scholarly journals A Machine Learning-Based Identification of Genes Affecting the Pharmacokinetics of Tacrolimus Using the DMETTM Plus Platform

2020 ◽  
Vol 21 (7) ◽  
pp. 2517
Author(s):  
Jeong-An Gim ◽  
Yonghan Kwon ◽  
Hyun A Lee ◽  
Kyeong-Ryoon Lee ◽  
Soohyun Kim ◽  
...  
Keyword(s):  
Machine Learning ◽  
Random Forest ◽  
Decision Tree ◽  
Therapeutic Index ◽  
Immunosuppressive Drug ◽  
Machine Learning Algorithms ◽  
Nucleotide Polymorphisms ◽  
Lasso Regression ◽  
Single Nucleotide ◽  
Selection Operator

Tacrolimus is an immunosuppressive drug with a narrow therapeutic index and larger interindividual variability. We identified genetic variants to predict tacrolimus exposure in healthy Korean males using machine learning algorithms such as decision tree, random forest, and least absolute shrinkage and selection operator (LASSO) regression. rs776746 (CYP3A5) and rs1137115 (CYP2A6) are single nucleotide polymorphisms (SNPs) that can affect exposure to tacrolimus. A decision tree, when coupled with random forest analysis, is an efficient tool for predicting the exposure to tacrolimus based on genotype. These tools are helpful to determine an individualized dose of tacrolimus.

scholarly journals Modified Decision Tree Technique for Ransomware Detection at Runtime through API Calls

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Faizan Ullah ◽  
Qaisar Javaid ◽  
Abdu Salam ◽  
Masood Ahmad ◽  
Nadeem Sarwar ◽  
...  
Keyword(s):  
Machine Learning ◽  
Random Forest ◽  
Decision Tree ◽  
Feature Vector ◽  
Machine Learning Algorithms ◽  
The Novel ◽  
Proposed Model ◽  
Testing Accuracy ◽  
Financial Losses

Ransomware (RW) is a distinctive variety of malware that encrypts the files or locks the user’s system by keeping and taking their files hostage, which leads to huge financial losses to users. In this article, we propose a new model that extracts the novel features from the RW dataset and performs classification of the RW and benign files. The proposed model can detect a large number of RW from various families at runtime and scan the network, registry activities, and file system throughout the execution. API-call series was reutilized to represent the behavior-based features of RW. The technique extracts fourteen-feature vector at runtime and analyzes it by applying online machine learning algorithms to predict the RW. To validate the effectiveness and scalability, we test 78550 recent malign and benign RW and compare with the random forest and AdaBoost, and the testing accuracy is extended at 99.56%.

scholarly journals Predicting Bank Operational Efficiency Using Machine Learning Algorithm: Comparative Study of Decision Tree, Random Forest, and Neural Networks

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Peter Appiahene ◽  
Yaw Marfo Missah ◽  
Ussiph Najim
Keyword(s):  
Machine Learning ◽  
Random Forest ◽  
Decision Tree ◽  
Banking Sector ◽  
Banking Industry ◽  
Predictive Accuracy ◽  
Learning Algorithm ◽  
Machine Learning Algorithms ◽  
Machine Learning Algorithm ◽  
And Performance

The financial crisis that hit Ghana from 2015 to 2018 has raised various issues with respect to the efficiency of banks and the safety of depositors’ in the banking industry. As part of measures to improve the banking sector and also restore customers’ confidence, efficiency and performance analysis in the banking industry has become a hot issue. This is because stakeholders have to detect the underlying causes of inefficiencies within the banking industry. Nonparametric methods such as Data Envelopment Analysis (DEA) have been suggested in the literature as a good measure of banks’ efficiency and performance. Machine learning algorithms have also been viewed as a good tool to estimate various nonparametric and nonlinear problems. This paper presents a combined DEA with three machine learning approaches in evaluating bank efficiency and performance using 444 Ghanaian bank branches, Decision Making Units (DMUs). The results were compared with the corresponding efficiency ratings obtained from the DEA. Finally, the prediction accuracies of the three machine learning algorithm models were compared. The results suggested that the decision tree (DT) and its C5.0 algorithm provided the best predictive model. It had 100% accuracy in predicting the 134 holdout sample dataset (30% banks) and a P value of 0.00. The DT was followed closely by random forest algorithm with a predictive accuracy of 98.5% and a P value of 0.00 and finally the neural network (86.6% accuracy) with a P value 0.66. The study concluded that banks in Ghana can use the result of this study to predict their respective efficiencies. All experiments were performed within a simulation environment and conducted in R studio using R codes.

