Assessment of COVID-19 Incidence and the Ability to Synthesise Anti-SARS-CoV-2 Antibodies of Paediatric Patients with Primary Immunodeficiency

Background: Data regarding the course of SARS-CoV-2 infection in children with primary immunodeficiency (PID) is insufficient. The purpose of the study was to evaluate the morbidity and clinical course of COVID-19 and the ability to produce anti-SARS-CoV-2 IgG antibodies in children with PID. Methods: In this retrospective study, medical records of 99 patients aged 0–18 were evaluated. The patients were divided into three groups: PID group (68.69%), control group (19.19%) and patients with ongoing or previous paediatric inflammatory multisystem syndrome (12.12%). Data such as morbidity, clinical outcome, and IgG anti-SARS-CoV-2 antibody titres were assessed. Results: A confirmed diagnosis of SARS-CoV-2 infection has been established in 26.47% of patients with PID. Among patients with PID infected with SARS-CoV-2, only three cases were hospitalised. Mortality in the PID group was 0%. Throughout an observation period of 1 year, 47.06% of patients with PID were tested positive for the anti-SARS-CoV-2 antibody. Conclusion: In the study group, in most cases the disease had a mild and self-limiting course. Remarkably, even though IgG deficiency was the most prevalent form of PID in the study group, the patients were able to respond satisfactorily to the infection in terms of anti-SARS-CoV-2 IgG.

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Prevalence and correlation of Neisseria gonorroheae, Mycoplasma hominis and Ureaplasma urealyticum antibodies in unexplained infertile women having positive post coital test

South Asian Journal of Experimental Biology ◽

10.38150/sajeb.5(4).p151-155 ◽

2015 ◽

Vol 5 (4) ◽

pp. 151-155

Author(s):

Poonam Tyagi

Keyword(s):

Research Study ◽

Ureaplasma Urealyticum ◽

Mycoplasma Hominis ◽

Control Group ◽

Study Group ◽

Igg Antibodies ◽

Vaginal Infection ◽

Infertile Women ◽

Pregnant Females ◽

Elisa Technique

The probability that a vaginal infection can interfere with fertility is often overlooked. The microorganisms, their products may inhibit sperm morphol-ogy and motility. Abnormal cervical mucus and sperm interactions clarify infertility in 5% to 10% of couples with a fertility problem. The aim of this research study was to estimate the prevalence of Gonococcal (IgG), Myco-plasma hominis (IgG) and Ureaplasma urealyticum (T. mycoplasma) (IgG) antibodies in unexplained infertile women having positive post coital test (PCT). Blood samples of 50 positive PCT identified infertile females and 50 healthy pregnant females (age group of 24-36 yrs) were collected and ana-lyzed for Gonococcal (IgG), M. hominis (IgG) and T. mycoplasma (IgG) anti-bodies by ELISA technique. In the study group patients, only 12 % cases (6/ 50) were positive for IgG gonococcal antibodies but no any positive case was found in control group. 28% cases (14/50) were found positive for M. homi-nis IgG antibodies in study group patients and only 10 % cases (5/50) were positive in control group. Results statistically were insignificant. In case of T. mycoplasma IgG antibodies, 76% (38/50) infertile women were observed as positive while only 24% (12/50) cases of control group were found positive for the same (p < 0.001). The results were not significant for gonococcal and M. hominis antibodies but were highly significant for U. urealyticum IgG an-tibodies and it was concluded that it may be a cause of infertility in positive PCT cases as no any other known reason of infertility is noticed in such cases.

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Metabolic and clinical events preceding diabetes mellitus onset in cystic fibrosis

Acta Endocrinologica ◽

10.1530/eje.0.1340731 ◽

1996 ◽

Vol 134 (6) ◽

pp. 731-736 ◽

Cited By ~ 11

Author(s):

Domenico Cucinotta ◽

Teresa Arrigo ◽

Filippo De Luca ◽

Antonino Di Benedetto ◽

Fortunato Lombardo ◽

...

