The Bisphenol F and Bisphenol S and Cardiovascular disease: results from NHANES 2013-2016

Abstract Background Bisphenol F (BPF) and bisphenol S (BPS) are replacing bisphenol A (BPA) in the manufacturing of products containing polycarbonates and epoxy resins, however, the effects of these substitutes on the risk of cardiovascular disease (CVD) have not been assessed. Objective To examine the association of urinary BPS and BPF with the CVD risk in a U.S. representative population. Method A cross-sectional data with 1,266 participants aged 20 to 80 years from the 2013–2016 National Health and Nutrition Examination Survey (NHANES) was analyzed. The logistic regression was used to assess the association between BPF, BPS and CVD. The Bayesian kernel machine regression (BKMR) model was applied to assess the mixed effect. Results A total of 138 patients with CVD were identified. After adjusting for potential confounding factors, T3 concentration of BPS increased the risk of total CVD (OR: 1.98, 95%CI: 1.20–3.28). When stratified by age, we found that BPS increased the risk of CVD in the 50–80 age groups (OR:1.40, 95%CI: 1.05–1.87). BPS was positively associated with the risk of stroke and T3 of BPS increased the stroke risk by 3.46 times (95%CI: 1.09–10.95). No significant association was observed between BPF and CVD. Although BKMR model did not identify the mixed exposure effect of BPS, the risk of CVD increased, with the increase of compound concentration. Conclusion Our results suggest that BPS may increase the risk of total CVD and stroke in the U.S population, and prospective studies are needed to confirm the results.

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The bisphenol F and bisphenol S and cardiovascular disease: results from NHANES 2013–2016

Environmental Sciences Europe ◽

10.1186/s12302-021-00586-9 ◽

2022 ◽

Vol 34 (1) ◽

Author(s):

Ruihua Wang ◽

Qiaoyuan Fei ◽

Shan Liu ◽

Xueqiong Weng ◽

Huanzhu Liang ◽

...

Keyword(s):

Cardiovascular Disease ◽

Coronary Heart Disease ◽

Heart Disease ◽

Disease Risk ◽

Bisphenol S ◽

Cvd Risk ◽

Cross Sectional ◽

Exposure Effect ◽

Bisphenol F ◽

Health And Nutrition

Abstract Background Bisphenol F (BPF) and bisphenol S (BPS) have replaced bisphenol A (BPA) in the manufacturing of products containing polycarbonates and epoxy resins; however, the effects of these substitutes on the risk of cardiovascular disease (CVD), including congestive heart failure, coronary heart disease, angina pectoris, heart attack, and stroke, have not been assessed. Objective To examine the association of urinary BPS and BPF with CVD risk in a U.S. representative U.S. population. Methods Cross-sectional data from 1267 participants aged 20–80 years from the 2013–2016 National Health and Nutrition Examination Survey (NHANES) were analyzed. Survey-weighted multiple logistic regression was used to assess the association between BPA, BPF, BPS and CVD. The Bayesian kernel machine regression (BKMR) model was applied to assess the mixture effect. Results A total of 138 patients with CVD were identified. After adjusting for potential confounding factors, the T3 tertile concentration of BPS increased the risk of total CVD (OR: 1.99, 95% CI 1.16–3.40). When stratified by age, we found that BPS increased the risk of CVD in the 50–80 age group (OR: 1.40, 95% CI 1.05–1.87). BPS was positively associated with the risk of coronary heart disease, and the T3 tertile concentration of BPS increased the coronary heart disease risk by 2.22 times (95% CI 1.04–4.74). No significant association was observed between BPF and CVD. Although the BKMR model did not identify the mixed exposure effect of BPS, the risk of CVD increased with increasing compound concentration. Conclusion Our results suggest that BPS may increase the risk of total CVD and coronary heart disease in the US population, and prospective studies are needed to confirm the results.

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Mediating effects of metabolic factors on the association between fruit or vegetable intake and cardiovascular disease: the Korean National Health and Nutrition Examination Survey

BMJ Open ◽

10.1136/bmjopen-2017-019620 ◽

2018 ◽

Vol 8 (2) ◽

pp. e019620 ◽

Cited By ~ 2

Author(s):

Hye Ah Lee ◽

Dohee Lim ◽

Kyungwon Oh ◽

Eun Jung Kim ◽

Hyesook Park

Keyword(s):

