scholarly journals Early Evaluation of Copper Radioisotope Production at ISOLPHARM

Molecules ◽  
2018 ◽  
Vol 23 (10) ◽  
pp. 2437 ◽  
Author(s):  
Francesca Borgna ◽  
Michele Ballan ◽  
Chiara Favaretto ◽  
Marco Verona ◽  
Marianna Tosato ◽  
...  
Keyword(s):  
Nuclear Physics ◽  
Specific Activity ◽  
Isotope Separation ◽  
Pure Copper ◽  
Mass Separation ◽  
Monte Carlo Code ◽  
Early Evaluation ◽  
On Line ◽  
Isol Facility

The ISOLPHARM (ISOL technique for radioPHARMaceuticals) project is dedicated to the development of high purity radiopharmaceuticals exploiting the radionuclides producible with the future Selective Production of Exotic Species (SPES) Isotope Separation On-Line (ISOL) facility at the Legnaro National Laboratories of the Italian National Institute for Nuclear Physics (INFN-LNL). At SPES, a proton beam (up to 70 MeV) extracted from a cyclotron will directly impinge a primary target, where the produced isotopes are released thanks to the high working temperatures (2000 °C), ionized, extracted and accelerated, and finally, after mass separation, only the desired nuclei are collected on a secondary target, free from isotopic contaminants that decrease their specific activity. A case study for such project is the evaluation of the feasibility of the ISOL production of 64Cu and 67Cu using a zirconium germanide target, currently under development. The producible activities of 64Cu and 67Cu were calculated by means of the Monte Carlo code FLUKA, whereas dedicated off-line tests with stable beams were performed at LNL to evaluate the capability to ionize and recover isotopically pure copper.

scholarly journals The ISOLPHARM project: A New ISOL production method of high specific activity beta-emitting radionuclides as radiopharmaceutical precursors

2018 ◽  
Vol 48 ◽  
pp. 1860103 ◽  
Author(s):  
A. Andrighetto ◽  
F. Borgna ◽  
M. Ballan ◽  
S. Corradetti ◽  
E. Vettorato ◽  
...  
Keyword(s):  
Nuclear Reactions ◽  
Specific Activity ◽  
Isotope Separation ◽  
High Specific Activity ◽  
Target Material ◽  
Mass Range ◽  
Production Method ◽  
Radioactive Isotopes ◽  
Innovative Technology ◽  
On Line

The ISOLPHARM project explores the feasibility of exploiting an innovative technology to produce extremely high specific activity beta-emitting radionuclides as radiopharmaceutical precursors. This technique is expected to produce radiopharmaceuticals that are virtually mainly impossible to obtain in standard production facilities, at lower cost and with less environmental impact than traditional techniques. The groundbreaking ISOLPHARM method investigated in this project has been granted an international patent (INFN). As a component of the SPES (Selective Production of Exotic Species) project at the Istituto Nazionale di Fisica Nucleare–Laboratori Nazionali di Legnaro (INFN–LNL), a new facility will produce radioactive ion beams of neutron-rich nuclei with high purity and a mass range of 80–160 amu. The radioactive isotopes will result from nuclear reactions induced by accelerating 40 MeV protons in a cyclotron to collide on a target of UC[Formula: see text]. The uranium in the target material will be [Formula: see text]U, yielding radioactive isotopes that belong to elements with an atomic number between 28 and 57. Isotope separation on line (ISOL) is adopted in the ISOLPHARM project to obtain pure isobaric beams for radiopharmaceutical applications, with no isotopic contaminations in the beam or subsequent trapping substrate. Isobaric contaminations may potentially affect radiochemical and radionuclide purity, but proper methods to separate chemically different elements can be developed.

scholarly journals RIB production and related experiments at EXOTIC

2018 ◽  
Vol 184 ◽  
pp. 01012
Author(s):  
Marco Mazzocco
Keyword(s):  
Nuclear Physics ◽  
Large Scale ◽  
Isotope Separation ◽  
Big Bang ◽  
Weakly Bound ◽  
Production Techniques ◽  
On Line ◽  
Main Production ◽  
Supernova Explosions ◽  
The Big Bang

Radioactive nuclei have a very deep relevance in many astrophysical scenarios, from the Big Bang nucleo-synthesis to supernova explosions. Several Nuclear Physics laboratories around the world have been constructing large-scale facilities for the production of Radioactive Ion Beams (RIBs). The main production techniques, i.e. In-Flight and Isotope Separation On Line, which will be reviewed in this contribution. In particular, we will concentrate on the production of light weakly-bound RIBs at the facility EXOTIC, located at INFN-LNL (Italy) and we will describe the most recent experiments.

scholarly journals Target and PADC Track Detectors for Rare Isotope Studies

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
J. Bermudez ◽  
L. Sajo-Bohus ◽  
L. Tecchio ◽  
J. K. Palfalvi ◽  
D. Palacios
Keyword(s):  
High Power ◽  
Theoretical Calculations ◽  
Ion Beam ◽  
Isotope Separation ◽  
Integral Form ◽  
Monte Carlo Code ◽  
Rare Isotope ◽  
Track Formation ◽  
Passive Detector ◽  
On Line

