scholarly journals Deep Eutectic Solvent-Based Ultrahigh Pressure Extraction of Baicalin from Scutellaria baicalensis Georgi

Molecules ◽  
2018 ◽  
Vol 23 (12) ◽  
pp. 3233 ◽  
Author(s):  
Hui Wang ◽  
Xiaodi Ma ◽  
Qibin Cheng ◽  
Li Wang ◽  
Liwei Zhang
Keyword(s):  
Extraction Method ◽  
Choline Chloride ◽  
Maximum Yield ◽  
Extraction Yield ◽  
Scutellaria Baicalensis ◽  
Extraction Time ◽  
Ultrahigh Pressure ◽  
Scutellaria Baicalensis Georgi ◽  
Solid Ratio ◽  
Pressure Extraction

Deep eutectic solvents (DESs), promising green solvents, and ultrahigh pressure extraction (UPE) as an effective auxiliary extraction method, have attracted wide attention. In this study, DES was coupled with UPE to efficiently extract baicalin from Scutellaria baicalensis Georgi. First, choline chloride: lactic acid (ChCl-LA, molar ratio 1:1) was selected as the most appropriate DES by comparing the extraction yield of different DESs. Second, the extraction protocol was optimized by response surface methodology (RSM) considering the impacts of ChCl-LA concentration, extraction pressure, extraction time and liquid-solid ratio on the extraction yield. Under the optimal condition (40 vol% water content, extraction pressure of 400 MPa, extraction time of 4 min and a liquid-solid ratio of 110 mL/g), a maximum yield of 116.8 mg/g was achieved, higher than that obtained by the traditional extraction method. The microstructure of the raw and extracted Scutellaria baicalensis Georgi samples according to scanning electron microscope (SEM) images revealed that the dissolution of chemical components was enhanced from the disrupted root tissues after DESs-UPE. DESs coupled with UPE could effectively extract the baicalin from Scutellaria baicalensis Georgi as a rapid and efficient extraction method.

scholarly journals Deep Eutectic Solvent-Based Microwave-Assisted Extraction of Baicalin from Scutellaria baicalensis Georgi

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Hui Wang ◽  
Xiaodi Ma ◽  
Qibin Cheng ◽  
Xiaoli Xi ◽  
Liwei Zhang
Keyword(s):  
Maximum Yield ◽  
Deep Eutectic Solvent ◽  
Extraction Yield ◽  
Scutellaria Baicalensis ◽  
Molar Ratio ◽  
Extraction Temperature ◽  
Microwave Assisted Extraction ◽  
Scutellaria Baicalensis Georgi ◽  
Microwave Assisted ◽  
Assisted Extraction

Deep eutectic solvents (DESs) have attracted significant attention as green media for the extraction and separation of natural compounds from Chinese medicine. In this study, a hydrophobic DESs-based microwave-assisted extraction (MAE) was successfully used to efficiently extract baicalin from Scutellaria baicalensis Georgi. Firstly, DecA: N4444-Cl (DES-1 , molar ratio 1 : 2) was screened and selected as the most appropriate DES by comparing the extraction yield in different hydrophobic DESs. Based on the extraction yield of baicalin, response surface methodology (RSM) was employed to model and optimize the parameters (extraction temperature, liquid-solid ratio, and extraction time). Furthermore, the maximum yield of 106.96 mg·g−1 was achieved under optimum conditions in DES-containing aqueous solutions (33 vol% water content), which reached a similar level that was conducted using the pharmacopoeia procedure (104.94 mg·g−1). These results indicated that the proposed method is an excellent alternative for the extraction of baicalin.