scholarly journals Prediction of COVID-19 Risk in Public Areas Using IoT and Machine Learning

Electronics ◽  
2021 ◽  
Vol 10 (14) ◽  
pp. 1677
Author(s):  
Ersin Elbasi ◽  
Ahmet E. Topcu ◽  
Shinu Mathew
Keyword(s):  
Machine Learning ◽  
Random Forest ◽  
Decision Tree ◽  
Naive Bayes ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
Bayes Classifier ◽  
Social Distancing ◽  
Public Areas ◽  
Iot Devices

COVID-19 is a community-acquired infection with symptoms that resemble those of influenza and bacterial pneumonia. Creating an infection control policy involving isolation, disinfection of surfaces, and identification of contagions is crucial in eradicating such pandemics. Incorporating social distancing could also help stop the spread of community-acquired infections like COVID-19. Social distancing entails maintaining certain distances between people and reducing the frequency of contact between people. Meanwhile, a significant increase in the development of different Internet of Things (IoT) devices has been seen together with cyber-physical systems that connect with physical environments. Machine learning is strengthening current technologies by adding new approaches to quickly and correctly solve problems utilizing this surge of available IoT devices. We propose a new approach using machine learning algorithms for monitoring the risk of COVID-19 in public areas. Extracted features from IoT sensors are used as input for several machine learning algorithms such as decision tree, neural network, naïve Bayes classifier, support vector machine, and random forest to predict the risks of the COVID-19 pandemic and calculate the risk probability of public places. This research aims to find vulnerable populations and reduce the impact of the disease on certain groups using machine learning models. We build a model to calculate and predict the risk factors of populated areas. This model generates automated alerts for security authorities in the case of any abnormal detection. Experimental results show that we have high accuracy with random forest of 97.32%, with decision tree of 94.50%, and with the naïve Bayes classifier of 99.37%. These algorithms indicate great potential for crowd risk prediction in public areas.

scholarly journals Incorporating metadata in HIV transmission network reconstruction: A machine learning feasibility assessment

2021 ◽  
Vol 17 (9) ◽  
pp. e1009336
Author(s):  
Sepideh Mazrouee ◽  
Susan J. Little ◽  
Joel O. Wertheim
Keyword(s):  
Machine Learning ◽  
Random Forest ◽  
Decision Tree ◽  
Hiv Transmission ◽  
Genetic Data ◽  
Network Reconstruction ◽  
Machine Learning Algorithms ◽  
Support Vector ◽  
Transmission Network ◽  
Viral Sequences

HIV molecular epidemiology estimates the transmission patterns from clustering genetically similar viruses. The process involves connecting genetically similar genotyped viral sequences in the network implying epidemiological transmissions. This technique relies on genotype data which is collected only from HIV diagnosed and in-care populations and leaves many persons with HIV (PWH) who have no access to consistent care out of the tracking process. We use machine learning algorithms to learn the non-linear correlation patterns between patient metadata and transmissions between HIV-positive cases. This enables us to expand the transmission network reconstruction beyond the molecular network. We employed multiple commonly used supervised classification algorithms to analyze the San Diego Primary Infection Resource Consortium (PIRC) cohort dataset, consisting of genotypes and nearly 80 additional non-genetic features. First, we trained classification models to determine genetically unrelated individuals from related ones. Our results show that random forest and decision tree achieved over 80% in accuracy, precision, recall, and F1-score by only using a subset of meta-features including age, birth sex, sexual orientation, race, transmission category, estimated date of infection, and first viral load date besides genetic data. Additionally, both algorithms achieved approximately 80% sensitivity and specificity. The Area Under Curve (AUC) is reported 97% and 94% for random forest and decision tree classifiers respectively. Next, we extended the models to identify clusters of similar viral sequences. Support vector machine demonstrated one order of magnitude improvement in accuracy of assigning the sequences to the correct cluster compared to dummy uniform random classifier. These results confirm that metadata carries important information about the dynamics of HIV transmission as embedded in transmission clusters. Hence, novel computational approaches are needed to apply the non-trivial knowledge collected from inter-individual genetic information to metadata from PWH in order to expand the estimated transmissions. We note that feature extraction alone will not be effective in identifying patterns of transmission and will result in random clustering of the data, but its utilization in conjunction with genetic data and the right algorithm can contribute to the expansion of the reconstructed network beyond individuals with genetic data.

