scholarly journals The Skeletal Effects of Tanshinones: A Review

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2319
Author(s):  
Sophia Ogechi Ekeuku ◽  
Kok-Lun Pang ◽  
Kok-Yong Chin
Keyword(s):  
Bone Resorption ◽  
Bone Formation ◽  
Literature Search ◽  
Web Of Science ◽  
Bone Remodelling ◽  
Salvia Miltiorrhiza ◽  
Hormone Deficiency ◽  
Inclusion Criteria ◽  
Beneficial Effects ◽  
Skeletal Effects

Background: Osteoporosis results from excessive bone resorption and reduced bone formation, triggered by sex hormone deficiency, oxidative stress and inflammation. Tanshinones are a class of lipophilic phenanthrene compounds found in the roots of Salvia miltiorrhiza with antioxidant and anti-inflammatory activities, which contribute to its anti-osteoporosis effects. This systematic review aims to provide an overview of the skeletal beneficial effects of tanshinones. Methods: A systematic literature search was conducted in January 2021 using Pubmed, Scopus and Web of Science from the inception of these databases. Original studies reporting the effects of tanshinones on bone through cell cultures, animal models and human clinical trials were considered. Results: The literature search found 158 unique articles on this topic, but only 20 articles met the inclusion criteria and were included in this review. The available evidence showed that tanshinones promoted osteoblastogenesis and bone formation while reducing osteoclastogenesis and bone resorption. Conclusions: Tanshinones modulates bone remodelling by inhibiting osteoclastogenesis and osteoblast apoptosis and stimulating osteoblastogenesis. Therefore, it might complement existing strategies to prevent bone loss.

scholarly journals Trapped Between Two Pandemics: Domestic Violence Cases Under COVID-19 Pandemic Lockdown: A Scoping Review

2021 ◽  
pp. 0272684X2110221
Author(s):  
Endurance Uzobo ◽  
Aboluwaji D Ayinmoro
Keyword(s):  
South Africa ◽  
Domestic Violence ◽  
Scoping Review ◽  
Literature Search ◽  
Web Of Science ◽  
Biomed Central ◽  
Inclusion Criteria ◽  
African Countries ◽  
The World ◽  
The Government

Background As it is common with the most devastating events in the world, women always seem to be at the most disadvantage position. This situation manifested during the period of COVID-19 lockdown throughout the world and Africa in particular. The purpose of this study is to explore Domestic Violence (DV) cases in African during the COVID-19 lockdown. Methods Data for this study were gleaned from an electronic literature search using various databases PubMed and BioMed Central, Web of Science, etc. Key search words were gender DV during and after COVID-19. A total of 68 records were identified during the search. However, only 46 of these sources met the inclusion criteria. Results From the review done in selected African countries which include Egypt, South Africa, Kenya, Nigeria, Ghana and Zimbabwe; it was discovered that COVID-19 lockdown across these countries worsens the already existing cases of DV. The study also noted that generally, the response of the government has been very poor in terms of dealing with DV cases in the period of COVID-19 lockdown. Conclusion The study concluded that despite the failures of government in tackling the DV pandemics, NGOs have been very active in championing the cause of those violated while also trying to provide succour to victims. Thus, the study recommended that countries in Africa need to join international initiatives in prioritising DV cases while trying to deal with the virus itself. Thus, one disease should not be traded for another.

scholarly journals Review of Terms and Definitions Used in Descriptions of Running Shoes

2020 ◽  
Vol 17 (10) ◽  
pp. 3562 ◽  
Author(s):  
Ana Marchena-Rodriguez ◽  
Ana Belen Ortega-Avila ◽  
Pablo Cervera-Garvi ◽  
David Cabello-Manrique ◽  
Gabriel Gijon-Nogueron
Keyword(s):  
Motion Control ◽  
Literature Search ◽  
Web Of Science ◽  
Google Scholar ◽  
Inclusion Criteria ◽  
Large Group ◽  
New Approaches ◽  
Running Shoes ◽  
Different Types ◽  
Definition Of

