scholarly journals Two Gaussian Bridge Processes for Mapping Continuous Trait Evolution along Phylogenetic Trees

Mathematics ◽  
2021 ◽  
Vol 9 (16) ◽  
pp. 1998
Author(s):  
Dwueng-Chwuan Jhwueng
Keyword(s):  
Gaussian Processes ◽  
Related Species ◽  
Phylogenetic Trees ◽  
Brownian Bridge ◽  
The Body ◽  
The Novel ◽  
Trait Evolution ◽  
Continuous Trait ◽  
Evolutionary Trajectories ◽  
Marsupial Species

Gaussian processes are powerful tools for modeling trait evolution along phylogenetic trees. As the value of a trait may change randomly throughout the evolution, two Gaussian bridge processes, the Brownian bridge (BB) and the Ornstein–Uhlenbeck bridge (OUB), are proposed for mapping continuous trait evolution for a group of related species along a phylogenetic tree, respectively. The corresponding traitgrams to the two bridge processes are created to display the evolutionary trajectories. The novel models are applied to study the body mass evolution of a group of marsupial species.

Diaghilev and British Writing

2009 ◽  
Vol 27 (1) ◽  
pp. 65-92
Author(s):  
Susan Jones
Keyword(s):  
Visual Arts ◽  
The Body ◽  
The Novel ◽  
Literary Responses ◽  
Literary Aesthetics ◽  
Ballets Russes ◽  
The Arts ◽  
The Subject ◽  
And Gender ◽  
Opening Up

This article explores the diversity of British literary responses to Diaghilev's project, emphasising the way in which the subject matter and methodologies of Diaghilev's modernism were sometimes unexpectedly echoed in expressions of contemporary British writing. These discussions emerge both in writing about Diaghilev's work, and, more discretely, when references to the Russian Ballet find their way into the creative writing of the period, serving to anchor the texts in a particular cultural milieu or to suggest contemporary aesthetic problems in the domain of literary aesthetics developing in the period. Figures from disparate fields, including literature, music and the visual arts, brought to their criticism of the Ballets Russes their individual perspectives on its aesthetics, helping to consolidate the sense of its importance in contributing to the inter-disciplinary flavour of modernism across the arts. In the field of literature, not only did British writers evaluate the Ballets Russes in terms of their own poetics, their relationship to experimentation in the novel and in drama, they developed an increasing sense of the company's place in dance history, its choreographic innovations offering material for wider discussions, opening up the potential for literary modernism's interest in impersonality and in the ‘unsayable’, discussions of the body, primitivism and gender.

Novel Nanolipoidal Systems for the Management of Skin Cancer

2020 ◽  
Vol 14 (2) ◽  
pp. 108-125
Author(s):  
Apoorva Singh ◽  
Nimisha
Keyword(s):  
Skin Cancer ◽  
Survival Rates ◽  
Cancer Therapeutics ◽  
The Body ◽  
Surgical Removal ◽  
The Novel ◽  
Skin Cancers ◽  
Recent Developments ◽  
Abnormal Cells ◽  
The Stability

: Skin cancer, among the various kinds of cancers, is a type that emerges from skin due to the growth of abnormal cells. These cells are capable of spreading and invading the other parts of the body. The occurrence of non-melanoma and melanoma, which are the major types of skin cancers, has increased over the past decades. Exposure to ultraviolet radiations (UV) is the main associative cause of skin cancer. UV exposure can inactivate tumor suppressor genes while activating various oncogenes. The conventional techniques like surgical removal, chemotherapy and radiation therapy lack the potential for targeting cancer cells and harm the normal cells. However, the novel therapeutics show promising improvements in the effectiveness of treatment, survival rates and better quality of life for patients. Different methodologies are involved in the skin cancer therapeutics for delivering the active ingredients to the target sites. Nano carriers are very efficient as they have the ability to improve the stability of drugs and further enhance their penetration into the tumor cells. The recent developments and research in nanotechnology have entitled several targeting and therapeutic agents to be incorporated into nanoparticles for an enhancive treatment of skin cancer. To protect the research works in the field of nanolipoidal systems various patents have been introduced. Some of the patents acknowledge responsive liposomes for specific targeting, nanocarriers for the delivery or co-delivery of chemotherapeutics, nucleic acids as well as photosensitizers. Further recent patents on the novel delivery systems have also been included here.

scholarly journals CRISPR-Cas System: The Powerful Modulator of Accessory Genomes in Prokaryotes

2021 ◽  
pp. 1-16
Author(s):  
Anca Butiuc-Keul ◽  
Anca Farkas ◽  
Rahela Carpa ◽  
Dumitrana Iordache
Keyword(s):  
Nucleic Acids ◽  
Pathogenic Bacteria ◽  
The Novel ◽  
Defense System ◽  
Guide Rnas ◽  
Crispr Array ◽  
Different Types ◽  
Evolutionary Trajectories ◽  
Novel Coronavirus ◽  
Cas Proteins