Cardiovascular Disease ◽

Vegetable Intake ◽

The Other ◽

Nutrition Examination Survey ◽

Mediating Effects ◽

Metabolic Factors ◽

Cvd Risk ◽

Cross Sectional ◽

Health And Nutrition ◽

The Relationship

ObjectiveWe assessed the mediating effects of metabolic components on the relationship between fruit or vegetable intake and cardiovascular disease (CVD).DesignCross-sectional study.SettingThis study was conducted using data from the 2013–2015 Korean National Health and Nutrition Examination Survey, which is a national representative cross-sectional survey to assess health and nutritional status in the Korean population.Method and analysisA total of 9040 subjects (3555 males and 5485 females) aged ≥25 years were included in the study. Physician-diagnosed CVD via self-report was used as the outcome. Fruit or vegetable intake was measured via a dish-based semiquantitative food frequency questionnaire and grouped into categories (<1 time/day, 1 time/day, 2 times/day and ≥3 times/day). Systolic blood pressure (SBP), cholesterol and fasting glucose were considered metabolic mediators, and the bootstrap method was used to assess mediating effect.ResultsAbout 1.8% of adults aged 25–64 years had CVD. According to the result of ‘process’ macro, the confounder-adjusted risk for CVD decreased by 14% (OR=0.86, 95% CI 0.74 to 0.98) as fruit, but not vegetable, intake was increased by one unit per day. After additional adjustment for three metabolic factors simultaneously, the OR was attenuated to 0.89 (95% CI 0.77 to 1.03). This result indicates that the indirect effect of three metabolic factors accounted for 21.4% of the relationship between fruit intake and CVD. SBP was a more important metabolic mediator than the other factors. The indirect effect by metabolic factors accounted for 30.0% when body mass index was additionally controlled as a mediator, and SBP still had an independent effect compared with the other mediators.ConclusionsOur results indicate that controlling SBP may lessen the CVD risk, and a diet rich in fruits can regulate SBP which, in turn, reduces CVD risk.

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Prevalence, awareness, treatment, and control of dyslipidemia among diabetes mellitus patients and predictors of optimal dyslipidemia control: results from the Korea National Health and Nutrition Examination Survey

Lipids in Health and Disease ◽

10.1186/s12944-021-01455-3 ◽

2021 ◽

Vol 20 (1) ◽

Author(s):

Seung Jae Kim ◽

Oh. Deog Kwon ◽

Kyung-Soo Kim

Keyword(s):

Diabetes Mellitus ◽

Optimal Control ◽

National Health ◽

Age Groups ◽

Density Lipoprotein ◽

Nutrition Examination Survey ◽

Cross Sectional ◽

Health And Nutrition ◽

Factors Influencing ◽

And Control

Abstract Background This study aimed to investigate the prevalence, awareness, treatment, and control rates of dyslipidemia and identify the predictors of optimal control (low-density lipoprotein cholesterol < 100 mg/dL) among patients with diabetes mellitus (DM). Methods A cross-sectional study was conducted using the representative Korea National Health and Nutrition Examination Survey (2014–2018). Overall, 4311 patients with DM, aged ≥19 years, and without cardiovascular diseases were selected, and the prevalence, awareness, treatment, and control rates of dyslipidemia were calculated. Univariate and multivariate logistic regression analyses were conducted to evaluate the factors influencing the optimal control of dyslipidemia. Results Dyslipidemia was prevalent in 83.3% of patients with DM, but the awareness and treatment rates were 36.5 and 26.9%, respectively. The control rate among all patients with dyslipidemia was 18.8%, whereas it was 61.1% among those being treated. Prevalence and awareness rates were also significantly higher in women than in men. Dyslipidemia was most prevalent in those aged 19–39 years, but the rates of awareness, treatment, and control among all patients with dyslipidemia in this age group were significantly lower than those in other age groups. The predictors of optimal control were age ≥ 40 years [range 40–49 years: adjusted odds ratio (aOR) 3.73, 95% confidence interval (CI) 1.43–9.72; 50–59 years: aOR 6.25, 95% CI 2.50–15.65; 60–69 years: aOR 6.96, 95% CI 2.77–17.44; 70–79 years: aOR 9.21, 95% CI 3.58–23.74; and ≥ 80 years: aOR 4.43, 95% CI 1.60–12.27]; urban living (aOR 1.44, 95% CI 1.15–1.80); higher body mass index (aOR 1.27, 95% CI 1.13–1.42); lower glycated hemoglobin levels (aOR 0.71, 95% CI 0.67–0.76); hypertension (aOR 1.53, 95% CI 1.22–1.92); poorer self-rated health status (aOR 0.72, 95% CI 0.62–0.84); and receiving regular health check-ups (aOR 1.58, 95% CI 1.25–2.00). Conclusions Most patients with DM were diagnosed with dyslipidemia, but many were unaware of or untreated for their condition. Therefore, their control rate was suboptimal. Thus, by understanding factors influencing optimal control of dyslipidemia, physicians should make more effort to encourage patients to undergo treatment and thus, adequately control their dyslipidemia.

