scholarly journals Graphene-Based Nanocomposites for Neural Tissue Engineering

Molecules ◽  
2019 ◽  
Vol 24 (4) ◽  
pp. 658 ◽  
Author(s):  
Ho Bei ◽  
Yuhe Yang ◽  
Qiang Zhang ◽  
Yu Tian ◽  
Xiaoming Luo ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cell ◽  
Neural Stem Cell ◽  
High Surface ◽  
High Surface Area ◽  
Neural Tissue ◽  
Stem Cell Differentiation ◽  
Neural Regeneration ◽  
Neural Tissue Engineering ◽  
Graphene Nanocomposites

Graphene has made significant contributions to neural tissue engineering due to its electrical conductivity, biocompatibility, mechanical strength, and high surface area. However, it demonstrates a lack of biological and chemical cues. Also, it may cause potential damage to the host body, limiting its achievement of efficient construction of neural tissues. Recently, there has been an increasing number of studies showing that combining graphene with other materials to form nano-composites can provide exceptional platforms for both stimulating neural stem cell adhesion, proliferation, differentiation and neural regeneration. This suggests that graphene nanocomposites are greatly beneficial in neural regenerative medicine. In this mini review, we will discuss the application of graphene nanocomposites in neural tissue engineering and their limitations, through their effect on neural stem cell differentiation and constructs for neural regeneration.

Three-Dimensional Collagen Gel Networks for Neural Stem Cell-Based Neural Tissue Engineering

2005 ◽  
Vol 227 (1) ◽  
pp. 327-334 ◽  
Author(s):  
Wu Ma ◽  
Silvia Chen ◽  
Wendy Fitzgerald ◽  
Dragan Maric ◽  
Hsingch J. Lin ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cell ◽  
Neural Stem Cell ◽  
Three Dimensional ◽  
Collagen Gel ◽  
Neural Tissue ◽  
Neural Tissue Engineering

scholarly journals Electrical Stimulation Promotes Stem Cell Neural Differentiation in Tissue Engineering

2021 ◽  
Vol 2021 ◽  
pp. 1-14
Author(s):  
Hong Cheng ◽  
Yan Huang ◽  
Hangqi Yue ◽  
Yubo Fan
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Stem Cell ◽  
Electrical Stimulation ◽  
Neural Differentiation ◽  
Biological Effects ◽  
Neural Tissue ◽  
Neural Regeneration ◽  
Neural Tissue Engineering ◽  
Conductive Materials

Nerve injuries and neurodegenerative disorders remain serious challenges, owing to the poor treatment outcomes of in situ neural stem cell regeneration. The most promising treatment for such injuries and disorders is stem cell-based therapies, but there remain obstacles in controlling the differentiation of stem cells into fully functional neuronal cells. Various biochemical and physical approaches have been explored to improve stem cell-based neural tissue engineering, among which electrical stimulation has been validated as a promising one both in vitro and in vivo. Here, we summarize the most basic waveforms of electrical stimulation and the conductive materials used for the fabrication of electroactive substrates or scaffolds in neural tissue engineering. Various intensities and patterns of electrical current result in different biological effects, such as enhancing the proliferation, migration, and differentiation of stem cells into neural cells. Moreover, conductive materials can be used in delivering electrical stimulation to manipulate the migration and differentiation of stem cells and the outgrowth of neurites on two- and three-dimensional scaffolds. Finally, we also discuss the possible mechanisms in enhancing stem cell neural differentiation using electrical stimulation. We believe that stem cell-based therapies using biocompatible conductive scaffolds under electrical stimulation and biochemical induction are promising for neural regeneration.

scholarly journals Electrospun fibers in regenerative tissue engineering and drug delivery

2017 ◽  
Vol 89 (12) ◽  
pp. 1799-1808 ◽  
Author(s):  
Sakthivel Nagarajan ◽  
Céline Pochat-Bohatier ◽  
Sébastien Balme ◽  
Philippe Miele ◽  
S. Narayana Kalkura ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cell ◽  
Cell Attachment ◽  
High Surface ◽  
High Surface Area ◽  
Engineering Application ◽  
Volume Ratio ◽  
Stem Cell Differentiation ◽  
Electrospun Fibers ◽  
Tissue Engineering Application

