scholarly journals Psoriasis: From Pathogenesis to Pharmacological and Nano-Technological-Based Therapeutics

2021 ◽  
Vol 22 (9) ◽  
pp. 4983
Author(s):  
Robert Gironés Petit ◽  
Amanda Cano ◽  
Alba Ortiz ◽  
Marta Espina ◽  
Josefina Prat ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Skin Diseases ◽  
Related Factors ◽  
Inflammatory Skin Diseases ◽  
Multifactorial Diseases ◽  
Age Related ◽  
Innovative Therapies ◽  
Disease Site ◽  
Chronic Skin ◽  
Chronic Skin Diseases

Research in the pathogenesis of inflammatory skin diseases, such as skin dermatitis and psoriasis, has experienced some relevant breakthroughs in recent years. The understanding of age-related factors, gender, and genetic predisposition of these multifactorial diseases has been instrumental for the development of new pharmacological and technological treatment approaches. In this review, we discuss the molecular mechanisms behind the pathological features of psoriasis, also addressing the currently available treatments and novel therapies that are under clinical trials. Innovative therapies developed over the last 10 years have been researched. In this area, advantages of nanotechnological approaches to provide an effective drug concentration in the disease site are highlighted, together with microneedles as innovative candidates for drug delivery systems in psoriasis and other inflammatory chronic skin diseases.

scholarly journals The Role of Thermal Water in Chronic Skin Diseases Management: A Review of the Literature

2020 ◽  
Vol 9 (9) ◽  
pp. 3047
Author(s):  
Sara Cacciapuoti ◽  
Maria Luciano ◽  
Matteo Megna ◽  
Maria Annunziata ◽  
Maddalena Napolitano ◽  
...  
Keyword(s):  
Thermal Water ◽  
Molecular Mechanisms ◽  
Skin Diseases ◽  
Current Knowledge ◽  
Well Being ◽  
Therapeutic Effects ◽  
Inflammatory Skin Diseases ◽  
Chronic Skin ◽  
Chronic Skin Diseases

The benefits of thermal water in different diseases have been known since ancient times. Over the past decades, a re-assessment of the use of mineral water for the treatment of several pathologic conditions has taken place around the world. Today, water therapy is being practiced in many countries that have a variety of mineral springs considerably different in their hydrogeologic origin, temperature, and chemical composition. Thermal water and balneotherapy offer several advantages: this approach needs no chemicals or potentially harmful drugs; there are almost no side effects during and after treatment, and there is a low risk to the patient’s general health and well-being. However, it is difficult to evaluate the efficacy of this therapeutic approach in clinical practice due to the complexity of molecular mechanisms underlying its efficacy. Here we review the current knowledge of the chemical, immunological, and microbiological basis for therapeutic effects of thermal water with a specific focus on chronic inflammatory skin diseases. We also describe recent evidence of the major dermatologic diseases that are frequently treated by balneotherapy with a remarkable rate of success. Moreover, we discuss the potential role of balneotherapy either alone or as a complement to conventional medical treatments.

scholarly journals Role of Aryl Hydrocarbon Receptor Activation in Inflammatory Chronic Skin Diseases

Cells ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 3559
Author(s):  
Maddalena Napolitano ◽  
Gabriella Fabbrocini ◽  
Fabrizio Martora ◽  
Vincenzo Picone ◽  
Paola Morelli ◽  
...  
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Skin Diseases ◽  
Inflammatory Diseases ◽  
Receptor Activation ◽  
Cell Physiology ◽  
Inflammatory Skin Diseases ◽  
Aryl Hydrocarbon ◽  
Chronic Skin ◽  
Chronic Skin Diseases

Aryl Hydrocarbon Receptor (AhR) is an evolutionary transcription factor which acts as a crucial sensor of different exogenous and endogenous molecules Recent data indicate that AhR is implicated in several physiological processes such as cell physiology, host defense, proliferation and differentiation of immune cells, and detoxification. Moreover, AhR involvement has been reported in the development and maintenance of several pathological conditions. In recent years, an increasing number of studies have accumulated highlighting the regulatory role of AhR in the physiology of the skin. However, there is evidence of both beneficial and harmful effects of AHR signaling. At present, most of the evidence concerns inflammatory skin diseases, in particular atopic dermatitis, psoriasis, acne, and hidradenitis suppurativa. This review examines the role of AhR in skin homeostasis and the therapeutic implication of its pharmacological modulation in these cutaneous inflammatory diseases.

scholarly journals Molecule guided laser ablation as a novel therapeutic strategy to control itch

