scholarly journals Bio-Catalysis and Biomedical Perspectives of Magnetic Nanoparticles as Versatile Carriers

2019 ◽  
Vol 5 (3) ◽  
pp. 42 ◽  
Author(s):  
Muhammad Bilal ◽  
Shahid Mehmood ◽  
Tahir Rasheed ◽  
Hafiz M. N. Iqbal
Keyword(s):  
Magnetic Field ◽  
Magnetic Properties ◽  
Magnetic Nanoparticles ◽  
Molecular Level ◽  
State Of The Art ◽  
Volume Ratio ◽  
Controlled Drug Delivery ◽  
High Mass ◽  
Biological Interactions ◽  
Magnetic Carriers

In recent years, magnetic nanoparticles (MNPs) have gained increasing attention as versatile carriers because of their unique magnetic properties, biocatalytic functionalities, and capabilities to work at the cellular and molecular level of biological interactions. Moreover, owing to their exceptional functional properties, such as large surface area, large surface-to-volume ratio, and mobility and high mass transference, MNPs have been employed in several applications in different sectors such as supporting matrices for enzymes immobilization and controlled release of drugs in biomedicine. Unlike non-magnetic carriers, MNPs can be easily separated and recovered using an external magnetic field. In addition to their biocompatible microenvironment, the application of MNPs represents a remarkable green chemistry approach. Herein, we focused on state-of-the-art two majorly studied perspectives of MNPs as versatile carriers for (1) matrices for enzymes immobilization, and (2) matrices for controlled drug delivery. Specifically, from the applied perspectives of magnetic nanoparticles, a series of different applications with suitable examples are discussed in detail. The second half is focused on different metal-based magnetic nanoparticles and their exploitation for biomedical purposes.

scholarly journals Biomedical Applications of Biomaterials Functionalized with Magnetic Nanoparticles

2020 ◽  
Author(s):  
Matteo Bruno Lodi ◽  
Alessandro Fanti
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Heat Dissipation ◽  
Hyperthermia Treatment ◽  
Prosthetic Implants ◽  
Magnetic Carriers ◽  
Magnetic Drug Delivery ◽  
Influence Parameter ◽  
Nonlinear Nature

The combination of magnetic nanoparticles and a biocompatible material leads to the manufacturing of a multifunctional and remotely controlled platform useful for diverse biomedical issues. If a static magnetic field is applied, a magnetic scaffold behaves like an attraction platform for magnetic carriers of growth factors, thus being a potential tool to enhance magnetic drug delivery in regenerative medicine. To translate in practice this potential application, a careful and critical description of the physics and the influence parameter is required. This chapter covers the mathematical modeling of the process and assesses the problem of establishing the influence of the drug delivery system on tissue regeneration. On the other hand, if a time-varying magnetic field is applied, the magnetic nanoparticles would dissipate heat, which can be exploited to perform local hyperthermia treatment on residual cancer cells in the bone tissue. To perform the treatment planning, it is necessary to account for the modeling of the intrinsic nonlinear nature of the heat dissipation dynamic in magnetic prosthetic implants. In this work, numeric experiments to investigate the physiopathological features of the biological system, linked to the properties of the nanocomposite magnetic material, to assess its effectiveness as therapeutic agents are presented.

scholarly journals Investigation of the physicochemical properties of magnetic nanoparticles: size, magnetic properties, concentration

2021 ◽  
Vol 931 (1) ◽  
pp. 012011
Author(s):  
VN Kuryakov ◽  
I V Sergeev ◽  
O O Efanova ◽  
O K Zheludkova
Keyword(s):  
Magnetic Field ◽  
Magnetic Properties ◽  
Magnetic Nanoparticles ◽  
Physicochemical Properties ◽  
Number Concentration ◽  
Scattering Method ◽  
Particle Sizes ◽  
Time Intervals ◽  
Aqueous Dispersions ◽  
Dynamic Scattering

Abstract This work presents the results of studies of a series of samples of aqueous dispersions of magnetic nanoparticles. The particle sizes were measured for these samples by the dynamic scattering method. Using the method of ultramicroscopy, the number concentration of particles in the samples and the concentration of particles remaining in the volume of the samples after exposure to a magnetic field at various time intervals were measured.

scholarly journals Evaluation of Magnetic Parameters and Kinetics of the Magnetic Nanoparticles in High Magnetic Fields and its Potential Applications

2020 ◽  
Vol 8 (A) ◽  
pp. 24-36
Author(s):  
Mark Christopher Arokiaraj ◽  
Aleksandr Liubimtcev
Keyword(s):  
Magnetic Field ◽  
Magnetic Properties ◽  
Magnetic Nanoparticles ◽  
Magnetic Fields ◽  
Flux Density ◽  
7 Tesla ◽  
High Magnetic Fields ◽  
Drag Forces ◽  
Magnetic Strength ◽  
Motion Characteristics