Optimization of Ultrahigh Pressure Extraction of Momordicosides from Bitter Melon

2010 ◽  
Vol 6 (6) ◽  
Author(s):  
Hongfang Ji ◽  
Lingwen Zhang ◽  
Jian Li ◽  
Mingduo Yang ◽  
Xin Liu
Keyword(s):  
Ethanol Concentration ◽  
Maximum Yield ◽  
Dry Weight ◽  
Extraction Time ◽  
Ultrahigh Pressure ◽  
Bitter Melon ◽  
Hplc Profile ◽  
Pressure Extraction ◽  
Independent Parameters ◽  
Sample Ratio

Response surface methodology was used to optimize the conditions of ultrahigh pressure extraction of momordicosides from fresh fruits of bitter melon. The effect of extraction pressure, extraction time, ethanol concentration and solvent to sample ratio, and their interactions on yield of total momordicosides was investigated. Results showed that data could be well fitted to a second-order polynomial model. The independent parameters of extraction pressure, extraction time, solvent to sample ratio, all quadratics as well as the interactions between extraction pressure and solvent to sample ratio affected the yield significantly (p < 0.05). The model predicted that the optimal conditions were 423.1 MPa, extraction time 7.0 min, ethanol concentration 70.0 percent (V/V) and solvent to sample ratio 45.3 : 1 mL/g, and under such conditions, the maximum yield of 3.270 g Rg1 equivalents /100 g bitter melon dry weight could be achieved. In comparison with conventional heat reflux extraction, ultrahigh pressure extraction is more efficient and rapid to extract momordicosides from bitter melon. Additionally, the momordicosides compositions in extracts by both the methods were similar, which were investigated by using HPLC profile.

Experiment Study on Ultrahigh Pressure Extraction of Protein Components from Sika Deer Pilose Antler

2012 ◽  
Vol 550-553 ◽  
pp. 1841-1844 ◽  
Author(s):  
Wen Jing Guo ◽  
Guo Jun Yang ◽  
Yong Ren Chen ◽  
Shou Qin Zhang
Keyword(s):  
Room Temperature ◽  
Sika Deer ◽  
Extraction Process ◽  
Extraction Methods ◽  
Extraction Time ◽  
Ultrahigh Pressure ◽  
Experimental Conditions ◽  
Solid Ratio ◽  
Pressure Extraction ◽  
Protein Components

An Ultrahigh pressure extraction technique (UPET) is presented for the extraction of protein components from sika deer pilose antler. Various experimental conditions of the UPET process, such as extraction pressure (50-300 MPa), extraction time (0-10 min) and liquid/solid ratio (2-10 mL•g−1), were investigated to optimize the extraction process. The content of protein components in pilose antler extract by UPET for 4 min was higher than those using ultrasonic extraction (UE) for 30 min, heat reflux extraction (RE) for 12 h and soaking extraction (SE) at room temperature for 24 h respectively. From the viewpoints of extraction time, the proteins content in pilose antler extract and energy consumption in the extraction process, UPET was more effective than the conventional extraction methods studied.

scholarly journals Optimization of Supercritical Carbon Dioxide Extraction of Quercus infectoria Oil

2015 ◽  
Vol 74 (7) ◽  
Author(s):  
Liza Md Salleh ◽  
Stashia ELeaness Rosland Abel ◽  
Gholamreza Zahedi ◽  
Russly Abd Rahman ◽  
Hasmida Mohd Nasir ◽  
...  
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Goodness Of Fit ◽  
Maximum Yield ◽  
Extraction Yield ◽  
Extraction Time ◽  
Extraction Temperature ◽  
Predicted Values ◽  
Artificial Neural Network Ann ◽  
Quercus Infectoria

This current study focuses on the modelling and optimization of supercritical fluid extraction of Quercus infectoria galls oil. In this case, response surface methodology (RSM) and artificial neural network (ANN) were applied for the modelling and prediction of extraction yield of galls oil. A 17-run Box-Behnken Design (BBD) was employed to statistically optimize the process parameters of SC-CO2 extraction of Quercus infectoria galls at a condition as follows: pressure (5000, 6000, 7000 Psi), temperature (40, 50, 60°C) and extraction time (30, 45, 60 min). The maximum yield of the extracted oil is1.12 % and the optimum conditions are at an extraction pressure of 5574 Psi; extraction temperature of 75°C and extraction time of 54 min. Under the optimal conditions, the experimental results agree with the predicted values obtained through analysis of variance (ANOVA). This indicates a successful response surface methodology and highly satisfactory goodness of fit of the model used. The analysis of experimental design for process optimization results demonstrates that temperature and extraction time are the main parameters that influence the oil extraction of Quercus infectoria.

scholarly journals Optimization of Ultrasound-Assisted Extraction of Antioxidant Polyphenols from the Seed Coats of Red Sword Bean (Canavalia gladiate (Jacq.) DC.)