Keyword(s):

Diabetes Mellitus ◽

Cystic Fibrosis ◽

Insulin Secretion ◽

Glucose Tolerance ◽

Control Group ◽

Study Group ◽

Clinical Parameters ◽

Clinical Events ◽

Over Time ◽

Observation Period

Cucinotta D, Arrigo T, De Luca F, Di Benedetto A, Lombardo F, Scoglio R, Sferlazzas C, Magazzú G. Metabolic and clinical events preceding diabetes mellitus onset in cystic fibrosis. Eur J Endocrinol 1996;134:731–6. ISSN 0804–4643 Serial assessments of glucose tolerance, of glucose and insulin areas during an oral glucose tolerance test (OGTT) and of clinical parameters as well were evaluated retrospectively in seven diabetic cystic fibrosis patients (study group) during the 4–6.3 years that preceded diabetes mellitus diagnosis. The same metabolic and clinical parameters were also evaluated in seven age-matched patients who did not develop diabetes during a similar observation period (control group). In the study group, glucose tolerance was impaired in all patients but one since the first OGTT and glucose areas progressively increased over time, whereas in the control group glucose tolerance remained stable during the whole observation period. A significant and progressive blunting of insulin secretion occurred over time in both groups. Insulin secretion, however, was reduced but not exhausted at diabetes diagnosis. Neither modification of glycosylated haemoglobin levels over time nor serum islet cell antibodies at diabetes onset were observed in the study group. The overall clinical course of the disease was not different in either group and remained stable during the observation period. These results indicate that in cystic fibrosis diabetes mellitus onset is preceded by a long-standing deterioration of glucose tolerance, whilst insulin secretion progressively declines over time, irrespectively of glucose tolerance status. The prediabetic worsening of glucose tolerance is not necessarily linked to a worsening of overall clinical status. Filippo De Luca, Istituto di Clinica Pediatrica, Policlinico Universitario, 98100 Messina, Italy

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Increased Risk for Coeliac Disease in Paediatric Patients with Migraine

Cephalalgia ◽

10.1111/j.1468-2982.2008.01630.x ◽

2008 ◽

Vol 28 (9) ◽

pp. 945-949 ◽

Cited By ~ 19

Author(s):

F Alehan ◽

F Ozçay ◽

I Eroi ◽

O Canan ◽

T Cemil

Keyword(s):

Coeliac Disease ◽

Tissue Transglutaminase ◽

Reliable Indicator ◽

Control Group ◽

Study Group ◽

Paediatric Patients ◽

Increased Risk ◽

Antibody Titres ◽

Age Range

The aim was to determine the prevalence of coeliac disease (CD) in paediatric patients with migraine. Serum tissue transglutaminase IgA (tTGA) antibodies and IgA concentrations were measured in 73 patients with migraine (age range 6-17 years) and the control group ( n = 147). Patients having positive tTGA antibodies underwent duedonal biopsy. Four patients (5.5%) from the study group and one (0.6%) from the control group had positive tTGA antibody titres ( P < 0.05). Three patients with migraine had normal duedonal histology and were considered as potential CD. One patient from the study group and one from the control group declined to have biopsy. tTGA antibody is considered as a reliable indicator for the presence of CD. However, some patients with positive antibodies may have normal biopsy initially and are classified as having potential CD. Our finding of a higher prevalance of tTGA antibodies in paediatric migraine patients suggests that an association between migraine and CD might exist.

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Frequency of celiac disease in patients with vitiligo

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20204060 ◽

2020 ◽

Vol 7 (10) ◽

pp. 1475

Author(s):

Cenk Sunu ◽

Ceyhun Varim ◽

Cengiz Karacaer ◽

Yasin Kalpakci

Keyword(s):

Body Mass Index ◽

Celiac Disease ◽

Essential Role ◽

Tissue Transglutaminase ◽

Serum Levels ◽

Duodenal Biopsy ◽

Control Group ◽

Study Group ◽

Igg Antibodies ◽

Significant Difference

Background: Celiac disease (CD) is an autoimmune and inflammatory disease that occurs in the small intestine as a result of gluten intake in individuals. Vitiligo, in which autoimmune factors play an essential role, is associated with depigmentation due to the loss of epidermal melanocytes. Many autoimmune diseases are known to be associated with vitiligo. This study aims to determine the frequency of CD in vitiligo cases.Methods: Out of 61 vitiligo patients, 32 (52.4%) are women, and 29 (47.6%) are men; of the 119 healthy volunteers, 58 (48.7%) are women, and 61 (51.3%) are men. Serum levels of tissue transglutaminase (tTG) IgA and tTG IgG antibodies were measured in all participants. If at least one of these two antibodies are positive, mucosal biopsies were taken from the second section of the duodenum by endoscopy.Results: There is no significant difference between the study group and the control group in terms of age and body mass index (BMI) (p=0.16, p=0.80, respectively). tTG IgA and tTG IgG were positive in one patient in each group. In both patients, the results of the duodenal biopsy were histopathological compatible with CD. There was no difference between the vitiligo group and the control group in terms of CD frequency (p=0.56).Conclusion: The frequency of CD in vitiligo patients is similar to the control group. However, it should be kept in mind that the frequency of CD in patients with vitiligo may be higher than the rates assumed incidental, and necessary research should be carried out for early diagnosis in such patients.