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Is night-time light intensity associated with cardiovascular disease risk factors among adults in early-stage urbanisation in South India? A cross-sectional study of the Andhra Pradesh Children and Parents Study

BMJ Open ◽

10.1136/bmjopen-2019-036213 ◽

2020 ◽

Vol 10 (11) ◽

pp. e036213

Author(s):

Tina Bonde Sorensen ◽

Robin Wilson ◽

John Gregson ◽

Bhavani Shankar ◽

Alan D Dangour ◽

...

Keyword(s):

Risk Factors ◽

Cardiovascular Disease ◽

Andhra Pradesh ◽

South India ◽

Early Stage ◽

Cvd Risk Factors ◽

Cvd Risk ◽

Night Time ◽

Cross Sectional ◽

Children And Parents

ObjectivesTo explore associations of night-time light intensity (NTLI), a novel proxy for continuous urbanisation levels, with mean systolic blood pressure (SBP), body mass index (BMI), fasting serum low-density lipoprotein (LDL) and fasting plasma glucose (FPG), among adults in early-stage urbanisation in Telangana, South India.DesignCross-sectional analysis of the third wave of the Andhra Pradesh Children and Parents Study cohort.Setting28 villages representing a continuum of urbanisation levels, ranging from rural settlement to medium-sized town in Telangana, South India.ParticipantsData were available from 6944 participants, 6236 of whom were eligible after excluding pregnant women, participants younger than 18 years of age and participants missing data for age. Participants were excluded if they did not provide fasting blood samples, had implausible or missing outcome values, were medicated for hypertension or diabetes or had triglyceride levels invalidating derived LDL. The analysis included 5924 participants for BMI, 5752 participants for SBP, 5287 participants for LDL and 5328 participants for FPG.ResultsIncreasing NTLI was positively associated with mean BMI, SBP and LDL but not FPG. Adjusted mean differences across the range of village-level NTLI were 1.0 kg/m2 (95% CI 0.01 to 1.9) for BMI; 4.2 mm Hg (95% CI 1.0 to 7.4) for SBP; 0.3 mmol/L (95% CI −0.01 to 0.7) for LDL; and −0.01 mmol/L (95% CI −0.4 to 0.4) for FPG. Associations of NTLI with BMI and SBP were stronger in older age groups.ConclusionThe association of NTLI with cardiovascular disease (CVD) risk factors identify NTLI as a potentially important tool for exploring urbanisation-related health. Consistent associations of moderate increases in urbanisation levels with important CVD risk factors warrant prevention strategies to curb expected large public health impacts from continued and rapid urbanisation in India.

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Trends in the prevalence of anaemia in Japanese adult women, 1989–2003

Public Health Nutrition ◽

10.1017/s1368980007000274 ◽

2008 ◽

Vol 11 (3) ◽

pp. 252-257 ◽

Cited By ~ 5

Author(s):

Fumi Hayashi ◽

Nobuo Yoshiike ◽

Katsushi Yoshita ◽

Kazuo Kawahara

Keyword(s):

Age Groups ◽

Data Sets ◽

Adult Women ◽

Residential Areas ◽

Nutrition Survey ◽

Japanese Adult ◽

Cross Sectional ◽

Health And Nutrition ◽

Trend Data ◽

National Trends

AbstractObjectiveThere is an increasing concern of anaemia in Japanese women, but no national trend data has existed to date. We analysed long-term national trends of anaemia in adult women.DesignSecondary analyses of 15 consecutive cross-sectional nationwide surveys conducted during the period 1989–2003. Analyses were based on 5-year intervals (1989–1993, 1994–1998, 1999–2003).SettingJapan.SubjectsThe subjects included the National Health and Nutrition Survey of Japan (NHNS-J) population. Analyses were based on 50 967 non-pregnant/non-lactating women aged 20 years and over, with complete data sets. We stratified subjects into six age groups (20–29 years, 30–39 years, 40–49 years, 50–59 years, 60–69 years and 70+ years), and three age groups (20–49 years, 50–69 years, 70+ years) for analyses on residential areas (metropolitan, cities and towns).ResultsDecreases in trends of mean haemoglobin values (intravenous) were significant in all age groups. Changes in the prevalence of anaemia were significant only in women aged 30–39 and 40–49 years. Anaemia (haemoglobin < 12.0 g dl−1) increased from 16.8% to 20.6% in women aged 30–39 years, and from 20.2% to 26.9% in women aged 40–49 years, respectively. Prevalence was highest in women aged 70 years and older in all times, but no significant change was observed.ConclusionsHaemoglobin values have declined significantly in all ages in the last 15 years. Anaemia was especially significant in women aged 30–39 years and 40–49 years. Our findings suggest that a large number of young women in Japan are at risk of anaemia, so continuous monitoring and controlling efforts of this trend are needed.

