scholarly journals Optimization Study on Specific Loss Power in Superparamagnetic Hyperthermia with Magnetite Nanoparticles for High Efficiency in Alternative Cancer Therapy

Nanomaterials ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 40
Author(s):  
Costica Caizer
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Cancer Therapy ◽  
Tumor Cells ◽  
Heating Temperature ◽  
Magnetic Hyperthermia ◽  
Optimal Conditions ◽  
Specific Loss ◽  
Specific Loss Power ◽  
The Magnetic Field

The cancer therapy with the lowest possible toxicity is today an issue that raises major difficulties in treating malignant tumors because chemo- and radiotherapy currently used in this field have a high degree of toxicity and in many cases are ineffective. Therefore, alternative solutions are rapidly being sought in cancer therapy, in order to increase efficacy and a reduce or even eliminate toxicity to the body. One of the alternative methods that researchers believe may be the method of the future in cancer therapy is superparamagnetic hyperthermia (SPMHT), because it can be effective in completely destroying tumors while maintaining low toxicity or even without toxicity on the healthy tissues. Superparamagnetic hyperthermia uses the natural thermal effect in the destruction of cancer cells, obtained as a result of the phenomenon of superparamagnetic relaxation of the magnetic nanoparticles (SPMNPs) introduced into the tumor; SPMNPs can heat the cancer cells to 42–43 °C under the action of an external alternating magnetic field with frequency in the range of hundreds of kHz. However, the effectiveness of this alternative method depends very much on finding the optimal conditions in which this method must be applied during the treatment of cancer. In addition to the type of magnetic nanoparticles and the biocompatibility with the biological tissue or nanoparticles biofunctionalization that must be appropriate for the intended purpose a key parameter is the size of the nanoparticles. Also, establishing the appropriate parameters for the external alternating magnetic field (AMF), respectively the amplitude and frequency of the magnetic field are very important in the efficiency and effectiveness of the magnetic hyperthermia method. This paper presents a 3D computational study on specific loss power (Ps) and heating temperature (ΔT) which allows establishing the optimal conditions that lead to efficient heating of Fe3O4 nanoparticles, which were found to be the most suitable for use in superparamagnetic hyperthermia (SPMHT), as a non-invasive and alternative technique to chemo- and radiotherapy. The size (diameter) of the nanoparticles (D), the amplitude of the magnetic field (H) and the frequency (f) of AMF were established in order to obtain maximum efficiency in SPMHT and rapid heating of magnetic nanoparticles at the required temperature of 42–43 °C for irreversible destruction of tumors, without affecting healthy tissues. Also, an analysis on the amplitude of the AMF is presented, and how its amplitude influences the power loss and, implicitly, the heating temperature, observables necessary in SPMHT for the efficient destruction of tumor cells. Following our 3D study, we found for Fe3O4 nanoparticles the optimal diameter of ~16 nm, the optimal range for the amplitude of the magnetic field of 10–25 kA/m and the optimal frequency within the biologically permissible limit in the range of 200–500 kHz. Under the optimal conditions determined for the nanoparticle diameter of 16.3 nm, the magnetic field of 15 kA/m and the frequency of 334 kHz, the magnetite nanoparticles can be quickly heated to obtain the maximum hyperthermic effect on the tumor cells: in only 4.1–4.3 s the temperature reaches 42–43 °C, required in magnetic hyperthermia, with major benefits in practical application in vitro and in vivo, and later in clinical trials.

scholarly journals Theoretical Study on Specific Loss Power and Heating Temperature in CoFe2O4 Nanoparticles as Possible Candidate for Alternative Cancer Therapy by Superparamagnetic Hyperthemia

2021 ◽  
Vol 11 (12) ◽  
pp. 5505
Author(s):  
Costica Caizer
Keyword(s):  
Magnetic Field ◽  
Cancer Therapy ◽  
Theoretical Study ◽  
Heating Temperature ◽  
Cofe2o4 Nanoparticles ◽  
Specific Loss ◽  
Specific Loss Power ◽  
Wide Range ◽  
Range Of Values ◽  
Optimal Heating

