scholarly journals Is a Mask That Covers the Mouth and Nose Free from Undesirable Side Effects in Everyday Use and Free of Potential Hazards?

2021 ◽  
Vol 18 (8) ◽  
pp. 4344
Author(s):  
Kai Kisielinski ◽  
Paul Giboni ◽  
Andreas Prescher ◽  
Bernd Klosterhalfen ◽  
David Graessel ◽  
...  
Keyword(s):  
Side Effects ◽  
Temperature Rise ◽  
Experimental Studies ◽  
Public Spaces ◽  
Respiratory Physiology ◽  
Comprehensive Investigation ◽  
Respiratory Impairment ◽  
Adverse Health Effects ◽  
Physical Deterioration ◽  
Multiple Symptoms

Many countries introduced the requirement to wear masks in public spaces for containing SARS-CoV-2 making it commonplace in 2020. Up until now, there has been no comprehensive investigation as to the adverse health effects masks can cause. The aim was to find, test, evaluate and compile scientifically proven related side effects of wearing masks. For a quantitative evaluation, 44 mostly experimental studies were referenced, and for a substantive evaluation, 65 publications were found. The literature revealed relevant adverse effects of masks in numerous disciplines. In this paper, we refer to the psychological and physical deterioration as well as multiple symptoms described because of their consistent, recurrent and uniform presentation from different disciplines as a Mask-Induced Exhaustion Syndrome (MIES). We objectified evaluation evidenced changes in respiratory physiology of mask wearers with significant correlation of O2 drop and fatigue (p < 0.05), a clustered co-occurrence of respiratory impairment and O2 drop (67%), N95 mask and CO2 rise (82%), N95 mask and O2 drop (72%), N95 mask and headache (60%), respiratory impairment and temperature rise (88%), but also temperature rise and moisture (100%) under the masks. Extended mask-wearing by the general population could lead to relevant effects and consequences in many medical fields.

scholarly journals Toxic Animal-Based Medicinal Materials Can Be Effective in Treating Endometriosis: A Scoping Review

Toxins ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 145
Author(s):  
Su-In Hwang ◽  
Young-Jin Yoon ◽  
Soo-Hyun Sung ◽  
Ki-Tae Ha ◽  
Jang-Kyung Park
Keyword(s):  
Side Effects ◽  
Clinical Studies ◽  
Malignant Tumors ◽  
Experimental Studies ◽  
Herbal Medicines ◽  
Treatment Method ◽  
Reproductive Age ◽  
Dependent Growth ◽  
Gynecological Disorder ◽  
Preclinical And Clinical Studies

Animal toxins and venoms have recently been developed as cancer treatments possessing tumor cell growth-inhibitory, antiangiogenesis, and proapoptotic effects. Endometriosis is a common benign gynecological disorder in reproductive-age women, and no definite treatment for this disorder is without severe side effects. As endometriosis and malignant tumors share similar characteristics (progressive, invasive, estrogen-dependent growth, and recurrence), animal toxins and venoms are thought to be effective against endometriosis. The objective of this study was to outline studies using toxic animal-based medicinal materials (TMM) as endometriosis treatment and to explore its clinical applicability. Preclinical and clinical studies using TMM were searched for in four databases from inception to October 2020. A total of 20 studies of TMM on endometriosis were included. In eight clinical studies, herbal medicines containing TMM were effective in relieving symptoms of endometriosis, with no side effects. In twelve experimental studies, the main therapeutic mechanisms of TMM against endometriosis were proapoptotic, antiangiogenesis, estrogen level-reducing, and possible anti-inflammatory effects. TMM are thus considered promising sources for the development of an effective treatment method for endometriosis. Further studies are needed to clarify the therapeutic mechanism of TMM against endometriosis and to provide sufficient grounds for clinical application.

Interface Temperature Measurement and Experimental Studies of Super-High Speed Polishing of CVD Diamond Films

2010 ◽  
Vol 135 ◽  
pp. 271-276
Author(s):  
Shu Tao Huang ◽  
Li Zhou ◽  
Li Fu Xu
Keyword(s):  
Stainless Steel ◽  
Temperature Measurement ◽  
Temperature Rise ◽  
Diamond Film ◽  
High Speed ◽  
Experimental Studies ◽  
Pure Titanium ◽  
Cvd Diamond ◽  
Interface Temperature ◽  
Cvd Diamond Film

Super-high speed polishing of diamond film is a newly proposed method due to its outstanding features such as low cost and simple apparatus. The interface temperature rise is due to the friction force and the relative sliding velocity between the CVD diamond film and the polishing metal plate surface. In this paper, the interface temperature rise in super-high speed polishing of CVD diamond film was investigated by using the single-point temperature measurement method. Additionally, the influence of polishing plate material on the characteristics of super-high speed polishing has been studied. The results showed that cast iron is not suitable for super-high polishing, while both 0Cr18Ni9 stainless steel and pure titanium can be used for the super-high polishing of CVD diamond film. The quality and efficiency of polishing with 0Cr18Ni9 stainless steel plate is much higher than those of pure titanium, and the material removal rate could reach to 36-51 m/h when the polishing speed and pressure are 100 m/s and 0.17-0.31 MPa, respectively.