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Urinary 2,5-dicholorophenol and 2,4-dichlorophenol concentrations and prevalent disease among adults in the National Health and Nutrition Examination Survey (NHANES)

Occupational and Environmental Medicine ◽

10.1136/oemed-2018-105278 ◽

2018 ◽

Vol 76 (3) ◽

pp. 181-188 ◽

Cited By ~ 1

Author(s):

Mary R Rooney ◽

Pamela L Lutsey ◽

Parveen Bhatti ◽

Anna Prizment

Keyword(s):

National Health ◽

Linear Trend ◽

Nutrition Examination Survey ◽

Cvd Risk ◽

Cross Sectional ◽

Adverse Health Outcomes ◽

Representative Study ◽

Health And Nutrition ◽

Prevalent Disease ◽

Nationally Representative

ObjectiveTo test cross-sectional associations between urinary concentrations of 2,5-dichlorophenol (2,5-DCP) and 2,4-dichlorophenol (2,4-DCP) with the prevalence of cardiovascular disease (CVD), cancer, lung disease, thyroid problems and liver conditions.MethodsLogistic regression was used to evaluate associations of urinary concentrations of 2,5-DCP and 2,4-DCP with prevalence of various medical conditions among 3617 National Health and Nutrition Examination Survey participants from 2007–2008 and 2009–2010. ORs and 95% CIs for each disease were estimated. All regression models were adjusted for urinary creatinine.ResultsWe observed a monotonically increasing association between quartiles of 2,5-DCP and prevalence of CVD. After adjustment for sociodemographic and lifestyle characteristics, participants with the highest versus lowest quartile of urinary 2,5-DCP had an OR=1.84 (95% CI 1.26 to 2.70) (p linear trend=0.006). The association was similar with further adjustment for established clinical CVD risk factors. Higher 2,5-DCP was also associated with prevalence of all cancers combined (ORQ4 vs Q1=1.50 (95% CI 1.00 to 2.26); p trend=0.05) and, in exploratory analyses, with gynaecological cancers (ORQ4 vs Q1=4.15 (95% CI 1.51 to 11.40; p trend=0.01)). No associations were detected between 2,5-DCP and lung diseases, thyroid problems or liver conditions, nor between 2,4-DCP and prevalent disease.ConclusionIn this nationally representative study, higher urinary 2,5-DCP concentrations were associated with greater prevalence of CVD and all cancers combined. Further examination may be warranted to assess whether chronic exposure to 2,5-DCP is associated with incidence of adverse health outcomes.

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Dinner consumption and cardiovascular disease risk factors among a nationally representative sample of Iranian adolescents: the CASPIAN-III Study

Journal of Cardiovascular and Thoracic Research ◽

10.15171/jcvtr.2019.24 ◽

2019 ◽

Vol 11 (2) ◽

pp. 138-146

Author(s):

Leila Azadbakht ◽

Fahime Akbari ◽

Mostafa Qorbani ◽

Mohammad Esmaeil Motlagh ◽

Gelayol Ardalan ◽

...

Keyword(s):

