Effects of Zeolite as a Drug Delivery System on Cancer Therapy: A Systematic Review

Zeolites and zeolitic imidazolate frameworks (ZIFs) are widely studied as drug carrying nanoplatforms to enhance the specificity and efficacy of traditional anticancer drugs. At present, there is no other systematic review that assesses the potency of zeolites/ZIFs as anticancer drug carriers. Due to the porous nature and inherent pH-sensitive properties of zeolites/ZIFs, the compounds can entrap and selectively release anticancer drugs into the acidic tumor microenvironment. Therefore, it is valuable to provide a comprehensive overview of available evidence on the topic to identify the benefits of the compound as well as potential gaps in knowledge. The purpose of this study was to evaluate the potential therapeutic applications of zeolites/ZIFs as drug delivery systems delivering doxorubicin (DOX), 5-fluorouracil (5-FU), curcumin, cisplatin, and miR-34a. Following PRISMA guidelines, an exhaustive search of PubMed, Scopus, Embase, and Web of Science was conducted. No language or time limitations were used up to 25th August 2021. Only full text articles were selected that pertained to the usage of zeolites/ZIFs in delivering anticancer drugs. Initially, 1279 studies were identified, of which 572 duplicate records were excluded. After screening for the title, abstract, and full texts, 53 articles remained and were included in the qualitative synthesis. An Inter-Rater Reliability (IRR) test, which included a percent user agreement and reliability percent, was conducted for the 53 articles. The included studies suggest that anticancer drug-incorporated zeolites/ZIFs can be used as alternative treatment options to enhance the efficacy of cancer treatment by mitigating the drawbacks of drugs under conventional treatment.

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Advances in Nanoparticles as Anticancer Drug Delivery Vector: Need of this Century

Current Pharmaceutical Design ◽

10.2174/1381612826666200203124330 ◽

2020 ◽

Vol 26 (15) ◽

pp. 1637-1649 ◽

Cited By ~ 3

Author(s):

Imran Ali ◽

Sofi D. Mukhtar ◽

Heyam S. Ali ◽

Marcus T. Scotti ◽

Luciana Scotti

Keyword(s):

Drug Delivery ◽

Anticancer Drug ◽

Medical Science ◽

Drug Carriers ◽

Anticancer Drug Delivery ◽

Ph Values ◽

Delivery Vector ◽

Future Challenges ◽

Smart Drug ◽

Smart Drug Delivery

Background: Nanotechnology has contributed a great deal to the field of medical science. Smart drugdelivery vectors, combined with stimuli-based characteristics, are becoming increasingly important. The use of external and internal stimulating factors can have enormous benefits and increase the targeting efficiency of nanotechnology platforms. The pH values of tumor vascular tissues are acidic in nature, allowing the improved targeting of anticancer drug payloads using drug-delivery vectors. Nanopolymers are smart drug-delivery vectors that have recently been developed and recommended for use by scientists because of their potential targeting capabilities, non-toxicity and biocompatibility, and make them ideal nanocarriers for personalized drug delivery. Method: The present review article provides an overview of current advances in the use of nanoparticles (NPs) as anticancer drug-delivery vectors. Results: This article reviews the molecular basis for the use of NPs in medicine, including personalized medicine, personalized therapy, emerging vistas in anticancer therapy, nanopolymer targeting, passive and active targeting transports, pH-responsive drug carriers, biological barriers, computer-aided drug design, future challenges and perspectives, biodegradability and safety. Conclusions: This article will benefit academia, researchers, clinicians, and government authorities by providing a basis for further research advancements.

