scholarly journals Effect of Adherence to Physical Exercise on Cardiometabolic Profile in Postmenopausal Women

2021 ◽  
Vol 18 (2) ◽  
pp. 656
Author(s):  
Valentina Bucciarelli ◽  
Francesco Bianco ◽  
Francesco Mucedola ◽  
Andrea Di Blasio ◽  
Pascal Izzicupo ◽  
...  
Keyword(s):  
Physical Exercise ◽  
Diastolic Function ◽  
Postmenopausal Women ◽  
Serum Glucose ◽  
Moderate Intensity ◽  
Adherence Rate ◽  
Before And After ◽  
Estrogen Depletion ◽  
The Impact ◽  
Cardiometabolic Profile

Background: Menopause is associated with negative cardiovascular adaptations related to estrogen depletion, which could be counteracted by physical exercise (PhE). However, the impact of total adherence-rate (TA) to PhE and sedentary time (SedT) on cardiometabolic profile in this population has not been elucidated. Methods: For 13-weeks, 43 women (57.1 ± 4.7 years) participated in a 4-days-a-week moderate-intensity walking training. They underwent laboratory, anthropometric and echocardiographic assessment, before and after training (T0–T1). Spontaneous physical activity (PhA) was assessed with a portable multisensory device. The sample was divided according to TA to PhE program: <70% (n = 17) and ≥70% (n = 26). Results: TA ≥ 70% group experienced a significant T1 improvement of relative wall thickness (RWT), diastolic function, VO2max, cortisol, cortisol/dehydroandrostenedione-sulphate ratio and serum glucose. After adjusting for SedT and 10-min bouts of spontaneous moderate-to-vigorous PhA, TA ≥ 70% showed the most significant absolute change of RWT and diastolic function, body mass index, weight and cortisol. TA ≥ 70% was major predictor of RWT and cortisol improvement. Conclusions: In a group of untrained, postmenopausal women, a high TA to a 13-weeks aerobic PhE program confers a better improvement in cardiometabolic profile, regardless of SedT and PhA levels.

scholarly journals Plasma BCAA concentrations during exercise of varied intensities in young healthy men—the impact of endurance training

PeerJ ◽  
2020 ◽  
Vol 8 ◽  
pp. e10491
Author(s):  
Anna Gawedzka ◽  
Marcin Grandys ◽  
Krzysztof Duda ◽  
Justyna Zapart-Bukowska ◽  
Jerzy A. Zoladz ◽  
...  
Keyword(s):  
Amino Acids ◽  
Endurance Training ◽  
Exercise Intensity ◽  
Energy Homeostasis ◽  
Lactate Concentration ◽  
Incremental Exercise ◽  
Moderate Intensity ◽  
Healthy Men ◽  
Before And After ◽  
The Impact

Background Branched-chain amino acids (BCAA) i.e., leucine (Leu), isoleucine (Ile) and valine (Val) are important amino acids, which metabolism play a role in maintaining system energy homeostasis at rest and during exercise. As recently shown lowering of circulating BCAA level improves insulin sensitivity and cardiac metabolic health. However, little is known concerning the impact of a single bout of incremental exercise and physical training on the changes in blood BCAA. The present study aimed to determine the impact of a gradually increasing exercise intensity—up to maximal oxygen uptake (VO2max) on the changes of the plasma BCAA [∑BCAA]pl, before and after 5-weeks of moderate-intensity endurance training (ET). Methods Ten healthy young, untrained men performed an incremental cycling exercise test up to exhaustion to reach VO2max, before and after ET. Results We have found that exercise of low-to-moderate intensity (up to ∼50% of VO2max lasting about 12 min) had no significant effect on the [∑BCAA]pl, however the exercise of higher intensity (above 70% of VO2max lasting about 10 min) resulted in a pronounced decrease (p < 0.05) in [∑BCAA]pl. The lowering of plasma BCAA when performing exercise of higher intensity was preceded by a significant increase in plasma lactate concentration, showing that a significant attenuation of BCAA during incremental exercise coincides with exercise-induced acceleration of glycogen utilization. In addition, endurance training, which significantly increased power generating capabilities at VO2max (p = 0.004) had no significant impact on the changes of [∑BCAA]pl during this incremental exercise. Conclusion We have concluded that an exercise of moderate intensity of relatively short duration generally has no effect on the [∑BCAA]pl in young, healthy men, whereas significant decrease in [∑BCAA]pl occurs when performing exercise in heavy-intensity domain. The impact of exercise intensity on the plasma BCAA concentration seems to be especially important for patients with cardiometabolic risk undertaken cardiac rehabilitation or recreational activity.