Being frequently exposed to foreign nucleic acids, bacteria and archaea have developed an ingenious adaptive defense system, called CRISPR-Cas. The system is composed of the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) array, together with CRISPR (<i>cas</i>)-associated genes. This system consists of a complex machinery that integrates fragments of foreign nucleic acids from viruses and mobile genetic elements (MGEs), into CRISPR arrays. The inserted segments (spacers) are transcribed and then used by cas proteins as guide RNAs for recognition and inactivation of the targets. Different types and families of CRISPR-Cas systems consist of distinct adaptation and effector modules with evolutionary trajectories, partially independent. The origin of the effector modules and the mechanism of spacer integration/deletion is far less clear. A review of the most recent data regarding the structure, ecology, and evolution of CRISPR-Cas systems and their role in the modulation of accessory genomes in prokaryotes is proposed in this article. The CRISPR-Cas system&apos;s impact on the physiology and ecology of prokaryotes, modulation of horizontal gene transfer events, is also discussed here. This system gained popularity after it was proposed as a tool for plant and animal embryo editing, in cancer therapy, as antimicrobial against pathogenic bacteria, and even for combating the novel coronavirus – SARS-CoV-2; thus, the newest and promising applications are reviewed as well.

scholarly journals Disease Mechanisms and Therapeutic Approaches in C9orf72 ALS-FTD

Biomedicines ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 601
Author(s):  
Keith Mayl ◽  
Christopher E. Shaw ◽  
Youn-Bok Lee
Keyword(s):  
The Body ◽  
The Novel ◽  
Therapeutic Approaches ◽  
Gain Of Function ◽  
Pathogenic Mechanisms ◽  
Hexanucleotide Repeat ◽  
Primary Driver ◽  
Hexanucleotide Repeat Expansion ◽  
Expansion Mutation ◽  
Lateral Sclerosis

A hexanucleotide repeat expansion mutation in the first intron of C9orf72 is the most common known genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. Since the discovery in 2011, numerous pathogenic mechanisms, including both loss and gain of function, have been proposed. The body of work overall suggests that toxic gain of function arising from bidirectionally transcribed repeat RNA is likely to be the primary driver of disease. In this review, we outline the key pathogenic mechanisms that have been proposed to date and discuss some of the novel therapeutic approaches currently in development.

scholarly journals The Embodiment of Insult: A Theory of Biobehavioral Response to Workplace Incivility

2021 ◽  
pp. 014920632198979
Author(s):  
Lilia M. Cortina ◽  
M. Sandy Hershcovis ◽  
Kathryn B. H. Clancy
Keyword(s):  
Behavioral Responses ◽  
Well Being ◽  
Workplace Incivility ◽  
The Body ◽  
Social Connections ◽  
The Novel ◽  
Target Response ◽  
Organizational Life ◽  
New Science ◽  
Broad Theory

This article builds a broad theory to explain how people respond, both biologically and behaviorally, when targeted with incivility in organizations. Central to our theorizing is a multifaceted framework that yields four quadrants of target response: reciprocation, retreat, relationship repair, and recruitment of support. We advance the novel argument that these behaviors not only stem from biological change within the body but also stimulate such change. Behavioral responses that revolve around affiliation and produce positive social connections are most likely to bring biological benefits. However, social and cultural features of an organization can stand in the way of affiliation, especially for employees holding marginalized identities. When incivility persists over time and employees lack access to the resources needed to recover, we theorize, downstream consequences can include harms to their physical health. Like other aspects of organizational life, this biobehavioral theory of incivility response is anything but simple. But it may help explain how seemingly “small” insults can sometimes have large effects, ultimately undermining workforce well-being. It may also suggest novel sites for incivility intervention, focusing on the relational and inclusive side of work. The overarching goal of this article is to motivate new science on workplace incivility, new knowledge, and ultimately, new solutions.

French Women, Italian Art, and Other “Advocates of the Body” in Harriet Beecher Stowe's The Minister's Wooing

2010 ◽  
Vol 83 (1) ◽  
pp. 47-72 ◽  
Author(s):  
Dorothy Z. Baker
Keyword(s):  
Female Body ◽  
The Body ◽  
The Novel ◽  
Religious Paintings ◽  
Italian Art

Displays of sanctified eroticism in The Minister's Wooing reveal Harriet Beecher Stowe's conviction that the body is inherently holy. The author's experience of religious paintings and her observation of French women in Europe deepened her belief that the female body is an instrument of spirituality, as can be traced in the novel.

scholarly journals Internalizing a Discourse: Reading Shauna Singh Baldwin’s What the Body Remembers

2020 ◽  
pp. 48-56
Author(s):  
Brahmjot Kaur
Keyword(s):  
The Body ◽  
The Novel

Shauna Singh Baldwin’s novel What the Body Remembers is mostly remembered as a Partition novel. No doubt, one of the best Partition novels, the novel is also successful in exemplifying how grand-narratives bring us into adherence and train our minds to pass on the same to our coming generations. Baldwin’s characters are prisoners to these grand-narratives but they hardly realize that, and thereby make no effort to shirk away from these beliefs. This paper endeavors to study these characters in the light of this socializing process, and the transformation that it brings.

