scholarly journals The Three Pillars of COVID-19 Convalescent Plasma Therapy

Life ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 354
Author(s):  
Massimo Franchini ◽  
Giancarlo Maria Liumbruno ◽  
Giorgio Piacentini ◽  
Claudia Glingani ◽  
Marco Zaffanello
Keyword(s):  
Public Health ◽  
Severe Acute Respiratory Syndrome ◽  
Biologic Therapy ◽  
Clinical Effectiveness ◽  
Pharmacological Therapy ◽  
Narrative Review ◽  
Therapeutic Management ◽  
Plasma Therapy ◽  
Passive Immunotherapy ◽  
The World

The new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has spread rapidly around the world in the last year causing the coronavirus disease 2019 (COVID-19), which still is a severe threat for public health. The therapeutic management of COVID-19 is challenging as, up until now, no specific and efficient pharmacological therapy has been validated. Translating the experience from previous viral epidemics, passive immunotherapy by means of plasma from individuals recovered from COVID-19 has been intensively investigated since the beginning of the pandemic. In this narrative review, we critically analyze the three factors, named “pillars”, that play a key role in determining the clinical effectiveness of this biologic therapy: the convalescent plasma, the disease (COVID-19), and the patients.

Plasma therapy a possible hope to fight against COVID-19

2020 ◽  
Author(s):  
Ravikant Piyush ◽  
Aroni Chatterjee ◽  
Shashikant Ray
Keyword(s):  
Middle East ◽  
Severe Acute Respiratory Syndrome ◽  
Viral Disease ◽  
Plasma Therapy ◽  
Therapeutic Drugs ◽  
Wild Fire ◽  
The World ◽  
Short Span ◽  
Game Changer

The world is currently going through a disastrous event and a catastrophic upheaval caused by the coronavirus disease 2019 (COVID-19). The pandemic has resulted in loss of more than 150000 deaths across the globe. Originating from China and spreading across all continents within a short span of time, it has become a matter of international emergency. Different agencies are adopting diverse approaches to stop and spread of this viral disease but still now nothing confirmatory has come up. Due to lack of vaccines and proper therapeutic drugs, the disease is still spreading like wild fire without control. An Old but very promising method- the convalescent plasma therapy could be the key therapy to stop this pandemic. This method has already proven its mettle on several occasions previously and has been found to be effective in curing the pandemics induced by Ebola, severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV). The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) belongs to the same group of β-Coronavirus that has resulted in the above diseases. Therefore, the role of plasma therapy is being explored for treatment of this disease. In this review, we have mainly focused on the role of convalescent plasma therapy and why its use should be promoted in fight against COVID-19, as it could turn out to be a game changer.

OBESITY IN SARS-COV-2 INFECTION: LITERATURE REVIEW

2021 ◽  
pp. 19-23
Author(s):  
Donizete Tavares Da Silva ◽  
Priscila De Sousa Barros Lima ◽  
Renato Sampaio Mello Neto ◽  
Gustavo Magalhães Valente ◽  
Débora Dias Cabral ◽  
...  
Keyword(s):  
Public Health ◽  
Acute Respiratory Distress Syndrome ◽  
Gastrointestinal Tract ◽  
Severe Acute Respiratory Syndrome ◽  
Distress Syndrome ◽  
Circulatory System ◽  
World Health ◽  
Global Public Health ◽  
The World ◽  
Health Organization

In March 2020, the World Health Organization (1) declared COVID-19 as a pandemic and a threat to global public health (2). The virus mainly affects the lungs and can cause acute respiratory distress syndrome (ARDS). In addition, coronavirus 2 severe acute respiratory syndrome (SARSCOV2) also has devastating effects on other important organs, including the circulatory system, brain, gastrointestinal tract, kidneys and liver

scholarly journals Is hydroxychloroquine beneficial for COVID-19 patients?

2020 ◽  
Vol 11 (7) ◽  
Author(s):  
Xing Li ◽  
Ying Wang ◽  
Patrizia Agostinis ◽  
Arnold Rabson ◽  
Gerry Melino ◽  
...  
Keyword(s):  
Public Health ◽  
Severe Acute Respiratory Syndrome ◽  
Emergency Care ◽  
Public Health Emergency ◽  
World Health ◽  
Beneficial Effects ◽  
The World ◽  
Health Organization ◽  
Almost All ◽  
Effective Drugs

Abstract The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in December 2019. As similar cases rapidly emerged around the world1–3, the World Health Organization (WHO) declared a public health emergency of international concern on January 30, 2020 and pronounced the rapidly spreading coronavirus outbreak as a pandemic on March 11, 20204. The virus has reached almost all countries of the globe. As of June 3, 2020, the accumulated confirmed cases reached 6,479,405 with more than 383,013 deaths worldwide. The urgent and emergency care of COVID-19 patients calls for effective drugs, in addition to the beneficial effects of remdesivir5, to control the disease and halt the pandemic.

