scholarly journals The In Vivo Net Energy Content of Resistant Starch and Its Effect on Macronutrient Oxidation in Healthy Adults

Nutrients ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 2484 ◽  
Author(s):  
Erin D. Giles ◽  
Ian L. Brown ◽  
Paul S. MacLean ◽  
Zhaoxing Pan ◽  
Edward L. Melanson ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Dietary Fiber ◽  
Resistant Starch ◽  
Energy Content ◽  
Healthy Adults ◽  
Carbohydrate Oxidation ◽  
Net Energy ◽  
Double Blind ◽  
Insulin Responses

The in vivo net energy content of resistant starch (RS) has not been measured in humans so it has not been possible to account for the contribution of RS to dietary energy intake. We aimed to determine the in vivo net energy content of RS and examine its effect on macronutrient oxidation. This was a randomized, double-blind cross-over study. Eighteen healthy adults spent 24 h in a whole room indirect calorimeter to measure total energy expenditure (TEE), substrate oxidation, and postprandial metabolites in response to three diets: 1) digestible starch (DS), 2) RS (33% dietary fiber; RS), or 3) RS with high fiber (RSF, 56% fiber). The in vivo net energy content of RS and RSF are 2.74 ± 0.41 and 3.16 ± 0.27 kcal/g, respectively. There was no difference in TEE or protein oxidation between DS, RS, and RSF. However, RS and RSF consumption caused a 32% increase in fat oxidation (p = 0.04) with a concomitant 18% decrease in carbohydrate oxidation (p = 0.03) versus DS. Insulin responses were unaltered after breakfast but lower in RS and RSF after lunch, at equivalent glucose concentrations, indicating improved insulin sensitivity. The average in vivo net energy content of RS is 2.95 kcal/g, regardless of dietary fiber content. RS and RSF consumption increase fat and decrease carbohydrate oxidation with postprandial insulin responses lowered after lunch, suggesting improved insulin sensitivity at subsequent meals.

scholarly journals Consumption of Cross-Linked Resistant Starch (RS4XL) on Glucose and Insulin Responses in Humans

2010 ◽  
Vol 2010 ◽  
pp. 1-6 ◽  
Author(s):  
Enas K. Al-Tamimi ◽  
Paul A. Seib ◽  
Brian S. Snyder ◽  
Mark D. Haub
Keyword(s):  
Dietary Fiber ◽  
Resistant Starch ◽  
Area Under The Curve ◽  
Postprandial Glucose ◽  
Wheat Starch ◽  
Blood Samples ◽  
Serial Blood ◽  
Insulin Levels ◽  
Insulin Responses ◽  
First Time

Objective. The objective was to compare the postprandial glycemic and insulinemic responses to nutrition bars containing either cross-linked RS type 4 (RS4XL) or standard wheat starch in normoglycemic adults (n= 13; age = 27±5 years; BMI = 25±3 kg/m2).Methods. Volunteers completed three trials during which they consumed a glucose beverage (GLU), a puffed wheat control bar (PWB), and a bar containing cross-linked RS4 (RS4XL) matched for available carbohydrate content. Serial blood samples were collected over two hours and glucose and insulin concentrations were determined and the incremental area under the curve (iAUC) was calculated.Results. TheRS4XLpeak glucose and insulin concentrations were lower than the GLU and PWB (P<.05). The iAUC for glucose and insulin were lower following ingestion of RS4 compared with the GLU and PWB trials.Conclusions. These data illustrate, for the first time, that directly substituting standard starch withRS4XL, while matched for available carbohydrates, attenuated postprandial glucose and insulin levels in humans. It remains to be determined whether this response was due to the dietary fiber and/or resistant starch aspects of theRS4XLbar.

scholarly journals Resistant Starch as Related to Companion Animal Nutrition

2004 ◽  
Vol 87 (3) ◽  
pp. 787-791 ◽  
Author(s):  
Julie K Spears ◽  
George C Fahey
Keyword(s):  
Dietary Fiber ◽  
Resistant Starch ◽  
Companion Animals ◽  
Short Chain Fatty Acids ◽  
Companion Animal ◽  
Animal Nutrition ◽  
Processing Conditions ◽  
Gastrointestinal Health

