 9 % (95 % CI 5, 13) reduction in the risk of depressive symptoms. Overall, these findings suggest that diet in accordance with national or international guidelines could have beneficial effects with regard to mental health.

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