scholarly journals Antiviral Activity of Jamaican Medicinal Plants and Isolated Bioactive Compounds

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 607
Author(s):  
Henry Lowe ◽  
Blair Steele ◽  
Joseph Bryant ◽  
Emadelden Fouad ◽  
Ngeh Toyang ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Antiviral Activity ◽  
Influenza A ◽  
Viral Infections ◽  
Skin Diseases ◽  
Hepatitis Virus ◽  
World Health ◽  
World Population ◽  
Oral Diseases ◽  
The World

Plants have had historical significance in medicine since the beginning of civilization. The oldest medical pharmacopeias of the African, Arabian, and Asian countries solely utilize plants and herbs to treat pain, oral diseases, skin diseases, microbial infections, multiple types of cancers, reproductive disorders among a myriad of other ailments. The World Health Organization (WHO) estimates that over 65% of the world population solely utilize botanical preparations as medicine. Due to the abundance of plants, plant-derived medicines are more readily accessible, affordable, convenient, and have safer side-effect profiles than synthetic drugs. Plant-based decoctions have been a significant part of Jamaican traditional folklore medicine. Jamaica is of particular interest because it has approximately 52% of the established medicinal plants that exist on earth. This makes the island particularly welcoming for rigorous scientific research on the medicinal value of plants and the development of phytomedicine thereof. Viral infections caused by the human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2), hepatitis virus B and C, influenza A virus, and the severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) present a significant global burden. This is a review of some important Jamaican medicinal plants, with particular reference to their antiviral activity.

scholarly journals Important Jamaican Medicinal Plants with Special Reference to their Antiviral Activity

2020 ◽  
Author(s):  
Henry Lowe ◽  
Blair Steele ◽  
Joseph Bryant ◽  
Emadelden Fouad ◽  
Ngeh Toyang ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Antiviral Activity ◽  
Influenza A ◽  
Viral Infections ◽  
Skin Diseases ◽  
Hepatitis Virus ◽  
World Health ◽  
World Population ◽  
Oral Diseases ◽  
The World

Plants have had historical significance in medicine since the beginning of civilization. The oldest medical pharmacopeias of the African, Arabian, and Asian countries solely utilize plants and herbs to treat pain, oral diseases, skin diseases, microbial infections, multiple types of cancers, reproductive disorders among a myriad of other ailments. The World Health Organization (WHO) estimates that over 65% of the world population solely utilize botanical preparations as medicine. Due to the abundance of plants, plant-derived medicines are more readily accessible, affordable, convenient, and have safer side-effect profiles than synthetic drugs. Plant-based decoctions have been a significant part of Jamaican traditional folklore medicine. Jamaica is of particular interest because it has approximately 52% of the established medicinal plants that exist on earth. This makes the island particularly welcoming for rigorous scientific research on the medicinal value of plants and the development of phytomedicine thereof. Viral infections like human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2), hepatitis virus B and C, influenza A virus, the severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) have significant global burden. This is a review of some important Jamaican medicinal plants, with particular reference to their antiviral activity.

scholarly journals Medicinal and Aromatic plants: “Natural bio-chemicals and medicine factories”

2021 ◽  
Vol 17 (2) ◽  
pp. 691-698
Author(s):  
Vandana ◽  
Rajesh Lather ◽  
Sridevi Tallapragada ◽  
Gurnam Singh
Keyword(s):  
Medicinal Plants ◽  
Plant Material ◽  
Herbal Medicines ◽  
Raw Material ◽  
World Health ◽  
World Population ◽  
Special Role ◽  
Aromatic Plants ◽  
Medicinal And Aromatic Plants ◽  
The World