Antioxidants ◽  
2019 ◽  
Vol 8 (7) ◽  
pp. 200 ◽  
Author(s):  
Yue Zhou ◽  
Xiao-Yu Xu ◽  
Ren-You Gan ◽  
Jie Zheng ◽  
Ya Li ◽  
...  
Keyword(s):  
Extraction Method ◽  
Natural Antioxidants ◽  
Extraction Time ◽  
Antioxidant Compounds ◽  
Extraction Temperature ◽  
Ultrasound Assisted Extraction ◽  
Solid Ratio ◽  
Assisted Extraction ◽  
Ultrasound Assisted ◽  
Seed Coats

The seed coat of red sword bean (Canavalia gladiata (Jacq.) DC.) is rich in antioxidant polyphenols. It is often discarded as a byproduct with the consumption of red sword bean, since it is very thick and not consumed by people. The aim of this study was to develop an ultrasound-assisted extraction method to extract natural antioxidants from the seed coats. The extraction process was optimized by using response surface methodology. After the single-factor experiments, three key factors, including ethanol concentration, liquid/solid ratio, and extraction time, were selected and their interactions were studied using a central composite design. The optimal extraction condition was 60.2% hydroethanol, a liquid/solid ratio of 29.3 mL/g, an extraction time of 18.4 min, an extraction temperature of 50 °C, and ultrasound power of 400 W. Under the optimal conditions, antioxidant activity of the extract was 755.98 ± 10.23 μmol Trolox/g dry weight (DW), much higher than that from maceration (558.77 ± 14.42 μmol Trolox/g DW) or Soxhlet extraction (479.81 ± 12.75 μmol Trolox/g DW). In addition, the main antioxidant compounds in the extract were identified and quantified by high-performance liquid chromatography–diode array detection–tandem mass spectrometry (HPLC–DAD–MS/MS). The concentrations of digalloyl hexoside, methyl gallate, gallic acid, trigalloyl hexoside, and digallic acid were 15.30 ± 0.98, 8.85 ± 0.51, 8.76 ± 0.36, 4.27 ± 0.21, and 2.89 ± 0.13 mg/g DW. This study provides an efficient and green extraction method for the extraction of natural antioxidants from the bean coat of red sword bean. The extract of antioxidants might be added into functional foods or nutraceuticals with potential beneficial functions.

scholarly journals The Effects of Extraction Conditions on Extraction Yield and Syringin Content in Producing Standardized Tinospora crispa Aqueous Extract with High Antioxidant Activity

2021 ◽  
pp. 106-120
Author(s):  
Zamree Md Shah ◽  
Mohd Kamal Nik Hasan ◽  
Khairul Kamilah Abdul Kadir ◽  
Mohd Shahidan Mohd Arshad ◽  
Zulkhairi Amom
Keyword(s):  
Antioxidant Activity ◽  
Antioxidant Activities ◽  
Pharmaceutical Preparations ◽  
Extraction Yield ◽  
Extraction Time ◽  
Extraction Temperature ◽  
Solid Ratio ◽  
Beneficial Effects ◽  
High Antioxidant Activity ◽  
Optimized Conditions

The herbal plant known as Tinospora crispa is reported to have many beneficial effects on health and has great potential in future to be developed as a health product either in the form of traditional medicine, food supplements or in pharmaceutical preparations. However, so far knowledge on processing procedures to produce quality standardized extracts of this plant to be used in product development has still not widely reported. Therefore, the objective of this study was to determine the optimal extraction conditions for producing a standardized T. crispa aqueos extract (STCAE) with high extraction yield and high syringin content. Experiments were conducted to determine the effects of various extraction conditions involving temperature (25–100 ° C), extraction time (0.5–6 hours) and liquid (water) to solid ratio (5: 1–25: 1 ml of solvent per g stem dry). Using optimized conditions obtained, the extract was standardized based on syringin and was further investigated on its antioxidant activity through DPPH, FRAP and TBA bioassays. Results revealed that the optimum extraction conditions were found to be 1 h extraction time and 15:1 ml g−1 liquid-to-solid ratio. For the extraction temperature, 60°C was found to be the best. STCAE was produced on the basis of the extract to contain with at least 0.4 wt% of syringin. STCAE was found to possess high antioxidant activities through DPPH, FRAP and TBA bioassays.

