scholarly journals Relationship between Serum Kallistatin and Afamin and Anthropometric Factors Associated with Obesity and of Being Overweight in Patients after Myocardial Infarction and without Myocardial Infarction

2021 ◽  
Vol 10 (24) ◽  
pp. 5792
Author(s):  
Grzegorz Józef Nowicki ◽  
Barbara Ślusarska ◽  
Maciej Polak ◽  
Katarzyna Naylor ◽  
Tomasz Kocki
Keyword(s):  
Myocardial Infarction ◽  
Cardiovascular Event ◽  
Regulatory Peptides ◽  
Cross Sectional Study ◽  
Visceral Adiposity Index ◽  
Anthropometric Parameters ◽  
Cross Sectional ◽  
Waist To Hip Ratio ◽  
Tyg Index ◽  
Triglyceride Glucose Index

Extensive clinical and epidemiological evidence has linked obesity to a broad spectrum of cardiovascular disease (CVD), including coronary disease, heart failure, hypertension, cerebrovascular disease, atrial fibrillation, ventricular arrhythmias, and sudden death. In addition, increasing knowledge of regulatory peptides has allowed an assessment of their role in various non-communicable diseases, including CVD. The study assessed the concentration of kallistatin and afamin in the blood serum of patients after a myocardial infarction and without a cardiovascular event, and determined the relationship between the concentration of kallistatin and afamin and the anthropometric indicators of being overweight and of obesity in these groups. Serum kallistatin and afamin were quantified by ELISA tests in a cross-sectional study of 160 patients who were divided into two groups: study group (SG) (n = 80) and another with no cardiovascular event (CG) (n = 80). Serum kallistatin concentration was significantly higher in the SG (p < 0.001), while the level of afamin was significantly lower in this group (p < 0.001). In addition, a positive correlation was observed in the SG between the afamin concentration and the waist to hip ratio (WHR), lipid accumulation product (LAP) and the triglyceride glucose index (TyG index). In the CG, the concentration of kallistatin positively correlated with the LAP and TyG index, while the concentration of afamin positively correlated with all the examined parameters: body mass index (BMI), waist circumference (WC), hip circumference (HC), waist to hip ratio (WHtR), visceral adiposity index (VAI), LAP and TyG index. Serum kallistatin and afamin concentrations are associated with the anthropometric parameters related to being overweight and to obesity, especially to those describing the visceral distribution of adipose tissue and metabolic disorders related to excessive fatness.

scholarly journals Mediation effect of obesity on the association between triglyceride-glucose index and hyperuricemia in Chinese hypertension adults.

2021 ◽  
Author(s):  
Jin Sun ◽  
Yongkang Su ◽  
Man Li ◽  
Shouyuan Ma ◽  
Yan Zhang ◽  
...  
Keyword(s):  
Fasting Blood Glucose ◽  
Surrogate Marker ◽  
Cross Sectional Study ◽  
Han Chinese ◽  
Mediation Effect ◽  
Cross Sectional ◽  
Tyg Index ◽  
Triglyceride Glucose Index ◽  
The Relationship

Abstract Background and Aims: The triglyceride glucose (TyG) index was regarded as a simple surrogate marker of insulin resistance (IR). It is confirmed that IR was significantly associated with hyperuricemia, and obesity was the risk factor for IR and hyperuricemia. However, the relationship between the TyG index and hyperuricemia and the potential role of obesity in Han Chinese hypertension are not entirely elucidated.Methods and Results： A community-based cross-sectional study was conducted in 4551 hypertension patients aged 40-75 years with clinical and biochemical data. The TyG index was calculated as ln [fasting triglyceride (mg/dl) × fasting blood glucose (mg/dl)/2]. Hyperuricemia was determined as serum uric acid ≥357μmol/L (6 mg/dl) for females and ≥417μmol/L (7 mg/dl) for males. The TyG index was higher in patients with hyperuricemia than in those without (8.99±0.61, 8.70±0.59, P<0.001). The prevalence of hyperuricemia in patients with the lowest (≤8.32), second (8.33-8.66), third (8.67-9.07) and the highest quartile (≥9.08) of the TyG index was 6.0%, 10.4%, 15.4%, 21.4%, respectively. Logistic regression analysis suggested that the higher quartile of TyG index was associated with increased hyperuricemia risk whether in crude or adjusted models (P<0.05). Mediation analysis showed that all of our obesity indexes partially mediated the association between the TyG index and hyperuricemia to some extent.Conclusion：TyG index is significantly associated with hyperuricemia in hypertension patients among Han Chinese, obesity plays a partial mediation role in this relationship.