A higher yield of rare isotope production methods, for example, isotope separation on-line (ISOL), is expected to be developed for the EURISOL facility. In this paper as a part of the ongoing project, high power-target assembly and passive detector inclusion are given. Theoretical calculations of several configurations were done using Monte Carlo code FLUKA aimed to produce 1015 fiss/s on LEU-Cx target. The proposed radioactive ion beam (RIB) production relies on a high-power (4 MW) multibody target; a complete target design is given. Additionally we explore the possibility to employ PADC passive detector as a complementary system for RIB characterization, since these already demonstrated their importance in nuclear interactions phenomenology. In fact, information and recording rare and complex reaction product or short-lived isotope detection is obtained in an integral form through latent track formation. Some technical details on track formation and PADC detector etching conditions complete this study.

On-line Tropical Epidemiology -A Case-Study from The Gambia

1987 ◽  
Vol 26 (02) ◽  
pp. 73-76 ◽  
Author(s):  
Kathryn Rowan ◽  
P. Byass ◽  
R. W. Snow
Keyword(s):  
Data Collection ◽  
Field Trial ◽  
Error Rates ◽  
Database Management System ◽  
Bed Nets ◽  
Completion Rates ◽  
On Line ◽  
Access To Data ◽  
Rapid Processing

SummaryThis paper reports on a computerised approach to the management of an epidemiological field trial, which aimed at determining the effects of insecticide-impregnated bed nets on the incidence of malaria in children. The development of a data system satisfying the requirements of the project and its implementation using a database management system are discussed. The advantages of this method of management in terms of rapid processing of and access to data from the study are described, together with the completion rates and error rates observed in data collection.

RECYCLED WATER RISK PERCEPTION - A COMPARISON OF TWO CASE STUDIES

2007 ◽  
Vol 2 (4) ◽  
Author(s):  
A. Hurlimann
Keyword(s):  
Risk Perception ◽  
Case Studies ◽  
Perceived Risk ◽  
Capital City ◽  
Recycled Water ◽  
Urban Centre ◽  
On Line ◽  
Line Survey ◽  
Water Uses

This paper reports results from a study comparing perceived risk associated with various recycled water uses in two Australian locations, both in the state of Victoria: the capital city Melbourne, and Bendigo a regional urban centre. Both locations are experiencing ‘drought’, but Bendigo is experiencing this in a more acute manner. A case study is used in each location. Both case studies involve future use of recycled water in new commercial buildings. An on-line survey was used to measure attitudes to recycled water of the future occupants of both buildings. The study found perceived risk associated with 11 uses of recycled water increased as the use became increasingly personal. Interestingly, no difference in perceived risk associated with 11 uses of recycled water was found between locations. Prior experience (use) of recycled water was found to be a significant and positive factor in reducing risk perception. Various attitudinal variables were found to be significant influences on perceived risk. Results indicate that reducing perceived risk of recycled water use may increase satisfaction with its use.

scholarly journals DOLARS, a Distributed On-Line Activity Recognition System by Means of Heterogeneous Sensors in Real-Life Deployments—A Case Study in the Smart Lab of The University of Almería

Sensors ◽  
2021 ◽  
Vol 21 (2) ◽  
pp. 405
Author(s):  
Marcos Lupión ◽  
Javier Medina-Quero ◽  
Juan F. Sanjuan ◽  
Pilar M. Ortigosa
Keyword(s):  
Real Time ◽  
Activity Recognition ◽  
Real Life ◽  
Recognition System ◽  
Machine Learning Algorithms ◽  
Sensor Data ◽  
Heterogeneous Sensors ◽  
On Line ◽  
The University

Activity Recognition (AR) is an active research topic focused on detecting human actions and behaviours in smart environments. In this work, we present the on-line activity recognition platform DOLARS (Distributed On-line Activity Recognition System) where data from heterogeneous sensors are evaluated in real time, including binary, wearable and location sensors. Different descriptors and metrics from the heterogeneous sensor data are integrated in a common feature vector whose extraction is developed by a sliding window approach under real-time conditions. DOLARS provides a distributed architecture where: (i) stages for processing data in AR are deployed in distributed nodes, (ii) temporal cache modules compute metrics which aggregate sensor data for computing feature vectors in an efficient way; (iii) publish-subscribe models are integrated both to spread data from sensors and orchestrate the nodes (communication and replication) for computing AR and (iv) machine learning algorithms are used to classify and recognize the activities. A successful case study of daily activities recognition developed in the Smart Lab of The University of Almería (UAL) is presented in this paper. Results present an encouraging performance in recognition of sequences of activities and show the need for distributed architectures to achieve real time recognition.

Case study: collaborative creation of an on‐line degree program

2006 ◽  
Vol 43 (3) ◽  
pp. 197-210 ◽  
Author(s):  
Barbara L. Stewart ◽  
Marcella Norwood ◽  
Shirley Ezell ◽  
Consuelo Waight
Keyword(s):  
Degree Program ◽  
On Line
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