Systematic Identification of Thiosemicarbazides for Inhibition of Toxoplasma gondii Growth In Vitro
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One of the key stages in the development of new therapies in the treatment of toxoplasmosis is the identification of new non-toxic small molecules with high specificity to Toxoplasma gondii. In the search for such structures, thiosemicarbazide-based compounds have emerged as a novel and promising leads. Here, a series of imidazole-thiosemicarbazides with suitable properties for CNS penetration was evaluated to determine the structural requirements needed for potent anti-Toxoplasma gondii activity. The best 4-arylthiosemicarbazides 3 and 4 showed much higher potency when compared to sulfadiazine at concentrations that are non-toxic to the host cells, indicating a high selectivity of their anti-toxoplasma activity.
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1997 ◽
Vol 41
(10)
◽
pp. 2137-2140
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2014 ◽
Vol 40
(3)
◽
pp. 1001-1005
◽
2011 ◽
Vol 22
(8)
◽
pp. 1290-1299
◽
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