scholarly journals Drug delivery strategies to control macrophages for tissue repair and regeneration

2016 ◽  
Vol 241 (10) ◽  
pp. 1054-1063 ◽  
Author(s):  
Reham Garash ◽  
Anamika Bajpai ◽  
Brandon M Marcinkiewicz ◽  
Kara L Spiller
Keyword(s):  
Drug Delivery ◽  
Tissue Repair ◽  
Chronic Wounds ◽  
Cellular Therapy ◽  
Inflammatory Diseases ◽  
Macrophage Phenotype ◽  
Tissue Repair And Regeneration ◽  
Complex Process ◽  
Tissue Healing ◽  
Delivery Strategies

Tissue repair and regeneration is a complex process. Our bodies have an excellent capacity to regenerate damaged tissues in many situations. However, tissue healing is impaired in injuries that exceed a critical size or are exacerbated by chronic inflammatory diseases like diabetes. In these instances, biomaterials and drug delivery strategies are often required to facilitate tissue regeneration by providing physical and biochemical cues. Inflammation is the body’s response to injury. It is critical for wound healing and biomaterial integration and vascularization, as long as the timing is well controlled. For example, chronic inflammation is well known to impair healing in chronic wounds. In this review, we highlight the importance of a well-controlled inflammatory response, primarily mediated by macrophages in tissue repair and regeneration and discuss various strategies designed to promote regeneration by controlling macrophage behavior. These strategies include temporally controlled delivery of anti-inflammatory drugs, delivery of macrophages as cellular therapy, controlled release of cytokines that modulate macrophage phenotype, and the design of nanoparticles that exploit the inherent phagocytic behavior of macrophages. A clear outcome of this review is that a deeper understanding of the role and timing of complex macrophage phenotypes or activation states is required to fully harness their abilities with drug delivery strategies.

scholarly journals Interactome Analysis of iPSC Secretome and Its Effect on Macrophages In Vitro

2021 ◽  
Vol 22 (2) ◽  
pp. 958
Author(s):  
Luca Tamò ◽  
Kleanthis Fytianos ◽  
Fabienne Caldana ◽  
Cedric Simillion ◽  
Anis Feki ◽  
...  
Keyword(s):  
Tissue Repair ◽  
Mononuclear Cells ◽  
Human Peripheral Blood ◽  
Critical Role ◽  
Organ Injury ◽  
Macrophage Phenotype ◽  
Gene Interaction Network ◽  
Tissue Repair And Regeneration ◽  
Secretory Pattern

Induced pluripotent stem cell secretome (iPSC-CM) mitigate organ injury and help in repair. Macrophages play a critical role in tissue repair and regeneration and can be directed to promote tissue repair by iPSC-CM, although the exact mechanisms are not known. In the current investigative study, we evaluated the possible mechanism by which iPSC-CM regulates the phenotype and secretory pattern of macrophages in vitro. Macrophages were obtained from human peripheral blood mononuclear cells and differentiated to various subpopulations and treated with either iPSC-CM or control media in vitro. Macrophage phenotype was assessed by flow cytometry, gene expression changes by qRT PCR and secretory pattern by multiplex protein analysis. The protein and gene interaction network revealed the involvement of Amyloid precursor protein (APP) and ELAV-like protein 1 (ELAVL-1) both present in the iPSC-CM to play an important role in regulating the macrophage phenotype and their secretory pattern. This exploratory study reveals, in part, the possible mechanism and identifies two potential targets by which iPSC-CM regulate macrophages and help in repair and regeneration.

Inorganic Nanomaterials for Soft Tissue Repair and Regeneration

2018 ◽  
Vol 20 (1) ◽  
pp. 353-374 ◽  
Author(s):  
Russell Urie ◽  
Deepanjan Ghosh ◽  
Inam Ridha ◽  
Kaushal Rege
Keyword(s):  
Soft Tissue ◽  
Tissue Repair ◽  
Cellular Therapy ◽  
Mechanical Stability ◽  
Wound Dressings ◽  
Soft Tissue Repair ◽  
Comprehensive Overview ◽  
Carbon Allotrope ◽  
Tissue Repair And Regeneration ◽  
Inorganic Nanomaterials

Inorganic nanomaterials have witnessed significant advances in areas of medicine including cancer therapy, imaging, and drug delivery, but their use in soft tissue repair and regeneration is in its infancy. Metallic, ceramic, and carbon allotrope nanoparticles have shown promise in facilitating tissue repair and regeneration. Inorganic nanomaterials have been employed to improve stem cell engraftment in cellular therapy, material mechanical stability in tissue repair, electrical conductivity in nerve and cardiac regeneration, adhesion strength in tissue approximation, and antibacterial capacity in wound dressings. These nanomaterials have also been used to improve or replace common surgical materials and restore functionality to damaged tissue. We provide a comprehensive overview of inorganic nanomaterials in tissue repair and regeneration, and discuss their promise and limitations for eventual translation to the clinic.