In this paper, we present a theoretical study on the maximum specific loss power in the admissible biological limit (PsM)l for CoFe2O4 ferrimagnetic nanoparticles, as a possible candidate in alternative and non-invasive cancer therapy by superparamagnetic hyperthermia. The heating time of the nanoparticles (Δto) at the optimum temperature of approx. 43 °C for the efficient destruction of tumor cells in a short period of time, was also studied. We found the maximum specific loss power PsM (as a result of superparamegnetic relaxation in CoFe2O4 nanoparticles) for very small diameters of the nanoparticles (Do), situated in the range of 5.88–6.67 nm, and with the limit frequencies (fl) in the very wide range of values of 83–1000 kHz, respectively. Additionally, the optimal heating temperature (To) of 43 °C was obtained for a very wide range of values of the magnetic field H, of 5–60 kA/m, and the corresponding optimal heating times (Δto) were found in very short time intervals in the range of ~0.3–44 s, depending on the volume packing fraction (ε) of the nanoparticles. The obtained results, as well as the very wide range of values for the amplitude H and the frequency f of the external alternating magnetic field for which superparamagnetic hyperthermia can be obtained, which are great practical benefits in the case of hyperthermia, demonstrate that CoFe2O4 nanoparticles can be successfully used in the therapy of cancer by superaparamagnetic hyperthermia. In addition, the very small size of magnetic nanoparticles (only a few nm) will lead to two major benefits in cancer therapy via superparamagnetic hyperthermia, namely: (i) the possibility of intracellular therapy which is much more effective due to the ability to destroy tumor cells from within and (ii) the reduced cell toxicity.

scholarly journals Role of zinc substitution in magnetic hyperthermia properties of magnetite nanoparticles: interplay between intrinsic properties and dipolar interactions

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Yaser Hadadian ◽  
Ana Paula Ramos ◽  
Theo Z. Pavan
Keyword(s):  
Magnetic Nanoparticles ◽  
Magnetite Nanoparticles ◽  
Linear Response Theory ◽  
Magnetic Hyperthermia ◽  
Superior Performance ◽  
Dipolar Interactions ◽  
Intrinsic Properties ◽  
Specific Loss ◽  
Heating Efficiency ◽  
Specific Loss Power

AbstractOptimizing the intrinsic properties of magnetic nanoparticles for magnetic hyperthermia is of considerable concern. In addition, the heating efficiency of the nanoparticles can be substantially influenced by dipolar interactions. Since adequate control of the intrinsic properties of magnetic nanoparticles is not straightforward, experimentally studying the complex interplay between these properties and dipolar interactions affecting the specific loss power can be challenging. Substituting zinc in magnetite structure is considered as an elegant approach to tune its properties. Here, we present experimental and numerical simulation results of magnetic hyperthermia studies using a series of zinc-substituted magnetite nanoparticles (ZnxFe1-xFe2O4, x = 0.0, 0.1, 0.2, 0.3 and 0.4). All experiments were conducted in linear regime and the results were inferred based on the numerical simulations conducted in the framework of the linear response theory. The results showed that depending on the nanoparticles intrinsic properties, interparticle interactions can have different effects on the specific loss power. When dipolar interactions were strong enough to affect the heating efficiency, the parameter σ = KeffV/kBT (Keff is the effective anisotropy and V the volume of the particles) determined the type of the effect. Finally, the sample x = 0.1 showed a superior performance with a relatively high intrinsic loss power 5.4 nHm2kg−1.

scholarly journals Principles of Magnetic Hyperthermia: A Focus on Using Multifunctional Hybrid Magnetic Nanoparticles

2019 ◽  
Vol 5 (4) ◽  
pp. 67 ◽  
Author(s):  
Ihab M. Obaidat ◽  
Venkatesha Narayanaswamy ◽  
Sulaiman Alaabed ◽  
Sangaraju Sambasivam ◽  
Chandu V. V. Muralee Gopi
Keyword(s):  
Magnetic Nanoparticles ◽  
Cancer Therapy ◽  
Tumor Cells ◽  
Heat Generation ◽  
Colloidal Stability ◽  
Field Research ◽  
Magnetic Hyperthermia ◽  
Cellular Level ◽  
Effect Of Temperature ◽  
Factors Affecting

