scholarly journals Progress on Self-Powered Wearable and Implantable Systems Driven by Nanogenerators

Micromachines ◽  
2021 ◽  
Vol 12 (6) ◽  
pp. 666
Author(s):  
Lanxin Yang ◽  
Zhihao Ma ◽  
Yun Tian ◽  
Bo Meng ◽  
Zhengchun Peng
Keyword(s):  
Mechanical Energy ◽  
Rapid Development ◽  
Electronic Devices ◽  
High Sensitivity ◽  
Self Powered ◽  
Triboelectric Nanogenerators ◽  
The Internet Of Things ◽  
Piezoelectric Nanogenerators

With the rapid development of the internet of things (IoT), sustainable self-powered wireless sensory systems and diverse wearable and implantable electronic devices have surged recently. Under such an opportunity, nanogenerators, which can convert continuous mechanical energy into usable electricity, have been regarded as one of the critical technologies for self-powered systems, based on the high sensitivity, flexibility, and biocompatibility of piezoelectric nanogenerators (PENGs) and triboelectric nanogenerators (TENGs). In this review, we have thoroughly analyzed the materials and structures of wearable and implantable PENGs and TENGs, aiming to make clear how to tailor a self-power system into specific applications. The advantages in TENG and PENG are taken to effectuate wearable and implantable human-oriented applications, such as self-charging power packages, physiological and kinematic monitoring, in vivo and in vitro healing, and electrical stimulation. This review comprehensively elucidates the recent advances and future outlook regarding the human body’s self-powered systems.

scholarly journals All 3D Printed Stretchable Piezoelectric Nanogenerator for Self-Powered Sensor Application

Sensors ◽  
2020 ◽  
Vol 20 (23) ◽  
pp. 6748
Author(s):  
Xinran Zhou ◽  
Kaushik Parida ◽  
Oded Halevi ◽  
Shlomo Magdassi ◽  
Pooi See Lee
Keyword(s):  
Piezoelectric Materials ◽  
Mechanical Energy ◽  
Rapid Development ◽  
The Internet ◽  
Electronic Systems ◽  
3D Printed ◽  
Wearable Electronic ◽  
Self Powered ◽  
The Internet Of Things ◽  
Piezoelectric Nanogenerators

With the rapid development of wearable electronic systems, the need for stretchable nanogenerators becomes increasingly important for autonomous applications such as the Internet-of-Things. Piezoelectric nanogenerators are of interest for their ability to harvest mechanical energy from the environment with its inherent polarization arising from crystal structures or molecular arrangements of the piezoelectric materials. In this work, 3D printing is used to fabricate a stretchable piezoelectric nanogenerator which can serve as a self-powered sensor based on synthesized oxide–polymer composites.

Measurement of the Optical Properties of Muscle Tissue In Vivo

2000 ◽  
Author(s):  
P. L. Kopsombut ◽  
D. Willis ◽  
A. E. Schen ◽  
L. X. Xu ◽  
X. Xu
Keyword(s):  
Optical Properties ◽  
Transport Theory ◽  
Rapid Development ◽  
Ccd Camera ◽  
High Sensitivity ◽  
Biological Tissues ◽  
In Vivo Measurement ◽  
Living Tissues

Abstract Along with rapid development of diagnostic and therapeutic applications of lasers in medicine, optical properties of various biological tissues have been extensively studied [1]. Most of the studies were performed in vitro owing to the complexity involved in in vivo measurement. To date, it is well understood that living tissue is an absorbing and scattering heterogeneous medium because of its complex structures including blood network. The transport theory cannot be readily used due to the heterogeneity and the absence of the optical properties of living tissues [2]. In this research, we have developed a procedure for measuring the total attenuation coefficient (μ1) of the exteriorized rat 2-D spinotrapezius muscle in the wavelength ranged from 480–560 nm using the collimated light from a Nitrogen-pumped dye laser and a high-sensitivity CCD camera.

scholarly journals Triboelectric Energy Harvesting Response of Different Polymer-Based Materials

Materials ◽  
2020 ◽  
Vol 13 (21) ◽  
pp. 4980
Author(s):  
Tiago Rodrigues-Marinho ◽  
Nelson Castro ◽  
Vitor Correia ◽  
Pedro Costa ◽  
Senentxu Lanceros-Méndez
Keyword(s):  
Energy Harvesting ◽  
Output Power ◽  
Polyvinylidene Fluoride ◽  
Light Emission ◽  
Mechanical Energy ◽  
Harvesting Systems ◽  
Self Powered ◽  
Triboelectric Nanogenerators ◽  
Vertical Contact ◽  
The Internet Of Things