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Cathepsin B-Responsive Liposomes for Controlled Anticancer Drug Delivery in Hep G2 Cells

Pharmaceutics ◽

10.3390/pharmaceutics12090876 ◽

2020 ◽

Vol 12 (9) ◽

pp. 876

Author(s):

Seulgi Lee ◽

Su Jeong Song ◽

Jeil Lee ◽

Tai Hwan Ha ◽

Joon Sig Choi

Keyword(s):

Drug Delivery ◽

Anticancer Drugs ◽

Cancer Cell ◽

Anticancer Drug ◽

Cathepsin B ◽

Chloride Salt ◽

Hep G2 ◽

Hep G2 Cells ◽

Anticancer Drug Delivery ◽

G2 Cells

In recent decades, several types of anticancer drugs that inhibit cancer cell growth and cause cell death have been developed for chemotherapeutic application. However, these agents are usually associated with side effects resulting from nonspecific delivery, which may induce cytotoxicity in healthy cells. To reduce the nonspecific delivery issue, nanoparticles have been successfully used for the delivery of anticancer drugs to specific target sites. In this study, a functional polymeric lipid, PEG-GLFG-K(C16)2 (PEG-GLFG, polyethylene glycol-Gly-Leu-Phe-Gly-Lys(C16)2), was synthesized to enable controlled anticancer drug delivery using cathepsin B enzyme-responsive liposomes. The liposomes composed of PEG-GLFG/DOTAP (1,2-dioleoyl-3-trimethylammonium-propane (chloride salt))/DPPC (dipalmitoylphosphatidylcholine)/cholesterol were prepared and characterized at various ratios. The GLFG liposomes formed were stable liposomes and were degraded when acted upon by cathepsin B enzyme. Doxorubicin (Dox) loaded GLFG liposomes (GLFG/Dox) were observed to exert an effective anticancer effect on Hep G2 cells in vitro and inhibit cancer cell proliferation in a zebrafish model.

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Preparation and characterization of magnetic nanoparticles and their impact on anticancer drug binding and release processes moderated through a 1sttier dendrimer

RSC Advances ◽

10.1039/c6ra02139e ◽

2016 ◽

Vol 6 (44) ◽

pp. 37391-37402 ◽

Cited By ~ 1

Author(s):

Shivani R. Pandya ◽

Man Singh

Keyword(s):

Drug Delivery ◽

Magnetic Nanoparticles ◽

Anticancer Drugs ◽

Anticancer Drug ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Drug Binding ◽

Potential Use ◽

Release Processes

MNPs show superparamagnetic character which moderates the structural ability of TTDMM to bind silibinin (SB) and methotrexate (MTX) anticancer drugs for their potential use in drug delivery systems.

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Computational investigation of metal organic frameworks for storage and delivery of anticancer drugs

Journal of Materials Chemistry B ◽

10.1039/c7tb01764b ◽

2017 ◽

Vol 5 (35) ◽

pp. 7342-7351 ◽

Cited By ~ 21

Author(s):

Ilknur Erucar ◽

Seda Keskin

Keyword(s):

Anticancer Drugs ◽

Anticancer Drug ◽

Metal Organic Frameworks ◽

Drug Carriers ◽

Computational Investigation ◽

Drug Molecules ◽

Metal Organic

The potential of metal organic frameworks (MOFs) as binary drug carriers was computationally investigated for storage and delivery of two anticancer drug molecules, methotrexate (MTX) and 5-fluorouracil (5-FU).

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NANOSTRUCTURED LIPOSOMAL SYSTEMS AS TRANSPORT AGENTS FOR ANTICANCER DRUGS

Annals of the Russian academy of medical sciences ◽

10.15690/vramn.v67i3.181 ◽

2012 ◽

Vol 67 (3) ◽

pp. 23-31 ◽

Cited By ~ 10

Author(s):

A. Yu. Baryshnikov

Keyword(s):

Drug Delivery ◽

Anticancer Drugs ◽

Anticancer Drug ◽

Cancer Chemotherapy ◽

Biological Membranes ◽

Liposomal Formulation ◽

Anticancer Drug Delivery ◽

Chemical Stimuli ◽

Physical And Chemical ◽

Selective Accumulation

Liposomes quite recently have turned from a model of biological membranes into an object of extensive research and practical use. The versatile traits of liposomal formulation allow its' universal implementation, especially in cancer chemotherapy. The advantages of liposomal use as a carrier of an anticancer drug for its targeted selective accumulation are discussed in this article. This article contains description of new types of liposomes, differing in contents and use, such as: simple, sterically stabilized, targeted (immunoliposomes),cationic, sensitive to physical and chemical stimuli. The characteristics of liposomal systems of anticancer drug delivery designed at Blokhin Russian Oncological Scientific Centre is given in the article.