Objective: Our study aim is to identify and describe the definitions used for different types of running shoes. In addition, we highlight the existence of gaps in these concepts and propose possible new approaches. Methods: This review was undertaken in line with the guidelines proposed by Green et al., based on a literature search (until December 2019) of the PubMed, Web of Science, Scopus, SPORTDiscus and Google Scholar databases. A total of 23 papers met the inclusion criteria applied to identify the definition of running shoes. Results: Although there is a certain consensus on the characteristics of minimalist footwear, it is also described by other terms, such as barefoot-style or barefoot-simulating. Diverse terms are also used to describe other types of footwear, and in these cases, there is little or no consensus regarding their characteristics. Conclusions: The terms barefoot-simulated footwear, barefoot-style footwear, lightweight shoes and full minimalist shoes are all used to describe minimalist footwear. The expressions partial minimalist, uncushioned minimalist and transition shoes are used to describe footwear with non-consensual characteristics. Finally, labels such as shod shoes, standard cushioned running shoes, modern shoes, neutral protective running shoes, conventional, standardised, stability style or motion control shoes span a large group of footwear styles presenting different properties.

Mental Practice Combined With Physical Practice to Enhance Upper Extremity Functional Ability Poststroke: A Systematic Review

2020 ◽  
Vol 3 (2) ◽  
pp. 51-61
Author(s):  
Anas R. Alashram ◽  
Giuseppe Annino ◽  
Mohammed Al-qtaishat ◽  
Elvira Padua
Keyword(s):  
Upper Extremity ◽  
Functional Ability ◽  
Randomized Clinical Trials ◽  
Web Of Science ◽  
Mental Practice ◽  
Inclusion Criteria ◽  
Physical Practice ◽  
Beneficial Effects ◽  
Stroke Population ◽  
Treatment Dosage

Background: Upper extremity deficits are one of the most common impairments in individuals with stroke. Mental practice is exercised cognitively in the absence of the physical trials. The effects of the combination of mental and physical practice remain unclear. Objectives: This study aimed to examine the effects of combined physical practice and mental practice on the upper extremity functional ability poststroke, to identify which stroke population is most likely to benefit from the intervention, and to determine the effective treatment dosage. Methods: We searched in the PubMed, SCOPUS, National Rehabilitation Information REHABDATA, PEDro, and Web of Science until February 2020. Randomized clinical trials examined the effects of combined physical practice and mental practice on the upper extremity functional ability in people with a stroke. The risk of bias was evaluated and the effect sizes were calculated. Results: Nine studies met our inclusion criteria. In total, 230 stroke survivors were included in this analysis (mean age: 60.84 years). This review found that combining physical practice and mental practice has beneficial effects in improving the upper extremity functional ability poststroke. Conclusion: Combining physical practice and mental practice improves the upper extremity functional ability poststroke, this improvement can extend for 3 months after the treatment intervention. We propose that using 30 to 60 min of physical practice followed by 30 min of mental practice, 2 to 3 times weekly for 6 to 10 weeks, may give meaningful effects in individuals with stroke.

scholarly journals SIKs control osteocyte responses to parathyroid hormone

2016 ◽  
Vol 7 (1) ◽  
Author(s):  
Marc N. Wein ◽  
Yanke Liang ◽  
Olga Goransson ◽  
Thomas B. Sundberg ◽  
Jinhua Wang ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Bone Resorption ◽  
Bone Formation ◽  
Small Molecule ◽  
Nuclear Translocation ◽  
Rna Seq ◽  
Once Daily ◽  
Skeletal Effects ◽  
Stimulation Of

Abstract Parathyroid hormone (PTH) activates receptors on osteocytes to orchestrate bone formation and resorption. Here we show that PTH inhibition of SOST (sclerostin), a WNT antagonist, requires HDAC4 and HDAC5, whereas PTH stimulation of RANKL, a stimulator of bone resorption, requires CRTC2. Salt inducible kinases (SIKs) control subcellular localization of HDAC4/5 and CRTC2. PTH regulates both HDAC4/5 and CRTC2 localization via phosphorylation and inhibition of SIK2. Like PTH, new small molecule SIK inhibitors cause decreased phosphorylation and increased nuclear translocation of HDAC4/5 and CRTC2. SIK inhibition mimics many of the effects of PTH in osteocytes as assessed by RNA-seq in cultured osteocytes and following in vivo administration. Once daily treatment with the small molecule SIK inhibitor YKL-05-099 increases bone formation and bone mass. Therefore, a major arm of PTH signalling in osteocytes involves SIK inhibition, and small molecule SIK inhibitors may be applied therapeutically to mimic skeletal effects of PTH.