Since thousands years back approximately around 900 BC, medicinal plants are considered as a source of many biomolecules with therapeutic potential. Herbal medicines are considered as safer, better, physiologically compatible and costeffective. The oldest evidence of medicinal and aromatic plants depicts that with the emergence of human civilization, plants have been considered as the main source to heal and cure various serious ailments. It has been proven that the secondary metabolites e.g. alkaloid, glycosides, flavonoides, steroids etc present in the medicinal plants possesses ability to prevent occurrence of some of the diseases, means medicinal plants acts as a “preventive medicine”. Medicinal plants have a paramount importance and a great interest due to its pharmaceutical, cosmetic and nutritional values. Some plants are also considered as an important source of nutrition and are known to have a variety of compounds with potential therapeutic properties. India is the principal repository of large number of medicinal and aromatic plants or we can say India is one of the rich mega-biodiversity countries of the world. Medicinal plants are “backbone” of traditional medicinal system (TMS). Crude drugs are usually dried parts of medicinal and aromatic plants (MAPs) such as roots, stems, wood, bark, seeds, fruits, flowers, leaves, rhizomes, whole plant etc. that form the essential raw material for the production of medicines in various systems of Ayurveda, Siddha, Unani, Tibatian, Tribal and Homeopathy. According to the survey of the World Health Organization (WHO), about 80% of the world population are using herbs and other traditional medicines for their primary healthcare and have established three kinds of herbal medicines: raw plant material, processed plant material, and herbal products. Now days, variety of available herbs are used throughout the world and they continue to promote good health. As the benefits from medicinal and aromatic plants are recognized, these plants will have a special role for humans in the future. The present review on medicinal and aromatic plants revealed similar combination of studies.

scholarly journals Bioactive Natural Antivirals: An Updated Review of the Available Plants and Isolated Molecules

Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 4878 ◽  
Author(s):  
Syam Mohan ◽  
Manal Mohamed Elhassan Taha ◽  
Hafiz A. Makeen ◽  
Hassan A. Alhazmi ◽  
Mohammed Al Bratty ◽  
...  
Keyword(s):  
Plant Extracts ◽  
Drug Targets ◽  
Viral Infections ◽  
Health Hazard ◽  
World Health ◽  
World Population ◽  
The World ◽  
Pure Compounds ◽  
Reduced Toxicity ◽  
Health Organization

Viral infections and associated diseases are responsible for a substantial number of mortality and public health problems around the world. Each year, infectious diseases kill 3.5 million people worldwide. The current pandemic caused by COVID-19 has become the greatest health hazard to people in their lifetime. There are many antiviral drugs and vaccines available against viruses, but they have many disadvantages, too. There are numerous side effects for conventional drugs, and active mutation also creates drug resistance against various viruses. This has led scientists to search herbs as a source for the discovery of more efficient new antivirals. According to the World Health Organization (WHO), 65% of the world population is in the practice of using plants and herbs as part of treatment modality. Additionally, plants have an advantage in drug discovery based on their long-term use by humans, and a reduced toxicity and abundance of bioactive compounds can be expected as a result. In this review, we have highlighted the important viruses, their drug targets, and their replication cycle. We provide in-depth and insightful information about the most favorable plant extracts and their derived phytochemicals against viral targets. Our major conclusion is that plant extracts and their isolated pure compounds are essential sources for the current viral infections and useful for future challenges.

The Crab Heparin-Like Compound Exhibits A Strong Inhibitory Effect On Infections By Dengue Virus-2

2020 ◽  
Vol 18 ◽  
Author(s):  
Marlyanne Maria Carvalho Silva de Almeida ◽  
Renato Ferreira de Almeida Júnior ◽  
Ana Alice de Aquino ◽  
Lívia de Lourdes Pinto ◽  
Paula Renata Lima Machado ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Viral Replication ◽  
Initial Step ◽  
Bleeding Risk ◽  
Vero Cells ◽  
Inhibitory Effect ◽  
World Health ◽  
Effective Vaccine ◽  
World Population ◽  
The World

