scholarly journals Synthesis of Mesoporous Silica Coated Gold Nanorods Loaded with Methylene Blue and Its Potentials in Antibacterial Applications

Nanomaterials ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1338
Author(s):  
Adrián Fernández-Lodeiro ◽  
Jamila Djafari ◽  
Javier Fernández-Lodeiro ◽  
Maria Paula Duarte ◽  
Elisabete Muchagato Mauricio ◽  
...  

In this work, the successful preparation and characterization of gold nanorods (AuNRs) coated with a mesoporous silica shell (AuNRs@Simes) was achieved. Conjugation with methylene blue (MB) as a model drug using ultrasound-stimulated loading has been explored for further application in light-mediated antibacterial studies. Lyophilization of this conjugated nanosystem was analyzed using trehalose (TRH) as a cryogenic protector. The obtained stable dry formulation shows potent antimicrobial activity against Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria after a simple post-treatment irradiation method with a red laser during a short time period.

2012 ◽  
pp. 61-83 ◽  
Author(s):  
M. Ershov

According to the latest forecasts, it will take 10 years for the world economy to get back to “decent shape”. Some more critical estimates suggest that the whole western world will have a “colossal mess” within the next 5–10 years. Regulators of some major countries significantly and over a short time‑period changed their forecasts for the worse which means that uncertainty in the outlook for the future persists. Indeed, the intensive anti‑crisis measures have reduced the severity of the past problems, however the problems themselves have not disappeared. Moreover, some of them have become more intense — the eurocrisis, excessive debts, global liquidity glut against the backdrop of its deficit in some of market segments. As was the case prior to the crisis, derivatives and high‑risk operations with “junk” bonds grow; budget problems — “fiscal cliff” in the US — and other problems worsen. All of the above forces the regulators to take unprecedented (in their scope and nature) steps. Will they be able to tackle the problems which emerge?


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sivarama Krishna Lakkaboyana ◽  
Khantong Soontarapa ◽  
Nabel Kalel Asmel ◽  
Vinay Kumar ◽  
Ravi Kumar Marella ◽  
...  

AbstractThe present study focused on the synthesis of copper hydroxide nanowires decorated on activated carbon (Cu(OH)2-NWs-PVA-AC). The obtained Cu(OH)2-NWs-PVA-AC Nano-composite was distinguished by XRD, SEM, EDX, BET, FTIR and XPS respectively. Besides, different variables such as solution pH, and initial dye concentration, contact time, and temperature were performed on the adsorption efficiency of MB in a small batch reactor. Further, the experimental results are analyzed by various kinetic models via PFO, PSO, intra-particle diffusion and Elovich models, and the results revealed that among the kinetic models, PSO shows more suitability. In addition, different adsorption isotherms were applied to the obtained experimental data and found that Langmuir–Freundlich and Langmuir isotherm were best fits with the maximum adsorption capacity of 139.9 and 107.6 mg/g, respectively. The Nano-composite has outstanding MB removal efficiency of 94–98.5% with a span of 10 min. and decent adsorption of about 98.5% at a pH of 10. Thermodynamic constants like Gibbs free energy, entropy, and enthalpy were analyzed from the temperature reliance. The results reveal the adsorption processes are spontaneous and exothermic in nature. The high negative value of ΔG° (− 44.11 to − 48.86 kJ/mol) and a low negative value of ΔH° (− 28.96 kJ/mol) show the feasibility and exothermic nature of the adsorption process. The synthesized dye was found to be an efficient adsorbent for the potential removal of cationic dye (methylene blue) from wastewater within a short time.


2021 ◽  
Author(s):  
Marc Debus ◽  
Jale Tosun

AbstractThe COVID-19 pandemic has forced governments to impose major restrictions on individual freedom in order to stop the spread of the virus. With the successful development of a vaccine, these restrictions are likely to become obsolete—on the condition that people get vaccinated. However, parts of the population have reservations against vaccination. While this is not a recent phenomenon, it might prove a critical one in the context of current attempts to manage the COVID-19 pandemic. Consequently, the task of designing policies suitable for attaining high levels of vaccination deserves enhanced attention. In this study, we use data from the Eurobarometer survey fielded in March 2019. They show that 39% of Europeans consider vaccines to cause the diseases which they should protect against, that 50% believe vaccines have serious side effects, that 32% think that vaccines weaken the immune system, and that 10% do not believe vaccines are tested rigorously before authorization. We find that—even when controlling for important individual-level factors—ideological extremism on both ends of the spectrum explains skepticism of vaccination. We conclude that policymakers must either politicize the issue or form broad alliances among parties and societal groups in order to increase trust in and public support for the vaccines in general and for vaccines against COVID-19 in particular, since the latter were developed in a very short time period and resulted—in particular in case of the AstraZeneca vaccine—in reservations because of the effectiveness and side effects of the new vaccines.


Author(s):  
Yudai Tamura ◽  
Tomohiro Sakamoto

Abstract Background Platypnoea–orthodeoxia syndrome (POS) is an uncommon condition characterized by dyspnoea and arterial desaturation in the standing or sitting position that improves in the supine position. Case summary We report two cases of POS caused by an atrial septal defect (ASD) and a patent foramen ovale (PFO). Both cases reported a recent decrease in body weight of more than 10 kg in a short time period. Transoesophageal echocardiography (TOE) with agitated saline bubble study revealed and a large amount of contrast bubble through the ASD (Patient 1) or the PFO (Patient 2) from the right atrium to the left atrium in the sitting position. Both patients were diagnosed by the finding of positional dyspnoea and the results of TOE using agitated saline bubble contrast. Discussion Taken together, their presentations suggest that weight loss in a short time period could be a pathogenic factor for POS.


