Urinary Concentrations of Bisphenol Mixtures during Pregnancy and Birth Outcomes: The MAKE Study

Bisphenols are endocrine disruptors that may be associated with altered fetal growth in humans, and they have similar biological functions to mimic hormones. In addition, aggregated chemicals showed an adverse effect although individual concentration was at a low level. However, most studies between bisphenols and birth outcomes have focused on the effect of individual bisphenol. Thus, we explored the associations of urinary bisphenol mixtures with birth outcomes. We conducted a prospective birth cohort study in South Korea. One hundred eighty mother-infant pairs were recruited from 2017 to 2019. Bisphenol A (BPA), bisphenol F (BPF), and bisphenol S (BPS) in one spot urine were analyzed using ultra-performance liquid chromatography–tandem mass spectrometry. We used two statistical approaches to examine potential associations of BPA, BPF, and BPS with birth weight and gestational age: (1) multivariable linear regression; (2) Bayesian kernel machine regression (BKMR). The geometric means of BPA, BPF, and BPS were 2.1, 0.2, and 0.1 μg/L, respectively. In stratified linear analyses by each median value, a higher BPF was positively associated with birth weight (g) (β = 125.5; 95% CI: 45.0 to 205.9). Mixture analyses using BKMR suggested an inverse association between bisphenol mixtures and birth weight. Our findings suggest that in utero bisphenol exposure may influence birth weight and that such relationships may differ considering non-linearity and the combined effect.

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Metabolomics Reveals That Bisphenol Pollutants Impair Protein Synthesis-Related Pathways in Daphnia magna

Metabolites ◽

10.3390/metabo11100666 ◽

2021 ◽

Vol 11 (10) ◽

pp. 666

Author(s):

Erico A. Oliveira Pereira ◽

Lisa M. Labine ◽

Sonya Kleywegt ◽

Karl J. Jobst ◽

André J. Simpson ◽

...

Keyword(s):

Protein Synthesis ◽

Daphnia Magna ◽

Acid Metabolism ◽

Model Organism ◽

Bisphenol S ◽

Bisphenol F ◽

Polar Metabolites ◽

Liquid Chromatography Tandem Mass ◽

Pathway Analyses ◽

Chemical Class

Bisphenols are used in the production of polycarbonate plastics and epoxy resins. Bisphenol A (BPA) has been widely studied and is believed to act as an endocrine disruptor. Bisphenol F (BPF) and bisphenol S (BPS) have increasingly been employed as replacements for BPA, although previous studies suggested that they yield similar physiological responses to several organisms. Daphnia magna is a common model organism for ecotoxicology and was exposed to sub-lethal concentrations of BPA, BPF, and BPS to investigate disruption to metabolic profiles. Targeted metabolite analysis by liquid chromatography-tandem mass spectrometry (LC-MS/MS) was used to measure polar metabolites extracted from D. magna, which are linked to a range of biochemical pathways. Multivariate analyses and individual metabolite changes showed similar non-monotonic concentration responses for all three bisphenols (BPA, BPF, and BPS). Pathway analyses indicated the perturbation of similar and distinct pathways, mostly associated with protein synthesis, amino acid metabolism, and energy metabolism. Overall, we observed responses that can be linked to a chemical class (bisphenols) as well as distinct responses that can be related to each individual bisphenol type (A, F, and S). These findings further demonstrate the need for using metabolomic analyses in exposure assessment, especially for chemicals within the same class which may disrupt the biochemistry uniquely at the molecular-level.

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The Bisphenol F and Bisphenol S and Cardiovascular disease: results from NHANES 2013-2016

10.21203/rs.3.rs-934237/v1 ◽

2021 ◽

Author(s):

Ruihua wang ◽

Qiaoyuan Fei ◽

Shan Liu ◽

Xueqiong Weng ◽

Huanzhu Liang ◽

...