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Synthesis and Biological Studies of New Multifunctional Curcumin Platforms for Anticancer Drug Delivery

Medicinal Chemistry ◽

10.2174/1573406415666181203112220 ◽

2019 ◽

Vol 15 (5) ◽

pp. 537-549

Author(s):

Andrii Bazylevich ◽

Helena Tuchinsky ◽

Eti Zigman-Hoffman ◽

Ran Weissman ◽

Ofer Shpilberg ◽

...

Keyword(s):

Drug Delivery ◽

Cell Survival ◽

Anticancer Drugs ◽

Anticancer Drug ◽

Antioxidant Properties ◽

Radical Scavenging ◽

Multiple Drug ◽

Anticancer Drug Delivery ◽

Biological Studies

Background: Scientists have extensively investigated curcumin, yielding many publications on treatments of cancer. Numerous derivatives of curcumin were synthesized, evaluated for their anti-oxidant and free-radical scavenging, SAR, ADME properties and tested in anticancer applications. Objective: We decided to exploit curcumin as a bioactive core platform for carrying anticancer drugs, which likely possesses a carboxyl moiety for potential linkage to the carrier for drug delivery. Methods: The goal of this work is to develop biolabile multifunctional curcumin platforms towards anticancer drug delivery, including determination of drug release profiling in hydrolytic media, in vitro cytotoxicity, antioxidant properties and blockage of relevant cell survival pathways. Results: We report on a facile synthesis of the bioactive multifunctional curcumin-based platforms linked to a variety of anticancer drugs like amonafide and chlorambucil, and release of the drugs in a hydrolytic environment. The leading curcumin-based platform has presented antioxidant activity similar to curcumin, but with much more potent cytotoxicity in vitro in agreement with the augmented blockage of the NF-kB cell survival pathway. Conclusion: The approach presented here may prove beneficial for bioactive curcumin-based delivery applications where multiple drug delivery is required in a consecutive and controlled mode.

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Theranostic unimolecular micelles of highly fluorescent conjugated polymer bottlebrushes for far red/near infrared bioimaging and efficient anticancer drug delivery

Polymer Chemistry ◽

10.1039/c6py01838f ◽

2016 ◽

Vol 7 (48) ◽

pp. 7455-7468 ◽

Cited By ~ 31

Author(s):

Cangjie Yang ◽

Shuo Huang ◽

Xiaochen Wang ◽

Mingfeng Wang

Keyword(s):

Drug Delivery ◽

Anticancer Drugs ◽

Anticancer Drug ◽

Conjugated Polymer ◽

Near Infrared ◽

Cancer Imaging ◽

Anticancer Drug Delivery

Theranostic unimolecular micelles of highly fluorescent amphiphilic conjugated bottlebrushes loaded with anticancer drugs are efficient for cancer imaging and therapy.

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Advances in living cell-based anticancer therapeutics

Biomaterials Science ◽

10.1039/d0bm00036a ◽

2020 ◽

Vol 8 (9) ◽

pp. 2344-2365 ◽

Cited By ~ 3

Author(s):

He Dong ◽

Xiao Xu ◽

Leikun Wang ◽

Ran Mo

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Anticancer Drug ◽

Living Cell ◽

Drug Carriers ◽

Living Cells ◽

Anticancer Drug Delivery ◽

Recent Advances ◽

Anticancer Therapeutics

This review summarizes recent advances in the applications of living cells as drug carriers or active drugs for anticancer drug delivery and cancer therapy.