2014 ◽  
Vol 2 (12) ◽  
pp. 7383-7408
Author(s):  
W. Liu ◽  
F. Yamazaki ◽  
M. Matsuoka ◽  
T. Nonaka ◽  
T. Sasagawa

Abstract. The Tohoku-Oki earthquake on 11 March 2011 caused significant widespread crustal movements. In a previous study, we proposed a method for capturing two-dimensional (2-D) surface displacements from a pair of pre- and post-event TerraSAR-X (TSX) intensity images. However, it is difficult to detect three-dimensional (3-D) displacements from one pair of TSX images. In this study, three pairs of pre- and post-event TSX images taken on different paths were used to estimate 3-D crustal movements. The relationship between the actual 3-D displacements and the converted 2-D movements in the SAR images was derived based on the observation model of a SAR sensor. The 3-D movements were then calculated from three sets of detected 2-D movements that occurred within a short time period. Compared with GPS observations, the proposed method was found to be capable of detecting the 3-D crustal movements with sub-pixel accuracy.


2020 ◽  
Vol 18 (2) ◽  
pp. 271-292
Author(s):  
Ulla Higdem ◽  
Hans Christian Høyer ◽  
Erik Neslein Mønness ◽  
Jon Helge Lesjø

Inland people’s attitude towards municipal amalgamation reform in Norway from 2013 to 2018 has become more positive. However, a majority does not support the ongoing reform, but the changes have been substantial during such a short time period. However, these changes seem not to be a result of new and more positive judgements of the reforms’ results and outcome. By contrast, the majority has been more critical of anticipated consequences of the amalgamation reform into larger municipalities. Instead, we considered the changes as a type of ‘resignation’ towards a reform pressure from the national government and general changes in their environment. More citizens’ assess that positive municipal economic development and more local competence are favourable effects of mergers, and this finding supports this claim. The reform is likely to catch up with their local units anyway, and the citizens’ attitudes are adapting to what they expect will occur in the upcoming years.


Author(s):  
Saloni Sarraf ◽  
Dipak Kumar Bose ◽  
Jahanara Jahanara ◽  
Amit Kumar

Mushrooms (vegetarian meat/vegetable beef stick) is becoming fast popular because of its short time period between cultivation and harvesting; less initial investment and can be grown with locally available resources. Though more technology is available for boosting mushroom production, the yield so far achieved is not high. Hence, an attempt is made to find out the constraints faced by mushroom growers in adoption of improved mushroom production practices. Samastipur district of Bihar was purposively selected for the study because, Dr. Rajendra Prasad Central Agricultural University, a pioneer in mushroom production technology is located in the study area. 120 respondents from six villages of Pusa, Samastipur, Bihar forms the respondents of the present study. Primary data was collected from the mushroom growers and the responses were subjected to statistical analysis. The results indicated that unavailability of quality spawn, unavailability of skilled labor, absence of technical guidance, high transport cost, unavailability of storage facilities, high cost of spawn and long distance market were the most problematic constraints faced by the mushroom growers. Thus, it can be concluded that adequate extension service should be made available to make mushroom cultivation popular, market and marketing of the products.


Author(s):  
Roman Malo

Nowadays, a problem of an e- technologies’ implementation represents one of the most important questions that are being solved within various subjects from business area. With respect of massive implementation of activities as e- commerce, e- payments and others the e- technologies’ implementation is the progressive way of these subjects’ expansion. However, due to relatively short time period in which enterprise subjects have solved there is a set of vague aspects going together with this problem. The paper analyses the area of e- technologies and defines relations between basic concepts. Following this theoretical system a few hypothesis are constructed and used as a base platform for a determination of the logical model for implementation of e- technologies in enterprise environment.


2020 ◽  
Vol 26 ◽  
pp. 00012
Author(s):  
Artem Poteshkin ◽  
Irina Talamova

In the article the authors give the example of own created methodology of coordinating abilities estimation and upbringing in children with spastic diplegia and hemiparetic forms of infantile cerebral paralysis at the age of 11-12 of the Ist level of functional abilities according to Gross Motor Function Classification Systems. The peculiarity of the methodology is its universal character: the created methodology of estimation helps to estimate within a short time period and in terms of free space deficiency estimate coordinating abilities development. According to the development results estimation of a girl with a hemiparetic form of infantile cerebral paralysis we see the best indices of coordinating abilities development in comparison with the girls with spastic diplegia and the boys of both forms. For coordinating abilities upbringing the authors offer the methodology. It includes two blocks: the 1st block- classical physical exercises; the second block- exercises at stable platform. The authors offer the algorithm of coordinating abilities estimation and upbringing in children with spastic diplegia and hemiparetic forms of infantile cerebral paralysis at the age of 11-12.


Author(s):  
Stephen R. Balzac

A major difficulty with teaching ethics is that it is relatively easy for participants to state the “right” thing to do when they have no personal stake in the outcome. One way of dealing with this problem is to teach ethics through engrossing, immersive, predictive scenario games in which players are forced to deal with ethical issues as they arise, where they have a personal stake in the outcome, and where there is not always a clear right answer. Predictive scenario games are a form of serious live-action roleplaying in which participants take on the roles of people involved in complex situations. In these games, knowledge of the game world is distributed among the players through overlapping and conflicting goals, and in which ethical dilemmas emerge naturally, without fanfare, much as they would in the real world. There is a high level of tension between cooperation and competition among the players. This structure creates the opportunity for players to experience the consequences of their own judgment in realistic, ethically fraught situations, to receive feedback, and to engage in constructive discussion, within a relatively short time period.


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