scholarly journals Female-Specific Role of Progranulin to Suppress Bone Formation

Endocrinology ◽  
2019 ◽  
Vol 160 (9) ◽  
pp. 2024-2037 ◽  
Author(s):  
Liping Wang ◽  
Theresa Roth ◽  
Mary C Nakamura ◽  
Robert A Nissenson
Keyword(s):  
Bone Resorption ◽  
Bone Formation ◽  
Microglial Cells ◽  
Treatment Of Osteoporosis ◽  
Female Mice ◽  
Diet Induced Obesity ◽  
Skeletal Effects ◽  
Female Specific ◽  
Osteogenic Factors

Abstract Progranulin (PGRN) is best known as a glial protein for which deficiency leads to the most common inherited form of frontotemporal dementia. Recently, PGRN has been found to be an adipokine associated with diet-induced obesity and insulin resistance. Therefore, PGRN may have homeostatic effects on bone because PGRN is reported to promote the differentiation of bone-resorbing osteoclasts. We investigated the actions of PGRN on bone using PGRN gene (Grn) knockout (KO) mice and transgenic mice with PGRN mutation and surprisingly found that loss of PGRN prevented the bone loss in female mice induced by aging and estrogen deficiency, whereas it had no effect on male bones during aging. Strikingly, bone formation was increased in female (but not male) PGRN KO mice. We also found that loss of PGRN inhibited bone resorption and osteoclastogenesis in both male and female mice and promoted the production of osteogenic factors in osteoclast lineage cells. These results indicate that PGRN serves to uncouple bone turnover in female mice by promoting bone resorption and suppressing bone formation. Furthermore, we demonstrated that microglial cells/macrophages, but not adipocytes, are an important source of PGRN in producing negative skeletal effects in females. Targeting PGRN production by microglial cells/macrophage-lineage cells may provide a therapeutic approach for the treatment of osteoporosis in females.

scholarly journals Influence of Sexuality on the Health of the Elderly in Process of Dementia: Integrative Review

Aquichan ◽  
2020 ◽  
Vol 20 (1) ◽  
pp. 1-13
Author(s):  
Edison Vitório de Souza Júnior ◽  
Cristiane dos Santos Silva ◽  
Poliana Souza Lapa ◽  
Laís Emily Souza Trindade ◽  
Benedito Fernandes da Silva Filho ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Web Of Science ◽  
The Elderly ◽  
Health Science ◽  
Integrative Review ◽  
Inclusion Criteria ◽  
Medical Subject Headings ◽  
Beneficial Effects ◽  
Perception Of Quality

Objective: this work sought to inquire on the influence of sexuality on the health of the elderly during dementia. Materials and Methods: this was an integrative review. A careful search was conducted in nine databases; however, only five databases provided articles fulfilling the scope of the study: Medline, Lilacs, BDENF, Scopus, and Web of Science (WoS). The health science descriptors (DeCS) were adopted: “sexualidad”, “demencia” and “anciano”, and the descriptors cataloged in the Medical Subject Headings (MeSH): “sexuality”, “dementia” and “aged”. After applying the inclusion criteria, eight articles were selected to comprise the study sample. Results: the practice of sexuality influences upon the health of the elderly with dementia with some beneficial effects, given that it provides, especially, better perception of quality of life and wellbeing. Nevertheless, it cannot be generalized due to methodological insufficiency evidenced in the studies found to construct this review. Conclusions: due to the limitation of studies addressing the theme and the methodological insufficiency of those included in this review, it is necessary to conduct research that shows in depth the influence of sexuality on this population, given that it can be constituted as another approach for the promotion and protection of health in the elderly with dementia.