Energy harvesting systems for low-power devices are increasingly being a requirement within the context of the Internet of Things and, in particular, for self-powered sensors in remote or inaccessible locations. Triboelectric nanogenerators are a suitable approach for harvesting environmental mechanical energy otherwise wasted in nature. This work reports on the evaluation of the output power of different polymer and polymer composites, by using the triboelectric contact-separation systems (10 N of force followed by 5 cm of separation per cycle). Different materials were used as positive (Mica, polyamide (PA66) and styrene/ethylene-butadiene/styrene (SEBS)) and negative (polyvinylidene fluoride (PVDF), polyurethane (PU), polypropylene (PP) and Kapton) charge materials. The obtained output power ranges from 0.2 to 5.9 mW, depending on the pair of materials, for an active area of 46.4 cm2. The highest response was obtained for Mica with PVDF composites with 30 wt.% of barium titanate (BT) and PA66 with PU pairs. A simple application has been developed based on vertical contact-separation mode, able to power up light emission diodes (LEDs) with around 30 cycles to charge a capacitor. Further, the capacitor can be charged in one triboelectric cycle if an area of 0.14 m2 is used.

scholarly journals Recent Progress in Self-Powered Sensors Based on Triboelectric Nanogenerators

Sensors ◽  
2021 ◽  
Vol 21 (21) ◽  
pp. 7129
Author(s):  
Junpeng Wu ◽  
Yang Zheng ◽  
Xiaoyi Li
Keyword(s):  
Mechanical Energy ◽  
Rapid Development ◽  
Electrical Energy ◽  
Displacement Current ◽  
Triboelectric Nanogenerator ◽  
Energy Harvesters ◽  
The Future ◽  
Quantitative Analysis Method ◽  
Self Powered ◽  
Triboelectric Nanogenerators

The emergence of the Internet of Things (IoT) has subverted people’s lives, causing the rapid development of sensor technologies. However, traditional sensor energy sources, like batteries, suffer from the pollution problem and the limited lifetime for powering widely implemented electronics or sensors. Therefore, it is essential to obtain self-powered sensors integrated with renewable energy harvesters. The triboelectric nanogenerator (TENG), which can convert the surrounding mechanical energy into electrical energy based on the surface triboelectrification effect, was born of this background. This paper systematically introduces the working principle of the TENG-based self-powered sensor, including the triboelectrification effect, Maxwell’s displacement current, and quantitative analysis method. Meanwhile, this paper also reviews the recent application of TENG in different fields and summarizes the future development and current problems of TENG. We believe that there will be a rise of TENG-based self-powered sensors in the future.

scholarly journals A High Sensitivity Self-Powered Wind Speed Sensor Based on Triboelectric Nanogenerators (TENGs)

Sensors ◽  
2021 ◽  
Vol 21 (9) ◽  
pp. 2951
Author(s):  
Yangming Liu ◽  
Jialin Liu ◽  
Lufeng Che
Keyword(s):  
Wind Speed ◽  
High Sensitivity ◽  
Electrical Signal ◽  
Geometrical Parameters ◽  
Sensor Systems ◽  
Speed Sensor ◽  
Speed Range ◽  
Self Powered ◽  
Triboelectric Nanogenerators ◽  
Application Prospects

Triboelectric nanogenerators (TENGs) have excellent properties in harvesting tiny environmental energy and self-powered sensor systems with extensive application prospects. Here, we report a high sensitivity self-powered wind speed sensor based on triboelectric nanogenerators (TENGs). The sensor consists of the upper and lower two identical TENGs. The output electrical signal of each TENG can be used to detect wind speed so that we can make sure that the measurement is correct by two TENGs. We study the influence of different geometrical parameters on its sensitivity and then select a set of parameters with a relatively good output electrical signal. The sensitivity of the wind speed sensor with this set of parameters is 1.79 μA/(m/s) under a wind speed range from 15 m/s to 25 m/s. The sensor can light 50 LEDs at the wind speed of 15 m/s. This work not only advances the development of self-powered wind sensor systems but also promotes the application of wind speed sensing.

scholarly journals Characterization of the SARS-CoV-2 coronavirus X4-like accessory protein

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Olanrewaju Ayodeji Durojaye ◽  
Nkwachukwu Oziamara Okoro ◽  
Arome Solomon Odiba
Keyword(s):  
Rapid Development ◽  
Protein A ◽  
The Novel ◽  
Quality Model ◽  
A Value ◽  
Model Protein ◽  
Novel Coronavirus ◽  
Global Threat