scholarly journals Enhancement of Solasodine Extracted from Fruits of Solanum nigrum L. by Microwave-Assisted Aqueous Two-Phase Extraction and Analysis by High-Performance Liquid Chromatography

Molecules ◽  
2019 ◽  
Vol 24 (12) ◽  
pp. 2294 ◽  
Author(s):  
Li Lin ◽  
Wen Yang ◽  
Xing Wei ◽  
Yi Wang ◽  
Li Zhang ◽  
...  
Keyword(s):  
Extraction Method ◽  
High Performance ◽  
Extraction Yield ◽  
Solanum Nigrum ◽  
Two Phase ◽  
Solid Ratio ◽  
Microwave Assisted ◽  
Assisted Extraction ◽  
Solanum Nigrum L ◽  
Aqueous Two Phase Extraction

Background: Solasodine is a major bioactive ingredient in Solanum nigrum L. that has strong pharmacological characteristics. Therefore, the development of a simple and effective extraction method for obtaining solasodine is highly important. This study aims to provide a rapid and effective method for extracting solasodine from Solanum nigrum L. by microwave-assisted aqueous two-phase extraction (MAATPE). Methods: First, the high-performance liquid chromatography (HPLC) conditions were established for the detection of solasodine. Then, the aqueous two-phase system (ATPS) compositions were examined. On the basis of the results of single-factor experiments, for a better yield, response surface methodology (RSM) was used to optimize influential factors including the extraction temperature, extraction time and liquid-to-solid ratio. Results: The maximum extraction yield of 7.11 ± 0.08 mg/g was obtained at 44 °C, an extraction time of 15 min, and a liquid-to-solid ratio of 42:1 mL/g in the ATPS consisting of EtOH solvent, (NH4)2SO4, and water (28:16:56, w/w/w). The extraction yield of the alkaloid obtained using this method was markedly higher than those of microwave-assisted extraction (MAE) and ultrasonic-assisted extraction (UAE). Conclusions: In this work, solasodine was extracted by MAATPE for the first time and a high yield was obtained. MAATPE is a simple, rapid, and green technique for extraction from medical plants. Thus, the present study will enable the development of a feasible extraction method of active alkaloids from Solanum nigrum L.

scholarly journals Tuning of Proanthocyanidin Extract’s Composition through Quaternary Eutectic Solvents Extraction

Antioxidants ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. 1124
Author(s):  
Rodrigo T. Neto ◽  
Sónia A. O. Santos ◽  
Joana Oliveira ◽  
Armando J. D. Silvestre
Keyword(s):  
Industrial Application ◽  
Extraction Method ◽  
Choline Chloride ◽  
Extraction Methods ◽  
Extraction Yield ◽  
Degree Of Polymerization ◽  
Grape Pomace ◽  
Custom Made ◽  
Conventional Extraction

Currently available proanthocyanidins extraction methods rely on dedicated crops and have low specificity and yield which limits their industrial application. Consequently, the development of novel methodologies and the use of sustainable sources is of great importance. Eutectic solvents have been proposed has good alternatives for conventional solvents due to their low price, easiness of preparation, biocompatibility and ability of being custom made to a specific application. Herein the effective extraction of proanthocyanidins from grape pomace and the possibility of tuning the extract’s characteristics such as mean degree of polymerization and galloylation percentage is explored by means of varying the composition of a quaternary eutectic solvent composed by choline chloride, glycerol, ethanol and water. It was found that mean degree of polymerization values can vary from 6.0 to 7.37 and galloylation percentage can vary from 32.5% to 47.1% while maintaining extraction yield above 72.2 mg of proanthocyanidins per g of biomass. Furthermore, the increase of temperature up to 100 °C has showed a significant effect on the extraction yield being possible to increase it by 238% when compared to the conventional extraction method.

