scholarly journals Is Metformin a Possible Beneficial Treatment for Psoriasis? A Scoping Review

2021 ◽  
Vol 11 (4) ◽  
pp. 251
Author(s):  
Ana Maria Alexandra Stanescu ◽  
Anca Angela Simionescu ◽  
Mira Florea ◽  
Camelia Cristina Diaconu
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Scoping Review ◽  
Therapeutic Response ◽  
Organ Damage ◽  
Current Evidence ◽  
Inflammatory Condition ◽  
Metformin Monotherapy ◽  
Chronic Inflammatory Condition ◽  
Scoping Reviews

Psoriasis is a chronic inflammatory condition with genetic, immunological, and metabolic etiology. The link between psoriasis and diabetes mellitus has been shown in genetic predisposition, environmental influences, inflammatory pathways, and insulin resistance, resulting in end-organ damage in both conditions. Because comorbidities often accompany psoriasis, the therapeutic management of the disease must also take into consideration the comorbidities. Given that metformin’s therapeutic role in psoriasis is not yet fully elucidated, we raised the question of whether metformin is a viable alternative for the treatment of psoriasis. We conducted this scoping review by searching for evidence in PubMed, Cochrane, and Scopus databases, and we used an extension for scoping reviews (PRISMA-ScR). Current evidence suggests that metformin is safe to use in psoriasis. Studies have shown an excellent therapeutic response to metformin in patients with psoriasis and comorbidities such as diabetes, metabolic syndrome, and obesity. There is no clear evidence supporting metformin monotherapy in patients with psoriasis without comorbidities. There is a need to further evaluate metformin in larger clinical trials, as a therapy in psoriasis.

Ein Scoping Review internationaler Diabetes-Leitlinien

2021 ◽  
Vol 29 (4) ◽  
pp. 352-356
Author(s):  
Paula Friedrichs ◽  
Kerstin Schmidt
Keyword(s):  
Diabetes Mellitus ◽  
Scoping Review ◽  
Evidenzbasierte Leitlinien ◽  
Scoping Reviews

Zusammenfassung Im Rahmen eines Scoping Reviews wurden internationale, evidenzbasierte Leitlinien, die für die Primär-, Sekundär- oder Tertiärprävention von Diabetes mellitus relevante Handlungsempfehlungen enthalten, identifiziert und qualitativ bewertet. Die Ergebnisse geben zum einen Aufschluss über die Qualität der identifizierten Leitlinien und zum anderen einen Überblick über die in ihnen veröffentlichten evidenzbasierten Handlungsempfehlungen zur Versorgung von Menschen mit Diabetes mellitus hinsichtlich Präventionsart, Diabetes-Typ und Zielgruppe.

scholarly journals Gluten in pharmaceutical products: a scoping review

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Irene Lizano-Díez ◽  
Eduardo L. Mariño ◽  
Pilar Modamio
Keyword(s):  
Scoping Review ◽  
Healthcare Professionals ◽  
Pharmaceutical Products ◽  
Current Evidence ◽  
Gluten Free ◽  
Scoping Reviews ◽  
The Us ◽  
Wide Variability ◽  
Definition Of

Abstract Background Celiac disease (CD) is one of the most common gluten-related disorders. Although the only effective treatment is a strict gluten-free diet, doubts remain as to whether healthcare professionals take this restriction into consideration when prescribing and dispensing medicines to susceptible patients. This scoping review aimed to find out the current evidence for initiatives that either describe the gluten content of medicines or intend to raise awareness about the risk of prescribing and dispensing gluten-containing medicines in patients with CD and other gluten-related disorders. Methods A scoping review was conducted using three search strategies in PubMed/MEDLINE, TripDatabase and Web of Science in April 2021, following the PRISMA extension for scoping reviews (PRISMA-ScR). References from included articles were also examined. Two researchers screened the articles and results were classified according to their main characteristics and outcomes, which were grouped according to the PCC (Population, Concept and Context) framework. The initiatives described were classified into three targeted processes related to gluten-containing medicines: prescription, dispensation and both prescription and dispensation. Results We identified a total of 3146 records. After the elimination of duplicates, 3062 articles remained and ultimately 13 full texts were included in the narrative synthesis. Most studies were conducted in the US, followed by Canada and Australia, which each published one article. Most strategies were focused on increasing health professional’s knowledge of gluten-containing/gluten-free medications (n = 8), which were basically based on database development from manufacturer data. A wide variability between countries on provided information and labelling of gluten-containing medicines was found. Conclusion Initiatives regarding the presence of gluten in medicines, including, among others, support for prescribers, the definition of the role of pharmacists, and patients’ adherence problems due to incomplete labelling of the medicines, have been continuously developed and adapted to the different needs of patients. However, information is still scarce, and some aspects have not yet been considered, such as effectiveness for the practical use of solutions to support healthcare professionals.