Omentin-1 attenuates glucocorticoid-induced cardiac injury by phosphorylating GSK3β

2021 ◽  
Vol 66 (4) ◽  
pp. 273-283
Author(s):  
Zhousheng Jin ◽  
Fangfang Xia ◽  
Jiaojiao Dong ◽  
Tingting Lin ◽  
Yaoyao Cai ◽  
...  
Keyword(s):  
Side Effects ◽  
Cardiac Hypertrophy ◽  
Cardiac Injury ◽  
Experimental Studies ◽  
Chronic Administration ◽  
Cardiovascular Complications ◽  
Rat Serum ◽  
Cardiac Side Effects ◽  
Beneficial Effects

Glucocorticoid excess often causes a variety of cardiovascular complications, including hypertension, atherosclerosis, and cardiac hypertrophy. To abrogate its cardiac side effects, it is necessary to fully disclose the pathophysiological role of glucocorticoid in cardiac remodelling. Previous clinical and experimental studies have found that omentin-1, one of the adipokines, has beneficial effects in cardiovascular diseases, and is closely associated with metabolic disorders. However, there is no evidence to address the potential role of omentin-1 in glucocorticoid excess-induced cardiac injuries. To uncover the links, the present study utilized rat model with glucocorticoid-induced cardiac injuries and clinical patients with abnormal cardiac function. Chronic administration of glucocorticoid excess reduced rat serum omentin-1 concentration, which closely correlated with cardiac functional parameters. Intravenous administration of adeno-associated virus encoding omentin-1 upregulated the circulating omentin-1 level and attenuated glucocorticoid excess-induced cardiac hypertrophy and functional disorders. Overexpression of omentin-1 also improved cardiac mitochondrial function, including the reduction of lipid deposits, induction of mitochondrial biogenesis, and enhanced mitochondrial activities. Mechanistically, omentin-1 phosphorylated and activated the GSK3β pathway in the heart. From a study of 28 patients with Cushing’s syndrome and 23 healthy subjects, the plasma level of glucocorticoid was negatively correlated with omentin-1, and was positively associated with cardiac ejection fraction and fractional shortening. Collectively, the present study provided a novel role of omentin-1 in glucocorticoid excess-induced cardiac injuries and found that the omentin-1/GSK3β pathway was a potential therapeutic target in combating the side effects of glucocorticoid.

New and safe experimental model of radiation-induced neurovascular histological changes for microsurgical research

2016 ◽  
Vol 51 (2) ◽  
pp. 124-137
Author(s):  
Sergi Barrera-Ochoa ◽  
Irene Gallardo-Calero ◽  
Andrea Sallent ◽  
Alba López-Fernández ◽  
Ramona Vergés ◽  
...  
Keyword(s):  
Side Effects ◽  
Experimental Model ◽  
Experimental Studies ◽  
Neurovascular Bundle ◽  
Control Group ◽  
Sprague Dawley ◽  
Histological Changes ◽  
Group I ◽  
Radiation Induced

The aim is to create a new and safe experimental model of radiation-induced neurovascular histological changes with reduced morbidity and mortality for use with experimental microsurgical techniques. Seventy-two Sprague–Dawley rats (250–300 g) were divided as follows: Group I: control group, 24 rats clinically evaluated during six weeks; Group II: evaluation of acute side-effects (two-week follow-up period), 24 irradiated (20 Gy) rats; and Group III: evaluation of subacute side-effects (six-week follow-up period), 24 irradiated (20 Gy) rats. Variables included clinical assessments, weight, vascular permeability (arterial and venous), mortality and histological studies. No significant differences were observed between groups with respect to the variables studied. Significant differences were observed between groups I vs II–III regarding survival rates and histological changes to arteries, veins and nerves. Rat body weights showed progressive increases in all groups, and the mortality rate of the present model is 10.4% compared with 30–40% in the previous models. In conclusion, the designed model induces selective changes by radiotherapy in the neurovascular bundle without histological changes affecting the surrounding tissues. This model allows therapeutic experimental studies to be conducted, including the viability of microvascular and microneural sutures post radiotherapy in the cervical neurovascular bundle.

