scholarly journals Vitamin B and Zinc Supplements and Capsaicin Oral Rinse Treatment Options for Burning Mouth Syndrome

Medicina ◽  
2021 ◽  
Vol 57 (4) ◽  
pp. 391
Author(s):  
Viktors Jankovskis ◽  
Guntars Selga
Keyword(s):  
Treatment Options ◽  
Salivary Flow ◽  
Burning Mouth Syndrome ◽  
Vitamin B ◽  
Zinc Supplement ◽  
Before And After ◽  
Burning Mouth ◽  
Zinc Supplements ◽  
Topical Capsaicin ◽  
Supplement Therapy

Background and Objectives: Burning mouth syndrome (BMS) is an enigmatic, idiopathic, chronic, often painful clinical entity, where patients experience oral burning without clear clinical changes on the oral mucosa. There are yet to be well established standardized and validated definitions, diagnostic criteria or classifications for burning mouth syndrome. The aim of this study is to determine whether vitamin B complex and zinc supplements or 0.02% topical capsaicin rinse, can help alleviate BMS pain/burning levels. The objectives: (1) Gather data before and after treatment with vitamin B complex and zinc supplements (2) After the vitamin B complex and zinc protocol gather data before and after treatment with 0.02% topical capsaicin rinse (3) Data analysis and assessment for both treatment methods. Materials and Methods: 89 patients took part in the vitamin B and zinc supplement treatment regimen, out of those 20 patients took part in the capsaicin rinse treatment regimen. Before and after each treatment pain/burning levels were determined using the Visual analogue scale, salivary flow was also determined. Results: Both treatment methods showed statistically significant data in reducing pain/burning levels. There were no statistically significant changes in the salivary flow after any treatment. Conclusion: vitamin B and zinc supplement therapy and topical capsaicin rinse therapy can be an effective way to decrease pain/burning sensation levels in patients with BMS. More research should be conducted to determine the benefit of either vitamin B and zinc supplement therapy or topical capsaicin rinse therapy, so that BMS patients have treatment options, that have as few side-effects as possible.

scholarly journals The role of xerostomia in burning mouth syndrome: a case-control study

2014 ◽  
Vol 72 (2) ◽  
pp. 91-98 ◽  
Author(s):  
Luciana Alvarenga da Silva ◽  
José Tadeu Tesseroli de Siqueira ◽  
Manoel Jacobsen Teixeira ◽  
Silvia Regina Dowgan Tesseroli de Siqueira
Keyword(s):  
International Association ◽  
Salivary Flow ◽  
Burning Mouth Syndrome ◽  
Pain Clinic ◽  
Topical Medication ◽  
Before And After ◽  
Burning Mouth ◽  
Xerostomia Questionnaire ◽  
Control Study

Objective : To assess the efficacy of anti-xerostomic topical medication (urea 10%) in patients with burning mouth syndrome (BMS). Method : Thirty-eight subjects diagnosed with BMS according to the International Association for the Study of Pain guidelines were randomized to either placebo (5% sodium carboxymethylcellulose, 0.15% methyl paraben, and 10% glycerol in distilled water qsp 100 g) or treatment (urea 10%) to be applied to the oral cavity 3-4 times per day for 3 months. The patients were evaluated before and after treatment with the following instruments: the EDOF-HC protocol (Orofacial Pain Clinic – Hospital das Clínicas), a xerostomia questionnaire, and quantitative sensory testing. Results : There were no differences in salivary flow or gustative, olfactory, or sensory thresholds (P>0.05). Fifteen (60%) patients reported improvement with the treatments (P=0.336). Conclusion : In conclusion, there were no differences between groups, and both exhibited an association between reported improvement and salivation.

scholarly journals Salivary Biomarkers and Their Correlation with Pain and Stress in Patients with Burning Mouth Syndrome

2020 ◽  
Vol 9 (4) ◽  
pp. 929
Author(s):  
Pia Lopez-Jornet ◽  
Candela Castillo Felipe ◽  
Luis Pardo-Marin ◽  
Jose J. Ceron ◽  
Eduardo Pons-Fuster ◽  
...  
Keyword(s):  
Immunoglobulin A ◽  
Salivary Flow ◽  
Health Impact ◽  
Burning Mouth Syndrome ◽  
Salivary Biomarkers ◽  
Inflammatory Protein ◽  
Whole Saliva ◽  
Burning Mouth ◽  
Positive Correlations