BACKGROUND: Multifunctional nanoparticles are known for their wide range of biomedical applications. Controlling the magnetic properties of these nanoparticles is imperative for various applications, including therapeutic angiogenesis. AIM: The study was performed to evaluate the magnetic properties and their control mechanisms by the external magnetic field. METHODS: A100 nm magnetic nanoparticle was placed in the magnetic field, and parametrically, the magnet field strength and distance were evaluated. Various models of magnetic strength and disposition were evaluated. Magnetic flux density, force/weight, and magnetic gradient strength were the parameters evaluated in the electromagnetic computational software. RESULTS: The seven-coil method with three centrally placed coils as Halbach array, and each coil with a flux density of 7 Tesla, and with a coil dimension of 20 cm × 20 cm (square model) of each coil showed a good magnetic strength and force/weight parameters in a distance of 15 cm from the centrally placed coil. The particles were then evaluated for their motion characteristics in saline. It showed good displacement and acceleration properties. After that, the particles were theoretically assessed in a similar mathematical model after parametrically correcting the drag force. After the application of high drag forces, the particles showed adequate motion characteristics. When the particle size was reduced further, the motion characteristics were preserved even with high drag forces. CONCLUSION: There is potential for a novel method of controlling multifunctional magnetic nanoparticles using high magnetic fields. Further studies are required to evaluate the motion characteristics of these particles in vivo and in vitro.

Linear stability analysis of non-Newtonian blood flow with magnetic nanoparticles: application to controlled drug delivery

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Pascalin Tiam Kapen ◽  
Cédric Gervais Njingang Ketchate ◽  
Didier Fokwa ◽  
Ghislain Tchuen
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Stability Analysis ◽  
Magnetic Nanoparticles ◽  
Linear Stability ◽  
Linear Stability Analysis ◽  
Controlled Drug Delivery ◽  
Darcy Number ◽  
Content Type ◽  
The Stability

Purpose For this purpose, a linear stability analysis based on the Navier–Stokes and Maxwell equations is made leading to an eigenvalue differential equation of the modified Orr–Sommerfeld type which is solved numerically by the spectral collocation method based on Chebyshev polynomials. Unlike previous studies, blood is considered as a non-Newtonian fluid. The effects of various parameters such as volume fraction of nanoparticles, Casson parameter, Darcy number, Hartmann number on flow stability were examined and presented. This paper aims to investigate a linear stability analysis of non-Newtonian blood flow with magnetic nanoparticles with an application to controlled drug delivery. Design/methodology/approach Targeted delivery of therapeutic agents such as stem cells and drugs using magnetic nanoparticles with the help of external magnetic fields is an emerging treatment modality for many diseases. To this end, controlling the movement of nanoparticles in the human body is of great importance. This study investigates controlled drug delivery by using magnetic nanoparticles in a porous artery under the influence of a magnetic field. Findings It was found the following: the Casson parameter affects the stability of the flow by amplifying the amplitude of the disturbance which reflects its destabilizing effect. It emerges from this study that the taking into account of the non-Newtonian character is essential in the modeling of such a system, and that the results can be very different from those obtained by supposing that the blood is a Newtonian fluid. The presence of iron oxide nanoparticles in the blood increases the inertia of the fluid, which dampens the disturbances. The Strouhal number has a stabilizing effect on the flow which makes it possible to say that the oscillating circulation mechanisms dampen the disturbances. The Darcy number affects the stability of the flow and has a stabilizing effect, which makes it possible to increase the contact surface between the nanoparticles and the fluid allowing very high heat transfer rates to be obtained. It also emerges from this study that the presence of the porosity prevents the sedimentation of the nanoparticles. By studying the effect of the magnetic field on the stability of the flow, it is observed that the Hartmann number keeps the flow completely stable. This allows saying that the magnetic field makes the dissipations very important because the kinetic energy of the electrically conductive ferrofluid is absorbed by the Lorentz force. Originality/value The originality of this paper resides on the application of the linear stability analysis for controlled drug delivery.

To the Theory of Hyperthermia Effect Induced by Magnetic Nanoparticles

2015 ◽  
Vol 233-234 ◽  
pp. 771-775 ◽  
Author(s):  
Andrey Zubarev ◽  
Ali Abu-Bakr
Keyword(s):  
Magnetic Field ◽  
Magnetic Properties ◽  
Magnetic Nanoparticles ◽  
Heat Production ◽  
Particle Rotation ◽  
Carrier Liquid ◽  
Linearly Polarized ◽  
Dilute Suspension ◽  
Oscillating Magnetic Field ◽  
Ferromagnetic Particles

In this paper, we present results of theoretical modeling of the rise of temperature for the unit of time in a dilute suspension of the fiber ferromagnetic particles under the action of the linearly polarized oscillating magnetic field. Two mechanisms of the heat production, namely the particle rotation in the liquid and its internal remagnetization are considered. We study effect of the particle shape, its magnetic properties and rheological properties of the carrier liquid on the rise of temperature for the unit of time by the particles.