scholarly journals Optimization of the CDC Protocol of Molecular Diagnosis of COVID-19 for Timely Diagnosis

Diagnostics ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 333 ◽  
Author(s):  
Chao-Ju Chen ◽  
Li-Ling Hsieh ◽  
Shu-Kai Lin ◽  
Chu-Feng Wang ◽  
Yi-Hui Huang ◽  
...  
Keyword(s):  
Public Health ◽  
Infectious Disease ◽  
Severe Acute Respiratory Syndrome ◽  
Reverse Transcriptase ◽  
Gold Standard ◽  
Health Needs ◽  
The Novel ◽  
Assay Optimization ◽  
The World ◽  
Polymerase Chain

Coronavirus disease 2019 (COVID-19), the current uncontrolled outbreak of infectious disease, has caused significant challenges throughout the world. A reliable rapid diagnostic test for COVID-19 is demanded worldwide. The real-time reverse transcriptase polymerase chain was one of the most quickly established methods in the novel viral pandemic and was considered as the gold standard for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this report, we illustrate our experience of applying a protocol from the Taiwan CDC and achieving assay optimization in the immediate circumstances to meet the urgent medical and public health needs.

scholarly journals Coronavirus Pandemic: a major public health crisis for the developed and developing world

2021 ◽  
Vol 15 (03) ◽  
pp. 366-369
Author(s):  
Rooh Ullah ◽  
Muhammad Suleman Rana ◽  
Mehmood Qadir ◽  
Muhammad Usman ◽  
Niaz Ahmed
Keyword(s):  
Public Health ◽  
Severe Acute Respiratory Syndrome ◽  
Viral Infection ◽  
The Novel ◽  
Global Public Health ◽  
Health Crisis ◽  
Public Health Crisis ◽  
The World ◽  
Novel Coronavirus ◽  
Day By Day

Pandemic of novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infections in China is now become global public health crisis. At present 87.64% of the world is infected by this deadly illness. The risk from this epidemic depends on the nature of the virus, including how well it transmits from person to person, and the complications resulting from this current illness. The novel coronavirus has killed thousands of people in China and other countries as well; its rate of mortality is increasing day by day. There is an urgent need to control the virus by developing vaccine or any other antiviral drugs to save the world from this deadly viral infection.

scholarly journals Kumbh Mela Religious Gathering as a Massive Superspreading Event: Potential Culprit for the Exponential Surge of COVID-19 Cases in India

2021 ◽  
Vol 105 (4) ◽  
pp. 868-871
Author(s):  
Ian Christopher N. Rocha ◽  
Mary Grace A. Pelayo ◽  
Sudhan Rackimuthu
Keyword(s):  
Public Health ◽  
Severe Acute Respiratory Syndrome ◽  
Preventive Measures ◽  
Health Concerns ◽  
Medical Supplies ◽  
The World ◽  
Second Wave ◽  
Affected Country ◽  
Manpower Shortage ◽  
Populous Country

ABSTRACT. The Kumbh Mela is a significant religious gathering of millions of Hindu devotees in India. It is celebrated on certain auspicious days in the Hindu calendar and attracts millions of pilgrims across the country. Despite the religious intention of millions of Hindu devotees, it raised public health concerns as it became a massive superspreading event for COVID-19. Being the second most populous country, India became the second most affected country during the COVID-19 pandemic. In addition to the arrival of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants and the presence of the double mutated variant, which was first identified in India, the Kumbh Mela probably aggravated the country’s COVID-19 situation which resulted in an uncontrollable second wave. Several cases of COVID-19 across India had been contact-traced to returnees from the event who acted as a nidus to help spread the infection. As a consequence, India’s healthcare system was severely challenged as a result of the overwhelming hospitalizations and increasing fatalities resulting in an acute manpower shortage in healthcare along with the depletion of drugs and medical supplies despite being one of the largest pharmaceutical hubs globally. Leaders and governments around the world should learn from India’s experience and thereby take preventive measures to manage potential superspreading events to curb the spike of COVID-19 cases.

scholarly journals Coronavirus respiratory illness in Saudi Arabia

2012 ◽  
Vol 6 (10) ◽  
pp. 692-694 ◽  
Author(s):  
Mohammed N. Al-Ahdal ◽  
Ahmed Ali Al-Qahtani ◽  
Salvatore Rubino
Keyword(s):  
Public Health ◽  
Saudi Arabia ◽  
Severe Acute Respiratory Syndrome ◽  
Viral Infection ◽  
Molecular Analysis ◽  
Respiratory Illness ◽  
Human Infection ◽  
Gulf Region ◽  
Health Authorities ◽  
The World