scholarly journals The triglyceride-glucose index (TyG) and Nonalcoholic fatty liver in the Japanese population: a retrospective cross-sectional study

2020 ◽  
Author(s):  
Enqian Liu ◽  
Yaping Weng ◽  
Aiming Zhou ◽  
Chunlai Zeng
Keyword(s):  
Logistic Regression ◽  
Japanese Population ◽  
Inflection Point ◽  
Binary Logistic Regression ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Nonalcoholic Fatty Liver ◽  
Tyg Index ◽  
Triglyceride Glucose Index

Abstract Background: Evidences regarding the association between triglyceride-glucose index (TyG) and Nonalcoholic fatty liver (NAFLD) are controversial. Therefore, the goals of this research are to evaluate whether TyG is independently associated with NAFLD and the ability of TyG index to detect NAFLD in the Japanese population. Methods: The present study was a cross-sectional study. The data was downloaded from the DATADRYAD website. A total of 13178 participants was involved in a hospital in Japan from 2004 to 2015. The correlation between TyG and NAFLD was detected by using binary logistic regression and Generalized additive models. The likelihood ration test was used to examine the modification and interaction of subgroups. Furthermore, the ability of TyG to predict NAFLD was evaluated by using receiver operating characteristic (ROC) curves. The formula for the TyG index was ln [fasting triglyceride level (mg / dl) × fasting blood glucose level (mg / dl) / 2] Results: The average age of the selected participants was 43.36±8.89 years old, and about 51.02% of them were male. In fully-adjusted binary logistic regression model, TyG was positively related with the risk of NAFLD (Odds ratio (OR)=2.45, 95%CI 2.12-2.82). The relationship between TyG and NAFLD was a non-linear relationship, and its inflection point was 8.22. The effect sizes and the confidence intervals of the left and right sides of inflection point were 3.26(2.44 - 4.35) and 2.09 (1.72 - 2.54), respectively. By subgroup analysis, the stronger association was found in females, low GGT, non-obesity, non-visceral fat obesity (P for interaction <0.05). Among the total population, the AUC for TyG [0.810 (0.804 - 0.817)] was worse than ALT [ 0.829 (0.822 - 0.835)] but better than TG [ 0.799 (0.792 - 0.805)] and FPG [ 0.715 (0.707 - 0.722)]. A similar result was found for men. In the women, the AUC for the TyG was superior to ALT, FPG, and TG. Conclusion: The association between TyG and NAFLD is non-linear. TyG is stronger positively correlated to the risk of NAFLD when TyG is less than 8.22. TyG is helpful to identify individuals with NAFLD.

scholarly journals Association Between the Triglyceride Glucose Index and Alanine Aminotransferase Levels: a Cross-sectional Study

2021 ◽  
Author(s):  
Yu Hua ◽  
Haiyue Yu ◽  
Shuang Chen ◽  
Xueyao Zhang ◽  
Xingang Zhang ◽  
...  
Keyword(s):  
Alanine Aminotransferase ◽  
Cardiovascular Health ◽  
Surrogate Marker ◽  
Cross Sectional Study ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Tyg Index ◽  
Triglyceride Glucose Index

Abstract Background: The triglyceride glucose index (TyG) has been proposed as a marker of insulin resistance or type 2 diabetes mellitus (T2DM). Risk of serum alanine aminotransferase (ALT) levels is increased in T2DM patients. We aimed to evaluate the association between TyG index and elevated ALT. Methods: A multicenter, cross-sectional study was conducted in China from Northeast China Rural Cardiovascular Health Study (NCRCHS), and 11,573 adults with complete data were included in our final analysis.Results: TyG index was positively associated with the prevalence of elevated ALT. Frequency of elevated ALT increased from the lowest to the top quartile of TyG in both sexes (p for trend <0.001). Compared with the participants in the lowest quartile of TyG, the adjusted odds ratio and 95% CIs for elevated ALT were 1.71 (1.32-2.21) and 2.46 (1.90-3.19) for those in the third and the fourth quartile of TyG (p<0.001). Compared with the first quartile of TyG, participants in the top quartile of TyG had more than 2 times risk for elevated ALT (2.38-times for men and 2.22-times for women, respectively, p<0.001). According to the ROC analysis, the optimal cut-off point of TyG for elevated ALT was 8.69 and 8.96 for men and women, respectively. Conclusions: TyG index is effective to identify individuals at risk for elevated ALT. TyG thresholds of 8.69 for men and 8.96 for women was highly sensitive for detecting elevated ALT subjects. Findings from this study underscore that TyG index may be suitable as a surrogate marker for abnormal liver enzymes in Chinese adults.