scholarly journals Impact of a Tailored Nutritional and Physical Exercise Programme on Efficacy and Functional Outcomes in Older Patients with Hematological Malignancies Classified By Frailty Profile

Blood ◽  
2019 ◽  
Vol 134 (Supplement_1) ◽  
pp. 3424-3424
Author(s):  
Maite Antonio ◽  
Montserrat Arnan Sangerman ◽  
Eva Domingo-Domenech ◽  
Eva González-Barca ◽  
Casimiro Javierre ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Exercise ◽  
Older Patients ◽  
Nutritional Support ◽  
Hematological Malignancies ◽  
Moderate Intensity ◽  
Control Group ◽  
Chi Square ◽  
Before And After

BACKGROUND As the result of population aging, hematologists increasingly face the challenge of effectively managing older adults with oncological diseases. The heterogeneity of the aging process means that chronological age does not serve as a pivotal variable on which the clinical or treatment decisions are based. To improve outcomes in older population it is critical to select treatment considering patients' frailty profile and patients' needs to ensure they complete the treatment proposedComprehensive geriatric assessment (CGA) is a gold-standard multidimensional tool to characterize older patients according to their biological frailty profile. CGA identifies patient- and condition-related factors that might be potentially reversible through subsequent clinical interventions Older patient may present some degree of physical decline during the treatment due to variables related to the disease itself and/or to the treatment. This can lead to an accelerated decline from aging, affect their functional independence, their quality of life, and their ability to complete the treatment There is evidence that nutritional support and physical exercise during and after oncological treatments provides benefits in muscular and aerobic condition, quality of life, fatigue and adherence to treatment. But data on hematological patient, usually treated with more intensive schemes associated with a higher incidence of cytopenia and fatigue is scarce ENDPOINT - PRIMARY To determine the impact of an individualized geriatric intervention program of physical exercise and nutritional support on adherence to planned oncological treatment in patients ≥ 70 years with hematological malignancies - SECONDARY Analyze the relation between CGA and aging biomarkersEvaluate adherence to the intervention programDetermine the rate of completion and causes for non-completion of treatmentMeasure at the beginning and end of intervention, and 6 months after treatment completion: The program's effect on physical condition parametersChanges in functional capacity: basic and instrumental activities of daily lifeLevels of fatigueQuality of lifeDetermine the incidence and degree of severity of toxicityDetermine treatment response parameters: time to treatment failure and to progression, disease-free, overall and cancer-specific survival METHODS DESIGN Prospective clinical trial, randomized, parallel and open groupsSETTING Comprehensive cancer centerINCLUSION CRITERIA Histopathological diagnosis of hematological malignancies: multiple myeloma, lymphoproliferative syndromes and myelodisplastic syndromesPatients who meet criteria for medical treatment: chemotherapy, radiotherapy, immunotherapy or targeted therapiesPatients in optimal conditions to perform moderate intensity physical exercise (responsible doctor's judgement)Signature of informed consentEXCLUSION CRITERIA Failure to meet any of the inclusion criteria.INTERVENTION All patients will be assessed through a CGA. The intervention group will received the standard treatment according to the clinical protocol of the institution and will participate in a program of personalized physical exercise and nutritional support. The control group will be treated in a standard manner according to the institution's clinical protocolRANDOMIZATION Subjects will be assigned a 1.1 ratio to one of the groups using a simple randomisation methodMAIN VARIABLE: rate of treatment compliance (relationship between the prescribed dose and the dose administered)SECONDARY VARIABLES: CGA scales, aging biomarkers, nutritional parameters and basal body composition before and after the intervention, quality of life before and after the intervention, toxicity and complications during treatment and response to treatment.STATISTICAL ANALYSIS The comparability of the components of the intervention and control group will be analyzed by Chi square test (qualitative variables) and Student's t test and Wilcoxson test (quantitative variables). The analysis of the intervention will be carried out according to the intention of treatment. The main variable will be analyzed by comparison test of chi-square proportions and confidence intervals will be calculated. The variable will be measured at the end of the intervention, according to the degree of compliance with the nutritional and physical exercise program. Disclosures Domingo-Domenech: Takeda: Consultancy, Membership on an entity's Board of Directors or advisory committees, Other: Travel expenses; Seattle Genetics: Research Funding; Bristol-Myers Squibb: Other: Travel expenses; Roche: Other: Travel expenses. González-Barca:Kiowa: Consultancy; Roche: Consultancy, Honoraria; Celgene: Consultancy; Celtrion: Consultancy; AbbVie: Consultancy, Honoraria; Janssen: Consultancy, Honoraria; Takeda: Honoraria. Sureda:Roche: Honoraria; BMS: Consultancy, Honoraria; Novartis: Consultancy, Honoraria; Janssen: Consultancy, Honoraria; Gilead: Consultancy; Sanofi: Consultancy, Honoraria; Takeda: Consultancy, Honoraria, Speakers Bureau.