Whole-body and site-specific bone remodelling in patients with previous femoral fractures: relationships between reduced physical activity, reduced bone mass and increased bone resorption

1992 ◽  
Vol 83 (6) ◽  
pp. 665-675 ◽  
Author(s):  
J. S. Wand ◽  
T. Smith ◽  
J. R. Green ◽  
R. Hesp ◽  
J. N. Bradbeer ◽  
...  
Keyword(s):  
Physical Activity ◽  
Bone Resorption ◽  
Bone Formation ◽  
Proximal Femur ◽  
Bone Remodelling ◽  
Femoral Fractures ◽  
Therapeutic Interventions ◽  
Whole Body ◽  
Hydroxyproline Excretion ◽  
Body Bone

1. A new tracer method is described for the noninvasive measurement of bone formation in the proximal femur. The method is based on our previously described whole-body method using 85Sr as the tracer (Reeve, J., Hesp, R. & Wootton, R. Calcif. Tissue Res. 1976; 22, 191–206). It allows correction to be made for long-term exchange processes within the skeleton. 2. The method has been applied in a study of regional and whole-body bone formation in 12 rehabilitated patients who had previously suffered a fracture of the proximal femur. Twelve healthy control subjects were studied, who were selected for their good health and continued physical activity. The aim was to explore the relationship between bone formation and physical activity. 3. Bone formation was similar in the two groups, both regionally and in the whole body. Based on analyses of four cadaver specimens, bone formation in the proximal femur was about one and two-thirds times that in the whole skeleton when related to mass of calcium in the region of interest. 4. Whole-body bone resorption, estimated from five measurements per subject of hydroxyproline excretion in relation to creatinine excretion, was significantly higher in the fracture patients (P<0.01, Wilcoxon's test). 5. Estimates of current physical activity (and immediate pre-fracture physical activity) were made with a newly devised questionnaire. Historical levels of physical activity (at ages 15–45 years) were determined with Astrom's questionnaire. No bone formation index correlated with any index of physical activity. Urinary hydroxyproline excretion correlated inversely both with current physical activity and historical physical activity (for both regression coefficients P<0.01). 6. The results are discussed in the light of our current understanding of the control of bone remodelling by the discrete basic multicellular units of bone. The opportunity to study regional bone resorption by the additional use of serial dual X-ray absorptiometry of the same region will in future allow the direct monitoring of the effects of therapeutic interventions which have been designed to prevent contralateral hip fracture.

scholarly journals Molecular understanding of pharmacological treatment of osteoporosis

2019 ◽  
Vol 4 (4) ◽  
pp. 158-164 ◽  
Author(s):  
Sakae Tanaka
Keyword(s):  
Bone Resorption ◽  
Bone Formation ◽  
Bone Turnover ◽  
Pharmacological Treatment ◽  
Bone Remodelling ◽  
Health Concern ◽  
Anabolic Agents ◽  
Treatment Of Osteoporosis ◽  
Turnover Process ◽  
Skeletal Integrity

Osteoporosis is a serious health concern, particularly in aged societies. The burden of osteoporosis with its associated morbidity and mortality due to fracture has become a critical socioeconomic problem. Skeletal integrity is maintained through a balance of bone resorption and bone formation. The bone turnover process, called bone remodelling. Recently, a number of anti-osteoporosis drugs with excellent anti-osteoporosis and fracture effects have been developed. They are mainly classified into two groups according to their effects on bone remodelling: anti-resorptive agents and anabolic agents. Cite this article: EFORT Open Rev 2019;4:158-164. DOI: 10.1302/2058-5241.4.180018

scholarly journals Heliotropium indicum L.: From Farm to a Source of Bioactive Compounds with Therapeutic Activity

2021 ◽  
Vol 2021 ◽  
pp. 1-21
Author(s):  
Chandan Sarkar ◽  
Milon Mondal ◽  
Bilkis Khanom ◽  
Md. Monir Hossain ◽  
Md. Solayman Hossain ◽  
...  
Keyword(s):  
Animal Models ◽  
Literature Search ◽  
Pyrrolizidine Alkaloids ◽  
Web Of Science ◽  
Therapeutic Activity ◽  
Bioactive Components ◽  
Volatile Oils ◽  
Beneficial Effects ◽  
Heliotropium Indicum