2017 ◽  
Author(s):  
Linda Nocchi ◽  
Mariangela D’Attilia ◽  
Nainika Roy ◽  
Rahul Dhandapani ◽  
Andrei Traista ◽  
...  
Keyword(s):  
Near Infrared ◽  
Skin Diseases ◽  
New Technology ◽  
Skin Damage ◽  
Inflammatory Skin Diseases ◽  
Novel Technology ◽  
Near Ir ◽  
Chronic Skin ◽  
Chronic Skin Diseases

AbstractItch is a major symptom of many chronic skin diseases that can exacerbate inflammation by provoking excessive scratching and causing skin damage. Here we develop a novel technology to control itch through molecular guided delivery of a phototoxic agent and near infrared (IR) illumination of the skin. Exploiting the selective binding of the pruritogen Interleukin-31 to itch sensing cells, we generate an engineered IL31SNAPligand derivative (IL31K138A-SNAP) that binds to cells but does not evoke signaling or provoke scratching when injected in vivo. Conjugation of IL31K138A-SNAPto the photosensitizer IRDye®700DX phthalocyanine (IR700) and injection of the skin results in long-term reversal of scratching behavior evoked by IL31 upon near IR illumination. We further develop a topical preparation of IL31K138A-SNAP-IR700 that strikingly, reverses behavioral and dermatological indicators in mouse models of Atopic Dermatitis (AD) and the genetic skin disease Familial Primary Localized Cutaneous Amyloidosis (FPLCA). We demonstrate that this therapeutic effect results from selective retraction of itch sensing neurons in the skin, breaking the cycle of itch and disruption of the skin’s barrier function. Thus, molecule guided photoablation is a powerful new technology for controlling itch and treating inflammatory skin diseases.

The Constructive Thinking Inventory: Factorial Structure in Healthy Individuals and Patients with Chronic Skin Diseases

1998 ◽  
Vol 14 (3) ◽  
pp. 226-233 ◽  
Author(s):  
Jürgen Hoyer ◽  
Mechthild Averbeck ◽  
Thomas Heidenreich ◽  
Ulrich Stangier ◽  
Karin Pöhlmann ◽  
...  
Keyword(s):  
Skin Diseases ◽  
Principal Component ◽  
Initial Study ◽  
Statistical Independence ◽  
Constructive Thinking ◽  
Global Factor ◽  
Emotional Coping ◽  
Factor Congruence ◽  
Chronic Skin ◽  
Chronic Skin Diseases

Epstein's “Constructive Thinking Inventory” (CTI) was developed to measure the construct of experiential intelligence, which is based on his cognitive-experiential self-theory. Inventory items were generated by sampling naturally occurring automatic cognitions. Using principal component analysis, the findings showed a global factor of coping ability as well as six main factors: Emotional Coping, Behavioral Coping, Categorical Thinking, Personal Superstitious Thinking, Esoteric Thinking, and Naive Optimism. We tested the replicability of this factor structure and the amount of statistical independence (nonredundancy) between these factors in an initial study of German students (Study 1, N = 439) and in a second study of patients with chronic skin disorders (Study 2, N = 187). Factor congruence with the original (American) data was determined using a formula proposed by Schneewind and Cattell (1970) . Our findings show satisfactory factor congruence and statistical independence for Emotional Coping and Esoteric Thinking in both studies, while full replicability or independence could not be found in both for the other factors. Implications for the use and further development of the CTI are discussed.

167 Influence of Chronic Skin Diseases on Male Sexual Function in Upper Egypt

2017 ◽  
Vol 14 (2) ◽  
pp. e69
Author(s):  
H. Abdel Hafez ◽  
A.A. Abdel-Motaleb ◽  
H.D. Gaber ◽  
G.S.T. Al-Attar
Keyword(s):  
Sexual Function ◽  
Skin Diseases ◽  
Upper Egypt ◽  
Male Sexual Function ◽  
Chronic Skin ◽  
Chronic Skin Diseases

scholarly journals Influência de fatores emocionais nas doenças crônicas de pele: O estresse como gatilho para o desenvolvimento, reincidência ou agravamento da psoríase / Influence of emotional factors on chronic skin diseases: Stress as a trigger for development, recurrence or worsening of psoriasis

2019 ◽  
Vol 13 (46) ◽  
pp. 584-608
Author(s):  
Manuela Sobral Bentes de Melo ◽  
Nara Freire Leão Rocha ◽  
Stéfany Silva Magalhães ◽  
Lais Landim Sousa
Keyword(s):  
Skin Diseases ◽  
Emotional Factors ◽  
Chronic Skin ◽  
Chronic Skin Diseases