scholarly journals KADAR KALIUM SERUM PADA LATIHAN FISIK INTENSITAS SEDANG MAHASISWA FAKULTAS KEDOKTERAN UNIVERSITAS SAM RATULANGI

2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Dewa Agung Brihaspati Raj ◽  
Youla A. Assa ◽  
Murniati Tiho
Keyword(s):  
Heart Rate ◽  
Physical Exercise ◽  
Serum Potassium ◽  
Potassium Level ◽  
Wilcoxon Test ◽  
Moderate Intensity ◽  
Extracellular Potassium ◽  
Moderate Intensity Exercise ◽  
Purposive Sampling ◽  
Before And After

Abstract: Excessive body heat while doing physical exercise will be excreted by sweating. Potassium is one of the electrolyte compounds incorporated and washed away together with sweat. In turn, the excessive lost of potassium in sweat can decrease the concentration of extracellular potassium level. Physical exercise can also lead to an increase in serum potassium concentration. The present study was aimed to determine the differences of potassium level before and after physical exercise at moderate intensity at students year 2010 Faculty of Medicine Sam Ratulangi University. Thirty students (27 men and 3 women) were involved in the present pre-experimental study designed with pretest-posttest. Samples were colected using purposive sampling method and analyzed further using wilcoxon test. Data was collected by determine the serum potassium levels before and after moderate intensity physical exercise. Exercise is done in the form of fast walking on a treadmill to maintain heart rate target 64-76 % of maximum heart rate (200 - age) for 30 minutes. The result showed that the average of serum potassium levels before moderate intensity exercise was 4,253±0,3683 mEq/L, and the average of serum potassium levels after moderate intensity exercise was 4,363±0,3908 mEq/L. Wilcoxon test significance values ​​in this study were p=0.110  (p>0,05). It can be concluded that there was no difference of potassium level before and after physical exercise at moderate intensity at students year 2010 Faculty of Medicine Sam Ratulangi University. Keywords: Potassium, Exercise, Moderate intensity.   Abstrak: Kelebihan panas tubuh saat melakukan latihan fisik akan dikeluarkan melalui keringat. Kalium merupakan salah satu elektolit yang terkandung dan dapat keluar bersama keringat. Kehilangan kalium yang berlebihan melalui keringat saat melakukan latihan fisik dapat menyebabkan penurunan konsentrasi kalium di dalam serum. Latihan fisik juga dapat menyebabkan peningkatan konsentrasi kalium. Penelitian ini bertujuan untuk mengetahui perubahan kadar kalium serum sebelum dan sesudah latihan fisik intensitas sedang pada mahasiswa Fakultas Kedokteran angkatan 2010 Universitas Sam Ratulangi. Penelitian ini merupakan penelitian pre-eksperimental dengan pretest-posttest design, dengan jumlah responden 30 mahasiswa (27 laki-laki dan 3 perempuan). Sampel dikumpulkan menggunakan metode purposive sampling dan dianalisis menggunakan uji Wilcoxon. Data dikumpulkan dengan menentukan kadar kalium serum sebelum dan sesudah melakukan latihan fisik intensitas sedang. Latihan fisik yang dilakukan berupa berjalan cepat di atas treadmill dengan mempertahankan target heart rate 64-76% dari heart rate maksimal (200-umur) selama 30 menit. Hasil yang diperoleh menunjukkan bahwa rata-rata kadar kalium serum sebelum melakukan latihan fisik intensitas sedang ialah 4,253±0,3683 mEq/L, dan rata-rata kadar kalium serum sesudah melakukan latihan fisik intensitas sedang ialah 4,363±0,3908 mEq/L. Nilai signifikansi uji Wilcoxon pada penelitian ini ialah p=0,110 (p>0,05). Dapat disimpulkan bahwa tidak terdapat perbedaan yang signifikan antara kadar kalium serum sebelum dan sesudah latihan fisik intensitas sedang pada mahasiswa angkatan 2010 Fakultas Kedokteran Universitas Sam Ratulangi. Kata kunci: Kalium, Latihan fisik, Intensitas sedang.