scholarly journals Directing the orientational alignment of anisotropic magnetic nanoparticles using dynamic magnetic fields

2015 ◽  
Vol 181 ◽  
pp. 449-461 ◽  
Author(s):  
Daniel Hoffelner ◽  
Matthias Kundt ◽  
Annette M. Schmidt ◽  
Emmanuel Kentzinger ◽  
Philipp Bender ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Electron Microscopy ◽  
Magnetic Properties ◽  
Magnetic Nanoparticles ◽  
Magnetic Fields ◽  
Rotating Magnetic Fields ◽  
X Ray ◽  
X Ray Scattering ◽  
Field Geometry ◽  
The Magnetic Field

The structure-directing influence of static and dynamic, i.e. rotating, magnetic fields on the orientational alignment of spindle-type hematite particles with a high aspect ratio is investigated. Structural characterization using electron microscopy and small-angle X-ray scattering confirms a nearly collinear particle arrangement with orientation of the main particle axis either parallel or perpendicular to the substrate as directed by the magnetic field geometry. The combination of large structural and magnetocrystalline anisotropies results in significantly different, strongly anisotropic magnetic properties of the assemblies revealed by directional magnetization measurements.

scholarly journals Evaluation of Magnetic Parameters and Kinetics of the Magnetic Nanoparticles in High Magnetic Fields

2019 ◽  
Author(s):  
Mark Christopher Arokiaraj ◽  
Aleksandr Liubimtcev
Keyword(s):  
Magnetic Field ◽  
Magnetic Properties ◽  
Magnetic Nanoparticles ◽  
Magnetic Fields ◽  
Flux Density ◽  
7 Tesla ◽  
High Magnetic Fields ◽  
Drag Forces ◽  
Magnetic Strength ◽  
Motion Characteristics

Background: Multifunctional nanoparticles are known for their wide range of biomedical applications. Controlling the magnetic properties of these nanoparticles is imperative for various applications, including therapeutic angiogenesis. The study was performed to evaluate the magnetic properties and their control mechanisms by the external magnetic field. Methods: A 100nm magnetic nanoparticle was placed in the magnetic field, and parametrically the magnet field strength and distance was evaluated. Various models of magnetic strength and disposition were evaluated. Magnetic flux density, force/weight, and magnetic gradient strength were the parameters evaluated in electromagnetic computational software. Results: The seven-coil method with three centrally placed coils as Halbach array, and each coil with a flux density of 7 Tesla, and with a coil dimension of 20cmx20cm (square model) of each coil showed a good magnetic strength and force/weight parameters in a distance of 15cm from the centrally placed coil. The particles were then evaluated for their motion characteristics in saline. It showed good displacement and acceleration properties. After that, the particles were theoretically assessed in a similar mathematical model after parametrically correcting the drag force. After application of high drag forces, the particles showed adequate motion characteristics. When the particle size was reduced further, the motion characteristics were preserved even with high drag forces. Conclusion: There is potential for a novel method of controlling multifunctional magnetic nanoparticles using high magnetic fields. Further studies are required to evaluate the motion characteristics of these particles in-vivo and invitro.

Quasistatic Magnetic Properties and Dynamic Hysteretic Losses in (La,Sr)MnO3 Nanoparticles Fabricated by Different Technological Routes

2015 ◽  
Vol 230 ◽  
pp. 101-107
Author(s):  
Alexander I. Tovstolytkin ◽  
S.O. Solopan ◽  
V.M. Kalita ◽  
S.M. Ryabchenko ◽  
Anatolii G. Belous
Keyword(s):  
Magnetic Field ◽  
Magnetic Properties ◽  
Magnetic Nanoparticles ◽  
Alternating Magnetic Field ◽  
Magnetic Characteristics ◽  
Specific Loss ◽  
Heating Efficiency ◽  
Specific Loss Power

Structural and magnetic characteristics of (La,Sr)MnO3 nanoparticles synthesized by different methods have been studied in the work. The specific loss power which is released on the exposure of an ensemble of synthesized particles to alternating magnetic field was calculated and measured experimentally. The contributions to the specific loss power resulted from different heating mechanisms have been discussed. The directions to enhance the heating efficiency of various kinds of magnetic nanoparticles are outlined

scholarly journals Current density and molecular magnetic properties

2021 ◽  
Author(s):  
Dage Sundholm ◽  
Maria Dimitrova ◽  
Raphael Berger
Keyword(s):  
Magnetic Field ◽  
Magnetic Properties ◽  
External Magnetic Field ◽  
Present State ◽  
Current Density ◽  
State Of The Art ◽  
Quantum Mechanical ◽  
Molecular Response ◽  
Induced Current ◽  
Quantum Mechanical Systems

We give an overview of the molecular response to an external magnetic field perturbing quantum mechanical systems. We present state-of-the-art methods for calculating magnetically-induced current-density susceptibilities. We discuss the essence...

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