Although viruses that belong to the coronavirus family are known since the 1930s, they only gained public health attention when they were discovered to be the causative agent of the severe acute respiratory syndrome (SARS) outbreak in China in 2002–2003. On 22 September 2012, the Ministry of Health (MOH) in Saudi Arabia announced the detection of what was described as a “rare pattern” of coronavirus respiratory infection in three individuals, two Saudi citizens and one person from the Gulf Region. Neither Saudi citizen survived the infection. Molecular analysis of the isolates showed that the virus belongs to the genus beta-coronavirus. It is not known if the new isolates are circulating in the population or has recently diverged. The emergence of these novel isolates that resulted in fatal human infection ascertains that health authorities all over the world must be vigilant for the possibility of new global pandemics due to novel viral infection.

scholarly journals Approach to Chilblains During the COVID-19 Pandemic

2020 ◽  
Vol 24 (5) ◽  
pp. 504-517 ◽  
Author(s):  
Malika A. Ladha ◽  
Nadia Luca ◽  
Cora Constantinescu ◽  
Karen Naert ◽  
Michele L. Ramien
Keyword(s):  
Public Health ◽  
Severe Acute Respiratory Syndrome ◽  
Narrative Review ◽  
Clinical Approach ◽  
Evidence Based ◽  
Cutaneous Pattern ◽  
Timing Of Onset ◽  
Distinguishing Features

Coronavirus disease (COVID-19) chilblains is a well-reported cutaneous pattern of severe acute respiratory syndrome coronavirus (SARS-CoV-2). Through this narrative review, we provide an evidence-based overview of idiopathic and secondary chilblains, distinguishing features of COVID-19 chilblains, and a systematic clinical approach to history, examination, investigations, and treatment. In the absence of cold or damp exposure, COVID-19 should be considered as a cause of acute chilblains. The timing of onset of COVID-19 chilblains relative to active SARS-CoV-2 viremia remains unclear. Patients with suspected COVID-19 chilblains should thus follow public health guidelines for COVID-19 testing and self-isolation.

Divergent Trust and Dissonant Truths in Public Health Science

2020 ◽  
pp. 95-114
Author(s):  
Katherine A. Mason
Keyword(s):  
Public Health ◽  
Severe Acute Respiratory Syndrome ◽  
Disease Control ◽  
Modern Science ◽  
Health Science ◽  
Pearl River ◽  
The Pearl River Delta ◽  
Health Community ◽  
The World ◽  
The Pearl River

This chapter is based on research conducted in the pseudonymous city of Tianmai between 2008 and 2014. It takes note of public health science after the severe acute respiratory syndrome (SARS) breakout was supposed to “save” China in part by promoting the reputation and standing of China's public health community throughout the world. With regard to this promise, the young, well-educated scientists who worked at the Center for Disease Control (CDC) in the Pearl River Delta in the years following the 2003 SARS epidemic were largely disappointed. They had arrived at their new posts full of idealism and ambition, but by the end of the decade they were voicing frustration, boredom, and embarrassment. What bothered these young scientists most of all was their feelings of powerlessness with regard to acting on this knowledge. The lingdao must still receive his statistics, the money must be spent, and the migrants must be counted and vaccinated. In this vein, the most commonly repeated phrase heard from the younger generation of scientists was one of fatalism: there is nothing to be done, it is all determined by the leaders. Modern science was contrasted with traditional clientelism to produce an ideal that felt impossible to attain.

scholarly journals Biomimetic nanovaccines for COVID-19

2020 ◽  
Vol 1 (1) ◽  
pp. 176-182
Author(s):  
Bijay Singh
Keyword(s):  
Public Health ◽  
Clinical Trials ◽  
Severe Acute Respiratory Syndrome ◽  
Causative Agent ◽  
Global Public Health ◽  
Vaccine Production ◽  
The World ◽  
Insight Into

The outbreak of Coronavirus Disease 2019 (COVID-19) has posed a serious threat to global public health, calling for the development of safe and effective prophylactics and therapeutics against infection of its causative agent, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Currently, there is no approved vaccines or medications exist to prevent infection by SARS-CoV-2. In this emergency, more than 100 vaccines formulated using conventional approaches are being explored against SARS-CoV-2 across the world. The vaccines formulated using nanotechnology are also on the race of clinical trials. The aim of this article is to provide an insight into the ways of vaccine production by conventional and nanotechnology platforms and expand the understanding on the possibilities and limitations of these approaches for vaccine developments.

Sign in / Sign up

Export Citation Format

Share Document