scholarly journals Nasal Epithelial Cell-Based Models for Individualized Study in Cystic Fibrosis

2021 ◽  
Vol 22 (9) ◽  
pp. 4448
Author(s):  
Duncan E. Keegan ◽  
John J. Brewington
Keyword(s):  
Cystic Fibrosis ◽  
Patient Outcomes ◽  
Ex Vivo ◽  
Nasal Epithelial Cell ◽  
Individual Level ◽  
Current State ◽  
Ex Vivo Culture ◽  
The Individual ◽  
Disease Study ◽  
Individual Disease

The emergence of highly effective CFTR modulator therapy has led to significant improvements in health care for most patients with cystic fibrosis (CF). For some, however, these therapies remain inaccessible due to the rarity of their individual CFTR variants, or due to a lack of biologic activity of the available therapies for certain variants. One proposed method of addressing this gap is the use of primary human cell-based models, which allow preclinical therapeutic testing and physiologic assessment of relevant tissue at the individual level. Nasal cells represent one such tissue source and have emerged as a powerful model for individual disease study. The ex vivo culture of nasal cells has evolved over time, and modern nasal cell models are beginning to be utilized to predict patient outcomes. This review will discuss both historical and current state-of-the art use of nasal cells for study in CF, with a particular focus on the use of such models to inform personalized patient care.

scholarly journals The Role of the Gut Microbiome in Predicting Response to Diet and the Development of Precision Nutrition Models—Part I: Overview of Current Methods

2019 ◽  
Vol 10 (6) ◽  
pp. 953-978 ◽  
Author(s):  
Riley L Hughes ◽  
Maria L Marco ◽  
James P Hughes ◽  
Nancy L Keim ◽  
Mary E Kable
Keyword(s):  
Gut Microbiome ◽  
Interindividual Variability ◽  
Current Knowledge ◽  
Dietary Advice ◽  
Future Research ◽  
Individual Level ◽  
Current State ◽  
Nutrition Research ◽  
The Individual

ABSTRACT Health care is increasingly focused on health at the individual level. In the rapidly evolving field of precision nutrition, researchers aim to identify how genetics, epigenetics, and the microbiome interact to shape an individual's response to diet. With this understanding, personalized responses can be predicted and dietary advice can be tailored to the individual. With the integration of these complex sources of data, an important aspect of precision nutrition research is the methodology used for studying interindividual variability in response to diet. This article stands as the first in a 2-part review of current research investigating the contribution of the gut microbiota to interindividual variability in response to diet. Part I reviews the methods used by researchers to design and carry out such studies as well as the statistical and bioinformatic methods used to analyze results. Part II reviews the findings of these studies, discusses gaps in our current knowledge, and summarizes directions for future research. Taken together, these reviews summarize the current state of knowledge and provide a foundation for future research on the role of the gut microbiome in precision nutrition.

scholarly journals Astrogliosis mapping in individual brains using multidimensional MRI

2022 ◽  
Author(s):  
Dan Benjamini ◽  
David S Priemer ◽  
Daniel P Perl ◽  
David L brody ◽  
Peter J Basser
Keyword(s):  
Ex Vivo ◽  
Correlation Study ◽  
Strongly Correlated ◽  
Cortical Tissue ◽  
Individual Level ◽  
Spatial Sensitivity ◽  
Protein Deposition ◽  
The Central Nervous System ◽  
Histological Images ◽  
The Individual

There are currently no noninvasive imaging methods available for astrogliosis mapping in the central nervous system despite its essential role in the response to injury, disease, and infection. We have developed a machine learning-based multidimensional MRI framework that provides a signature of astrogliosis, distinguishing it from normative brain at the individual level. We investigated ex vivo cortical tissue specimen derived from subjects who sustained blast induced injuries, which resulted in scar-border forming astrogliosis without being accompanied by other types of neuropathology. By performing a combined postmortem radiology and histopathology correlation study we found that astrogliosis induces microstructural changes that are robustly detected using our framework, resulting in MRI neuropathology maps that are significantly and strongly correlated with co-registered histological images of increased glial fibrillary acidic protein deposition. The demonstrated high spatial sensitivity in detecting reactive astrocytes at the individual level has great potential to significantly impact neuroimaging studies in diseases, injury, repair, and aging.