Background: - According to the World Health Organization (WHO), two fifths of the world population is at risk of infection by DENV. There are not any safe and effective vaccine established. Sulfated glycosaminoglycans such as heparin, used as anticoagulant inhibit the initial step of dengue viral replication. Recently, an isolated heparin analogue Goniopsis cruentata (cCTH) has presented low anticoagulant effect with reduced bleeding risk. Methods : - The antiviral activity of cCTH and heparin compounds against DENV-2 in Vero cell culture was determined by quantitative RT-PCR (qRT-PCR) and titration. For this, it was carried out four trials: treatment of the cells for 2 h before viral inoculation, concomitant viral inoculation treatment, treatment after viral inoculation and virucidal assay. Subsequently, the culture supernatants were collected for periods of 24, 48 and 72 h. Results: - Our results have been demonstrated that cCTH and heparin showed antiviral activity against DENV-2. Conclusion : - These data suggest that both compounds prevented viral replication in cultured Vero cells.

scholarly journals Potential Natural Products Against Respiratory Viruses: A Perspective to Develop Anti-COVID-19 Medicines

2021 ◽  
Vol 11 ◽  
Author(s):  
Marzieh Omrani ◽  
Mohsen Keshavarz ◽  
Samad Nejad Ebrahimi ◽  
Meysam Mehrabi ◽  
Lyndy J. McGaw ◽  
...  
Keyword(s):  
Natural Products ◽  
Perceived Risk ◽  
Influenza A ◽  
Viral Infections ◽  
Respiratory Viruses ◽  
World Health ◽  
Screening Programs ◽  
The World ◽  
Novel Coronavirus ◽  
Health Organization

The emergence of viral pneumonia caused by a novel coronavirus (CoV), known as the 2019 novel coronavirus (2019-nCoV), resulted in a contagious acute respiratory infectious disease in December 2019 in Wuhan, Hubei Province, China. Its alarmingly quick transmission to many countries across the world and a considerable percentage of morbidity and mortality made the World Health Organization recognize it as a pandemic on March 11, 2020. The perceived risk of infection has led many research groups to study COVID-19 from different aspects. In this literature review, the phylogenetics and taxonomy of COVID-19 coronavirus, epidemiology, and respiratory viruses similar to COVID-19 and their mode of action are documented in an approach to understand the behavior of the current virus. Moreover, we suggest targeting the receptors of SARS-CoV and SARS-CoV-2 such as ACE2 and other proteins including 3CLpro and PLpro for improving antiviral activity and immune response against COVID-19 disease. Additionally, since phytochemicals play an essential role in complementary therapies for viral infections, we summarized different bioactive natural products against the mentioned respiratory viruses with a focus on influenza A, SARS-CoV, MERS, and COVID-19.Based on current literature, 130 compounds have antiviral potential, and of these, 94 metabolites demonstrated bioactivity against coronaviruses. Interestingly, these are classified in different groups of natural products, including alkaloids, flavonoids, terpenoids, and others. Most of these compounds comprise flavonoid skeletons. Based on our survey, xanthoangelol E (88), isolated from Angelica keiskei (Miq.) Koidz showed inhibitory activity against SARS-CoV PLpro with the best IC50 value of 1.2 μM. Additionally, hispidulin (3), quercetin (6), rutin (8), saikosaponin D (36), glycyrrhizin (47), and hesperetin (55) had remarkable antiviral potential against different viral infections. Among these compounds, quercetin (6) exhibited antiviral activities against influenza A, SARS-CoV, and COVID-19 and this seems to be a highly promising compound. In addition, our report discusses the obstacles and future perspectives to highlight the importance of developing screening programs to investigate potential natural medicines against COVID-19.

scholarly journals Treatment of urinary tract infections with medicinal plants: Monographs of some plants species revealed by traditherapists

2020 ◽  
Vol 1 (1) ◽  
Author(s):  
Victorien Dougnon ◽  
Phénix Assogba ◽  
Hornel Koudokpon ◽  
Césaire Ayena ◽  
Sosthéne Vissoh ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Medicinal Plants ◽  
Urinary Tract Infections ◽  
Viral Infections ◽  
Skin Diseases ◽  
Scientific Evidence ◽  
Traditional Use ◽  
Suitable Alternative ◽  
The World ◽  
Tract Infections