Abstract Companion animal dietsmay contain up to 50% starch, derived from cereal grains. The amount of resistant starch (RS) in an ingredient depends on the origin and form of the ingredient and on the processing conditions to which the ingredient has been exposed. Extrusion has proven to be a means of optimizing utilization of starch by companion animals. Although the RS fraction of starch typically decreases by extrusion, retrogradation can result in increased concentrations of this fraction. Limited research exists regarding the effects of RS in companion animal nutrition and gastrointestinal health. Existing in vitro and in vivo research indicates that certain RS sources are readily fermented in the large bowel, producing short-chain fatty acids, whereas others are less fermentable, resulting in excellent laxation properties. Feeding dogs a diet high in RS may result in an increase in fecal bulk due to an increased excretion of microbial matter in those cases where RS is highly fermentable, or to indigestibility of the RS source in other cases. RS has a role to play as a potential proxy for dietary fiber, especially for those companion animals fed diets high in protein and fat and devoid of traditional dietary fiber.

scholarly journals In vivo and in vitro techniques for the assessment of the energy content of feed grains for poultry: a review

1999 ◽  
Vol 50 (5) ◽  
pp. 881 ◽  
Author(s):  
D. J. Farrell
Keyword(s):  
Near Infrared ◽  
Energy Content ◽  
Energy Systems ◽  
Great Promise ◽  
Net Energy ◽  
Near Infrared Reflectance ◽  
Food Grains ◽  
Metabolisable Energy

The focus of this paper is on the energy evaluation of foodstuffs, particularly of food grains for poultry. Apparent metabolisable energy (AME) is currently the preferred feeding system for poultry but net energy systems are future possibilities and one is currently being used in some poultry growth models. These systems take into account the efficiency with which AME is being utilised by the bird. Aspects such as AME adjusted to zero nitrogen retention and true metabolisable energy (TME) are discussed. Shortcomings of the AME system are also discussed and recent net energy systems are described briefly. The in vitro prediction of AME or TME has not shown great promise although the European Tables of Energy Values for Foodstuffs contain detailed analysis of chemical composition and AMEn data allowing improved accuracy of prediction. It is suggested that data generated on Australian grains should be tested using these tables, and if successful, these tables may be useful to industry. Near infrared reflectance analysis (NIRA) is likely to be the preferred in vitro method for predicting a range of characteristics of food grains including AME. A new method of grain evaluation developed in Canada is described and this approach, with modification, may be worth pursuing in Australia. For the in vivo method of measuring AME of grains, the classical total collection method with broiler chickens is recommended with minor changes. The use of acid-insoluble ash for estimating dry matter digestibility for subsequent determination of AME may have merit. A rapid assay appropriate to laying hens is proposed because of the known increase in AME of grains as birds age. It has been established that AME values generated using adult cockerels also apply reasonably well to hens.

scholarly journals An assessment by in vivo methods of grain quality for ruminants

1999 ◽  
Vol 50 (5) ◽  
pp. 843 ◽  
Author(s):  
J. P. Hogan ◽  
P. C. Flinn
Keyword(s):  
Weight Gain ◽  
Energy Storage ◽  
Grain Quality ◽  
Energy Content ◽  
Nutrient Release ◽  
Net Energy ◽  
Paper Briefly ◽  
And Storage ◽  
In Vivo Assessment

For the purpose of this review, grain quality refers to the efficiency with which a grain supports growth in cattle fed diets which contain grain as a major component. Grains are fed as concentrated sources of energy. Their quality depends on the energy content of the grain, the amount eaten, and the efficiency, both of extraction of nutrients from the diet and of conversion of nutrients to weight gain. This paper briefly describes the fermentative and digestive processes involved in releasing energy from grain and in ensuring an adequate supply of other essential nutrients to the animal. Methods are then described for measuring net energy storage, nutrient release in various sections of the tract, and storage of energy and protein both directly and indirectly in studies of growth. It is recommended that in vivo assessment of the energy content of grains for ruminants be conducted in stages. Digestibility in the whole tract should be used to rank a range of grains, then comparisons made between grains using growth studies. Discrepancies arising from these assessments should then be investigated using more detailed measurements, particularly starch digestion in the stomach and intestines.