scholarly journals Medicinal Activities and Nanomedicine Delivery Strategies for Brucea javanica Oil and Its Molecular Components

Molecules ◽  
2020 ◽  
Vol 25 (22) ◽  
pp. 5414
Author(s):  
Bo Kyeong Yoon ◽  
Zheng Yi Lim ◽  
Won-Yong Jeon ◽  
Nam-Joon Cho ◽  
Jeong Hoon Kim ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Inflammatory Diseases ◽  
Delivery Vehicle ◽  
Drug Delivery Vehicles ◽  
Brucea Javanica ◽  
Development Processes ◽  
Delivery Vehicles ◽  
Delivery Strategies ◽  
Molecular Components ◽  
Brucea Javanica Oil

Brucea javanica oil (BJO) is widely used in traditional Chinese medicine to treat various types of cancer and inflammatory diseases. There is significant interest in understanding the medicinal activities of BJO and its molecular components, especially quassinoids, and in exploring how they can be incorporated into nanomedicine delivery strategies for improved application prospects. Herein, we cover the latest progress in developing different classes of drug delivery vehicles, including nanoemulsions, liposomes, nanostructured lipid carriers, and spongosomes, to encapsulate BJO and purified quassinoids. An introduction to the composition and medicinal activities of BJO and its molecular components, including quassinoids and fatty acids, is first provided. Application examples involving each type of drug delivery vehicle are then critically presented. Future opportunities for nanomedicine delivery strategies in the field are also discussed and considered within the context of translational medicine needs and drug development processes.

scholarly journals Hydrogen Sulfide as Potential Regulatory Gasotransmitter in Arthritic Diseases

2020 ◽  
Vol 21 (4) ◽  
pp. 1180 ◽  
Author(s):  
Flavia Sunzini ◽  
Susanna De Stefano ◽  
Maria Sole Chimenti ◽  
Sonia Melino
Keyword(s):  
Hydrogen Sulfide ◽  
Tissue Repair ◽  
Potential Role ◽  
Therapeutic Agent ◽  
Inflammatory Diseases ◽  
Biological Effects ◽  
Tissue Repair And Regeneration ◽  
Immune Mediated ◽  
The Social ◽  
Innate Immunity Cells

The social and economic impact of chronic inflammatory diseases, such as arthritis, explains the growing interest of the research in this field. The antioxidant and anti-inflammatory properties of the endogenous gasotransmitter hydrogen sulfide (H2S) were recently demonstrated in the context of different inflammatory diseases. In particular, H2S is able to suppress the production of pro-inflammatory mediations by lymphocytes and innate immunity cells. Considering these biological effects of H2S, a potential role in the treatment of inflammatory arthritis, such as rheumatoid arthritis (RA), can be postulated. However, despite the growing interest in H2S, more evidence is needed to understand the pathophysiology and the potential of H2S as a therapeutic agent. Within this review, we provide an overview on H2S biological effects, on its role in immune-mediated inflammatory diseases, on H2S releasing drugs, and on systems of tissue repair and regeneration that are currently under investigation for potential therapeutic applications in arthritic diseases.

scholarly journals The Dynamic Inflammatory Tissue Microenvironment: Signality and Disease Therapy by Biomaterials

Research ◽  
2021 ◽  
Vol 2021 ◽  
pp. 1-31
Author(s):  
Rani Mata ◽  
Yuejun Yao ◽  
Wangbei Cao ◽  
Jie Ding ◽  
Tong Zhou ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Tissue Repair ◽  
Cellular Response ◽  
Inflammatory Diseases ◽  
Inflammatory Microenvironment ◽  
Tissue Microenvironment ◽  
Tissue Repair And Regeneration ◽  
Disease Therapy ◽  
Anti Inflammation ◽  
Inflammatory Tissue

Tissue regeneration is an active multiplex process involving the dynamic inflammatory microenvironment. Under a normal physiological framework, inflammation is necessary for the systematic immunity including tissue repair and regeneration as well as returning to homeostasis. Inflammatory cellular response and metabolic mechanisms play key roles in the well-orchestrated tissue regeneration. If this response is dysregulated, it becomes chronic, which in turn causes progressive fibrosis, improper repair, and autoimmune disorders, ultimately leading to organ failure and death. Therefore, understanding of the complex inflammatory multiple player responses and their cellular metabolisms facilitates the latest insights and brings novel therapeutic methods for early diseases and modern health challenges. This review discusses the recent advances in molecular interactions of immune cells, controlled shift of pro- to anti-inflammation, reparative inflammatory metabolisms in tissue regeneration, controlling of an unfavorable microenvironment, dysregulated inflammatory diseases, and emerging therapeutic strategies including the use of biomaterials, which expand therapeutic views and briefly denote important gaps that are still prevailing.