Hyperthermia is a noninvasive method that uses heat for cancer therapy where high temperatures have a damaging effect on tumor cells. However, large amounts of heat need to be delivered, which could have negative effects on healthy tissues. Thus, to minimize the negative side effects on healthy cells, a large amount of heat must be delivered only to the tumor cells. Magnetic hyperthermia (MH) uses magnetic nanoparticles particles (MNPs) that are exposed to alternating magnetic field (AMF) to generate heat in local regions (tissues or cells). This cancer therapy method has several advantages, such as (a) it is noninvasive, thus requiring surgery, and (b) it is local, and thus does not damage health cells. However, there are several issues that need to achieved: (a) the MNPs should be biocompatible, biodegradable, with good colloidal stability (b) the MNPs should be successfully delivered to the tumor cells, (c) the MNPs should be used with small amounts and thus MNPs with large heat generation capabilities are required, (d) the AMF used to heat the MNPs should meet safety conditions with limited frequency and amplitude ranges, (e) the changes of temperature should be traced at the cellular level with accurate and noninvasive techniques, (f) factors affecting heat transport from the MNPs to the cells must be understood, and (g) the effect of temperature on the biological mechanisms of cells should be clearly understood. Thus, in this multidisciplinary field, research is needed to investigate these issues. In this report, we shed some light on the principles of heat generation by MNPs in AMF, the limitations and challenges of MH, and the applications of MH using multifunctional hybrid MNPs.

scholarly journals Magnetic nanoparticles hyperthermia in a non-adiabatic and radiating process

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
C. A. M. Iglesias ◽  
J. C. R. de Araújo ◽  
J. Xavier ◽  
R. L. Anders ◽  
J. M. de Araújo ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Loss Rate ◽  
Thermal Conductance ◽  
Magnetic Hyperthermia ◽  
Point Of View ◽  
Magnesium Ferrite ◽  
Specific Loss ◽  
Heat Loss Rate ◽  
Specific Loss Power

AbstractWe investigate the magnetic nanoparticles hyperthermia in a non-adiabatic and radiating process through the calorimetric method. Specifically, we propose a theoretical approach to magnetic hyperthermia from a thermodynamic point of view. To test the robustness of the approach, we perform hyperthermia experiments and analyse the thermal behavior of magnetite and magnesium ferrite magnetic nanoparticles dispersed in water submitted to an alternating magnetic field. From our findings, besides estimating the specific loss power value from a non-adiabatic and radiating process, thus enhancing the accuracy in the determination of this quantity, we provide physical meaning to a parameter found in literature that still remained not fully understood, the effective thermal conductance, and bring to light how it can be obtained from experiment. In addition, we show our approach brings a correction to the estimated experimental results for specific loss power and effective thermal conductance, thus demonstrating the importance of the heat loss rate due to the thermal radiation in magnetic hyperthermia.

scholarly journals Specific Loss Power of Co/Li/Zn-Mixed Ferrite Powders for Magnetic Hyperthermia

Sensors ◽  
2020 ◽  
Vol 20 (7) ◽  
pp. 2151
Author(s):  
Gabriele Barrera ◽  
Marco Coisson ◽  
Federica Celegato ◽  
Luca Martino ◽  
Priyanka Tiwari ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Magnetic Properties ◽  
Cation Distribution ◽  
Biomedical Applications ◽  
Magnetic Measurements ◽  
Magnetic Hyperthermia ◽  
Alternating Magnetic Field ◽  
Specific Loss ◽  
Specific Loss Power ◽  
Auto Combustion

An important research effort on the design of the magnetic particles is increasingly required to optimize the heat generation in biomedical applications, such as magnetic hyperthermia and heat-assisted drug release, considering the severe restrictions for the human body’s exposure to an alternating magnetic field. Magnetic nanoparticles, considered in a broad sense as passive sensors, show the ability to detect an alternating magnetic field and to transduce it into a localized increase of temperature. In this context, the high biocompatibility, easy synthesis procedure and easily tunable magnetic properties of ferrite powders make them ideal candidates. In particular, the tailoring of their chemical composition and cation distribution allows the control of their magnetic properties, tuning them towards the strict demands of these heat-assisted biomedical applications. In this work, Co0.76Zn0.24Fe2O4, Li0.375Zn0.25Fe2.375O4 and ZnFe2O4 mixed-structure ferrite powders were synthesized in a ‘dry gel’ form by a sol-gel auto-combustion method. Their microstructural properties and cation distribution were obtained by X-ray diffraction characterization. Static and dynamic magnetic measurements were performed revealing the connection between the cation distribution and magnetic behavior. Particular attention was focused on the effect of Co2+ and Li+ ions on the magnetic properties at a magnetic field amplitude and the frequency values according to the practical demands of heat-assisted biomedical applications. In this context, the specific loss power (SLP) values were evaluated by ac-hysteresis losses and thermometric measurements at selected values of the dynamic magnetic fields.

scholarly journals Study on Maximum Specific Loss Power in Fe3O4 Nanoparticles Decorated with Biocompatible Gamma-Cyclodextrins for Cancer Therapy with Superparamagnetic Hyperthermia