Abstract Background The novel coronavirus SARS-CoV-2 is currently a global threat to health and economies. Therapeutics and vaccines are in rapid development; however, none of these therapeutics are considered as absolute cure, and the potential to mutate makes it necessary to find therapeutics that target a highly conserved regions of the viral structure. Results In this study, we characterized an essential but poorly understood coronavirus accessory X4 protein, a core and stable component of the SARS-CoV family. Sequence analysis shows a conserved ~ 90% identity between the SARS-CoV-2 and previously characterized X4 protein in the database. QMEAN Z score of the model protein shows a value of around 0.5, within the acceptable range 0–1. A MolProbity score of 2.96 was obtained for the model protein and indicates a good quality model. The model has Ramachandran values of φ = − 57o and ψ = − 47o for α-helices and values of φ = − 130o and ψ = + 140o for twisted sheets. Conclusions The protein data obtained from this study provides robust information for further in vitro and in vivo experiment, targeted at devising therapeutics against the virus. Phylogenetic analysis further supports previous evidence that the SARS-CoV-2 is positioned with the SL-CoVZC45, BtRs-BetaCoV/YN2018B and the RS4231 Bat SARS-like corona viruses.

scholarly journals Advanced Functional Materials Based on Nanocellulose for Pharmaceutical/Medical Applications

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1125
Author(s):  
Raluca Nicu ◽  
Florin Ciolacu ◽  
Diana E. Ciolacu
Keyword(s):  
Rapid Development ◽  
Cellulose Nanofibrils ◽  
Functional Materials ◽  
Medical Applications ◽  
Bacterial Nanocellulose ◽  
Green Materials ◽  
Wide Range ◽  
In Vivo Cytotoxicity

Nanocelluloses (NCs), with their remarkable characteristics, have proven to be one of the most promising “green” materials of our times and have received special attention from researchers in nanomaterials. A diversity of new functional materials with a wide range of biomedical applications has been designed based on the most desirable properties of NCs, such as biocompatibility, biodegradability, and their special physicochemical properties. In this context and under the pressure of rapid development of this field, it is imperative to synthesize the successes and the new requirements in a comprehensive review. The first part of this work provides a brief review of the characteristics of the NCs (cellulose nanocrystals—CNC, cellulose nanofibrils—CNF, and bacterial nanocellulose—BNC), as well as of the main functional materials based on NCs (hydrogels, nanogels, and nanocomposites). The second part presents an extensive review of research over the past five years on promising pharmaceutical and medical applications of nanocellulose-based materials, which have been discussed in three important areas: drug-delivery systems, materials for wound-healing applications, as well as tissue engineering. Finally, an in-depth assessment of the in vitro and in vivo cytotoxicity of NCs-based materials, as well as the challenges related to their biodegradability, is performed.

scholarly journals Textile-Based Triboelectric Nanogenerators for Wearable Self-Powered Microsystems

Micromachines ◽  
2021 ◽  
Vol 12 (2) ◽  
pp. 158
Author(s):  
Peng Huang ◽  
Dan-Liang Wen ◽  
Yu Qiu ◽  
Ming-Hong Yang ◽  
Cheng Tu ◽  
...  
Keyword(s):  
Rapid Development ◽  
Electronic Devices ◽  
Quantitative Relationship ◽  
Triboelectric Nanogenerator ◽  
Output Performance ◽  
Integrated Microsystems ◽  
Wearable Electronic ◽  
Self Powered ◽  
Representative Work ◽  
Wearable Electronic Devices

In recent years, wearable electronic devices have made considerable progress thanks to the rapid development of the Internet of Things. However, even though some of them have preliminarily achieved miniaturization and wearability, the drawbacks of frequent charging and physical rigidity of conventional lithium batteries, which are currently the most commonly used power source of wearable electronic devices, have become technical bottlenecks that need to be broken through urgently. In order to address the above challenges, the technology based on triboelectric effect, i.e., triboelectric nanogenerator (TENG), is proposed to harvest energy from ambient environment and considered as one of the most promising methods to integrate with functional electronic devices to form wearable self-powered microsystems. Benefited from excellent flexibility, high output performance, no materials limitation, and a quantitative relationship between environmental stimulation inputs and corresponding electrical outputs, TENGs present great advantages in wearable energy harvesting, active sensing, and driving actuators. Furthermore, combined with the superiorities of TENGs and fabrics, textile-based TENGs (T-TENGs) possess remarkable breathability and better non-planar surface adaptability, which are more conducive to the integrated wearable electronic devices and attract considerable attention. Herein, for the purpose of advancing the development of wearable electronic devices, this article reviews the recent development in materials for the construction of T-TENGs and methods for the enhancement of electrical output performance. More importantly, this article mainly focuses on the recent representative work, in which T-TENGs-based active sensors, T-TENGs-based self-driven actuators, and T-TENGs-based self-powered microsystems are studied. In addition, this paper summarizes the critical challenges and future opportunities of T-TENG-based wearable integrated microsystems.