scholarly journals Lipid indices as simple and clinically useful surrogate markers for insulin resistance in the U.S. population

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Juncheol Lee ◽  
Bongyoung Kim ◽  
Wonhee Kim ◽  
Chiwon Ahn ◽  
Hyun Young Choi ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
The United States ◽  
Cross Sectional Study ◽  
Visceral Adiposity Index ◽  
Model Assessment ◽  
Cross Sectional ◽  
Resistance Risk ◽  
Tyg Index ◽  
Health And Nutrition ◽  
Cutoff Values

AbstractThis study aimed to compare the accuracy of novel lipid indices, including the visceral adiposity index (VAI), lipid accumulation product (LAP), triglycerides and glucose (TyG) index, TyG-body mass index (TyG-BMI), and TyG-waist circumference (TyG-WC), in identifying insulin resistance and establish valid cutoff values. This cross-sectional study used the data of 11,378 adults, derived from the United States National Health and Nutrition Examination Survey (1999–2016). Insulin resistance was defined as a homeostasis model assessment-insulin resistance value above the 75th percentile for each sex and race/ethnicities. The area under the curves (AUCs) were as follows: VAI, 0.735; LAP, 0.796; TyG index, 0.723; TyG-BMI, 0.823, and; TyG-WC, 0.822. The AUCs for TyG-BMI and TyG-WC were significantly higher than those for VAI, LAP, and TyG index (vs. TyG-BMI, p < 0.001; vs. TyG-WC, p < 0.001). The cutoff values were as follows: VAI: men 1.65, women 1.65; LAP: men 42.5, women 42.5; TyG index: men 4.665, women 4.575; TyG-BMI: men 135.5, women 135.5; and TyG-WC: men 461.5, women 440.5. Given that lipid indices can be easily calculated with routine laboratory tests, these values may be useful markers for insulin resistance risk assessments in clinical settings.

scholarly journals Mediation Effect of Obesity on the Association Between Triglyceride-glucose Index and Hyperuricemia in Chinese Hypertension Adults.

2021 ◽  
Author(s):  
Jin Sun ◽  
Yongkang Su ◽  
Man Li ◽  
Shouyuan Ma ◽  
Yan Zhang ◽  
...  
Keyword(s):  
Fasting Blood Glucose ◽  
Surrogate Marker ◽  
Cross Sectional Study ◽  
Han Chinese ◽  
Mediation Effect ◽  
Cross Sectional ◽  
Tyg Index ◽  
Triglyceride Glucose Index ◽  
Relationship Of

Abstract Background: The triglyceride glucose (TyG) index was regarded as a simple surrogate marker of insulin resistance (IR). It is confirmed that IR was significantly associated with hyperuricemia, and obesity was the risk factor for IR and hyperuricemia. However, the relationship of TyG index and hyperuricemia and the potential role of obesity in Han Chinese hypertension are not entirely elucidated.Method：A community-based cross-sectional study was conducted in 4551 hypertension patients aged 40-75 years with clinical and biochemical data. The TyG index was calculated as ln [fasting triglyceride (mg/dl) × fasting blood glucose (mg/dl)/2]. Hyperuricemia was determined as serum uric acid ≥357μmol/L (6 mg/dl) for females and ≥417μmol/L (7 mg/dl) for males. Body mass index (BMI), waist (WC) and hip circumference (HC) were regarded as obesity indexes, to evaluate the mediation effect of the association between TyG index and hyperuricemia.Result：The TyG index was higher in patients with hyperuricemia than in those without (8.99±0.61, 8.70±0.59, P<0.001). The prevalence of hyperuricemia in patients with the lowest (≤8.32), second (8.33-8.66), the third (8.67-9.07) and the highest quartile (≥9.08) of TyG index was 6.0%, 10.4%, 15.4%, 21.4%, respectively. Logistic regression analysis suggested that the higher quartile of TyG index were associated with increased hyperuricemia risk whether in crude or adjusted models (P<0.05). Mediation analysis showed that all of our obesity indexes partially mediated the association between TyG index and hyperuricemia to some extent.Conclusion：TyG index is significantly associated with hyperuricemia in hypertension patients among Han Chinese, obesity plays a partial mediation role in this relationship.

