scholarly journals Exploring Gunnera tinctoria: From Nutritional and Anti-Tumoral Properties to Phytosome Development Following Structural Arrangement Based on Molecular Docking

Molecules ◽  
2021 ◽  
Vol 26 (19) ◽  
pp. 5935
Author(s):  
Faezeh Fathi ◽  
Samad N. Ebrahimi ◽  
Ana I. G. Valadão ◽  
Nelson Andrade ◽  
Anabela S. G. Costa ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Phenolic Compounds ◽  
Invasive Plant ◽  
Molecular Size ◽  
Key Factors ◽  
Natural Polymers ◽  
Phenolic Fraction ◽  
Molecular Arrangement ◽  
Anionic Charge ◽  
Micrometer Size

Gunnera tinctoria, an underexplored invasive plant found in Azores, Portugal, was studied regarding its nutritional, antioxidant, and antitumoral properties. Higher antioxidant activity was found in baby leaves, followed by adult leaves and inflorescences. A phenolic fraction of the plant was enriched using adsorbent resin column chromatography (DiaionTM HP20LX, and Relite EXA90). Antitumoral effects were observed with the enriched fractions in breast (MCF-7) and pancreatic (AsPC-1) cancer cell lines, being more pronounced in the latter. To improve protection and membrane absorption rates of phenolic compounds, nano-phytosomes and cholesterol-conjugated phytosomes coated with natural polymers were loaded with the enriched fraction. The particles were characterized, and their physiochemical properties were evaluated and compared. All samples presented anionic charge and nanometer size in relation to the inner layer and micrometer size regarding the external layers. In addition, the molecular arrangement of phenolics within both types of phytosomes were studied for the first time by molecular docking. Polarity and molecular size were key factors on the molecular arrangement of the lipid bilayer. In conclusion, G. tinctoria showed to be an interesting source of nutrients and phenolic compounds with anti-tumoral potential. Moreover, phytosome loading with these compounds can increase their stability and bioavailability having in view future applications.

scholarly journals Analysis of Antioxidant and Antiallergic Active Components Extracted From the Edible Insect Oxya yezoensis

2021 ◽  
Vol 16 (5) ◽  
pp. 1934578X2110233
Author(s):  
Masahiro Saiki ◽  
Naomichi Takemoto ◽  
Maki Nagata ◽  
Masako Matsumoto ◽  
Yhiya Amen ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Phenolic Compounds ◽  
Unsaturated Fatty Acids ◽  
Soluble Fraction ◽  
Total Phenolic ◽  
Key Factors ◽  
Active Components ◽  
Food And Agriculture ◽  
Food And Agriculture Organization

In recent years, entomophagy has attracted increased attention, as it was recommended as a potential source of food by the Food and Agriculture Organization of the United Nations. In Japan, Oxya yezoensisis one of the most widely eaten insect species, but studies of its functionality as a food are limited. In this study, we reported the optimal characterization of the total phenolic compounds in methanolic extract (OME) and different fractions of OME. Additionally, the antioxidant and antiallergic activities of the OME fractions were evaluated. The results showed that the ethyl acetate-soluble fraction of OME has potential antioxidant activity, whereas the n-hexane-soluble fraction showed the strongest inhibition of β-hexosaminidase, which is one of the key factors in allergic reactions. It was concluded that phenolic compounds might contribute to the antioxidant activity while unsaturated fatty acids contribute to the antiallergy activity.

scholarly journals Molecular docking of phenolic compounds and screening of antioxidant and antidiabetic potential of Olea europaea L. Ethanolic leaves extract

2021 ◽  
Vol 14 (11) ◽  
pp. 103422
Author(s):  
Sridevi Chigurupati ◽  
Fayhaa Saad Alharbi ◽  
Suliman Almahmoud ◽  
Maha Aldubayan ◽  
Yosif Almoshari ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Phenolic Compounds ◽  
Olea Europaea ◽  
Olea Europaea L ◽  
Olea Europaéa

scholarly journals A Phenolic Fraction from Catharanthus roseus L. Stems Decreases Glycemia and Stimulates Insulin Secretion

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Janet Alejandra Espejel-Nava ◽  
Elisa Vega-Avila ◽  
Francisco Alarcon-Aguilar ◽  
Alejandra Contreras-Ramos ◽  
Guadalupe Díaz-Rosas ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Phenolic Compounds ◽  
Chlorogenic Acid ◽  
Gallic Acid ◽  
Catharanthus Roseus ◽  
Chromatographic Analysis ◽  
Hypoglycemic Effect ◽  
Diabetic Mice ◽  
Rinm5f Cells ◽  
Phenolic Fraction

Catharanthus roseus (L.) G. (C. roseus) is a medicinal plant used traditionally for diabetes mellitus control. Several compounds of an alkaloidal nature have been proposed as hypoglycemic principles. However, little attention has been paid to other compounds in this plant that could also participate in this hypoglycemic activity. This study aimed to analyze the hypoglycemic effect of a polyphenolic fraction from C. roseus, as well as its action on insulin secretion and expression in RINm5F cells. Methods. An alkaloid-free aqueous extract was obtained from C. roseus stems. The hypoglycemic effect of different doses of this extract was evaluated in normal and streptozotocin-induced diabetic mice. This extract was fractionated by bipartition, and the resultant fractions were assessed by their hypoglycemic effects. Subsequently, the fraction with the greater hypoglycemic activity was added to the RINm5F cells, and the expression and secretion of insulin were analyzed. The antioxidant activity was determined by the DPPH method and through chromatographic analysis of the most active fraction by HPLC, using an Econosphere C18 column. Results. The aqueous alkaloid-free extract of C. roseus stems significantly reduced blood glucose in normal and diabetic mice. The fractionation of this extract provided three fractions, one of which (a precipitate) showed significant reductions in glycemia at 6 h (48.1 and 64.5% in normal and diabetic mice, respectively). This precipitate contained phenolic compounds and saponins. Its chromatographic analysis showed that it is formed by several phenolic compounds; gallic acid (0.053%) and chlorogenic acid (0.216%) were identified and quantified. Conclusion. The phenolic fraction of C. roseus containing gallic acid and chlorogenic acid had a hypoglycemic effect that may be explained by an increase in insulin secretion.