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Clinical Characteristics of Newborns Born to Mothers with COVID-19

Journal of Clinical Medicine ◽

10.3390/jcm10194383 ◽

2021 ◽

Vol 10 (19) ◽

pp. 4383

Author(s):

Katarzyna Wróblewska-Seniuk ◽

Agnieszka Basiukajć ◽

Dobrochna Wojciechowska ◽

Mayanthi Telge ◽

Izabela Miechowicz ◽

...

Keyword(s):

Medical Records ◽

Clinical Characteristics ◽

Post Partum ◽

Mode Of Delivery ◽

Control Group ◽

Study Group ◽

Short Term ◽

Common Diagnosis ◽

Tertiary Center ◽

Dramatic Fall

(1) Background: According to the literature, most outcomes of neonates born to mothers infected with SARS-CoV-2 are favorable. This study aimed to assess the clinical characteristics of newborns born to infected women in a tertiary center in Poznan, Poland. (2) Methods: The study comprised 101 newborns delivered by women infected with SARS-CoV-2. The control group consisted of 101 newborns born before the pandemic. Data were collected retrospectively from the medical records. (3) Results: Most newborns of SARS-CoV-2-positive mothers were delivered by cesarean section—83.17% vs. 40.59% in the control group (p < 0.05). The groups did not differ in Apgar scores and the need for resuscitation. Newborns of SARS-CoV-2-positive mothers were more likely to present with respiratory distress and require respiratory support. The most common diagnosis was transient tachypnea of the newborn, not correlated with the mode of delivery. Newborns of the study group were never exclusively breastfed, 0% vs. 64.36% (p < 0.05). None of the patients in the study group was tested positive for the virus. (4) Conclusions: Infants born to SARS-CoV-2-positive mothers seem to be more at risk of moderate respiratory failure than other newborns. Separation of mother–baby dyads results in a dramatic fall in breastfeeding in the short-term post-partum period.

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Pregnancy outcomes among women with systemic lupus erythematosus: a retrospective cohort study from Thailand

Lupus ◽

10.1177/0961203317721353 ◽

2017 ◽

Vol 27 (1) ◽

pp. 158-164 ◽

Cited By ~ 16

Author(s):

S Phansenee ◽

R Sekararithi ◽

P Jatavan ◽

T Tongsong

Keyword(s):

Lupus Erythematosus ◽

Pregnancy Outcomes ◽

Medical Records ◽

Retrospective Cohort ◽

Control Group ◽

Chronic Hypertension ◽

Study Group ◽

Systemic Lupus ◽

Adverse Pregnancy ◽

Active Disease

Objective The objective of this paper is to compare adverse pregnancy outcomes between normal pregnancies and pregnancies with systemic lupus erythematosus (SLE), particularly focusing on uncomplicated SLE with remission. Methods A retrospective cohort study was conducted by accessing the Maternal-Fetal Medicine (MFM) Unit database and the full medical records of the women. The records of singleton pregnancies with SLE and no underlying disease were assigned as the study group and their medical records were reviewed. The low-risk pregnancies were randomly selected as the controls. The adverse pregnancy outcomes were compared between the control group vs women with SLE, control group vs uncomplicated SLE, and between the subgroups within the study group. Results Of 28,003 births during the study period, 1400 controls and 140 pregnancies with SLE were compared. The rates of fetal loss, preterm birth, small-for-date, low birth weight and preeclampsia were significantly higher in the study groups with a relative risk of 5.6 (95% CI: 2.9–10.9), 3.2 (95% CI: 2.5–4.1), 3.5 (95% CI: 2.4–4.9), 4.2 (95% CI: 3.4–5.3) and 2.9 (95% CI: 1.9–4.4), respectively. The increased rates of most adverse outcomes were still noted even in the cases of uncomplicated SLE. Among women with SLE, lupus nephritis, chronic hypertension, antiphospholipid syndrome, active disease at the onset of pregnancies, and proteinuria were significantly associated with such outcomes. Conclusions Pregnancies with SLE, even in uncomplicated cases with remission, increase the risk of poor pregnancy outcomes. The presence of lupus nephritis, chronic hypertension, antiphospholipid syndrome, active disease at the onset of pregnancies, and proteinuria were significantly associated with such outcomes.

