scholarly journals Surgical Management of Neuroendocrine Tumours of the Pancreas

2020 ◽  
Vol 9 (9) ◽  
pp. 2993
Author(s):  
Regis Souche ◽  
Christian Hobeika ◽  
Elisabeth Hain ◽  
Sebastien Gaujoux
Keyword(s):  
Neuroendocrine Tumours ◽  
Islet Cells ◽  
Preoperative Evaluation ◽  
High Volume ◽  
Genetic Syndromes ◽  
Active Peptides ◽  
Wide Range ◽  
Precise Diagnosis ◽  
Short And Long Term ◽  
Open Versus

Neuroendocrine tumours of the pancreas (pNET) are rare, accounting for 1–2% of all pancreatic neoplasms. They develop from pancreatic islet cells and cover a wide range of heterogeneous neoplasms. While most pNETs are sporadic, some are associated with genetic syndromes. Furthermore, some pNETs are ‘functioning’ when there is clinical hypersecretion of metabolically active peptides, whereas others are ‘non-functioning’. pNET can be diagnosed at a localised stage or a more advanced stage, including regional or distant metastasis (in 50% of cases) mainly located in the liver. While surgical resection is the cornerstone of the curative treatment of those patients, pNET management requires a multidisciplinary discussion between the oncologist, radiologist, pathologist, and surgeon. However, the scarcity of pNET patients constrains centralised management in high-volume centres to provide the best patient-tailored approach. Nonetheless, no treatment should be initiated without precise diagnosis and staging. In this review, the steps from the essential comprehensive preoperative evaluation of the best surgical approach (open versus laparoscopic, standard versus sparing parenchymal pancreatectomy, lymphadenectomy) according to pNET staging are analysed. Strategies to enhance the short- and long-term benefit/risk ratio in these particular patients are discussed.

Enzymes as a Reservoir of Host Defence Peptides

2020 ◽  
Vol 20 (14) ◽  
pp. 1310-1323
Author(s):  
Andrea Bosso ◽  
Antimo Di Maro ◽  
Valeria Cafaro ◽  
Alberto Di Donato ◽  
Eugenio Notomista ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Biological Activity ◽  
Internal Structure ◽  
Catalytic Properties ◽  
Cellular Responses ◽  
Host Defence ◽  
Present Review ◽  
Active Peptides ◽  
Wide Range

Host defence peptides (HDPs) are powerful modulators of cellular responses to various types of insults caused by pathogen agents. To date, a wide range of HDPs, from species of different kingdoms including bacteria, plant and animal with extreme diversity in structure and biological activity, have been described. Apart from a limited number of peptides ribosomally synthesized, a large number of promising and multifunctional HDPs have been identified within protein precursors, with properties not necessarily related to innate immunity, consolidating the fascinating hypothesis that proteins have a second or even multiple biological mission in the form of one or more bio-active peptides. Among these precursors, enzymes constitute certainly an interesting group, because most of them are mainly globular and characterized by a fine specific internal structure closely related to their catalytic properties and also because they are yet little considered as potential HDP releasing proteins. In this regard, the main aim of the present review is to describe a panel of HDPs, identified in all canonical classes of enzymes, and to provide a detailed description on hydrolases and their corresponding HDPs, as there seems to exist a striking link between these structurally sophisticated catalysts and their high content in cationic and amphipathic cryptic peptides.

scholarly journals Behavioral medicine challenges in the shadow of a global pandemic

2020 ◽  
Author(s):  
Alyssa T Brooks ◽  
Hannah K Allen ◽  
Louise Thornton ◽  
Tracy Trevorrow
Keyword(s):  
Environmental Factors ◽  
Health Behavior ◽  
Health Behaviors ◽  
Natural Experiment ◽  
Direct Effects ◽  
Global Pandemic ◽  
Wide Range ◽  
Future Data ◽  
Short And Long Term

Abstract Health behavior researchers should refocus and retool as it becomes increasingly clear that the challenges of the COVID-19 pandemic surpass the direct effects of COVID-19 and include unique, drastic, and ubiquitous consequences for health behavior. The circumstances of the pandemic have created a natural experiment, allowing researchers focusing on a wide range of health behaviors and populations with the opportunity to use previously collected and future data to study: (a) changes in health behavior prepandemic and postpandemic, (b) health behavior prevalence and needs amidst the pandemic, and (c) the effects of the pandemic on short- and long-term health behavior. Our field is particularly challenged as we attempt to consider biopsychosocial, political, and environmental factors that affect health and health behavior. These realities, while daunting, should call us to action to refocus and retool our research, prevention, and intervention efforts

scholarly journals A Slot-Die Technique for the Preparation of Continuous, High-Area, Chitosan-Based Thin Films

Polymers ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 1566
Author(s):  
Oliver J. Pemble ◽  
Maria Bardosova ◽  
Ian M. Povey ◽  
Martyn E. Pemble
Keyword(s):  
Thin Films ◽  
Mechanical Properties ◽  
High Volume ◽  
Mechanical Anisotropy ◽  
Diverse Range ◽  
Direction Parallel ◽  
High Area ◽  
Wide Range ◽  
Slot Die ◽  
Potential Applications