scholarly journals The COVID States Project #43: COVID-19 vaccine rates and attitudes among Americans

2021 ◽  
Author(s):  
David Lazer ◽  
Katherine Ognyanova ◽  
Matthew Baum ◽  
James Druckman ◽  
Jon Green ◽  
...  
Keyword(s):  
Primary Care Physicians ◽  
Multivariable Analysis ◽  
Vaccination Rate ◽  
Individual Level ◽  
Vaccination Rates ◽  
Vaccine Refusal ◽  
Current State ◽  
Distribution Process ◽  
The Individual ◽  
The Relationship

Who has been most likely to be vaccinated? And who is most likely to be vaccine resistant? Among the early, eligible individuals, who has received the vaccine, and who has refused to be vaccinated? In this report we address these questions by examining the relationship between various sociodemographic categories and vaccination rates, vaccination resistance, vaccination hesitancy, vaccine accessibility, and vaccine refusal. We examine both the current state of these relationships, as well as changes in vaccine resistance over time. We find strong relationships between these vaccine outcomes at the individual level and age, education, income, race, partisanship, gender, and urbanicity. All of these relationships are statistically significant in a multivariable analysis; but education stands out as a particularly powerful predictor. The divergent vaccination rate likely partially reflects the complex distribution process for the vaccine that has hurt those with the least resources and knowledge to navigate that complexity. Further, the emphasis in many states on mass vaccination sites reduces the contact of vaccine skeptics with the person best able to discuss the benefits and risks of vaccination: their primary care physicians.

scholarly journals The dynamics of dominance: open questions, challenges and solutions

2022 ◽  
Vol 377 (1845) ◽  
Author(s):  
Eli D. Strauss ◽  
Daizaburo Shizuka
Keyword(s):  
Model Systems ◽  
Practical Reasons ◽  
Individual Level ◽  
Current State ◽  
Open Questions ◽  
Conceptual Clarity ◽  
Status Seeking ◽  
Decision Making Processes ◽  
The Individual ◽  
The Impact

Although social hierarchies are recognized as dynamic systems, they are typically treated as static entities for practical reasons. Here, we ask what we can learn from a dynamical view of dominance, and provide a research agenda for the next decades. We identify five broad questions at the individual, dyadic and group levels, exploring the causes and consequences of individual changes in rank, the dynamics underlying dyadic dominance relationships, and the origins and impacts of social instability. Although challenges remain, we propose avenues for overcoming them. We suggest distinguishing between different types of social mobility to provide conceptual clarity about hierarchy dynamics at the individual level, and emphasize the need to explore how these dynamic processes produce dominance trajectories over individual lifespans and impact selection on status-seeking behaviour. At the dyadic level, there is scope for deeper exploration of decision-making processes leading to observed interactions, and how stable but malleable relationships emerge from these interactions. Across scales, model systems where rank is manipulable will be extremely useful for testing hypotheses about dominance dynamics. Long-term individual-based studies will also be critical for understanding the impact of rare events, and for interrogating dynamics that unfold over lifetimes and generations. This article is part of the theme issue ‘The centennial of the pecking order: current state and future prospects for the study of dominance hierarchies’.

Employee perspective on CSR: a review of the literature and research agenda

2019 ◽  
Vol 10 (4) ◽  
pp. 355-381
Author(s):  
Anuja Akhouri ◽  
Richa Chaudhary
Keyword(s):  
Research Trend ◽  
Future Research ◽  
Recent Theory ◽  
Comprehensive Review ◽  
Content Type ◽  
Individual Level ◽  
Current State ◽  
The Individual ◽  
Future Work ◽  
Conference Papers

Purpose This paper aims to review the available academic literature on CSR from employees’ perspective, with an objective to better understand the individual-level analysis of CSR and clarify the current state of thinking in the area. Specifically, the authors present the evolution of the concept of CSR, from the historical overview to the emergence of recent theory and conceptualizations; the underlying theoretical foundations of CSR; the studied variables for CSR; and the research gaps and future work avenues in the field of CSR. Design/methodology/approach In all, 158 articles from 72 journals were included in the review, and a comprehensive analysis of the reviewed articles was performed. Findings This paper makes a significant contribution to the literature by presenting a comprehensive review of the articles published in academic journals, focusing on employees’ perspective of CSR. The findings advance the understanding of the research trend in employee-focused micro-level CSR research. They will assist organizations better understand “why,” “how” and “when” employees react to CSR initiatives of an organization. This paper also identifies the existing gaps in employee-centric CSR research, which will provide important directions for future research in the area. Research limitations/implications The review focused exclusively on journal publications. Dissertations, conference papers, working papers and practitioner papers were excluded, as they are not peer-reviewed. Originality/value This paper is one of the comprehensive review papers that focus exclusively on employees’ perspective of CSR, by analyzing 158 articles from the period 1961-2017.