Keyword(s):

Cardiovascular Disease ◽

Age Groups ◽

Bisphenol S ◽

Cvd Risk ◽

Cross Sectional ◽

Mixed Effect ◽

Exposure Effect ◽

Kernel Machine ◽

Bisphenol F ◽

Health And Nutrition

Abstract Background Bisphenol F (BPF) and bisphenol S (BPS) are replacing bisphenol A (BPA) in the manufacturing of products containing polycarbonates and epoxy resins, however, the effects of these substitutes on the risk of cardiovascular disease (CVD) have not been assessed. Objective To examine the association of urinary BPS and BPF with the CVD risk in a U.S. representative population. Method A cross-sectional data with 1,266 participants aged 20 to 80 years from the 2013–2016 National Health and Nutrition Examination Survey (NHANES) was analyzed. The logistic regression was used to assess the association between BPF, BPS and CVD. The Bayesian kernel machine regression (BKMR) model was applied to assess the mixed effect. Results A total of 138 patients with CVD were identified. After adjusting for potential confounding factors, T3 concentration of BPS increased the risk of total CVD (OR: 1.98, 95%CI: 1.20–3.28). When stratified by age, we found that BPS increased the risk of CVD in the 50–80 age groups (OR:1.40, 95%CI: 1.05–1.87). BPS was positively associated with the risk of stroke and T3 of BPS increased the stroke risk by 3.46 times (95%CI: 1.09–10.95). No significant association was observed between BPF and CVD. Although BKMR model did not identify the mixed exposure effect of BPS, the risk of CVD increased, with the increase of compound concentration. Conclusion Our results suggest that BPS may increase the risk of total CVD and stroke in the U.S population, and prospective studies are needed to confirm the results.

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Relatively Low Maternal Aflatoxin Exposure Is Associated with Small-for-Gestational-Age but Not with Other Birth Outcomes in a Prospective Birth Cohort Study of Nepalese Infants

Journal of Nutrition ◽

10.1093/jn/nxz122 ◽

2019 ◽

Vol 149 (10) ◽

pp. 1818-1825 ◽

Cited By ~ 4

Author(s):

Johanna Y Andrews-Trevino ◽

Patrick Webb ◽

Gerald Shively ◽

Beatrice L Rogers ◽

Kedar Baral ◽

...

Keyword(s):

Cohort Study ◽

Birth Weight ◽

Birth Cohort ◽

Birth Outcomes ◽

Gestational Age ◽

Small For Gestational Age ◽

Maternal Serum ◽

Birth Cohort Study ◽

Adverse Birth Outcomes ◽

Z Scores

ABSTRACT Background Exposure to aflatoxin has garnered increased attention as a possible contributor to adverse birth outcomes. Objective The objective of this study was to investigate the relation of maternal aflatoxin exposure with adverse birth outcomes such as birth weight, birth length, anthropometric z scores, low birth weight (LBW), small-for-gestational-age (SGA), stunting, and preterm birth (PTB). Methods This study used maternal and newborn data from the AflaCohort Study, an ongoing birth cohort study in Banke, Nepal (n = 1621). Data on aflatoxin B1 (AFB1)-lysine adducts in maternal serum were collected once during pregnancy (at mean ± SD: 136 ± 43 d of gestation). Maternal serum AFB1-lysine adduct concentration was measured via HPLC. Linear and logistic regression analyses were used to determine if maternal aflatoxin exposure was associated with 1) birth weight and length (primary outcomes) and 2) anthropometric z scores, LBW (weight <2.5 kg), SGA (weight <10th percentile for gestational age and sex), stunting at birth (length-for-age z score less than −2), or PTB (born <37 weeks of gestation) (secondary outcomes). Results The geometric mean of maternal serum AFB1-lysine adduct concentration was 1.37 pg/mg albumin (95% CI: 1.30, 1.44 pg/mg albumin). Twenty percent of infants were of LBW and 32% were SGA. Sixteen percent of infants were stunted at birth. In addition, 13% of infants were born preterm. In logistic multivariate regression models, mean maternal serum AFB1-lysine adduct concentrations were significantly associated with SGA (OR: 1.13; 95% CI: 1.00, 1.27; P < 0.05). Conclusions Findings from this study suggest a small but significant association between serum AFB1-lysine adduct concentrations in pregnant women and SGA. Maternal aflatoxin exposure was not associated with other birth outcomes. These results highlight the need for future research on a threshold level of aflatoxin exposure needed to produce detectable adverse birth outcomes. This trial was registered at clinicaltrials.gov as NCT03312049.

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Iron status in late pregnancy is inversely associated with birth weight in Colombia

Public Health Nutrition ◽

10.1017/s136898002100166x ◽

2021 ◽

pp. 1-29

Author(s):

Alejandra Puerto ◽

Annabelle Trojan ◽

Nelson Rafael Alvis-Zakzuk ◽

Rossana López-Saleme ◽

Francisco Edna-Estrada ◽

...