scholarly journals Gut Microbiota Profile and Its Association with Clinical Variables and Dietary Intake in Overweight/Obese and Lean Subjects: A Cross-Sectional Study

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 2032
Author(s):  
Judit Companys ◽  
Maria José Gosalbes ◽  
Laura Pla-Pagà ◽  
Lorena Calderón-Pérez ◽  
Elisabet Llauradó ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Dietary Intake ◽  
Saturated Fatty Acids ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Anthropometric Parameters ◽  
Cross Sectional ◽  
Negatively Associated ◽  
Clinical Variables ◽  
Obese Subjects

We aimed to differentiate gut microbiota composition of overweight/obese and lean subjects and to determine its association with clinical variables and dietary intake. A cross-sectional study was performed with 96 overweight/obese subjects and 32 lean subjects. Anthropometric parameters were positively associated with Collinsella aerofaciens, Dorea formicigenerans and Dorea longicatena, which had higher abundance the overweight/obese subjects. Moreover, different genera of Lachnospiraceae were negatively associated with body fat, LDL and total cholesterol. Saturated fatty acids (SFAs) were negatively associated with the genus Intestinimonas, a biomarker of the overweight/obese group, whereas SFAs were positively associated with Roseburia, a biomarker for the lean group. In conclusion, Dorea formicigenerans, Dorea longicatena and Collinsella aerofaciens could be considered obesity biomarkers, Lachnospiraceae is associated with lipid cardiovascular risk factors. SFAs exhibited opposite association profiles with butyrate-producing bacteria depending on the BMI. Thus, the relationship between diet and microbiota opens new tools for the management of obesity.

scholarly journals Metabolic syndrome in patients with prostate cancer

2008 ◽  
Vol 126 (5) ◽  
pp. 274-278 ◽  
Author(s):  
Iúri Amorim de Santana ◽  
Gustavo Souza Moura ◽  
Nivaldo Farias Vieira ◽  
Rosana Cipolotti
Keyword(s):  
Prostate Cancer ◽  
Metabolic Syndrome ◽  
Body Mass ◽  
Specific Antigen ◽  
Density Lipoprotein ◽  
Positive Association ◽  
Serum Glucose ◽  
Anthropometric Parameters ◽  
Cross Sectional ◽  
Waist To Hip Ratio

CONTEXT AND OBJECTIVE: Prostate cancer (PCa) is the second most common cancer among men in Brazil. Recently, several studies have hypothesized a relationship between PCa and metabolic syndrome (MS). The aim here was to identify an association between MS and PCa. DESIGN AND SETTING: Cross-sectional study, Fundação de Beneficência Hospital de Cirurgia (FBHC) and Universidade Federal de Sergipe. METHODS: Laboratory and anthropometric parameters were compared between PCa patients (n = 16) and controls (n = 16). RESULTS: The PCa patients showed significantly greater frequency of MS than did the controls (p = 0.034). Serum glucose was higher and high-density lipoprotein-cholesterol was lower than in the controls, although without significant differences. There were significant differences in blood pressure (p = 0.029) and waist-to-hip ratio (p = 0.004). Pearson linear correlation showed a positive association between waist-to-hip ratio and prostate specific antigen (r = 0.584 and p = 0.028). Comparing subgroups with and without MS among the PCa patients, significant differences (p < 0.05) in weight, height, body mass index, hip circumference and lean body mass were observed, thus showing higher central obesity in those with MS. The serum glucose values were also higher in MS patients (p = 0.006), thus demonstrating that insulin resistance has a role in MS physiopathology. CONCLUSIONS: Our study suggests that MS may exert an influence on the development of PCa. However, it would be necessary to expand the investigation field with larger sample sizes and cohorts studied, to test the hypothesis generated in this study.

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