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Dietary Interventions for Gastroparesis in Pediatric and Adult Populations: A Systematic Review Protocol

10.21203/rs.3.rs-100214/v1 ◽

2020 ◽

Author(s):

Debra Okafor ◽

Tanya Su ◽

Keya Lee ◽

Bruno Chumpitazi ◽

Robert J Shulman ◽

...

Keyword(s):

Systematic Review ◽

Pediatric Patients ◽

Meta Analysis ◽

Treatment Options ◽

Future Research ◽

Dietary Interventions ◽

Time Data ◽

Comprehensive Overview ◽

Specific Patient ◽

Patient Reported

Abstract Background: Dietary interventions are the first-line treatment for patients with gastroparesis. It is unclear which diets are the most efficacious as well as clear guidance as to which diets should be recommended to adult versus pediatric patients. We plan to conduct this systematic review to assess the literature on the efficacy and effectiveness of dietary interventions on clinical outcomes in adult and pediatric patients with gastroparesis. Methods: We will search PubMed and EMBASE databases, evaluating randomized control trials and cohort studies that reported dietary interventions in gastroparesis. Our primary outcomes are to evaluate changes in symptom-specific patient-reported outcomes, changes in perception of quality of life, and changes in gastric emptying time. Data collected from the studies will be analyzed using meta-analysis. Depending on the outcome, we will use quantitative summary estimates (e.g., standardized mean difference with 95% Confidence Intervals, 95%CI) or dichotomous outcomes (e.g., odds ratio and 95%CI).Discussion: This review will explore the use of dietary interventions in the treatment of both adult and pediatric patients with gastroparesis, which has yet to be published in the literature. By assessing what has been investigated by researchers as effective non-pharmacologic treatments in patients, and providing a comprehensive overview of treatment options, healthcare providers will be able to better guide patient care. Furthermore, this review will act as a means to provide direction for future research. Systematic Review Registration: PROSPERO registration ID: CRD42020210536.

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Human fascioliasis in Africa: A systematic review

PLoS ONE ◽

10.1371/journal.pone.0261166 ◽

2021 ◽

Vol 16 (12) ◽

pp. e0261166

Author(s):

Veronique Dermauw ◽

Joan Muchai ◽

Yara Al Kappany ◽

Ana Lucia Fajardo Castaneda ◽

Pierre Dorny

Keyword(s):

Risk Factors ◽

Systematic Review ◽

Fasciola Hepatica ◽

Case Reports ◽

Relevant Literature ◽

Qualitative Synthesis ◽

African Countries ◽

Comprehensive Overview ◽

Actual Distribution ◽

Human Fascioliasis

Fascioliasis is a globally distributed, parasitic zoonosis, caused by Fasciola hepatica and F. gigantica. A comprehensive overview of the epidemiology of human fascioliasis in Africa is missing up to now. Therefore, our objective was to conduct a systematic review aiming to summarize recent knowledge on the distribution, prevalence, and risk factors of human fascioliasis in Africa. A key word search was performed in PubMed, Web of Science and Africa Wide, to gather relevant literature, published between the 1st of January 2000 and 31st of December 2020. A total of 472 records were initially retrieved, with 40 full text articles retained for the qualitative synthesis. Human fascioliasis was reported in 12 African countries, namely Algeria, Angola, Cape Verde, Egypt, Ethiopia, Ghana, Morocco, Nigeria, Senegal, South-Africa, Tanzania and Tunisia. The majority of the studies was conducted in Egypt. A total of 28 records were population surveys. Coproscopy was the most commonly used tool for fascioliasis diagnosis in these surveys. Gender (being female), consumption of raw vegetables/seeds, age, owning livestock, and use of unsafe drinking water sources, were identified as risk factors in 7 studies. Furthermore, 43 case reports were retrieved, described in 12 studies. Eosinophilia was present in 39 of these cases, while 11 had positive coproscopy results. Eight cases described having eaten raw wild vegetables. Overall, the low number and quality of records retrieved indicates that human fascioliasis remains a truly neglected disease in Africa, and more epidemiological studies are urgently needed to both establish the actual distribution as well as risk factors on the continent.

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