scholarly journals Improving breastfeeding support through the implementation of the baby friendly hospital and community initiatives: a scoping review protocol

2021 ◽  
Vol 4 ◽  
pp. 1
Author(s):  
Aisling Walsh ◽  
Pieternella Pieterse ◽  
Zoe McCormack ◽  
Ellen Chirwa ◽  
Anne Matthews
Keyword(s):  
Scoping Review ◽  
Best Practice ◽  
Descriptive Analysis ◽  
World Health ◽  
Current Evidence ◽  
Future Research ◽  
Breastfeeding Support ◽  
Quantitative Descriptive Analysis ◽  
Global Campaign ◽  
Scoping Reviews

Background: Improved breastfeeding practices have the potential to save the lives of over 823,000 children under 5 years old globally every year. Exclusively breastfeeding infants for the first six months would lead to the largest infant mortality reduction. The Baby-Friendly Hospital Initiative (BFHI) is a global campaign by the World Health Organization and the United Nations Children's Fund (UNICEF), which promotes best practice to support breastfeeding in maternity services. The Baby-Friendly Community Initiative (BFCI) is an extension of the BHFI’s 10 th step of the Ten Steps to Successful Breastfeeding and of the BFHI overall. Its focus is on community-based breastfeeding supports for women. There have been no known attempts to synthesise the overall body of evidence on the BFHI in recent years, and no synthesis of empirical research on the BFCI. This scoping review asks the question: what is known about the implementation of the BFHI and the BFCI globally? Methods and analysis: This scoping review will be conducted according to the Joanna Briggs Institute methodology for scoping reviews. Inclusion criteria will follow the Population, Concepts, Contexts approach. A data charting form will be developed and applied to all the included articles. Qualitative and quantitative descriptive analysis will be undertaken. The PAGER (Patterns, Advances, Gaps, Evidence for practice and Research recommendations) methodological framework will be used to analyse and report review findings. Conclusion: This review will establish gaps in current evidence which will inform areas for future research in relation to this global initiative.

scholarly journals Myo-inositol supplementation as a preventive consideration for gestational diabetes mellitus

2020 ◽  
Vol 19 (1) ◽  
pp. 45-50
Author(s):  
George Asimakopoulos ◽  
Panagiotis Antsaklis ◽  
Mariana Theodora ◽  
Michael Sindos ◽  
Alexandros Rodolakis ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Current Evidence ◽  
Insulin Resistant ◽  
Improve Insulin Resistance ◽  
Prevalence Of Obesity ◽  
Ovarian Syndrome

Gestational diabetes mellitus (GDM) is defined as impaired glucose tolerance with onset or first recognition during pregnancy, which is characterized by increased insulin resistance. GDM affects about 10% of pregnancies and its prevalence is rising worldwide mainly due to the advancing maternal age and the increased prevalence of obesity. GDM is associated with pregnancy-related maternal and fetal morbidity (both antenatal and perinatal). Traditional treatments for the GDM include diet and, if it is necessary, insulin. However, the percentage of macrosomic newborns does not appear to be significantly reduced. Safe and effective preventive interventions are therefore, needed in an attempt to lower the incidence of gestational diabetes. Myo-inositol has been suggested to improve insulin resistance in women with insulin resistant syndromes such as GDM, polycystic ovarian syndrome, type 2 diabetes and metabolic syndrome. Several studies report a significant decrease in GDM incidence in women at risk for GDM comparing to the placebo group. However, the option of myo-inositol supplementation needs to be further explored as the current evidence is relatively limited.

scholarly journals Epidemiology of sleep disorders during COVID-19 pandemic: A systematic scoping review protocol

2020 ◽  
Author(s):  
Samia Tasnim ◽  
Mariya Rahman ◽  
Priyanka Pawar ◽  
Liye Zou ◽  
Abida Sultana ◽  
...  
Keyword(s):  
Mental Health ◽  
Sleep Disorders ◽  
Scoping Review ◽  
Mental Health Problems ◽  
Empirical Studies ◽  
Professional Community ◽  
Health Problems ◽  
Current Evidence ◽  
Future Research ◽  
Scoping Reviews