Medicinal plants are a precious heritage for humanity and especially for the majority of poor communities in developing countries who depend on them for primary health care and livelihoods. They are used in traditional practices against urinary tract infections without any scientific evidence for most of the species used. This work aims to have a summary of the literature on some medicinal plants used in the treatment of urinary tract infections. To do this, this study was carried out based on the different medicinal plants cited by herbalists in southern Togo against urinary tract infections. The names of these different plants have each been the subject of research with keywords in search engines such as Google Scholar, PubMed, FreefullPdf, and others to bring out the traditional use of these plants in the world. From all of the above, it appears that the medicinal plant species cited by actors of the Togolese pharmacopoeia are used to treat several diseases in the world. The organs of these plants, such as leaves, bark, and roots are used in the treatment of common illnesses such as typhoid fever, diarrhea, malaria, bronchitis, and hypofertility. Coughs, colds, skin diseases, toothache, gonorrhoea, viral infections, and many other diseases are treated with these plants. The plants are often combined with other plants in traditional medicine. They are used in the form of decoction, fumigation, herbal tea, and others. The type of disease treated by the plants changes from region to region and is also dependent on the culture of the region in the world. The use of medicinal plants is a very ancient practice. It is a very suitable alternative to modern medicine. However, there is a need to have more detailed studies on these plants, such as their toxicological effects.

Natural products from the traditional Moroccan pharmacopoeia: A potential lead for the prevention and treatment of COVID-19

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1278-1285
Author(s):  
Mohamed Yafout ◽  
Amine Ousaid ◽  
Ibrahim Sbai El Otmani ◽  
Youssef Khayati ◽  
Amal Ait Haj Said
Keyword(s):  
Medicinal Plants ◽  
Plant Extracts ◽  
Molecular Mechanisms ◽  
Scientific Literature ◽  
Treatment Protocol ◽  
World Health ◽  
The World ◽  
Health Organization ◽  
Promising Source

The new SARS-CoV-2 belonging to the coronaviruses family has caused a pandemic affecting millions of people around the world. This pandemic has been declared by the World Health Organization as an international public health emergency. Although several clinical trials involving a large number of drugs are currently underway, no treatment protocol for COVID-19 has been officially approved so far. Here we demonstrate through a search in the scientific literature that the traditional Moroccan pharmacopoeia, which includes more than 500 medicinal plants, is a fascinating and promising source for the research of natural molecules active against SARS-CoV-2. Multiple in-silico and in-vitro studies showed that some of the medicinal plants used by Moroccans for centuries possess inhibitory activity against SARS-CoV or SARS-CoV-2. These inhibitory activities are achieved through the different molecular mechanisms of virus penetration and replication, or indirectly through stimulation of immunity. Thus, the potential of plants, plant extracts and molecules derived from plants that are traditionally used in Morocco and have activity against SARS-CoV-2, could be explored in the search for a preventive or curative treatment against COVID-19. Furthermore, safe plants or plant extracts that are proven to stimulate immunity could be officially recommended by governments as nutritional supplements.

scholarly journals Endovascular Bariatric Surgery as Novel Minimally Invasive Technique for Weight Management in the Morbidly Obese: Review of the Literature

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2541
Author(s):  
Giuseppe Massimo Sangiorgi ◽  
Alberto Cereda ◽  
Nicola Porchetta ◽  
Daniela Benedetto ◽  
Andrea Matteucci ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Minimally Invasive ◽  
Weight Management ◽  
World Health ◽  
Invasive Technique ◽  
Morbidly Obese ◽  
World Population ◽  
Obese Patients ◽  
The World ◽  
Open Bariatric Surgery

Nowadays, obesity represents one of the most unresolved global pandemics, posing a critical health issue in developed countries. According to the World Health Organization, its prevalence has tripled since 1975, reaching a prevalence of 13% of the world population in 2016. Indeed, as obesity increases worldwide, novel strategies to fight this condition are of the utmost importance to reduce obese-related morbidity and overall mortality related to its complications. Early experimental and initial clinical data have suggested that endovascular bariatric surgery (EBS) may be a promising technique to reduce weight and hormonal imbalance in the obese population. Compared to open bariatric surgery and minimally invasive surgery (MIS), EBS is much less invasive, well tolerated, with a shorter recovery time, and is probably cost-saving. However, there are still several technical aspects to investigate before EBS can be routinely offered to all obese patients. Further prospective studies and eventually a randomized trial comparing open bariatric surgery vs. EBS are needed, powered for clinically relevant outcomes, and with adequate follow-up. Yet, EBS may already appear as an appealing alternative treatment for weight management and cardiovascular prevention in morbidly obese patients at high surgical risk.