Effect of Aerobic Walking Exercise on Stress Urinary Incontinence in Postmenopausal Women

2021 ◽  
pp. 1-7
Author(s):  
Asmaa M. Elbandrawy ◽  
Sara G. Mahmoud ◽  
Mohamed F. AboElinin ◽  
Amel M. Yousef
Keyword(s):  
Urinary Incontinence ◽  
Stress Urinary Incontinence ◽  
Training Program ◽  
Postmenopausal Women ◽  
Pelvic Floor Muscle ◽  
Care Group ◽  
Before And After ◽  
Walking Exercise ◽  
The Impact ◽  
Pfm Strength

The purpose of this study was to explore the impact of aerobic walking exercise on stress urinary incontinence (SUI) among postmenopausal women. Thirty females diagnosed with SUI participated in the research. Participants were assigned randomly into two groups: The usual care group (UC) and the UC plus aerobic walking exercise (TMT) group. The UC group performed pelvic floor muscle (PFM) training only, while the TMT group performed PFM training in addition to aerobic exercise. Myomed biofeedback was used to assess the PFM strength both before and after a 12-week period. The Revised Urinary Incontinence Scale was utilized to assess changes in incontinence severity symptoms after intervention. Findings revealed a significant increase in PFM strength in both UC and TMT groups (p = .011 and p = .010, respectively) and a significant reduction in their Revised Urinary Incontinence Scale (p = .011 and p = .001, respectively) after the end of the 12 weeks of the training program. In addition, there was a more significant increase in PFM strength in the TMT group than in the UC group (p = .010) and a more significant decrease in Revised Urinary Incontinence Scale (p = .011) after 12 weeks of the training program. This study concluded that aerobic walking exercise with PFM training is more effective than PFM training only in increasing PFM strength and improving symptoms of SUI in postmenopausal women with SUI.

Correlation between the rate of weight loss and changes in body composition in obese postmenopausal women after 5 weeks: a pilot study

2008 ◽  
Vol 33 (2) ◽  
pp. 347-355 ◽  
Author(s):  
Hélène Arguin ◽  
Danielle R. Bouchard ◽  
Mélissa Labonté ◽  
André Carpentier ◽  
Jean-Luc Ardilouze ◽  
...  
Keyword(s):  
Weight Loss ◽  
Body Composition ◽  
Postmenopausal Women ◽  
Weight Loss Intervention ◽  
Obese Women ◽  
X Ray ◽  
Before And After ◽  
The Impact ◽  
Current Guidelines ◽  
Similar Decrease