scholarly journals Biological nanoscale fluorescent probes: From structure and performance to bioimaging

2020 ◽  
Vol 39 (1) ◽  
pp. 209-221
Author(s):  
Jiafeng Wan ◽  
Xiaoyuan Zhang ◽  
Kai Zhang ◽  
Zhiqiang Su
Keyword(s):  
Fluorescent Probes ◽  
Organic Dyes ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
High Sensitivity ◽  
Biological Imaging ◽  
Fluorescent Materials ◽  
And Performance

Abstract In recent years, nanomaterials have attracted lots of attention from researchers due to their unique properties. Nanometer fluorescent materials, such as organic dyes, semiconductor quantum dots (QDs), metal nano-clusters (MNCs), carbon dots (CDs), etc., are widely used in biological imaging due to their high sensitivity, short response time, and excellent accuracy. Nanometer fluorescent probes can not only perform in vitro imaging of organisms but also achieve in vivo imaging. This provides medical staff with great convenience in cancer treatment. Combined with contemporary medical methods, faster and more effective treatment of cancer is achievable. This article explains the response mechanism of three-nanometer fluorescent probes: the principle of induced electron transfer (PET), the principle of fluorescence resonance energy transfer (FRET), and the principle of intramolecular charge transfer (ICT), showing the semiconductor QDs, precious MNCs, and CDs. The excellent performance of the three kinds of nano fluorescent materials in biological imaging is highlighted, and the application of these three kinds of nano fluorescent probes in targeted biological imaging is also introduced. Nanometer fluorescent materials will show their significance in the field of biomedicine.

scholarly journals Bacteriophage-derived CHAP domain protein, P128, kills Staphylococcus cells by cleaving interpeptide cross-bridge of peptidoglycan

Microbiology ◽  
2014 ◽  
Vol 160 (10) ◽  
pp. 2157-2169 ◽  
Author(s):  
Sudarson Sundarrajan ◽  
Junjappa Raghupatil ◽  
Aradhana Vipra ◽  
Nagalakshmi Narasimhaswamy ◽  
Sanjeev Saravanan ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Mechanism Of Action ◽  
Catalytic Domain ◽  
Antibiotic Sensitivity ◽  
High Sensitivity ◽  
Common Mechanism ◽  
Cross Bridge ◽  
Sensitivity Pattern

P128 is an anti-staphylococcal protein consisting of the Staphylococcus aureus phage-K-derived tail-associated muralytic enzyme (TAME) catalytic domain (Lys16) fused with the cell-wall-binding SH3b domain of lysostaphin. In order to understand the mechanism of action and emergence of resistance to P128, we isolated mutants of Staphylococcus spp., including meticillin-resistant Staphylococcus aureus (MRSA), resistant to P128. In addition to P128, the mutants also showed resistance to Lys16, the catalytic domain of P128. The mutants showed loss of fitness as shown by reduced rate of growth in vitro. One of the mutants tested was found to show reduced virulence in animal models of S. aureus septicaemia suggesting loss of fitness in vivo as well. Analysis of the antibiotic sensitivity pattern showed that the mutants derived from MRSA strains had become sensitive to meticillin and other β-lactams. Interestingly, the mutant cells were resistant to the lytic action of phage K, although the phage was able to adsorb to these cells. Sequencing of the femA gene of three P128-resistant mutants showed either a truncation or deletion in femA, suggesting that improper cross-bridge formation in S. aureus could be causing resistance to P128. Using glutathione S-transferase (GST) fusion peptides as substrates it was found that both P128 and Lys16 were capable of cleaving a pentaglycine sequence, suggesting that P128 might be killing S. aureus by cleaving the pentaglycine cross-bridge of peptidoglycan. Moreover, peptides corresponding to the reported cross-bridge of Staphylococcus haemolyticus (GGSGG, AGSGG), which were not cleaved by lysostaphin, were cleaved efficiently by P128. This was also reflected in high sensitivity of S. haemolyticus to P128. This showed that in spite of sharing a common mechanism of action with lysostaphin, P128 has unique properties, which allow it to act on certain lysostaphin-resistant Staphylococcus strains.

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