scholarly journals Oppression and Female Body: A Feminist Critique of the Novel 'Half the Sky'

2021 ◽  
Vol VI (I) ◽  
pp. 79-85
Author(s):  
Ayesha Khaliq ◽  
Mamona Yasmin Khan ◽  
Rabia Hayat
Keyword(s):  
Female Body ◽  
Sampling Technique ◽  
The Body ◽  
Feminist Critique ◽  
The Novel ◽  
Theoretical Frameworks ◽  
Second Sex ◽  
Interpretive Paradigm ◽  
A Site ◽  
Body Theory

The female body is more than often used as a site to perpetuate violence and oppress women in patriarchal societies. The current study aims to explore how patriarchal oppression targets the female body and how it enforces women to become subalterns having no voice in the selected fictional work, Half the Sky by Kristoff and WuDunn. For this purpose, Simone De Beauvoir's The Second Sex (1949) and Bryan Turner's The Body theory (1984) are used as theoretical frameworks to explore the selected novel. The research is descriptive qualitative, and placed within the interpretive paradigm. The data for the present study is in the form of textual paragraphs, which is taken from the selected novel and is collected through the purposive sampling technique. The study argues on women's oppression and violence. The findings of the study revealed that the dominancy of male counterpart in every field of life is the basic reason for women oppression which leads to the women being subalterns.

scholarly journals Ciało, trup, śmierć w utworze Götz i Meyer Davida Albahariego

2019 ◽  
Vol 168 ◽  
pp. 553-564
Author(s):  
Sabina Giergiel
Keyword(s):  
World War Ii ◽  
The Body ◽  
The Novel ◽  
World War ◽  
City Center ◽  
Independent State ◽  
The City

Body, corpse and death in David Albahari’s Gotz and MeyerThe article investigates the broadly understood record of Jewish death that emerges from the text of the Serbian prose writer David Albahari. Emphasizing the dominance of economy in the Nazi system, the author indicates those procedures described in Albahari’s book which justify such an assessment e.g. human reification, the body as debris, technical syntax used by German officials. Additionally, these considerations on death representation are supplemented with an endeavor to establish the Belgrade dwellers’ attitude towards the fortunes of the Jews. According to the author, the novel explicitly marks the spatial opposition enclosure vs. opening, the camp vs. the city center that is reinforced by the river, which during World War II divided the capital into Zemun belonging to the Independent State of Croatia, also the place where the camp was situated and Belgrade’s Serbian center. This demarcation intensifies the victims’ feelings of separation and loneliness, at the same time enabling the capital’s dwellers to occupy a comfortable position of bystanders.  Telo, mrtvac, smrt u romanu Gec i Majer Davida AlbaharijaRad se bavi vidovima smrti u romanu Gec i Majer Davida Albaharija. Pokazuje mehanizme koje potvrđuju opštepoznatu činjenicu da je u nacističkom sistemu dominirala ekonomija. U te mehanizme se ubrajaju, između ostalih: reifikacija čoveka, tretiranje tela kao otpada i tehnička leksika koju upotrebljavaju nemački funkcioneri. Analiza uključuje i pokušaj odgovora na pitanje kakav je bio odnos stanovnika Beograda prema sudbini Jevreja. Istraživanje pokazuje prostornu opoziciju zatvoren i otvoren prostor, logor i centar grada. Nju naglašava reka koja je za vreme Drugog svetskog rata delila srpsku prestonicu na Zemun, gde je bio smešten logor, a koji je pripadao NDH, i srpski centar Beograda. Ova granica je vezana za osećaj separacije i usamljenost žrtava, s jedne starne, i udobnost i bajstander-efekat stanovnika prestonice, s druge strane

scholarly journals Respiratory Care in Corona

2021 ◽  
Vol 58 (2) ◽  
pp. 613-620
Author(s):  
Mustafa Amdani, Dr. Swaroopa Chakole
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Human Life ◽  
The Body ◽  
Respiratory Care ◽  
The Novel ◽  
Specific Therapy ◽  
History Of ◽  
Novel Coronavirus ◽  
Almost All ◽  
The Impact

BACKGROUND The expanse of the coronavirus disease 2019 or COVID-19 is huge. The impact is multispectral and affected almost all aspects of human life. SUMMARY Respiratory impact of the COVID-19 is the most felt and widely reported impact. As the novel coronavirus maintained its history of affecting lungs as seen previously in severe acute respiratory syndrome (SARS) outbreak. Ventilators and oxygen support system are required mostly in comorbid patients particularly amongpatientsbearing illnesses like asthma, bronchial impairment and so on. CONCLUSION More study needs to be done in order to assess the impact on the respiratory functioning of the body. Respiratory care must be including proper instruments so that more efficient result can be obtained. Research is needed to promote the invention of specific therapy for targeted action for respiratory functioning improvement.

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