scholarly journals The Role of Melatonin on Behavioral Changes and Concomitant Oxidative Stress in icvAβ1-42 Rat Model with Pinealectomy

2021 ◽  
Vol 22 (23) ◽  
pp. 12763
Author(s):  
Rumiana Tzoneva ◽  
Irina Georgieva ◽  
Natasha Ivanova ◽  
Veselina Uzunova ◽  
Zlatina Nenchovska ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant System ◽  
Rat Model ◽  
Brain Structures ◽  
Behavioral Changes ◽  
Cognitive Responses ◽  
Object Recognition Test ◽  
Sod Activity ◽  
Elevated Plus Maze Test

One of the pathological hallmarks of Alzheimer’s disease (AD) associated with its progression that contributes to β-amyloid (Aβ) generation is oxidative stress (OS). Clinical data suggest that melatonin is a potent antioxidant that might be effective in the adjunctive therapy of this neurodegenerative disease. The present study aimed to explore the role of melatonin on behavioral changes and markers of OS in three rat models, namely, pinealectomy (pin) model of melatonin deficit, intracerebroventricular (icv)Aβ1-42 model of AD, and combination of both pin and Aβ1-42 model (pin+icvAβ1-42). The chronic injection with vehicle/melatonin (50 mg/kg, i.p. for 40 days) started on the same day of sham/pin and icv vehicle/Aβ1-42 infusion procedures. Anxiety in the open field and the elevated plus-maze test and cognitive responses in the object recognition test were tested between the 30th–35th day after the surgical procedures. Markers of OS in the frontal cortex (FC) and hippocampus were detected by the ELISA method. Melatonin treatment corrected the exacerbated anxiety response only in the pin+icvAβ1-42 model while it alleviated the cognitive impairment in the three models. Pinealectomy disturbed the antioxidant system via enhanced SOD activity and decreased GSH levels both in the FC and hippocampus. The Aβ1-42 model decreased the SOD activity in the FC and elevated the MDA level in the two brain structures. The pin+icvAβ1-42 model impaired the antioxidant system and elevated lipid peroxidation. Melatonin supplementation restored only the elevated MDA level of icvAβ1-42 and pin+icvAβ1-42 model in the hippocampus. In conclusion, our study reveals that the pin+icvAβ1-42 rat model triggers more pronounced anxiety and alterations in markers of OS that may be associated with melatonin deficit concomitant to icvAβ1-42-induced AD pathology.

scholarly journals A Subpressor Dose of Angiotensin II Elevates Blood Pressure in a Normotensive Rat Model by Oxidative Stress

2015 ◽  
pp. 153-159 ◽  
Author(s):  
M. M. GOVENDER ◽  
A. NADAR
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Angiotensin Ii ◽  
Mrna Expression ◽  
Rat Model ◽  
Wistar Rat ◽  
Control Group ◽  
Sod Activity ◽  
Male Wistar Rats ◽  
Experimental Group

Oxidative stress is an imbalance between free radicals and antioxidants, and is an important etiological factor in the development of hypertension. Recent experimental evidence suggests that subpressor doses of angiotensin II elevate oxidative stress and blood pressure. We aimed to investigate the oxidative stress related mechanism by which a subpressor dose of angiotensin II induces hypertension in a normotensive rat model. Normotensive male Wistar rats were infused with a subpressor dose of angiotensin II for 28 days. The control group was sham operated and infused with saline only. Plasma angiotensin II and H2O2 levels, whole-blood glutathione peroxidase, and AT-1a, Cu/Zn SOD, and p22phox mRNA expression in the aorta was assessed. Systolic and diastolic blood pressures were elevated in the experimental group. There was no change in angiotensin II levels, but a significant increase in AT-1a mRNA expression was found in the experimental group. mRNA expression of p22phox was increased significantly and Cu/Zn SOD decreased significantly in the experimental group. There was no significant change to the H2O2 and GPx levels. Angiotensin II manipulates the free radical-antioxidant balance in the vasculature by selectively increasing O2− production and decreasing SOD activity and causes an oxidative stress induced elevation in blood pressure in the Wistar rat.

scholarly journals Oxidative stress in animals: a pathophysiologist's view

2020 ◽  
Vol 2020 (4) ◽  
pp. 10-18
Author(s):  
Dmitriy Gildikov
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Antioxidant System ◽  
Review Article ◽  
Publication Activity ◽  
Pathophysiological Mechanism ◽  
Oxygen Species ◽  
The World ◽  
Intracellular Oxidative Stress