Keyword(s):

Birth Weight ◽

Prenatal Care ◽

Birth Outcomes ◽

Gestational Age ◽

Small For Gestational Age ◽

Rural Areas ◽

Iron Status ◽

Perinatal Outcomes ◽

Caribbean Region ◽

Birth Cohort Study

ABSTRACT OBJECTIVE: Gestational Anaemia (GA) is common in developing countries. This study assessed the relationship of late GA and negative perinatal outcomes in participants recruited in a reference maternity unit of the Caribbean region of Colombia. DESIGN: Prospective analytical birth cohort study. Maternal haemoglobin and serum ferritin (SF) levels were measured. GA was defined as haemoglobin levels <11 g/dL, SF depletion as SF levels <12 ng/mL. Birth outcomes such as low birth weight (LBW), preterm birth (PB) and small for gestational age (SGA) were examined. SETTING: Mothers in the first stage of labour, living in urban or rural areas of Bolívar, were enrolled in an obstetrical centre located in Cartagena, Colombia. Blood and stool samples were taken prior delivery. Maternal blood count, SF levels and infant anthropometric data were recorded for analysis. PARTICIPANTS: 1,218 pregnant women aged 18 - 42 years-old and their newborns. RESULTS: Prevalence of GA and SF depletion was 41.6% and 41.1%, respectively. GA was positively associated with poverty-related sociodemographic conditions. Prenatal care attendance lowered the risk of PB, LBW and SGA. Birth weight was inversely associated with haemoglobin levels, observing a -36.8 g decrease in newborn weight per 1 g/dl of maternal haemoglobin. SF depletion, but not anaemia was associated with PB. Small for gestational age (SGA) outcome showed a significant association with anaemia, but not a significant relationship with SF depletion. CONCLUSION: Birth weight and other-related perinatal outcomes are negatively associated to haemoglobin and SF depletion. Prenatal care attendance reduced the risk of negative birth outcomes.

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Impact of prenatal exposure to polycyclic aromatic hydrocarbons from maternal diet on birth outcomes: a birth cohort study in Korea

Public Health Nutrition ◽

10.1017/s1368980016000550 ◽

2016 ◽

Vol 19 (14) ◽

pp. 2562-2571 ◽

Cited By ~ 10

Author(s):

Dirga Kumar Lamichhane ◽

Jong-Han Leem ◽

Hwan-Cheol Kim ◽

Ji-Young Lee ◽

Myung-Sook Park ◽

...

Keyword(s):

Cohort Study ◽

Polycyclic Aromatic Hydrocarbons ◽

Birth Weight ◽

Birth Cohort ◽

Birth Outcomes ◽

Aromatic Hydrocarbons ◽

Maternal Diet ◽

Birth Cohort Study ◽

Consumption Level ◽

Polycyclic Aromatic

AbstractObjectivePolycyclic aromatic hydrocarbons (PAH) are common dietary exposures that cross the human placenta and are classified as a probable human carcinogen. The aim of the present study was to investigate the potential impact of exposure to PAH-containing meat consumed during pregnancy on birth outcomes.DesignProspective birth cohort study. Only non-smoking women with singleton pregnancies, who were free from chronic disease such as diabetes and hypertension, were included in the study. Maternal consumption of PAH-rich meat was estimated through FFQ. Multiple linear regression was used to assess factors related to higher intake and the association between dietary PAH and birth outcomes.SettingRepublic of Korea, 2006–2011.SubjectsPregnant women (n 778) at 12–28 weeks of gestation enrolled in the Mothers and Children’s Environmental Health (MOCEH) study.ResultsThe multivariable regression model showed a significant reduction in birth weight associated with higher consumption level of foods rich in PAH, such as grilled or roasted meat, during pregnancy (β=−17·48 g, P<0·05 for every 1 point higher in meat score). Further adjusting for biomarkers of airborne PAH did not alter this association. There was no evidence that higher consumption level of PAH-rich meat shortens the duration of gestation (P=0·561). Regression models performed for birth length and head circumference produced negative effects that were not statistically significant.ConclusionsConsumption of higher levels of barbecued, fried, roasted and smoked meats during pregnancy was associated with reduced birth weight. Dietary risk of PAH exposure in Korean women is of concern.

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