Objective: To evaluate a panel of salivary analytes involving biomarkers of inflammation, stress, immune system and antioxidant status in patients with burning mouth syndrome (BMS) and to study their relationship with clinical variables. Materials and Methods: A total of 51 patients with BMS and 31 controls were consecutively enrolled in the study, with the recording of oral habits, the severity of pain using a visual analogue scale (VAS), the Hospital Anxiety and Depression (HAD) score and the Oral Health Impact Profile-14 (OHIP14) score. Resting whole saliva was collected with the drainage technique, followed by the measurement of 11 biomarkers. Results: The salivary flow was higher in patients with BMS. Among all the biomarkers studied, significantly higher levels of alpha-amylase, immunoglobulin A (IgA), and macrophage inflammatory protein-4 (MIP4) and lower levels of uric acid and ferric reducing activity of plasma (FRAP) were observed in the saliva of patients with BMS as compared to the controls (p < 0.05 in all cases). Positive correlations were found between pain, oral quality of life and anxiety scores and salivary biomarkers. Conclusions: BMS is associated with changes in salivary biomarkers of inflammation, oxidative stress and stress, being related to the degree of pain and anxiety.

scholarly journals Support Group as a Management Modality for Burning Mouth Syndrome: A Randomized Prospective Study

2021 ◽  
Vol 11 (16) ◽  
pp. 7207
Author(s):  
Talia Becker ◽  
Yafit Hamzani ◽  
Gavriel Chaushu ◽  
Shlomit Perry ◽  
Bahaa Haj Yahya
Keyword(s):  
Support Group ◽  
Clinical Symptoms ◽  
Medical Center ◽  
Life Quality ◽  
Burning Mouth Syndrome ◽  
Rank Test ◽  
Control Group ◽  
Before And After ◽  
Burning Mouth ◽  
Group Sessions

We aimed to investigate the effectiveness of a support group in the management of burning mouth syndrome (BMS). The cohort included 22 adult patients with BMS who attended the oral and maxillofacial department of a tertiary medical center in 2014–2019 and agreed to participate in the study. Eleven patients were assigned to a support group and took part in 90 min sessions held once weekly for 4 weeks (a total of 4 sessions), and the remainder continued their previous individual BMS management routine (control group). All patients completed a life-quality questionnaire before and 3 months after the group sessions. Scores for each group were compared between the two time points with a Wilcoxon signed-rank test. There was a significant decrease in scores for malaise (p = 0.041), total pain (p = 0.046), and difficulty enjoying food (p = 0.026) before and after the group sessions in the study group. No significant changes were found in the control group in any of the parameters examined. A group support can alleviate pain and other clinical symptoms of BMS. Further longer-term prospective studies are needed to corroborate our findings.

Proinflammatory cytokine levels in saliva in patients with burning mouth syndrome before and after treatment with low-level laser therapy

2012 ◽  
Vol 28 (1) ◽  
pp. 297-301 ◽  
Author(s):  
Sonja Pezelj-Ribarić ◽  
Lumnije Kqiku ◽  
Gordana Brumini ◽  
Miranda Muhvić Urek ◽  
Robert Antonić ◽  
...  
Keyword(s):  
Laser Therapy ◽  
Proinflammatory Cytokine ◽  
Burning Mouth Syndrome ◽  
Low Level Laser Therapy ◽  
Low Level ◽  
Low Level Laser ◽  
Level Laser ◽  
Cytokine Levels ◽  
Before And After ◽  
Burning Mouth

scholarly journals Burning mouth syndrome

Cephalalgia ◽  
2017 ◽  
Vol 37 (7) ◽  
pp. 627-647 ◽  
Author(s):  
Satu K Jääskeläinen ◽  
Alain Woda
Keyword(s):  
Treatment Options ◽  
Clinical Signs ◽  
Burning Mouth Syndrome ◽  
Diagnostic Methods ◽  
Future Research ◽  
Trigeminal System ◽  
Nerve Blocks ◽  
Central Type ◽  
Pathophysiological Mechanisms ◽  
Burning Mouth