scholarly journals Plant Phenolics as Pathogen-Carrier Immunogenicity Modulator Haptens

2020 ◽  
Vol 21 (10) ◽  
pp. 897-905
Author(s):  
Castillo-Maldonado Irais ◽  
Sevilla-González María-de-la-Luz ◽  
Delgadillo-Guzmán Dealmy ◽  
Ramírez-Moreno Agustina ◽  
Cabral-Hipólito Nidia ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Protein Interactions ◽  
Structural Complexity ◽  
Molecular Size ◽  
Structural Heterogeneity ◽  
Antigenic Determinants ◽  
Plant Phenolics ◽  
Protein Protein Interactions ◽  
Related Factors ◽  
Molecular Events

Background: Pathogens use multiple mechanisms to disrupt cell functioning in their host and allow pathogenesis. These mechanisms involve communication between the pathogen and the host cell through protein-protein interactions. Methods: Protein-protein interactions chains referred to as signal transduction pathways are the processes by which a chemical or physical signal transmits through a cell as series of molecular events so the pathogen needs to intercept these molecular pathways at few positions to induce pathogenesis such as pathogen viability, infection or hypersensitivity. Results: The pathogen nodes of interception are not necessarily the most immunogenic; so that novel immunogenicity-improvement strategies need to be developed thought a chemical conjugation of the pathogen-carrier nodes to develop an efficient immune response in order to block pathogenesis. On the other hand, if pathogen-carriers are immunogens; toleration ought to be induced by this conjugation avoiding hypersensitivity. Thus, this paper addresses the biological plausibility of plant-phenolics as pathogen-carrier immunogenicity modulator haptens. Conclusion: The plant-phenolic compounds have in their structure functional groups such as hydroxyl, carbonyl, carboxyl, ester, or ether, capable of reacting with the amino or carbonyl groups of the amino acids of a pathogen-carrier to form conjugates. Besides, the varied carbon structures these phenolic compounds have; it is possible to alter the pathogen-carrier related factors that determine the immunogenicity: 1) Structural complexity, 2) Molecular size, 3) Structural heterogeneity, 4) Accessibility to antigenic determinants or epitopes, 5) Optical configuration, 6) Physical state, or 7) Molecular rigidity.

Synthesis of bio-based epoxy monomers from natural allyl- and vinyl phenols and the estimation of their affinity to the estrogen receptor α by molecular docking

2016 ◽  
Vol 40 (9) ◽  
pp. 7701-7710 ◽  
Author(s):  
Erika Zago ◽  
Eric Dubreucq ◽  
Jérôme Lecomte ◽  
Pierre Villeneuve ◽  
Frédéric Fine ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Molecular Docking ◽  
Phenolic Compounds ◽  
Bisphenol A ◽  
Estrogen Receptor Α ◽  
Diglycidyl Ether ◽  
Metathesis Reaction

Potential substitutes of diglycidyl ether of bisphenol A (DGEBA) were synthesized by the metathesis reaction of glycidylated biobased phenolic compounds.

scholarly journals Antioxidant activity of phenolic fraction of pea (Pisum sativum)

2013 ◽  
Vol 19 (No. 4) ◽  
pp. 139-142 ◽  
Author(s):  
R. Amarowicz ◽  
M. Karamać ◽  
S. Weidner
Keyword(s):  
Antioxidant Activity ◽  
Phenolic Compounds ◽  
Total Phenolics ◽  
Antioxidant Activities ◽  
Beta Carotene ◽  
Uv Spectra ◽  
Model System ◽  
Total Phenolic ◽  
Total Phenolic Compounds ◽  
Phenolic Fraction

An extract of seeds of pea was prepared using 80% (v/v) acetone. Six fractions (I–VI) were separated from the crude extract on a Sephadex LH-20 column using methanol as the mobile phase. The antioxidant activity of fractions was investigated in a β-carotene-linoleate model system. For individual fractions, UV spectra were recorded and the content of total phenolics was determined. Results of the β-carotene-linoleate model system indicated that antioxidant activities of separated fractions correlated with their content of total phenolic compounds and they decreased in the order of IV = VI > V > III > I > II. The antioxidant activity of fractions IV and VI was very strong as compared with that of butylated hydroxyanisole (BHA). Absorption maxima from UV spectra showed that flavonoids, and not phenolic acids, were the main phenolic compounds in separated fractions.

Lactoperoxidase inhibition of some natural phenolic compounds: Kinetics and molecular docking studies

2019 ◽  
Vol 44 (2) ◽  
Author(s):  
Zeynep Koksal ◽  
Ramazan Kalin ◽  
Pinar Kalin ◽  
Muhammet Karaman ◽  
İlhami Gulcin ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Phenolic Compounds ◽  
Docking Studies ◽  
Molecular Docking Studies ◽  
Natural Phenolic Compounds
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