Chitosan-based films have a diverse range of potential applications but are currently limited in terms of commercial use due to a lack of methods specifically designed to produce thin films in high volumes. To address this limitation directly, hydrogels prepared from chitosan, chitosan-tetraethoxy silane, also known as tetraethyl orthosilicate (TEOS) and chitosan-glutaraldehyde have been used to prepare continuous thin films using a slot-die technique which is described in detail. By way of preliminary analysis of the resulting films for comparison purposes with films made by other methods, the mechanical strength of the films produced was assessed. It was found that as expected, the hybrid films made with TEOS and glutaraldehyde both show a higher yield strength than the films made with chitosan alone. In all cases, the mechanical properties of the films were found to compare very favorably with similar measurements reported in the literature. In order to assess the possible influence of the direction in which the hydrogel passes through the slot-die on the mechanical properties of the films, testing was performed on plain chitosan samples cut in a direction parallel to the direction of travel and perpendicular to this direction. It was found that there was no evidence of any mechanical anisotropy induced by the slot die process. The examples presented here serve to illustrate how the slot-die approach may be used to create high-volume, high-area chitosan-based films cheaply and rapidly. It is suggested that an approach of the type described here may facilitate the use of chitosan-based films for a wide range of important applications.

Editorial

2009 ◽  
Vol 11 (1) ◽  
pp. 1-14 ◽  
Author(s):  
Manasi Kumar ◽  
Erica Burman
Keyword(s):  
Millennium Development Goals ◽  
Health Management ◽  
The Political ◽  
Special Issue ◽  
Wide Range ◽  
Critical Approaches ◽  
Development Goals ◽  
Short And Long Term ◽  
Primary Focus

We welcome readers to the first special issue (11.1) of the Journal of Health Management. We hope the readers find the articles and various reviews enriching and provocative, both in terms of the range of ideas and critical approaches addressed. The key theme of this double issue concerns the political limits of mega-development projects such as the Millennium Development Goals (MDGs). The primary focus of the articles collected here is to provide an insightful, constructive and in-depth critique of the United Nations (UN) MDGs along with critical deliberations on their short- and long-term implications not only for health management but also for a wide range of issues around development and social change.

scholarly journals Fish Allergy Around the World—Precise Diagnosis to Facilitate Patient Management

2021 ◽  
Vol 2 ◽  
Author(s):  
Tanja Kalic ◽  
Christian Radauer ◽  
Andreas L. Lopata ◽  
Heimo Breiteneder ◽  
Christine Hafner
Keyword(s):  
Fish Species ◽  
False Negative ◽  
Management Approach ◽  
Fish Allergy ◽  
Wide Range ◽  
Precise Diagnosis ◽  
Diagnostic Approaches ◽  
Geographic Regions

The accurate and precise diagnosis of IgE-mediated fish allergy is one of the biggest challenges in allergy diagnostics. A wide range of fish species that belong to evolutionary distant classes are consumed globally. Moreover, each fish species may contain multiple isoforms of a given allergen that often differ in their allergenicity. Recent studies indicated that the cross-reactivity between different fish species is limited in some cases and depends on the evolutionary conservation of the involved allergens. Fish allergens belong to several protein families with different levels of stability to food processing. Additionally, different preparation methods may contribute to specific sensitization patterns to specific fish species and allergens in different geographic regions. Here, we review the challenges and opportunities for improved diagnostic approaches to fish allergy. Current diagnostic shortcomings include the absence of important region-specific fish species in commercial in vitro and in vivo tests as well as the lack of their standardization as has been recently demonstrated for skin prick test solutions. These diagnostic shortcomings may compromise patients' safety by missing some of the relevant species and yielding false negative test results. In contrast, the avoidance of all fish as a common management approach is usually not necessary as many patients may be only sensitized to specific species and allergens. Although food challenges remain the gold standard, other diagnostic approaches are investigated such as the basophil activation test. In the context of molecular allergy diagnosis, we discuss the usefulness of single allergens and raw and heated fish extracts. Recent developments such as allergen microarrays offer the possibility to simultaneously quantify serum IgE specific to multiple allergens and allergen sources. Such multiplex platforms may be used in the future to design diagnostic allergen panels covering evolutionary distant fish species and allergens relevant for particular geographic regions.

scholarly journals Russian Public Relations in 2020: Peculiar Features of Transformation

2021 ◽  
Vol 26 (2) ◽  
pp. 302-310
Author(s):  
Marina G. Shilina ◽  
Irina I. Volkova
Keyword(s):  
Public Relations ◽  
High Volume ◽  
Corporate Communication ◽  
Professional Communication ◽  
Organizational Strategies ◽  
Strategic Communications ◽  
Corporate Strategies ◽  
Wide Range ◽  
Knowledge Competencies ◽  
Increasing Demand