Experimental studies on temperature rise within a hydrogen cylinder during refueling

2010 ◽  
Vol 35 (7) ◽  
pp. 2627-2632 ◽  
Author(s):  
Yan-Lei Liu ◽  
Yong-Zhi Zhao ◽  
Lei Zhao ◽  
Xiang Li ◽  
Hong-gang Chen ◽  
...  
Keyword(s):  
Temperature Rise ◽  
Experimental Studies

scholarly journals Intelligent Predicting Learning Disabilities in School Going Children using Fuzzy Logic K Mean Clustering in Machine Learning.

2019 ◽  
Vol 8 (4) ◽  
pp. 1694-1698
Keyword(s):  
Social Sciences ◽  
Machine Learning ◽  
Decision Making ◽  
Learning Disabilities ◽  
Fuzzy Logic ◽  
Side Effects ◽  
Early Analysis ◽  
Comprehensive Investigation ◽  
Engineering Statistics ◽  
Decision Making System

Learning disabilities (LD) is turning into a major issue in various nations around the globe which can even contrarily influence human common advancement. The undertaking of this work is to help the specialized programme network in their task to be with the standard. The underlying section of the paper gives a comprehensive investigation of the distinctive components of diagnosing learning disabilities. Despite the fact that LD can be analysed early - before 5 years of age, most youngsters were not determined to have LD until the age of nine on account of its unpredictable side effects and unclear indication in children disorder issue. Fuzzy logic K-means clustering has inspired a tremendous transformation in Machine learning and can take and able to resolve a variation of problems. This paper is the elaboration on the strategy for utilizing this mix to encourage the early analysis of LD. Since Fuzzy Logic clustering in Machine Learning is generally considered and connected in different areas of science, we invite all the related analysts from the fields of computer science, engineering, statistics, social sciences, healthcare, and so on, etc. The result of the paper demonstrates that the previously mentioned methodology can possibly be the potential of the supporting decision-making system in LD investigating and diagnosing.

scholarly journals Experimental Studies on a Solar Air Heater Having V-Corrugated Absorber Plate with Obstacles Bent Vertically

2014 ◽  
Vol 493 ◽  
pp. 86-92 ◽  
Author(s):  
Ekadewi A. Handoyo ◽  
Djatmiko Ichsani ◽  
Prabowo ◽  
S. Sutardi
Keyword(s):  
Heat Transfer ◽  
Pressure Drop ◽  
Flat Plate ◽  
Air Temperature ◽  
Temperature Rise ◽  
Experimental Studies ◽  
Bottom Plate ◽  
Solar Air Heater ◽  
Absorber Plate ◽  
Air Heater

A solar air heater (SAH) is a simple heater using solar radiation that is useful for drying or space heating. Unfortunately, heat transfer from the absorber plate to the air inside the solar air heater is low. Some researchers reported that obstacles are able to improve the heat transfer in a flat plate solar air collector and others found that a v-corrugated absorber plate gives better heat transfer than a flat plate. Yet, no work of combining these two findings is found.This paper describes the result of experimental study on a SAH with v-corrugated absorber plate and obstacles bent vertically started from 80oto 0owith interval 10oon its bottom plate. Experiments were conducted indoor at five different Reynolds numbers (1447 Re 7237) and three different radiation intensities (430, 573, and 716 W/m2).It is found that the obstacles improve SAH performance. Both the air temperature rise and efficiency increase with inserting obstacles bent at any angle vertically. Unfortunately, the air pressure drop is increasing, too. Obstacles bent vertically at smaller angle (means more straight) give higher air temperature rise and efficiency. However, the optimum angle is found 30o. The air temperature rise and efficiency will be 5.3% lower when the obstacles bent 30oinstead of 0o, but the pressure drop will be 17.2% lower.

scholarly journals Prolonged anesthesia alters brain synaptic architecture

2019 ◽  
Author(s):  
Michael Wenzel ◽  
Alexander Leunig ◽  
Shuting Han ◽  
Darcy S. Peterka ◽  
Rafael Yuste
Keyword(s):  
Cognitive Impairment ◽  
Cognitive Function ◽  
Side Effects ◽  
Synapse Formation ◽  
Experimental Studies ◽  
Synaptic Loss ◽  
Two Photon ◽  
Brain Mechanism ◽  
Cortical Synapses ◽  
Behavioral Object