Drug Delivery Technologies and Stem Cells for Tissue Repair and Regeneration

2015 ◽  
Vol 16 (7) ◽  
pp. 646-654
Author(s):  
Gorka Orive ◽  
Raquel Cobos ◽  
Janire Gorriti ◽  
Jose Pedraz ◽  
Mirella Meregalli ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Stem Cells ◽  
Tissue Repair ◽  
Tissue Repair And Regeneration

scholarly journals Targeted drug-delivery approaches by nanoparticulate carriers in the therapy of inflammatory diseases

2009 ◽  
Vol 7 (suppl_1) ◽  
Author(s):  
Wiebke Ulbrich ◽  
Alf Lamprecht
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Drug Targeting ◽  
Inflammatory Diseases ◽  
Site Of Action ◽  
Specific Uptake ◽  
Inflammatory Bowel ◽  
Delivery Strategies ◽  
Targeted Drug ◽  
High Doses

Limitations in therapy induced by adverse effects due to unselective drug availability and therefore the use of potentially too high doses are a common problem. One prominent example for this dilemma are inflammatory diseases. Colloidal carriers allow one to improve delivery of drugs to the site of action and appear promising to overcome this general therapeutic drawback. Specific uptake of nanoparticles by immune-related cells in inflamed barriers offers selective drug targeting to the inflamed tissue. Here we focus on nanocarrier-based drug delivery strategies for the treatment of common inflammatory disorders like rheumatoid arthritis, multiple sclerosis, uveitis or inflammatory bowel disease.

Annexin A1 and resolution of inflammation: tissue repairing properties and signalling signature

2016 ◽  
Vol 397 (10) ◽  
pp. 981-993 ◽  
Author(s):  
Thomas Gobbetti ◽  
Sadani N. Cooray
Keyword(s):  
Tissue Repair ◽  
Tissue Injury ◽  
Inflammatory Diseases ◽  
Molecular Targets ◽  
Biological Properties ◽  
Innate Immune ◽  
Therapeutic Effects ◽  
Annexin A1 ◽  
Persistent Inflammation ◽  
Tissue Healing

AbstractInflammation is essential to protect the host from exogenous and endogenous dangers that ultimately lead to tissue injury. The consequent tissue repair is intimately associated with the fate of the inflammatory response. Restoration of tissue homeostasis is achieved through a balance between pro-inflammatory and anti-inflammatory/pro-resolving mediators. In chronic inflammatory diseases such balance is compromised, resulting in persistent inflammation and impaired healing. During the last two decades the glucocorticoid-regulated protein Annexin A1 (AnxA1) has emerged as a potent pro-resolving mediator acting on several facets of the innate immune system. Here, we review the therapeutic effects of AnxA1 on tissue healing and repairing together with the molecular targets responsible for these complex biological properties.

Innovations in drug delivery for chronic wound healing

2021 ◽  
Vol 27 ◽  
Author(s):  
Erfan Rezvani Ghomi ◽  
Mohamadreza Shakiba ◽  
Ali Saedi Ardahaei ◽  
Mahsa Akbari ◽  
Mehdi Faraji ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Drug Delivery Systems ◽  
Chronic Wounds ◽  
Chronic Wound ◽  
Healing Process ◽  
Skin Structure ◽  
Physical Problems ◽  
Complex Process ◽  
Chronic Ulcers

: Wound healing is a varied and complex process designed to promptly restore standard skin structure, function, and appearance. To achieve this goal, different immune and biological systems participate in coordination through four separate steps, including homeostasis, inflammation, proliferation, and regeneration. Each step involves the function of other cells, cytokines, and growth factors. However, chronic ulcers, which are classified into three types of ulcers, namely vascular ulcers, diabetic ulcers, and pressure ulcers, cannot heal through the mentioned natural stages. It causes mental and physical problems for these people and, as a result, imposes high economic and social costs on society. In this regard, using a system that can accelerate the healing process of such chronic wounds, as an urgent need in the community, should be considered. Therefore, in this study, the innovations of drug delivery systems for the healing of chronic wounds using hydrogels, nanomaterial, and membranes are discussed and reviewed.

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