Diversos estudos têm revelado a existência de uma relação entre aspectos psicossociais e o desenvolvimento ou agravamento de dermatoses crônicas, dentre as quais se encontra a psoríase. Fatores psicológicos, stress e outros eventos da vida são capazes de agravar de 40 e 80% dos casos. O estudo objetivou analisar a forma como esses aspectos podem ensejar o surgimento, a reincidência ou a acentuação do quadro clínico. Metodologia: Estudo de casos concretos com pacientes portadores da psoríase, além de uma vasta literatura bibliográfica acerca da temática. Conclusão: Ficou demonstrada a importância do tratamento psíquico e fisiológico, bem como a necessidade do desenvolvimento de estratégias de coping para enfretamento das situações sociais envolvidas.   

scholarly journals Shedding Light on the Effects of Calorie Restriction and Its Mimetics on Skin Biology

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1529 ◽  
Author(s):  
Yeon Ja Choi
Keyword(s):  
Calorie Restriction ◽  
Skin Diseases ◽  
Skin Aging ◽  
Peroxisome Proliferator ◽  
Extrinsic Factors ◽  
Inflammatory Skin Diseases ◽  
Peroxisome Proliferator Activated Receptor ◽  
Beneficial Effects ◽  
Age Related ◽  
Skin Biology

During the aging process of an organism, the skin gradually loses its structural and functional characteristics. The skin becomes more fragile and vulnerable to damage, which may contribute to age-related diseases and even death. Skin aging is aggravated by the fact that the skin is in direct contact with extrinsic factors, such as ultraviolet irradiation. While calorie restriction (CR) is the most effective intervention to extend the lifespan of organisms and prevent age-related disorders, its effects on cutaneous aging and disorders are poorly understood. This review discusses the effects of CR and its alternative dietary intake on skin biology, with a focus on skin aging. CR structurally and functionally affects most of the skin and has been reported to rescue both age-related and photo-induced changes. The anti-inflammatory, anti-oxidative, stem cell maintenance, and metabolic activities of CR contribute to its beneficial effects on the skin. To the best of the author’s knowledge, the effects of fasting or a specific nutrient-restricted diet on skin aging have not been evaluated; these strategies offer benefits in wound healing and inflammatory skin diseases. In addition, well-known CR mimetics, including resveratrol, metformin, rapamycin, and peroxisome proliferator-activated receptor agonists, show CR-like prevention against skin aging. An overview of the role of CR in skin biology will provide valuable insights that would eventually lead to improvements in skin health.

Comparison of Personality Traits among Patients with Psoriasis, Atopic Dermatitis, and Stress: A Pilot Study

Dermatology ◽  
2020 ◽  
Vol 236 (4) ◽  
pp. 324-328 ◽  
Author(s):  
Lynda Grine ◽  
Giulia Tochtermann ◽  
Hilde Lapeere ◽  
Nele Maes ◽  
Günther F.L. Hofbauer ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Pilot Study ◽  
Personality Traits ◽  
Skin Diseases ◽  
Work Related Stress ◽  
Work Related ◽  
Chronic Skin ◽  
Related Stress ◽  
Chronic Skin Diseases ◽  
The Impact

Background: Psoriasis and atopic dermatitis are chronic skin diseases that greatly affect the quality of life. Both diseases can be triggered or exacerbated by stress. Objective: We aimed to differentiate personality traits between patients with chronic skin conditions and people treated for stress in a pilot study. Methods: Patients participating voluntarily in educational programs in Belgium and Switzerland were recruited to complete personality trait questionnaires, including the Temperament and Character Inventory (TCI) and the Tridimensional Personality Questionnaire (TPQ). A comparison was made with patients treated for work-related stress. Results: A total of 48 and 91 patients suffering from skin diseases and work-related stress, respectively, were included in the study. Based on the questionnaires, we found that dermatology patients were less persistent and impulsive than those with work-related stress. Dermatology patients also exhibited more rigidness and less focus on performance. Finally, patients with work-related stress seem more likely to change in response to health-promoting programs than patients with chronic dermatoses. Conclusion: Patients with chronic skin diseases may perceive and cope with stress differently in comparison to patients with work-related stress due to inherent personality traits. Therefore, stress coping mechanisms may differ among different diseases. More research is needed into the design of educational interventions and the impact of personality traits in disease-specific groups.

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