Risk Factors ◽

Cardiovascular Disease ◽

Representative Sample ◽

Disease Risk ◽

Cardiovascular Disease Risk ◽

Cluster Sampling ◽

Cvd Risk Factors ◽

Cvd Risk ◽

Cross Sectional ◽

Nationally Representative

Introduction: This cross-sectional study aimed to assess the association between cardiovascular disease (CVD) risk factors and dinner consumption in a nationally representative sample of Iranian adolescents. Methods: The present study was conducted on 5642 adolescents aged 10-18 years old in 27 provinces in Iran. The subjects were included applying by multistage random cluster sampling. Participants who ate ≥5 dinners during a week were considered as a dinner consumer. Results: Among 5642 subjects, 1412 (25%) did not consume dinner. Dinner consumers were less likely to be overweight or obese (P < 0.001) and abdominally obese (P < 0.001) as well as to have an abnormal level of HDL-C (P = 0.02). Dinner skipper youths had a higher risk for overweight or obesity (odds ratio [OR]: 1.62; 95% CI: 1.39-1.89) and abdominal obesity (OR: 1.59; 95% CI: 1.36-1.85) which remained significant after adjusting confounding factors (P <0001). No relationship was observed between dinner consumption and the rest of the CVD risk factors, neither in crude nor in adjusted models. A higher proportion of dinner-consumer adolescents had no CVD risk factors in comparison to dinner-skipper subjects (31.1% vs. 28%). Conclusion: Eating dinner might be inversely associated with some CVD risk factors among Iranian adolescents. Further prospective studies will need to prove this theory.

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Prevalence of Self-reported Polycystic Ovary Syndrome and Profiles of Health Among Women of Different Generations: A Cross Sectional Study

Fertility & Reproduction ◽

10.1142/s2661318219500154 ◽

2019 ◽

Vol 01 (03) ◽

pp. 141-147

Author(s):

Jodie C. Avery ◽

Lisa J. Moran ◽

Vivienne Moore ◽

Renae C. Fernandez ◽

Melissa Whitrow ◽

...

Keyword(s):

Cardiovascular Disease ◽

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Age Groups ◽

South Australia ◽

Cross Sectional Study ◽

Age Group ◽

Ovary Syndrome ◽

Cross Sectional ◽

Younger Women

Objective: Although polycystic ovary syndrome (PCOS) is considered a lifelong disorder, very little is understood about the diagnosis and impact of this condition in women outside of the peak reproductive years. We examined the frequency of diagnosed PCOS and concurrent health conditions in women across the lifespan. Methods: Data were analysed from 1509 women aged 15–95 years participating in a cross-sectional, face-to-face population survey in South Australia, 2015. We assessed the prevalence of PCOS in 10-year age groups and the frequency of comorbidities in women with and without PCOS subgrouped by age (< 45, [Formula: see text] 45 years). The main outcome measures were Diagnosed PCOS and other chronic conditions; lifestyle factors. Logistic regression analyses determined the risk of comorbidities in women with PCOS adjusting for age and BMI. Results: Overall prevalence of PCOS was 5.6% (95% confidence interval (CI) 4.6–6.9%), peaking in the 35–44 year age group (9.1%), and lowest in those aged 15–24 (4.1%) or [Formula: see text] 65 (3.7%) years. Women with PCOS and aged <45 years were more likely to report diabetes (16.7% vs. 3.8%), cardiovascular disease (15.5% vs. 7.2%) and arthritis (15.5% vs. 7.2%) than their peers; these differences were diminished in the [Formula: see text] 45 year age group. The odds of diabetes and cardiovascular disease were more than doubled among women with PCOS (adjOR 2.23, 95% CI 1.49–4.31; adjOR 3.18, 95% CI 1.31–7.68). Conclusion: PCOS is underdiagnosed in young and post-menopausal women. Diabetes and cardiovascular disease are key comorbidities requiring greater attention in younger women with PCOS.

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Health-related quality of life and readmission of patients with cardiovascular disease in South Korea

Perspectives in Public Health ◽

10.1177/1757913919892026 ◽

2019 ◽

Vol 141 (1) ◽

pp. 28-36

Author(s):

Hyun Su Kim ◽

Yoonjung Kim ◽

Haejin Kwon

Keyword(s):

Quality Of Life ◽

Myocardial Infarction ◽

Cardiovascular Disease ◽

Cross Sectional Study ◽

Health Related Quality ◽

Cross Sectional ◽

Health And Nutrition ◽

Related Quality ◽

Health Related

Aims: The purpose of this study was to investigate the health-related quality of life (HRQOL) of patients with cardiovascular disease and its relationship to hospital readmission. Methods: The cross-sectional study used data from 1037 adults aged ⩾19 years diagnosed with myocardial infarction or angina pectoris. Raw data were obtained from the fourth to sixth Korea National Health and Nutrition Examination Survey (2007–2014). Results: Readmission was found to be associated with age, living status, education level, unemployment, individual income level, stroke, osteoarthritis, diabetes, depression, low stress level, walking days per week, and activity limitations due to cardiovascular disease. Conclusion: In summary, readmission was related to HRQOL among patients with myocardial infarction. Interventions that consider efforts to reduce readmission through improved diagnosis and development of systematic management of cardiovascular disease symptoms are required.

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