scholarly journals Machine Learning Algorithms for Visualization and Prediction Modeling of Boston Crime Data

2020 ◽  
Author(s):  
Jiarui Yin ◽  
Inikuro Afa Michael ◽  
Iduabo John Afa
Keyword(s):  
Machine Learning ◽  
Random Forest ◽  
Decision Tree ◽  
Data Science ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
Crime Data ◽  
Detection Analysis ◽  
Supervised Learning Algorithms ◽  
Supervised Methods

Machine learning plays a key role in present day crime detection, analysis and prediction. The goal of this work is to propose methods for predicting crimes classified into different categories of severity. We implemented visualization and analysis of crime data statistics in recent years in the city of Boston. We then carried out a comparative study between two supervised learning algorithms, which are decision tree and random forest based on the accuracy and processing time of the models to make predictions using geographical and temporal information provided by splitting the data into training and test sets. The result shows that random forest as expected gives a better result by 1.54% more accuracy in comparison to decision tree, although this comes at a cost of at least 4.37 times the time consumed in processing. The study opens doors to application of similar supervised methods in crime data analytics and other fields of data science

scholarly journals Data Driven Approach for Eye Disease Classification with Machine Learning

2019 ◽  
Vol 9 (14) ◽  
pp. 2789 ◽  
Author(s):  
Sadaf Malik ◽  
Nadia Kanwal ◽  
Mamoona Naveed Asghar ◽  
Mohammad Ali A. Sadiq ◽  
Irfan Karamat ◽  
...  
Keyword(s):  
Machine Learning ◽  
Random Forest ◽  
Decision Tree ◽  
Naive Bayes ◽  
Learning Algorithms ◽  
Naïve Bayes ◽  
Machine Learning Algorithms ◽  
Multiple Features ◽  
Standard Format ◽  
Free Data

Medical health systems have been concentrating on artificial intelligence techniques for speedy diagnosis. However, the recording of health data in a standard form still requires attention so that machine learning can be more accurate and reliable by considering multiple features. The aim of this study is to develop a general framework for recording diagnostic data in an international standard format to facilitate prediction of disease diagnosis based on symptoms using machine learning algorithms. Efforts were made to ensure error-free data entry by developing a user-friendly interface. Furthermore, multiple machine learning algorithms including Decision Tree, Random Forest, Naive Bayes and Neural Network algorithms were used to analyze patient data based on multiple features, including age, illness history and clinical observations. This data was formatted according to structured hierarchies designed by medical experts, whereas diagnosis was made as per the ICD-10 coding developed by the American Academy of Ophthalmology. Furthermore, the system is designed to evolve through self-learning by adding new classifications for both diagnosis and symptoms. The classification results from tree-based methods demonstrated that the proposed framework performs satisfactorily, given a sufficient amount of data. Owing to a structured data arrangement, the random forest and decision tree algorithms’ prediction rate is more than 90% as compared to more complex methods such as neural networks and the naïve Bayes algorithm.

scholarly journals The importance of disease incidence rate on performance of GBLUP, threshold BayesA and machine learning methods in original and imputed data set

2020 ◽  
Vol 18 (3) ◽  
pp. e0405
Author(s):  
Yousef Naderi ◽  
Saadat Sadeghi
Keyword(s):  
Machine Learning ◽  
Disease Incidence ◽  
Predictive Ability ◽  
High Sensitivity ◽  
Machine Learning Algorithms ◽  
Genotype Imputation ◽  
Nucleotide Polymorphisms ◽  
Data Set ◽  
Single Nucleotide ◽  
Boosting Method