Background: The coronavirus disease (COVID-19) is impacting human health globally. In addition to physical health problems, a growing burden of mental health problems has become a global concern amid this pandemic. Sleep disorders are major mental health problems associated with increased psychosocial stressors; however, no research synthesis is available on the epidemiology of sleep disorders. In this systematic scoping review, we aim to assess the current evidence on the epidemiological burden, associated factors, and interventions from the existing literature on sleep disorders. Methods: We will search seven major health databases and additional sources to identify, evaluate, and synthesize empirical studies on the prevalence and correlates of sleep disorders and available interventions addressing the same. We will use the Joanna Briggs Institute Methodology for Scoping Review and report the findings using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) checklist. Conclusion: This review will identify the epidemiological burden of and interventions for sleep disorders. The findings of this review will be widely communicated with the research and professional community to facilitate future research and practice.

scholarly journals Patient and Public Involvement (PPI) in preclinical research: A scoping review protocol

2021 ◽  
Vol 4 ◽  
pp. 61
Author(s):  
Pádraig Carroll ◽  
Adrian Dervan ◽  
Anthony Maher ◽  
Ciarán McCarthy ◽  
Ian Woods ◽  
...  
Keyword(s):  
Scoping Review ◽  
Public Involvement ◽  
Positive Impact ◽  
Patient And Public Involvement ◽  
The Body ◽  
Current Evidence ◽  
Future Research ◽  
Advisory Panel ◽  
Preclinical Research ◽  
Scoping Reviews

Introduction: Patient and public involvement (PPI) aims to improve the quality, relevance, and appropriateness of research and ensure that it meets the needs and expectations of those affected by particular conditions to the greatest possible degree. The evidence base for the positive impact of PPI on clinical research continues to grow, but the role of PPI in preclinical research (an umbrella term encompassing ‘basic’, ‘fundamental’, ‘translational’ or ‘lab-based’ research) remains limited. As funding bodies and policymakers continue to increase emphasis on the relevance of PPI to preclinical research, it is timely to map the PPI literature to support preclinical researchers involving the public, patients, or other service users in their research. Therefore, the aim of this scoping review is to explore the literature on patient and public involvement in preclinical research from any discipline. Methods: This scoping review will search the literature in Medline (PubMed), Embase, CINAHL, PsycINFO, Web of Science Core Collection, Scopus, and OpenGrey.net to explore the application of PPI in preclinical research. This review will follow the Joanna Briggs Institute (JBI) guidelines for scoping reviews. It will be reported according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR). Two reviewers will independently review articles for inclusion in the final review. Data extraction will be guided by the research questions. The PPI advisory panel will then collaboratively identify themes in the extracted data. Discussion: This scoping review will provide a map of current evidence surrounding preclinical PPI, and identify the body of literature on this topic, which has not been comprehensively reviewed to date. Findings will inform ongoing work of the research team, support the work of other preclinical researchers aiming to include PPI in their own research, and identify knowledge and practice gaps. Areas for future research will be identified.

The clinical significance of insulin resistance, impaired carbohydrate and lipid metabolism in the development of microcirculation pathology in patients with chronic heart failure and type 2 diabetes mellitus

2016 ◽  
Vol 94 (6) ◽  
pp. 439-444
Author(s):  
Mihail E. Statsenko ◽  
S. V. Turkina ◽  
N. N. Shilina ◽  
M. A. Kosivtsova
Keyword(s):  
Diabetes Mellitus ◽  
Heart Failure ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Chronic Heart Failure ◽  
Endothelial Dysfunction ◽  
Organ Damage ◽  
Carbohydrate And Lipid Metabolism

Patients with chronic heart failure and diabetes mellitus type 2 experience continuous progression of organ damage as a result of hemodynamic and metabolic disorders. An important role in pathogenesis of organ damage belongs to pathological types of microcirculation, endothelial dysfunction and insulin resistance. But the role of insulin resistance and its contribution to the formation of endothelial dysfunction and peculiarities of microcirculation in patients with chronic heart failure and type 2 diabetes mellitus is unknown. This study shows significant association between insulin resistance, disorders of carbohydrate and lipid metabolism, development of microcirculatory disturbances and endothelial dysfunction.

scholarly journals Patient and Public Involvement (PPI) in preclinical research: A scoping review protocol