In the review article, from the modern standpoint, oxidative stress is considered as a universal pathophysiological mechanism of the vast majority of diseases in animals. A brief review of the publication activity in the world on this topic; the significance of reactive oxygen species in the physiology and development of intracellular oxidative stress, the role of etiological factors that initiate their hyperproduction are presented, as well the methods of detecting oxidative stress are characterizited. General concepts of the antioxidant system of the animal body are examined, and the pathophysiological targets of oxidative stress in animals are generalized.

scholarly journals The role of the antioxidant: Selenopyran in the stability of the antioxidant system to toxic effect of cadmium chloride

2007 ◽  
Vol 23 (5-6-1) ◽  
pp. 181-191
Author(s):  
U. Kravchenko ◽  
G. Borjaev ◽  
M. Nevitov ◽  
A. Ostapchuk ◽  
E. Kistanova
Keyword(s):  
Oxidative Stress ◽  
Antioxidant System ◽  
Antioxidant Defense ◽  
Age Groups ◽  
Selenium Concentration ◽  
Antioxidant Defense System ◽  
The Stability ◽  
Gpx Activity ◽  
Preventive Role

The purpose of the present work was, under conditions of the model experiment on rats, to tap the information about the features of shortterm acclimatization of the antioxidant system in various organs to toxicity of cadmium at stages of an ontogenesis and about the preventive role of the antioxidant selenopyran in this process. The obtained results showed the ontogenetic differences in the adaptive reactivity of the enzymatic antioxidant defense system in the most important organs and tissues of rats under conditions of oxidative stress induced by cadmium. The ontogenetic differences of Se redistribution in a body under influence of cadmium administration were found. The discovered decrease of Se concentration in the liver of young animals and the increase of its concentration in the liver of old animals correlated positively with the changes of GPx activity. Preventive administration of selenopyran (9- phenyl-simmetrical octa-hydroselenoxanthene) to old animals reduced the oxidative stress intensity. Animals of all age groups showed higher selenium concentration in the tissues and the increase in the selenium-dependent GPx activity.

Protective role of β-carotene against oxidative stress and neuroinflammation in a rat model of spinal cord injury

2018 ◽  
Vol 61 ◽  
pp. 92-99 ◽  
Author(s):  
Lihui Zhou ◽  
Lian Ouyang ◽  
Shuangzhi Lin ◽  
Song Chen ◽  
YingJie Liu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Rat Model ◽  
Protective Role ◽  
Cord Injury ◽  
Β Carotene

Protective role of chrysin against oxidative stress ind-galactose-induced aging in an experimental rat model

2012 ◽  
Vol 12 (4) ◽  
pp. 741-750 ◽  
Author(s):  
Kalaiselvi Velayutham Anand ◽  
Mohamed Sultan Mohamed Jaabir ◽  
Philip A Thomas ◽  
Pitchairaj Geraldine
Keyword(s):  
Oxidative Stress ◽  
Rat Model ◽  
Protective Role ◽  
Experimental Rat Model

The state of the blood antioxidant system in the patients presenting with acromegaly

2015 ◽  
Vol 61 (2) ◽  
pp. 8-11
Author(s):  
M V Faassen ◽  
M S Pankratova ◽  
N N Molitvoslovova ◽  
A A Baizhumanov ◽  
S S Kovalenko ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Superoxide Dismutase ◽  
Blood Plasma ◽  
Antioxidant System ◽  
The State ◽  
Total Antioxidant Activity ◽  
Sod Activity ◽  
Protein Thiols ◽  
Total Antioxidant

The state of the blood antioxidant system in the patients presenting with acromegaly. The objective of the present study was to evaluate the total antioxidant activity (TAA) of blood plasma, the levels of non-protein thiols and 2-thyobarbituric acid-active products (TBA-AP), superoxide dismutase (SOD) and catalase (CAT) activities as well as ceruloplasmin (CP) level in the patients presenting with acromegaly. It was shown that plasma TAA and SOD activity in this patients was on the average 20 and 30% lower respectively than in the control subjects. At the same time, the TBA-AP and CP levels increased by 50 and 40% respectively. These data suggest the development of oxidative stress in the acromegalic patients.

scholarly journals Role of oxidative stress in anxiety‐like behavior and learning and memory impairment in a rat model of social stress

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Gaurav Patki ◽  
Farida Allam ◽  
Ritu Bohat ◽  
Faizan Jafri ◽  
Mohammad Saleem ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Learning And Memory ◽  
Rat Model ◽  
Social Stress ◽  
Memory Impairment
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