This study aimed to summarize the available data on the ethnomedicinal and phytopharmacological activities of Heliotropium indicum L. based on database reports. For this purpose, an up-to-date literature search was carried out in the Google Scholar, Scopus, Springer Link, Web of Science, ScienceDirect, ResearchGate, PubMed, Chem Spider, Elsevier, BioMed Central, and patent offices (e.g., USPTO, CIPO, NPI, Google patents, and Espacenet) for the published materials. The findings suggest that the plant contains many important phytochemicals, including pyrrolizidine alkaloids, indicine, echinitine, supinine, heleurine, heliotrine, lasiocarpine, acetyl indicine, indicinine, indicine N-oxide, cynoglossine, europine N-oxide, heleurine N-oxide, heliotridine N-oxide, heliotrine N-oxide, heliotrine, volatile oils, triterpenes, amines, and sterols. Scientific reports revealed that the herb showed antioxidant, analgesic, antimicrobial, anticancer, antituberculosis, antiplasmodial, anticataract, antifertility, wound healing, antiinflammatory, antinociceptive, antihyperglycemic, anthelmintic, diuretic, antitussive, antiglaucoma, antiallergic, and larvicidal activity. In conclusion, in vitro studies with animal models seem to show the potential beneficial effects of H. indicum against a wide variety of disorders and as a source of phytotherapeutic compounds. However, clinical studies are necessary to confirm the effects observed in animal models, determine the toxicity of the therapeutic dose and isolate the truly bioactive components.

scholarly journals Tanshinol Alleviates Microcirculation Disturbance and Impaired Bone Formation by Attenuating TXNIP Signaling in GIO Rats

2021 ◽  
Vol 12 ◽  
Author(s):  
Wenxiu Lai ◽  
Yulin Mo ◽  
Dongtao Wang ◽  
Ying Zhong ◽  
Lujiao Lu ◽  
...  
Keyword(s):  
Bone Formation ◽  
Salvia Miltiorrhiza ◽  
Underlying Mechanism ◽  
Sprague Dawley ◽  
Migration Ability ◽  
Beneficial Effects ◽  
Western Blot Method ◽  
Mg63 Cells ◽  
Microcirculation Disturbance ◽  
And Function

Impaired bone formation is the main characteristics of glucocorticoid (GC)-induced osteoporosis (GIO), which can be ameliorated by tanshinol, an aqueous polyphenol isolated from Salvia miltiorrhiza Bunge. However, the underlying mechanism is still not entirely clear. In the present study, we determined the parameters related to microstructure and function of bone tissue, bone microcirculation, and TXNIP signaling to investigate the beneficial effects of tanshinol on skeleton and its molecular mechanism in GIO rats. Male Sprague-Dawley rats aged 4 months were administrated orally with distilled water (Con), tanshinol (Tan, 25 mg kg−1 d−1), prednisone (GC, 5 mg kg−1 d−1) and GC plus tanshinol (GC + Tan) for 14 weeks. The results demonstrated that tanshinol played a significant preventive role in bone loss, impaired microstructure, dysfunction of bone metabolism and poor bone quality, based on analysis of correlative parameters acquired from the measurement by using Micro-CT, histomorphometry, ELISA and biomechanical assay. Tanshinol also showed a significant protective effect in bone microcirculation according to the evidence of microvascular perfusion imaging of cancellous bone in GIO rats, as well as the migration ability of human endothelial cells (EA.hy926, EA cells). Moreover, tanshinol also attenuated GC-elicited the activation of TXNIP signaling pathway, and simultaneously reversed the down-regulation of Wnt and VEGF pathway as manifested by using Western-blot method in GIO rats, EA cells, and human osteoblast-like MG63 cells (MG cells). Collectively, our data highlighted that tanshinol ameliorated poor bone health mediated by activation of TXNIP signaling via inhibiting microcirculation disturbance and the following impaired bone formation in GIO rats.

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