Extraction of Fish Oil from the Muscle of Sturgeon Using Supercritical Fluids

2013 ◽  
Vol 655-657 ◽  
pp. 1975-1981 ◽  
Author(s):  
Shu Xian Hao ◽  
Hui Huang ◽  
Lai Hao Li ◽  
Xian Qing Yang ◽  
Jian Wei Cen ◽  
...  
Keyword(s):  
Fish Oil ◽  
Supercritical Fluids ◽  
Flow Rate ◽  
Polynomial Regression ◽  
Maximum Yield ◽  
Extraction Time ◽  
Coefficient Of Determination ◽  
Acipenser Baeri ◽  
Pressure Extraction ◽  
Co2 Flow

This study evaluated the extraction of oil from sturgeon (Acipenser baeri) muscle using supercritical fluids. Response surface methodology (RSM) was used to identify and quantify the variables, namely extraction pressure, extraction time and CO2 flow rate on the yield of oil. Statistical analysis indicated that for all three variables, the quadratic terms and interactions between the variables had significant effects on yield (p < 0.05). Polynomial regression model predictions were in good agreement with the experimental results, with a coefficient of determination of 0.9936 for yield. Maximum yield from sturgeon muscle was 26.83% with a pressure of 315.8 bar, extraction time of 10.8 min and CO2 flow rate of 3.5 l/min, which closely matched the predicted value (26.70%). The characteristics of the fish oil extracted with the supercritical fluids were superior to those of oil obtained by other methods.

scholarly journals Recycling of pomegranate peel and mandarin peel with ultrasound assisted solvent extraction

2020 ◽  
Vol 3 (1) ◽  
pp. 161-169
Author(s):  
Merve Hüseyinbaş ◽  
Berkay Korkmaz ◽  
Selin Yücelen ◽  
Afife Güvenç
Keyword(s):  
Particle Size ◽  
Extraction Yield ◽  
Green Technology ◽  
Extraction Time ◽  
Total Phenolic ◽  
Distilled Water ◽  
Pomegranate Peel ◽  
Solid Ratio ◽  
Mandarin Peel ◽  
Ultrasound Assisted

According to the data of Food and Agriculture Organization, approximately one third of the food produced in the world (1.6 billion tons/year) is lost when it is not reused at the end of consumption. For the recovery and reuse of valuable ingredients (flavonoids, anthocyanins, phenolic acids) in &amp;lsquo;Katırbaşı&amp;rsquo; pomegranate peel and &amp;lsquo;Satsuma&amp;rsquo; type mandarin peel, which are food industry wastes, ultrasound assisted extraction method (UAEM) which is green technology was used. The effects of various solvents and particle size on extraction yield were investigated by applying solvent / solid ratio of 5 ml/g , particle size of 0.5-1 mm pomegranate peels and 10 min. extraction time for UAEM. The highest efficiency was achieved by using water with 18%. Total phenolic content (TPC) values are 16.55 mg GAE/g dry peel(dp), 14.4 mg GAE/g dp, 12.55 mg GAE/g dp, 10.9 mg GAE/g dp, 14.45 mg GAE/g dp for distilled water, methanol, 50% methanol-water, ethanol, 70% ethanol-water solvents, respectively, for 0.5-1 mm particle size. TPC was found as 11.75 mg GAE/g dp for particle size of 0.25mm and below and 17.5 mg GAE/g dp for the range of particle size of 1-2 mm using water. Also, similar experiments were made for mandarin peels; TPC and AA (Antioxidant Activity, with DPPH) were determined. The parameters were chosen as different solvent type (water, 100% ethanol, 80% ethanol-water, 100% methanol, 80% methanol-water), extraction time (10 and 20 min.) and solvent/solid ratio (10, 20 ml/g) as well. TPC and AA were found 17.8 mg GAE/g dp and 90% for 100% methanol, 10 minutes and 20 ml/g solvent/solid ratio, respectively. When the ultrasound application time was 20 min, TPC and AA were found 18.24 mg GAE/g dp and 90% for 20 ml/g solvent/solid ratio and 80% methanol, respectively. The highest extraction yield was 19% using distilled water for 20 min, 10 ml/g solvent/solid ratio.

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