The paper presents the current transformations of Russian public relations during the SaRS-COVID-19 pandemic and remote working in 2020. In response to the crisis and uncertainty, companies have adapted and restructured corporate strategies and communications. The increasing demand for communication support of strategies and daily support of corporate activities indicates the growing significance of PR and the implementation of organizational strategies, as well as the demand for the optimization of corporate communication in society. The PR industry in general and professional communication are becoming more and more integrated due to the attraction of knowledge, competencies, specialists from a wide range of related industries: marketing, sociology, management. The current communication situation caused changes in the characteristics of Russian PR in the segment of communication agencies. Despite the traditionally high volume of the agencies marketing services, the growth of crisis and digital communications has turned to be stable, which indicates the demand for more flexible PR formats. Based on an analysis of public relations of the leading local communication agencies in 2020, the authors put forward a hypothesis on the formation of the prerequisites for the transition of Russian public relations to the format of strategic communications.

scholarly journals The role of Edge-Driven Convection in the generation of volcanism I: a 2D systematic study

2020 ◽  
Author(s):  
Antonio Manjón-Cabeza Córdoba ◽  
Maxim Ballmer
Keyword(s):  
Numerical Models ◽  
High Volume ◽  
Oceanic Lithosphere ◽  
Companion Paper ◽  
Small Scale ◽  
Continental Lithosphere ◽  
Transient Phenomenon ◽  
Mantle Viscosity ◽  
Wide Range

Abstract. The origin of intraplate volcanism is not explained by the plate tectonic theory, and several models have been put forward for explanation. One of these models involves Edge-Driven Convection (EDC), in which cold and thick continental lithosphere is juxtaposed to warm and thin oceanic lithosphere to trigger convective instability. To test whether EDC can produce long-lived high-volume magmatism, we run numerical models of EDC for a wide range of mantle properties and edge (i.e., the oceanic-continental transition) geometries. We find that the most important parameters that govern EDC are the rheological paramaters mantle viscosity η0 and activation energy Ea. However, even the maximum melting volumes found in our models are insufficient to account for island-building volcanism on old seafloor, such as at the Canary Islands and Cape Verde. Also, beneath old seafloor, localized EDC-related melting commonly transitions into widespread melting due to small-scale sublithospheric convection, inconsistent with the distribution of volcanism at these volcanic chains. In turn, EDC is a good candidate to sustain the formation of small seamounts on young seafloor, as it is a highly transient phenomenon that occurs in all our models soon after initiation. In a companion paper, we investigate the implications of interaction of EDC with mantle-plume activity.

scholarly journals The role of edge-driven convection in the generation of volcanism – Part 1: A 2D systematic study

Solid Earth ◽  
2021 ◽  
Vol 12 (3) ◽  
pp. 613-632
Author(s):  
Antonio Manjón-Cabeza Córdoba ◽  
Maxim D. Ballmer
Keyword(s):  
Numerical Models ◽  
High Volume ◽  
Oceanic Lithosphere ◽  
Companion Paper ◽  
Rheological Parameters ◽  
Small Scale ◽  
Transient Phenomenon ◽  
Mantle Viscosity ◽  
Wide Range

Abstract. The origin of intraplate volcanism is not explained by plate tectonic theory, and several models have been put forward for explanation. One of these models involves edge-driven convection (EDC), in which cold and thick continental lithosphere is juxtaposed with warm and thin oceanic lithosphere to trigger convective instability. To test whether EDC can produce long-lived high-volume magmatism, we run numerical models of EDC for a wide range of mantle properties and edge (i.e., the oceanic–continental transition) geometries. We find that the most important parameters that govern EDC are the rheological parameters mantle viscosity η0 and activation energy Ea. However, even the maximum melting volumes predicted by our most extreme cases are insufficient to account for island-building volcanism on old seafloor, such as at the Canary Islands and Cabo Verde. Also, beneath old seafloor, localized EDC-related melting commonly transitions into widespread melting due to small-scale sublithospheric convection, inconsistent with the distribution of volcanism at these volcano chains. In turn, EDC is a good candidate to sustain the formation of small seamounts on young seafloor, as it is a highly transient phenomenon that occurs in all our models soon after initiation. In a companion paper, we investigate the implications of interaction of EDC with mantle plume activity (Manjón-Cabeza Córdoba and Ballmer, 2021).

Autonomous Control of Non-Silicon MEMS Flexible Micro-Assembly Line

2014 ◽  
Vol 496-500 ◽  
pp. 1468-1472
Author(s):  
Gao Yang Zhang ◽  
Xin Jin ◽  
Zhi Jing Zhang
Keyword(s):  
Assembly Line ◽  
High Volume ◽  
Research Community ◽  
Autonomous Control ◽  
Assembly System ◽  
Micro Fabrication ◽  
Micro Assembly ◽  
Wide Range ◽  
Micro Systems ◽  
Real Challenge

A wide range of micro-components can today be produced using various micro-fabrication techniques. The efficient high volume assembly of complex micro-systems consisting of vast single components (i.e., hybrid micro-systems) is, however, a difficult task that is seen to be a real challenge for the robotic research community. It is necessary to conceive flexible, highly precise and fast micro-assembly methods. In this paper, a frame of a micro-assembly system in the form of flexible micro-assembly line and its autonomous control is presented. Implementation of the control system are described and the procedure of autonomous control is described as well.

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