SUMMARYProlonged medically-induced coma (pMIC), a procedure performed in millions of patients worldwide, leads to cognitive impairment, yet the underlying brain mechanism remains unknown. No experimental studies of medically-induced coma (MIC) exceeding ~6 hours exist. For MIC of less than 6 hours, studies in developing rodents have documented transient changes of cortical synapse formation. However, in adulthood, cortical synapses are thought to become stabilized. Here, we establish pMIC (up to 24 hrs) in adolescent and mature mice, and combine repeated behavioral object recognition assessments with longitudinal two-photon imaging of cortical synapses. We find that pMIC affects cognitive function, and is associated with enhanced synaptic turnover, generated by enhanced synapse formation during pMIC, while the post-anesthetic period is dominated by synaptic loss. These results carry profound implications for intensive medical care, as they point out at significant structural side effects of pMIC on cortical brain synaptic architecture across age levels.

scholarly journals TUBE Project: Transport-Derived Ultrafines and the Brain Effects

2021 ◽  
Vol 19 (1) ◽  
pp. 311
Author(s):  
Maria-Viola Martikainen ◽  
Päivi Aakko-Saksa ◽  
Lenie van den Broek ◽  
Flemming R. Cassee ◽  
Roxana O. Carare ◽  
...  
Keyword(s):  
Air Pollution ◽  
Health Effects ◽  
Air Pollutants ◽  
Experimental Studies ◽  
Air Pollutant ◽  
Adverse Health Effects ◽  
Adverse Health ◽  
Organ Systems ◽  
The Brain

The adverse effects of air pollutants on the respiratory and cardiovascular systems are unquestionable. However, in recent years, indications of effects beyond these organ systems have become more evident. Traffic-related air pollution has been linked with neurological diseases, exacerbated cognitive dysfunction, and Alzheimer’s disease. However, the exact air pollutant compositions and exposure scenarios leading to these adverse health effects are not known. Although several components of air pollution may be at play, recent experimental studies point to a key role of ultrafine particles (UFPs). While the importance of UFPs has been recognized, almost nothing is known about the smallest fraction of UFPs, and only >23 nm emissions are regulated in the EU. Moreover, the role of the semivolatile fraction of the emissions has been neglected. The Transport-Derived Ultrafines and the Brain Effects (TUBE) project will increase knowledge on harmful ultrafine air pollutants, as well as semivolatile compounds related to adverse health effects. By including all the major current combustion and emission control technologies, the TUBE project aims to provide new information on the adverse health effects of current traffic, as well as information for decision makers to develop more effective emission legislation. Most importantly, the TUBE project will include adverse health effects beyond the respiratory system; TUBE will assess how air pollution affects the brain and how air pollution particles might be removed from the brain. The purpose of this report is to describe the TUBE project, its background, and its goals.

scholarly journals Human Exposures to Rare Earth Elements: Present Knowledge and Research Prospects

2018 ◽  
Author(s):  
Giovanni Pagano ◽  
Philippe J. Thomas ◽  
Marco Trifuoggi
Keyword(s):  
Rare Earth ◽  
Rare Earth Elements ◽  
Human Health ◽  
Diesel Exhaust ◽  
Case Reports ◽  
Experimental Studies ◽  
Occupational Exposures ◽  
Adverse Health Effects ◽  
Limited Series ◽  
Waste Separation

The extensive use of rare earth elements (REEs) in a number of technologies is expected to impact on human health, including occupational REE exposures. A body of experimental evidence on REE-associated toxicity has been accumulated in recent decades. Unlike experimental studies, the consequences of REE exposures to human health have been subjected to relatively fewer investigations. Geographical studies have been conducted on residents in the Chinese REE mining districts, reporting on REE bioaccumulation, and associations between REE residential exposures and adverse health effects. A more limited series of studies has been focused on occupational REE exposures, such as movie operator (with occurrence of cerium aerosol) with the observation of pneumoconiosis and lung fibrosis. Similar effects have been reported in case reports for other workers, such as a lens grinder and a printer exposed to carbon-arc lamp emission. As for the occupations related to REE mining and processing, REE bioaccumulation in scalp hair and excess REE urine levels were reported. A study was devoted to workers employed in e-waste separation, showing alterations of several plasma markers. As for other REE occupational exposures, mention should be made of: a) mechanical workshops, with exposures to diesel exhaust microparticulate (containing nanoCeO2 as a catalytic additive) and, b) production and manufacture of REE supermagnets for hybrid engines and wind turbines. Diesel exhaust microparticulate has been studied in animal models, leading to evidence of several pathological effects in animals exposed by respiratory or systemic routes. As for supermagnet production and manufacture, a body of literature is reviewed of experimental studies, and of human exposure studies showing several pathological effects of static magnetic fields, warranting further investigations.

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