Approximately 25% of weight lost during restrictive diets (without exercise) is lean body mass (LBM). No study has yet investigated the impact of the rate of weight loss (RWL) on LBM and fat mass (FM). The purpose of this study was to investigate the relationships between the RWL and body composition in older obese women. Twenty obese postmenopausal women aged between 51 and 74 years enrolled in a 5 week dietary weight loss intervention. Subjects were characterized according to their RWL (low RWL < 0.74 kg·week–1 (n = 9) vs. high RWL ≥ 0.74 kg·week–1 (n = 11)). Total and trunk FM and LBM (by dual-energy X-ray absorptiometry) were measured before and after weight loss. A significant correlation was observed between the RWL (kg·week–1) and changes in LBM (kg·week–1) (r = 0.75; p = 0.0002). However, no association was observed with changes in FM (kg·week–1) (r = 0.40; p = 0.08). Both groups showed a similar decrease in FM (low RWL, –2.7 ± 0.9 kg,; high RWL, –3.2 ± 0.8 kg; p = 0.38), whereas losses in LBM were significantly higher in the high RWL than in the low RWL group (–1.6 ± 1.2 kg vs. –0.4 ± 1.1 kg; p = 0.05). An RWL > 0.74 kg·week–1 was associated with a greater loss of LBM, but had no extra benefits on FM after a 5 week weight loss program. Current guidelines, which recommend RWL up to 0.91 kg·week–1, might not be optimal to prevent decreases in LBM in postmenopausal women when no exercise is added.

scholarly journals Multicomponent Exercise Improves Physical Functioning but Not Cognition and Hemodynamic Parameters in Elderly Osteoarthritis Patients Regardless of Hypertension

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Hélio José Coelho-Júnior ◽  
Ivan de Oliveira Gonçalvez ◽  
Iris Callado Sanches ◽  
Leandro Gonçalves ◽  
Erico Chagas Caperuto ◽  
...  
Keyword(s):  
Physical Functioning ◽  
Walking Speed ◽  
Exercise Program ◽  
The Other ◽  
Moderate Intensity ◽  
Hemodynamic Parameters ◽  
Physical Exercises ◽  
Before And After ◽  
Walking Speeds ◽  
The Impact

The present study aimed to investigate the impact of a 6-month multicomponent exercise program (MCEP) on physical function, cognition, and hemodynamic parameters of elderly normotensive (NTS) and hypertensive (HTS) osteoarthritis patients. A total of 99 elderly osteoarthritis patients (44 NTS and 55 HTS) were recruited and submitted to functional, cognitive, and hemodynamic evaluations before and after six months of a MCEP. The program of exercise was performed twice a week at moderate intensity. The physical exercises aggregated functional and walking exercises. Results indicate that 6 months of MCEP were able to improve one-leg stand and mobility (walking speeds) of osteoarthritis patients regardless of hypertension. On the other hand, cognitive and hemodynamic parameters were not altered after the MCEP. The findings of the present study demonstrate that 6 months of MCEP were able to improve the physical functioning (i.e., usual and maximal walking speed and balance) of osteoarthritis patients regardless of hypertensive condition.

scholarly journals Pengaruh latihan fisik akut terhadap kadar protein urin pada mahasiswa angkatan 2015 Fakultas Kedokteran Universitas Sam Ratulangi

2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Paul Y. Limuria ◽  
Hedison Polii ◽  
Vanda D. Doda
Keyword(s):  
Physical Exercise ◽  
The Body ◽  
Urinary Protein ◽  
Urine Protein ◽  
Medical Practitioners ◽  
Protein Levels ◽  
Before And After ◽  
Renal Tubular ◽  
Acute Physical Exercise ◽  
The Impact