2021 ◽  
Vol 22 (18) ◽  
pp. 10071
Author(s):  
Costica Caizer ◽  
Isabela Simona Caizer
Keyword(s):  
Cancer Therapy ◽  
Fe3o4 Nanoparticles ◽  
Magnetic Hyperthermia ◽  
Organic Layer ◽  
Cellular Toxicity ◽  
Innovative Strategy ◽  
Specific Loss ◽  
Beneficial Effects ◽  
Specific Loss Power ◽  
Magnetite Fe3o4

Different chemical agents are used for the biocompatibility and/or functionality of the nanoparticles used in magnetic hyperthermia to reduce or even eliminate cellular toxicity and to limit the interaction between them (van der Waals and magnetic dipolar interactions), with highly beneficial effects on the efficiency of magnetic hyperthermia in cancer therapy. In this paper we propose an innovative strategy for the biocompatibility of these nanoparticles using gamma-cyclodextrins (γ-CDs) to decorate the surface of magnetite (Fe3O4) nanoparticles. The influence of the biocompatible organic layer of cyclodextrins, from the surface of Fe3O4 ferrimagnetic nanoparticles, on the maximum specific loss power in superparamagnetic hyperthermia, is presented and analyzed in detail in this paper. Furthermore, our study shows the optimum conditions in which the magnetic nanoparticles covered with gamma-cyclodextrin (Fe3O4–γ-CDs) can be utilized in superparamagnetic hyperthermia for an alternative cancer therapy with higher efficiency in destroying tumoral cells and eliminating cellular toxicity.

scholarly journals Radio frequency plasma assisted surface modification of Fe3O4 nanoparticles using polyaniline/polypyrrole for bioimaging and magnetic hyperthermia applications

2021 ◽  
Vol 32 (9) ◽  
Author(s):  
Beena Mol ◽  
Ansar Ereath Beeran ◽  
Prasad S. Jayaram ◽  
Prabha Prakash ◽  
Ramapurath S. Jayasree ◽  
...  
Keyword(s):  
Surface Modification ◽  
Radio Frequency ◽  
Plasma Polymerization ◽  
Magnetic Hyperthermia ◽  
Radio Frequency Plasma ◽  
Specific Loss ◽  
Specific Loss Power ◽  
Frequency Plasma ◽  
The Magnetic Field ◽  
Superparamagnetic Properties

AbstractSurface modification of superparamagnetic Fe3O4 nanoparticles using polymers (polyaniline/polypyrrole) was done by radio frequency (r.f.) plasma polymerization technique and characterized by XRD, TEM, TG/DTA and VSM. Surface-passivated Fe3O4 nanoparticles with polymers were having spherical/rod-shaped structures with superparamagnetic properties. Broad visible photoluminescence emission bands were observed at 445 and 580 nm for polyaniline-coated Fe3O4 and at 488 nm for polypyrrole-coated Fe3O4. These samples exhibit good fluorescence emissions with L929 cellular assay and were non-toxic. Magnetic hyperthermia response of Fe3O4 and polymer (polyaniline/polypyrrole)-coated Fe3O4 was evaluated and all the samples exhibit hyperthermia activity in the range of 42–45 °C. Specific loss power (SLP) values of polyaniline and polypyrrole-coated Fe3O4 nanoparticles (5 and 10 mg/ml) exhibit a controlled heat generation with an increase in the magnetic field.

Quasistatic Magnetic Properties and Dynamic Hysteretic Losses in (La,Sr)MnO3 Nanoparticles Fabricated by Different Technological Routes

2015 ◽  
Vol 230 ◽  
pp. 101-107
Author(s):  
Alexander I. Tovstolytkin ◽  
S.O. Solopan ◽  
V.M. Kalita ◽  
S.M. Ryabchenko ◽  
Anatolii G. Belous
Keyword(s):  
Magnetic Field ◽  
Magnetic Properties ◽  
Magnetic Nanoparticles ◽  
Alternating Magnetic Field ◽  
Magnetic Characteristics ◽  
Specific Loss ◽  
Heating Efficiency ◽  
Specific Loss Power

Structural and magnetic characteristics of (La,Sr)MnO3 nanoparticles synthesized by different methods have been studied in the work. The specific loss power which is released on the exposure of an ensemble of synthesized particles to alternating magnetic field was calculated and measured experimentally. The contributions to the specific loss power resulted from different heating mechanisms have been discussed. The directions to enhance the heating efficiency of various kinds of magnetic nanoparticles are outlined

Sign in / Sign up

Export Citation Format

Share Document