Differential Effects of Competence and Morality on Self-Esteem at the Individual and the Collective Level

2020 ◽  
Vol 51 (3) ◽  
pp. 183-198
Author(s):  
Wiktor Soral ◽  
Mirosław Kofta
Keyword(s):  
Self Esteem ◽  
Differential Effects ◽  
Individual Level ◽  
The Subject ◽  
The Individual

Abstract. The importance of various trait dimensions explaining positive global self-esteem has been the subject of numerous studies. While some have provided support for the importance of agency, others have highlighted the importance of communion. This discrepancy can be explained, if one takes into account that people define and value their self both in individual and in collective terms. Two studies ( N = 367 and N = 263) examined the extent to which competence (an aspect of agency), morality, and sociability (the aspects of communion) promote high self-esteem at the individual and the collective level. In both studies, competence was the strongest predictor of self-esteem at the individual level, whereas morality was the strongest predictor of self-esteem at the collective level.

Metonymy in Dance: Ballet Bunheads Take a Cognitive Turn

2019 ◽  
Vol 37 (1) ◽  
pp. 18-34
Author(s):  
Edward C. Warburton
Keyword(s):  
Identity Formation ◽  
Cognitive Science ◽  
Artistic Development ◽  
Individual Level ◽  
Figures Of Speech ◽  
Self Image ◽  
Level I ◽  
Dance Educators ◽  
The Individual ◽  
Metaphor And Metonymy

This essay considers metonymy in dance from the perspective of cognitive science. My goal is to unpack the roles of metaphor and metonymy in dance thought and action: how do they arise, how are they understood, how are they to be explained, and in what ways do they determine a person's doing of dance? The premise of this essay is that language matters at the cultural level and can be determinative at the individual level. I contend that some figures of speech, especially metonymic labels like ‘bunhead’, can not only discourage but dehumanize young dancers, treating them not as subjects who dance but as objects to be danced. The use of metonymy to sort young dancers may undermine the development of healthy self-image, impede strong identity formation, and retard creative-artistic development. The paper concludes with a discussion of the influence of metonymy in dance and implications for dance educators.

Exploring the effect of weight loss on food reward at the individual level

2019 ◽  
Author(s):  
Pauline Oustric ◽  
Kristine Beaulieu ◽  
Nuno Casanova ◽  
Francois Husson ◽  
Catherine Gibbons ◽  
...  
Keyword(s):  
Weight Loss ◽  
Food Reward ◽  
Individual Level ◽  
The Individual

Personality change and environmental concerns

2020 ◽  
Author(s):  
Christopher James Hopwood ◽  
Ted Schwaba ◽  
Wiebke Bleidorn
Keyword(s):  
Personality Traits ◽  
Personality Change ◽  
Environmental Concerns ◽  
Big Five Personality ◽  
German Population ◽  
Individual Level ◽  
Sustainable Behavior ◽  
Nationally Representative ◽  
The Individual ◽  
Over Time

Personal concerns about climate change and the environment are a powerful motivator of sustainable behavior. People’s level of concern varies as a function of a variety of social and individual factors. Using data from 58,748 participants from a nationally representative German sample, we tested preregistered hypotheses about factors that impact concerns about the environment over time. We found that environmental concerns increased modestly from 2009-2017 in the German population. However, individuals in middle adulthood tended to be more concerned and showed more consistent increases in concern over time than younger or older people. Consistent with previous research, Big Five personality traits were correlated with environmental concerns. We present novel evidence that increases in concern were related to increases in the personality traits neuroticism and openness to experience. Indeed, changes in openness explained roughly 50% of the variance in changes in environmental concerns. These findings highlight the importance of understanding the individual level factors associated with changes in environmental concerns over time, towards the promotion of more sustainable behavior at the individual level.

Sign in / Sign up

Export Citation Format

Share Document