AbstractElectrospinning is a versatile technique to produce micron or nano sized fibers using synthetic or bio polymers. The unique structural characteristic of the electrospun mats (ESM) which mimics extracellular matrix (ECM) found influential in regenerative tissue engineering application. ESM with different morphologies or ESM functionalizing with specific growth factors creates a favorable microenvironment for the stem cell attachment, proliferation and differentiation. Fiber size, alignment and mechanical properties affect also the cell adhesion and gene expression. Hence, the effect of ESM physical properties on stem cell differentiation for neural, bone, cartilage, ocular and heart tissue regeneration will be reviewed and summarized. Electrospun fibers having high surface area to volume ratio present several advantages for drug/biomolecule delivery. Indeed, controlling the release of drugs/biomolecules is essential for sustained delivery application. Various possibilities to control the release of hydrophilic or hydrophobic drug from the ESM and different electrospinning methods such as emulsion electrospinning and coaxial electrospinning for drug/biomolecule loading are summarized in this review.

scholarly journals Microfluidic systems for stem cell-based neural tissue engineering

Lab on a Chip ◽  
2016 ◽  
Vol 16 (14) ◽  
pp. 2551-2571 ◽  
Author(s):  
Mahdi Karimi ◽  
Sajad Bahrami ◽  
Hamed Mirshekari ◽  
Seyed Masoud Moosavi Basri ◽  
Amirala Bakhshian Nik ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Cell Culture ◽  
Stem Cell ◽  
Neural Tissue ◽  
Microfluidic Systems ◽  
Neural Tissue Engineering ◽  
Stem Cell Culture ◽  
Stem Cell Derivation

Overall process of stem cell derivation and isolation, as well as microfluidic stem cell culture and neural tissue engineering.

The study of P19 stem cell behavior on aligned oriented electrospun poly(lactic-co-glycolic acid) nano-fibers for neural tissue engineering

2014 ◽  
Vol 25 (5) ◽  
pp. 562-567 ◽  
Author(s):  
Shiva Irani ◽  
Mojgan Zandi ◽  
Najmeh Salamian ◽  
Seyed Mahdi Saeed ◽  
Morteza Daliri Joupari ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cell ◽  
Glycolic Acid ◽  
Neural Tissue ◽  
Cell Behavior ◽  
Neural Tissue Engineering

Double coating of graphene oxide–polypyrrole on silk fibroin scaffolds for neural tissue engineering

2020 ◽  
Vol 35 (3) ◽  
pp. 216-227
Author(s):  
Yuqing Wang ◽  
Haoran Yu ◽  
Haifeng Liu ◽  
Yubo Fan
Keyword(s):  
Electrical Conductivity ◽  
Tissue Engineering ◽  
Graphene Oxide ◽  
Silk Fibroin ◽  
Electrochemical Property ◽  
Neural Tissue ◽  
Neural Regeneration ◽  
Neural Tissue Engineering ◽  
Double Coating

The desired scaffolds for neural tissue engineering need to have electrical conductivity. In this study, we doubly coated graphene oxide and polypyrrole on silk fibroin scaffolds (SF@GO-PPY) by a facile method to improve its electrical conductivity. The graphene oxide–polypyrrole double coating was distributed homogeneously on silk fibroin scaffolds. Compared with silk fibroin scaffolds, the SF@GO-PPY scaffold showed higher electrical conductivity, electrochemical property, mechanical property, and thermal stability. The π–π stacking interaction between polypyrrole and graphene oxide might contribute to the superior conductive and electrochemical property of the SF@GO-PPY scaffold. Moreover, in vitro cell experiment carried out on SH-SY5Y cells showed no cytotoxicity of all the scaffolds. Thus, the results indicated that the SF@GO-PPY scaffold might be a suitable candidate for the application in neural regeneration field.

Neural stem cell proliferation and differentiation in the conductive PEDOT-HA/Cs/Gel scaffold for neural tissue engineering

2017 ◽  
Vol 5 (10) ◽  
pp. 2024-2034 ◽  
Author(s):  
Shuping Wang ◽  
Shui Guan ◽  
Jianqiang Xu ◽  
Wenfang Li ◽  
Dan Ge ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Cell Proliferation ◽  
Stem Cell ◽  
Regenerative Medicine ◽  
Neural Tissue ◽  
Neural Tissue Engineering ◽  
Stem Cell Proliferation ◽  
Neural Stem Cell Proliferation ◽  
Cell Proliferation And Differentiation ◽  
Proliferation And Differentiation

Engineering scaffolds with excellent electro-activity is increasingly important in tissue engineering and regenerative medicine.

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