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Changes in Platelet Aggregability after Ovariectomy

Thrombosis and Haemostasis ◽

10.1055/s-0038-1657029 ◽

1979 ◽

Vol 42 (04) ◽

pp. 1332-1339 ◽

Cited By ~ 7

Author(s):

Hiroh Yamazaki ◽

Takeshi Motomiya ◽

Minoru Sonoda ◽

Noboru Miyagawa

Keyword(s):

Platelet Count ◽

Platelet Activation ◽

Ovarian Hormones ◽

Control Group ◽

Platelet Aggregability ◽

Appearance Rate ◽

Before And After ◽

The Difference ◽

Induced Aggregation ◽

Observation Period

SummaryChanges in platelets in 48 patients with uterine myoma before and after hysterectomy with and without ovariectomy were examined. Bilateral ovariectomy in 25 cases (ovariec-tomized group) and unilateral or non-ovariectomy in 23 cases (control group) were performed at the hysterectomy. Platelet count and an appearance rate of secondary aggregation decreased at one day after and increased at one week after the operation, similarly in both the ovariectomized and the control group. The appearance rate of secondary aggregation was reflected in an intensity of aggregation at 5 min after the addition of reagent to PRP. At one month after the operation, the appearance rate of secondary aggregation induced by 3 μM ADP showed a statistically significant decrease in comparison with the preoperation value (P <0.05) and the enhancement of 5-min aggregation was still observed in the control group, while ceased in the ovariectomized group. The difference between the two groups was significant (P < 0.05). There was almost no change in the speed and intensity of primary and secondary aggregation during the observation period. No significant differences in collagen-induced aggregation were noted between the two groups. The results suggest that ovarian hormones, mainly estrogen, facilitate platelet activation which is mediated by the so-called secondary aggregation.

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Pretreatment with Methylprednisolone Improves Myocardial Protection during On-Pump Coronary Artery Bypass Surgery

The Heart Surgery Forum ◽

10.1532/hsf.1367 ◽

2015 ◽

Vol 18 (4) ◽

pp. 171 ◽

Cited By ~ 1

Author(s):

Tolga Demir ◽

Mehmet Umit Ergenoglu ◽

Hale Bolgi Demir ◽

Nursen Tanrikulu ◽

Mazlum Sahin ◽

...

Keyword(s):

Coronary Artery ◽

Coronary Artery Bypass ◽

Myocardial Protection ◽

Troponin T ◽

Artery Bypass ◽

Control Group ◽

Study Group ◽

Cabg Surgery ◽

Anti Inflammatory ◽

Pump Coronary Artery Bypass

Background: This study was undertaken to determine whether methylprednisolone could improve myocardial protection by altering the cytokine profile toward an anti-inflammatory course in patients undergoing elective coronary artery bypass grafting (CABG) surgery with cardiopulmonary bypass (CPB). Methods: Forty patients who were scheduled for elective CABG surgery were randomized into two groups: the study group (n = 20), who received 1 g of methylprednisolone intravenously before CPB, and the control group (n = 20), who underwent a standard CABG surgery without any additional medication. Blood samples were withdrawn prior to surgery (T1) and then 4 hours (T2), 24 hours (T3), and 36 hours (T4) after CPB. Plasma levels of interleukin (IL)-6, IL-10, creatine kinase isoenzyme MB (CK-MB), cardiac troponin-t (cTnT), and blood glucose as well as neutrophil counts were measured at each sampling time. Results: A comparison of patients between both groups revealed significantly high levels of IL-6 in the control group at T2, T3, and T4 with respect to T1 (T2: P < .001; T3: P < .001; T4: P < .001). IL-10 levels were significantly higher in the study group at T2 compared with the control group (P = .007). CK-MB levels were significantly lower in the study group than in the control group at T4 (P = .001). The increase of cTnT was higher in the control group at T3 and T4 compared with the study group (T3: P = .002; T4: P = .001). Conclusions: This study demonstrates that methylprednisolone is effective for ensuring better myocardial protection during cardiac surgery by suppressing the inflammatory response via decreasing the levels of IL-6 and by increasing anti-inflammatory activity through IL-10.

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Possibilities of correction of menopausal disorders in women with the use of medicine Menopace

HEALTH OF WOMAN ◽

10.15574/hw.2016.111.95 ◽

2016 ◽

pp. 95-100

Author(s):

G.I. Reznichenko ◽

◽

N.Yu. Reznichenko ◽

V.Yu. Potebnya ◽

K.I. Kovalenko ◽

...