Objective To review the clinical entity of primary burning mouth syndrome (BMS), its pathophysiological mechanisms, accurate new diagnostic methods and evidence-based treatment options, and to describe novel lines for future research regarding aetiology, pathophysiology, and new therapeutic strategies. Description Primary BMS is a chronic neuropathic intraoral pain condition that despite typical symptoms lacks clear clinical signs of neuropathic involvement. With advanced diagnostic methods, such as quantitative sensory testing of small somatosensory and taste afferents, neurophysiological recordings of the trigeminal system, and peripheral nerve blocks, most BMS patients can be classified into the peripheral or central type of neuropathic pain. These two types differ regarding pathophysiological mechanisms, efficacy of available treatments, and psychiatric comorbidity. The two types may overlap in individual patients. BMS is most frequent in postmenopausal women, with general population prevalence of around 1%. Treatment of BMS is difficult; best evidence exists for efficacy of topical and systemic clonazepam. Hormonal substitution, dopaminergic medications, and therapeutic non-invasive neuromodulation may provide efficient mechanism-based treatments for BMS in the future. Conclusion We present a novel comprehensive hypothesis of primary BMS, gathering the hormonal, neuropathic, and genetic factors presumably required in the genesis of the condition. This will aid in future research on pathophysiology and risk factors of BMS, and boost treatment trials taking into account individual mechanism profiles and subgroup-clusters.

scholarly journals Clinical characteristics and therapeutic response in patients with Burning Mouth Syndrome: accompanying 2 years

2017 ◽  
Vol 46 (1) ◽  
pp. 45-50
Author(s):  
Vanessa Juliana Gomes CARVALHO ◽  
Camila de Barros GALLO ◽  
Norberto Nobuo SUGAYA ◽  
Carina DOMANESCHI
Keyword(s):  
Effective Treatment ◽  
Therapeutic Response ◽  
International Headache Society ◽  
Clinical Signs ◽  
Burning Mouth Syndrome ◽  
Low Level Laser Therapy ◽  
Modifying Factors ◽  
Level Laser ◽  
Burning Mouth ◽  
Topical Capsaicin

Abstract Introduction Burning Mouth Syndrome (BMS) is a condition characterized by burning symptom of the oral mucosa in the absence of clinical signs. Its etiology is still unknown and, and to date there is no effective treatment. Purpose The aim of this study was to evaluate patients with BMS profile and the therapies results in a retrospective study. Material and method Clinical and therapeutic data were collected from records of patients with BMS diagnosed between January 2013 to April 2015 at the Clinic of Stomatology Clinic, Faculdade de Odontologia of Universidade de São Paulo, according to the criteria established by the International Headache Society in 2013. The therapies used for BMS control were also evaluated. Result Twelve patients were diagnosed with BMS at this period. All of them were women with a mean age of 61.18 years and the apex of the tongue was the most common affected site and the duration of the burning sensation ranged from 6 months to 25 years. Many therapies were prescribed for BMS control, such as topical capsaicin, topical clonazepan, low level laser therapy and homeopathy. Among the established therapies, capsaicin has immediate effect in reducing symptoms. Conclusion The present study showed that the challenges towards an effective treatment for BMS are varied and are mainly related to the lack knowing of the pathogenesis of this disease. The demographic profile of patients studied here was similar to that described in the available literature, however, the variables represented by secondary symptoms (medical history, anxiety and depression levels) may be modifying factors of therapeutic response and the pathogenesis of the disease itself.

scholarly journals Burning mouth syndrome – a burning enigma

2021 ◽  
Vol 57 (1) ◽  
pp. 4-16
Author(s):  
Ana Andabak Rogulj ◽  
Ivana Škrinjar ◽  
Danica Vidović Juras ◽  
Vanja Vučićević Boras † ◽  
Božana Lončar Brzak
Keyword(s):  
Current Knowledge ◽  
Salivary Flow ◽  
Burning Mouth Syndrome ◽  
Burning Sensation ◽  
Unknown Etiology ◽  
Laboratory Findings ◽  
Chronic Pain Condition ◽  
Appropriate Treatment ◽  
Oral Mucosal Lesions ◽  
Burning Mouth

Burning Mouth Syndrome (BMS) is a chronic pain condition characterized by an intraoral burning sensation and an absence of oral mucosal lesions and disturbances in laboratory findings. Burning symptoms usually affect the anterior two-thirds of the tongue, its lateral borders, hard palate and labial mucosa, but other oral cavity sites may also be affected. Taste alterations and a decrease in the salivary flow rate frequently accompany the burning symptoms. This condition mostly affects peri- and postmenopausal women. To date, the etiology of BMS remains unclear. This unknown etiology means that no appropriate treatment is currently available. A large number of the treatments and medications have been tried for BMS, but treatment management remains unsatisfactory in some patients. The purpose of this article is to present current knowledge on the treatment of BMS.

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