Abstract: Acute physical exercise is an exercise that is performed in a short time, it was performed only for a few minutes or <30 minutes. Physical exercise will cause some changes in the body, such as increased levels of urinary protein. Increased levels of urinary protein generally occurs in people with kidney disease, so that medical practitioners are often mistaken about this. This is because when doing physical exercise occurs decreases blood flow to the kidneys and cause disruption of glomerular and renal tubular function. This situation is not dangerous because it is only temporary, and reversible. In the previous studies, there is still controversy about the effect of acute physical exercise on levels of urinary protein. Based on that, researchers interested to know the impact of acute physical exercise kinds of anaerobic (sprint) towards levels of urinary protein. This study used an experimental design on one group pre-post test. Subjects were 30 male students who are in the Faculty of Medicine Sam Ratulangi. Urine protein levels assessed before and after sprint. The results obtained were processed using Wilcoxon Signed Ranks test. On the results, there was a significant increase of urinary protein (p = 0,00) after performing an acute physical exerise (sprint).Keywords: urine protein, acute physical exercise, studentAbstrak: Latihan fisik akut adalah latihan yang dilakukan dalam waktu yang singkat, sekitar beberapa menit atau <30 menit. Latihan fisik akan menyebabkan beberapa perubahan dalam tubuh, seperti peningkatan kadar protein urin. Peningkatan kadar protein urin umumnya terjadi pada orang dengan penyakit ginjal, sehingga tenaga kesehatan sering keliru akan hal ini. Peningkatan kadar protein urin terjadi karena pada saat melakukan latihan fisik aliran darah menuju ginjal berkurang dan menyebabkan terganggunya fungsi glomerulus dan tubulus ginjal. Keadaan ini tidak berbahaya karena hanya bersifat sementara, dan reversibel. Pada penelitian-penelitian sebelumnya masih terdapat kontroversi tentang pengaruh latihan fisik akut terhadap kadar protein urin. Hal ini membuat peneliti tertarik untuk mengetahui pengaruh latihan fisik akut jenis anaerobik (sprint) terhadap kadar protein urin. Penelitian ini menggunakan desain penelitian eksperimental dengan rancangan pre-post one group test. Subjek berjumlah 30 orang mahasiswa laki-laki yang berada di fakultas kedokteran universitas sam ratulangi. Kadar protein urin dinilai terlebih dahulu sebelum melakukan sprint, setelah melakukan sprint kadar protein urin dinilai kembali. Hasil yang didapatkan diolah dengan menggunakan uji Wilcoxon Signed Ranks. Pada hasil penelitian didapatkan peningkatan yang signifikan (p = 0,00) kadar protein urin setelah melakukan latihan fisik akut (sprint).Kata kunci: protein urin, latihan fisik akut, mahasiswa

scholarly journals Assessment of Hepatic and Lipid Profiles Following 12 Weeks of Aerobic Exercise in Overweight Postmenopausal Women

2018 ◽  
Vol 3 (4) ◽  
pp. 159-167 ◽  
Author(s):  
Bakhtyar Tartibian ◽  
Abbas Malandish ◽  
Roghaiyeh Afsargharehbagh ◽  
Rasoul Eslami ◽  
Zeinab Sheikhlou
Keyword(s):  
Liver Function ◽  
Aerobic Exercise ◽  
Postmenopausal Women ◽  
Serum Levels ◽  
Lipid Profiles ◽  
Moderate Intensity ◽  
Time To Exhaustion ◽  
Hepatic Enzymes ◽  
Overweight Women ◽  
The Impact

Introduction: The impact of aerobic training on liver function by modulating hepatic enzymes and lipid profiles in overweight women is uncertain. The aim of our study was to examine the impact of 12-week aerobic exercise training on hepatic and lipid profiles and cardiorespiratory indices in overweight women aged over 50 years.Methods: Thirty sedentary and overweight postmenopausal women (PMW) over 50 years old were randomly divided into 2 groups: exercise (Ex, n=15) and control (C, n=15) groups. The Ex group performed moderate-intensity aerobic exercise (60 min/d, 3 days/week at 65%-70% of maximal heart rate reserve [HRmax]) for 12 weeks. The C group participated in no intervention during a 3-month period and maintained their normal daily lifestyle. The serum levels of hepatic and lipid profiles were assessed at baseline and after week 12. Descriptive and inferential (ANCOVA test) statistics were used to analyze the data using SPSS software version 23.0 at a significance level of P < 0.05. Results: After 12 weeks of exercise intervention, the serum levels of hepatic and lipid profiles were not significantly different in the Ex group compared to the C group (P > 0.05). However, maximal oxygen uptake (VO2max), walking-jogging time to exhaustion (WJTE), and alkaline phosphatase (ALP) significantly increased in the Ex group (P < 0.05). In contrast, systolic blood pressure (SBP) significantly decreased in the Ex group (P < 0.05). Conclusion: The results demonstrated that 12-week moderate-intensity aerobic exercise (jogging and walking) at 65%-70% of HRmax did not affect the liver function without modulating hepatic enzymes and lipid profiles in overweight women over 50 years old, whereas cardiorespiratory fitness (CRF) by modulating VO2max, WJTE, and SBP was improved.