Keyword(s):

General Condition ◽

Clinical Symptoms ◽

Average Score ◽

Control Group ◽

Climacteric Syndrome ◽

Basic Subgroup ◽

Menopausal Syndrome ◽

Natural Menopause ◽

Surgical Menopause ◽

Observation Period

The objective: to determine the efficacy of medicine «Menopace» in treatment of women with natural and surgical menopause. Patients and methods. 20 women (I group) with a natural menopause were examined (basic subgroup consisted of 10 patients who used Menopace for 3 months; control subgroup consisted of 10 patients). 20 women (II group) with surgical menopause were examined (basic subgroup consisted of 10 patients who received Menopace for 3 months; control subgroup consisted of 10 patients). Results. The average score of neurovegetative and emotional manifestations of climacteric syndrome during the observation period decreased in women with natural and surgical menopause who used Menopace, compared with subgroups of patients who had not used the medicine. Conclusions. 1. The use of the medicine Menopace in women with natural menopause after 3 months showed the disappearance of clinical symptoms of climacteric syndrome in 70% of the cases, and significant improvement in general condition in 30% of cases. 2. During surgical menopause after 1 month of treatment with Menopace manifestations of sweating were observed 4.5 times less often than in control group, tides were observed 7 times less often than in control group. Neurovegetative and psychoemotional symptoms of menopause were absent in 80% of women after 3 months of treatment and in 20% of cases significant improvement was shown. 3. The obtained results give grounds to recommend wide use of Menopace in practical work for the treatment of menopausal syndrome during natural and surgical menopause. Key words: menopause, therapy, Menopace.

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Modern approaches to the treatment of mastitis in women of reproductive age

HEALTH OF WOMAN ◽

10.15574/hw.2016.111.101 ◽

2016 ◽

pp. 191-108

Author(s):

A.A. Sukhanova ◽

◽

Yu.M. Melnik ◽

O.O. Karlova ◽

◽

...

Keyword(s):

Ultrasound Examination ◽

Clinical Signs ◽

Reproductive Age ◽

Herbal Remedies ◽

Control Group ◽

Women Of Reproductive Age ◽

Clinical Method ◽

Gynecological Examination ◽

Study Results ◽

Observation Period

The aim of the study: to study the efficacy and safety of use Mastofemin in the treatment of various forms of mastitis in women of reproductive age. Materials and methods. The study included 62 women of reproductive age (mean age of 33.5±2.3 years) who were screened in the Kiev city center reproductive and perinatal medicine. Women were divided into 2 groups. The first (main) group consisted of 32 patients who received the proposed treatment using herbal remedies Mastofemin 1 capsule 2 times per day for 3 months; 30 patients of the second (control) group were under observation and received no treatment. These groups were representative and homogeneous on age, clinical symptoms and sonographic characteristics. The clinical method included evaluation of complaints of patients, anamnesis, presence of concomitant gynecologic pathology, inspection, palpation of the lymph nodes and the breast and obtaining a discharge from the nipples to conduct cytological examination, which allowed excluding from the study women with suspected malignancy of the process. All the patients were performed ultrasound examination of the breast. The review was supplemented with vaginal gynecological examination and ultrasound examination of small pelvis organs to assess the condition of the uterus and its appendages, the diagnosis of gynecological diseases. Results. Summarizing obtained in this study results one should stress the positive long-term effect of applying Mastofemin for the treatment of proliferative changes of the breast in women of reproductive age. This is manifested by a decrease in the intensity of clinical signs of mastitis, consistent with the results of sonographic control. Established positive dynamics in the treatment of cystic mastitis, dectective and when combined cystic mastopathy with dectective. In the control group of patients for a given observation period (6 months) no significant changes in clinical signs of mastitis and sonographic characteristics. Regression of disease has not occurred in any of the patients, in 2 patients increased sensitivity of the breast after 6 months moved to the soreness. Sonographic characteristics of mastitis during the observation period did not change. Thus, the use of Mastofemin aimed at pathogenetic treatment of mastitis and prevention of breast cancer. Conclusion. Application of Mastofemin during the treatment of mastitis in women of reproductive age significantly improves the clinical condition of patients; reduce the subjective and objective symptoms of the disease. The positive effect of the treatment with Mastofemin proved in the case of the treatment of sonographic following forms of mastitis: cystic mastopathy, cystic mastopathy with dectectasy. Mastofemin may be the drug of choice for complex conservative monotherapy in women of reproductive age with proliferative changes in the breast, and can also be used as part of complex treatment in patients with diffuse changes of the breast when combined with hyperplastic processes of the myometrium and endometrium. Keywords: mastopathy, breast gland, herbal medicine, herbal remedies, Mastofemin.

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