2021 ◽  
Vol 4 ◽  
pp. 61
Author(s):  
Pádraig Carroll ◽  
Adrian Dervan ◽  
Anthony Maher ◽  
Ciarán McCarthy ◽  
Ian Woods ◽  
...  
Keyword(s):  
Scoping Review ◽  
Public Involvement ◽  
Positive Impact ◽  
Patient And Public Involvement ◽  
The Body ◽  
Current Evidence ◽  
Future Research ◽  
Advisory Panel ◽  
Preclinical Research ◽  
Scoping Reviews

Introduction: Patient and public involvement (PPI) aims to improve the quality, relevance, and appropriateness of research and ensure that it meets the needs and expectations of those affected by particular conditions to the greatest possible degree. The evidence base for the positive impact of PPI on clinical research continues to grow, but the role of PPI in preclinical research (an umbrella term encompassing ‘basic’, ‘fundamental’, ‘translational’ or ‘lab-based’ research) remains limited. As funding bodies and policymakers continue to increase emphasis on the relevance of PPI to preclinical research, it is timely to map the PPI literature to support preclinical researchers involving the public, patients, or other service users in their research. Therefore, the aim of this scoping review is to explore the literature on patient and public involvement in preclinical research from any discipline. Methods: This scoping review will search the literature in Medline (PubMed), Embase, CINAHL, PsycINFO, Web of Science Core Collection, Scopus, and OpenGrey.net to explore the application of PPI in preclinical research. This review will follow the Joanna Briggs Institute (JBI) guidelines for scoping reviews. It will be reported according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR). Two reviewers will independently review articles for inclusion in the final review. Data extraction will be guided by the research questions. The PPI advisory panel will then collaboratively identify themes in the extracted data. Discussion: This scoping review will provide a map of current evidence surrounding preclinical PPI, and identify the body of literature on this topic, which has not been comprehensively reviewed to date. Findings will inform ongoing work of the research team, support the work of other preclinical researchers aiming to include PPI in their own research, and identify knowledge and practice gaps. Areas for future research will be identified.

scholarly journals Psoriasis and Obesity: A Review of the Current Literature

2018 ◽  
Author(s):  
Jeremy N Orloff ◽  
Joshua R Kaminetsky ◽  
Mina Aziz
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Syndrome ◽  
Heart Disease ◽  
Current Literature ◽  
Low Grade ◽  
Inflammatory Condition ◽  
Chronic Inflammatory Condition ◽  
Relationship Of ◽  
The Relationship ◽  
Shed Light

Obesity is currently considered a low-grade chronic inflammatory condition that has well-documented associations with heart disease, hypertension, diabetes mellitus, and metabolic syndrome. In addition to these conditions, there is growing evidence that the inflammatory cytokines produced in obesity may play contributory roles in other inflammatory phenomena. Notably, numerous studies over the last several decades have shed light on the genetic, mechanistic, and epidemiologic links between obesity and psoriasis, with implications for the treatment of these patients. This article reviews the current literature regarding the relationship of obesity and psoriasis, with exploration of their common mechanistic etiology and the necessary considerations in the management, both pharmacological and otherwise, of this patient population.

scholarly journals Risk Communication and Factors Influencing Private Well Testing Behavior: A Systematic Scoping Review

2019 ◽  
Vol 16 (22) ◽  
pp. 4333 ◽  
Author(s):  
Sarah K. Colley ◽  
Peter K.M. Kane ◽  
Jacqueline MacDonald Gibson
Keyword(s):  
Risk Communication ◽  
Scoping Review ◽  
Empirical Studies ◽  
Experimental Studies ◽  
Current Evidence ◽  
Well Testing ◽  
Specific Content ◽  
Scoping Reviews ◽  
Current Evidence Base ◽  
Communication Interventions

Unregulated private wells may be at risk for certain types of contamination associated with adverse health effects. Well water testing is a primary method to identify such risks, although testing rates are generally low. Risk communication is used as an intervention to promote private well testing behavior; however, little is known about whether these efforts are effective as well as the mechanisms that influence effectiveness. A systematic scoping review was conducted to evaluate the current evidence base for risk communication effectiveness and factors that influence well testing behavior. The review was conducted with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) framework. Data were synthesized using a health behavior model (Health Belief Model) to identify areas amenable to intervention and factors to consider when designing risk communication interventions. We identified a significant shortage of studies examining the effectiveness of risk communication interventions targeted to well testing behavior, with only two quasi-experimental studies identified. The review also identified seventeen studies that examined or described factors relating to well testing behavior. The two empirical studies suggest risk communication methods can be successful in motivating private well owners to test their water, while the remaining studies present considerations for developing effective, community-specific content.

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