scholarly journals Progression and Trends in Virus from Influenza A to COVID-19: An Overview of Recent Studies

Viruses ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1145
Author(s):  
Hakimeh Baghaei Daemi ◽  
Muhammad Fakhar-e-Alam Kulyar ◽  
Xinlin He ◽  
Chengfei Li ◽  
Morteza Karimpour ◽  
...  
Keyword(s):  
Influenza A ◽  
H1n1 Virus ◽  
World Health ◽  
H1n1 Pandemic ◽  
Global Pandemic ◽  
First Case ◽  
Influenza A H1n1 ◽  
The World ◽  
Novel Coronavirus ◽  
Health Organization

Influenza is a highly known contagious viral infection that has been responsible for the death of many people in history with pandemics. These pandemics have been occurring every 10 to 30 years in the last century. The most recent global pandemic prior to COVID-19 was the 2009 influenza A (H1N1) pandemic. A decade ago, the H1N1 virus caused 12,500 deaths in just 19 months globally. Now, again, the world has been challenged with another pandemic. Since December 2019, the first case of a novel coronavirus (COVID-19) infection was detected in Wuhan. This infection has risen rapidly throughout the world; even the World Health Organization (WHO) announced COVID-19 as a worldwide emergency to ensure human health and public safety. This review article aims to discuss important issues relating to COVID-19, including clinical, epidemiological, and pathological features of COVID-19 and recent progress in diagnosis and treatment approaches for the COVID-19 infection. We also highlight key similarities and differences between COVID-19 and influenza A to ensure the theoretical and practical details of COVID-19.

In vitro evaluation of the anti-mycobacterial properties of the extracts of Momordica Charantia

2021 ◽  
Vol 16 (7) ◽  
pp. 15-22
Author(s):  
Paul Giftson ◽  
Jerrine Joseph ◽  
Revathy Kalyanasundaram ◽  
V. Ramesh Kumar ◽  
Wilson Aruni
Keyword(s):  
Medicinal Plants ◽  
Fungal Pathogens ◽  
Communicable Disease ◽  
Antimycobacterial Activity ◽  
Bitter Gourd ◽  
World Population ◽  
Methanol Extracts ◽  
Crude Extracts ◽  
The World

Tuberculosis (TB) is a communicable disease and remains one of the top 10 causes of death worldwide. One fourth of the world population is infected with TB at a risk of developing disease. The increase in the incidence of drug resistant TB around the world urges the need to develop a new candidate to fight against the disease. Plants were considered as the rich source of bioactive components to be used as potential drugs. Medicinal plants are used in pure as well as crude materials for their medicinal properties. Our research aims in identifying the phyto-molecules which have anti- tuberculosis property. Four medicinal plants namely, Acalyphaciliata (Kuppaimeni), Solanumtrilobatum (Thuthuvalai), Momordicacharantia (Bitter Gourd) and Sennaauriculata (Avaram) were chosen to evaluate their antimicrobial activity focusing on anti-tubercular activity. The methanol extracts of the medicinal plants showed significant inhibitory activity against bacterial and fungal pathogens. Sennaauriculata methanol extracts showed activity against S. aureus, E. coli, P. aeruginosa and C. albicans. In the screening of antimycobacterial activity done by LRP assay, among the plant extracts tested, the hexane crude extracts of Momordicacharantia (Bitter Gourd) showed 82.2% and 81.03% of inhibition against M. tuberculosis H37Rv at 500µg/ml and 250µg/ml concentration respectively. Similarly, the methanol crude extracts of Momordicacharantia showed 87.14% and 63.55% of inhibition at 500µg/ml and 250µg/ml concentration respectively.

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