Aim of study: To predict genomic accuracy of binary traits considering different rates of disease incidence.Area of study: SimulationMaterial and methods: Two machine learning algorithms including Boosting and Random Forest (RF) as well as threshold BayesA (TBA) and genomic BLUP (GBLUP) were employed. The predictive ability methods were evaluated for different genomic architectures using imputed (i.e. 2.5K, 12.5K and 25K panels) and their original 50K genotypes. We evaluated the three strategies with different rates of disease incidence (including 16%, 50% and 84% threshold points) and their effects on genomic prediction accuracy.Main results: Genotype imputation performed poorly to estimate the predictive ability of GBLUP, RF, Boosting and TBA methods when using the low-density single nucleotide polymorphisms (SNPs) chip in low linkage disequilibrium (LD) scenarios. The highest predictive ability, when the rate of disease incidence into the training set was 16%, belonged to GBLUP, RF, Boosting and TBA methods. Across different genomic architectures, the Boosting method performed better than TBA, GBLUP and RF methods for all scenarios and proportions of the marker sets imputed. Regarding the changes, the RF resulted in a further reduction compared to Boosting, TBA and GBLUP, especially when the applied data set contained 2.5K panels of the imputed genotypes.Research highlights: Generally, considering high sensitivity of methods to imputation errors, the application of imputed genotypes using RF method should be carefully evaluated.

scholarly journals Statistical Analysis for Selective Identifications of VOCs by Using Surface Functionalized MoS2 Based Sensor Array

2021 ◽  
Vol 5 (1) ◽  
pp. 35
Author(s):  
Uttam Narendra Thakur ◽  
Radha Bhardwaj ◽  
Arnab Hazra
Keyword(s):  
Machine Learning ◽  
Logistic Regression ◽  
Random Forest ◽  
Decision Tree ◽  
Sensor Array ◽  
Multinomial Logistic Regression ◽  
Learning Algorithms ◽  
Disease Diagnosis ◽  
Machine Learning Algorithms ◽  
Human Breath

Disease diagnosis through breath analysis has attracted significant attention in recent years due to its noninvasive nature, rapid testing ability, and applicability for patients of all ages. More than 1000 volatile organic components (VOCs) exist in human breath, but only selected VOCs are associated with specific diseases. Selective identification of those disease marker VOCs using an array of multiple sensors are highly desirable in the current scenario. The use of efficient sensors and the use of suitable classification algorithms is essential for the selective and reliable detection of those disease markers in complex breath. In the current study, we fabricated a noble metal (Au, Pd and Pt) nanoparticle-functionalized MoS2 (Chalcogenides, Sigma Aldrich, St. Louis, MO, USA)-based sensor array for the selective identification of different VOCs. Four sensors, i.e., pure MoS2, Au/MoS2, Pd/MoS2, and Pt/MoS2 were tested under exposure to different VOCs, such as acetone, benzene, ethanol, xylene, 2-propenol, methanol and toluene, at 50 °C. Initially, principal component analysis (PCA) and linear discriminant analysis (LDA) were used to discriminate those seven VOCs. As compared to the PCA, LDA was able to discriminate well between the seven VOCs. Four different machine learning algorithms such as k-nearest neighbors (kNN), decision tree, random forest, and multinomial logistic regression were used to further identify those VOCs. The classification accuracy of those seven VOCs using KNN, decision tree, random forest, and multinomial logistic regression was 97.14%, 92.43%, 84.1%, and 98.97%, respectively. These results authenticated that multinomial logistic regression performed best between the four machine learning algorithms to discriminate and differentiate the multiple VOCs that generally exist in human breath.

APPLICATION OF MACHINE LEARNING IN ANALYSING HISTORICAL AND NON-HISTORICAL CHARACTERISTICS OF HERITAGE PRE-WAR SHOPHOUSES

2021 ◽  
Vol 19 (16) ◽  
Author(s):  
Nur Shahirah Ja'afar ◽  
Junainah Mohamad
Keyword(s):  
Machine Learning ◽  
Random Forest ◽  
Root Mean Square Error ◽  
Current Practice ◽  
Machine Learning Algorithms ◽  
Mean Square ◽  
Lasso Regression ◽  
North East ◽  
Best Fitting ◽  
Fitting Model

Real estate is complex and its value is influenced by many characteristics. However, the current practice in Malaysia shows that historical characteristics have not been given primary consideration in determining the value of heritage properties. Thus, the accuracy of the values produced is questionable. This paper aims to determine whether the historical characteristics of the pre-war shophouses at North-East Penang Island, Malaysia contribute any significance to their value. Several Machine Learning algorithms have been developed for this purpose namely Random Forest, Decision Tree, Lasso Regression, Ridge Regression and Linear Regression. The result shows that the Random Forest Regressor with historical characteristics is the best fitting model with higher values of R-squared (R²) and lowest value of Root Mean Square Error (RMSE). This indicates that the historical characteristics of the heritage property under study contribute to its significant value. By considering the historical characteristics, the property’s value can be better predicted.

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