scholarly journals THE SIMILAR CHANGES OF GLUCOSE LEVELS BEFORE AND AFTER MODERATE INTENSITY EXERCISE ACUTELY IN THE MORNING AND NIGHT

2020 ◽  
Vol 30 (2) ◽  
pp. 45
Author(s):  
Ronik Harsono Kamal ◽  
Kristanti Wanito Wigati ◽  
Achmad Lefi
Keyword(s):  
Blood Glucose ◽  
Physical Exercise ◽  
Asia Pacific ◽  
Moderate Intensity ◽  
Maximum Heart Rate ◽  
Moderate Intensity Exercise ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Before And After ◽  
The Mean

Background: There is a lot of research on the importance of exercise but studies on the effective time of exercise regarding regulation of blood glucose levels are not clearly known. Objective: This study aims to determine the comparison of changes in blood glucose levels before and after moderate intensity physical exercise in the morning and night. Material and method: Healthy men (n=34), Age between 17-22 years, Body Mass Index (BMI) between 18.5-22.9 kg/m2 (normal Asia Pacific), participating in the morning group (8.00 am) or the night group (20.00 pm) are asked to do moderate intensity physical exercise (55-70% of maximum heart rate) using ergocycle for a total of 40 minutes. Blood glucose levels 2 hours post prandial capillaries are taken before exercise and blood glucose levels after exercise are taken acutely. Result: The mean decrease in blood glucose levels in the morning group was -8.353±9.16 mg/dL and in the night group was -6.294±10.10 mg/dL. Blood glucose levels decreased significantly for the morning group (p=0.002) and the night group (p=0.021). The comparison of changes in blood glucose levels between the morning and night groups was not significant (p=0.538). Conclusion: There is no difference between morning or night exercise related to changes in blood glucose levels.

Impact of Oral Chemotherapy Management Program on Capecitabine Toxicity Management

2021 ◽  
pp. OP.20.00947
Author(s):  
Salin Nhean ◽  
Diana Kostoff ◽  
Jessica J. Yang ◽  
Vishnuprabha Vogel ◽  
Igor I. Rybkin
Keyword(s):  
Medication Adherence ◽  
Management Program ◽  
Oral Chemotherapy ◽  
Adherence Rate ◽  
Before And After ◽  
Henry Ford ◽  
Quasi Experimental ◽  
Ed Visits ◽  
Grade 3 ◽  
The Impact

PURPOSE: Increasing use of oral chemotherapy has created unique challenges related to patient safety and compliance. To address this issue, the Henry Ford Cancer Institute at Henry Ford Health System developed and implemented a system-wide, multidisciplinary program named the Oral Chemotherapy Management Program (OCMP). The purpose of this study was to evaluate the impact of OCMP on patient outcomes in those receiving capecitabine. METHODS: This was a retrospective, quasi-experimental study that compared outcomes in patients receiving capecitabine before and after OCMP implementation. The co-primary outcomes were incidence(s) of grade 1-4 and grade 3-4 adverse effects (AEs) associated with capecitabine. Secondary outcomes were emergency department (ED) visits, hospitalizations because of toxicity, and adherence rate. RESULTS: OCMP patients had significantly lower overall incidence of AE of any grade (58.9% v 70.3%; 95% CI, 0.39 to 0.94; P = .03). OCMP implementation significantly lowered incidence of any grade and grade 3-4 nausea, vomiting, and/or diarrhea, and grade 3-4 hand-foot syndrome. It resulted in the decreased number of ED visits (8.9% v 18.9%; P = .005) and hospitalizations (6.3% v 17.1%; P = .002), as well as improved medication adherence rates (0.94 v 0.97; P = .03). CONCLUSION: Most patients who developed capecitabine-related AE required intervention by OCMP. Implementation of OCMP reduced the incidence of high-grade AE, decreased the number of ED visits and hospitalizations because of AE, and improved the medication adherence rate.

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