scholarly journals Safety and Pharmacokinetics of CD101 IV, a Novel Echinocandin, in Healthy Adults

2016 ◽  
Vol 61 (2) ◽  
Author(s):  
Taylor Sandison ◽  
Voon Ong ◽  
Jonathan Lee ◽  
Dirk Thye
Keyword(s):  
Adverse Events ◽  
Vital Signs ◽  
High Plasma ◽  
Primary Objective ◽  
Healthy Adults ◽  
Serious Adverse Events ◽  
Double Blind ◽  
Content Type

ABSTRACT CD101 IV is a novel echinocandin with distinctive pharmacokinetic properties that is being developed as a once-weekly treatment for candidemia and invasive candidiasis. CD101 has potent in vitro activity and in vivo efficacy against a broad range of Candida and Aspergillus species. The primary objective of two randomized, double-blind, placebo-controlled, dose-escalation studies in healthy adults was to determine the safety and tolerability of CD101 IV. Sequential cohorts of 8 subjects (n = 6, active; n = 2, placebo) were administered single (50, 100, 200, 400 mg) or multiple once-weekly (100 mg given once weekly for two weeks [×2], 200 mg ×2, 400 mg ×3) doses of CD101 IV infused over 1 h. There were no deaths, serious adverse events (SAEs), severe adverse events (AEs), or withdrawals from the study due to an AE. The majority of AEs were mild, and all completely resolved. There was a higher incidence of total AEs and mild transient infusion reactions in the 400-mg ×3 dose group. There were no clinically meaningful trends in postbaseline laboratory abnormalities and no safety issues related to electrocardiograms, vital signs, or physical exams. CD101 showed dose-proportional plasma exposures, minor accumulation (30% to 55%), low apparent clearance (<0.28 liter/h), long half-life (t 1/2) (>80 h), and minimal urine excretion. CD101 IV was safe and well tolerated at single and multiple doses of up to 400 mg given once weekly for 3 weeks and exhibited a long t 1/2, minimal accumulation over several weeks, negligible renal excretion, and high plasma exposures enabling once-weekly dosing.

scholarly journals Gastrointestinal effects of resistant starch, soluble maize fibre and pullulan in healthy adults

2013 ◽  
Vol 110 (6) ◽  
pp. 1068-1074 ◽  
Author(s):  
Abby S. Klosterbuer ◽  
Meredith A. J. Hullar ◽  
Fei Li ◽  
Elizabeth Traylor ◽  
Johanna W. Lampe ◽  
...  
Keyword(s):  
Resistant Starch ◽  
Human Subjects ◽  
Healthy Adults ◽  
Significant Shift ◽  
Gut Health ◽  
Healthy Human ◽  
Double Blind ◽  
Gi Symptoms ◽  
And Control ◽  
Gut Microbial Community

Fibre has been shown to exert a number of benefits on gastrointestinal (GI) health, yet its intake is low. Addition of novel fibres to food products may increase fibre intake and improve gut health. The objective of the present study was to evaluate the influence of three novel fibres on GI outcomes in healthy human subjects. A total of twenty healthy participants (ten men and ten women) with normal BMI (23 (sem 2) kg/m2) participated in the present randomised, double-blind, cross-over study with five treatment periods. Participants consumed a maltodextrin control or 20–25 g/d fibre from soluble maize fibre (SCF) or resistant starch (RS), alone or in combination with pullulan (SCF+P and RS+P). The treatment periods were 7 d with a 3-week washout between the periods. Stool samples were collected on day 7 of each period, and GI tolerance was assessed via a questionnaire on days 1 and 6. There were no treatment differences in stool weight or consistency. SCF significantly reduced stool pH and increased total SCFA production compared with RS and control. RS+P significantly increased the percentage of butyrate compared with all the other treatments. Overall, GI symptoms were minimal. SCF+P led to the highest GI score on day 1, while RS+P had the highest score on day 6. Both SCF treatments caused a significant shift in the gut microbial community. These functional fibres are generally well tolerated, have minimal effects on laxation and may lead to beneficial changes in SCFA production in healthy adults.

scholarly journals Effect of chicory inulin-type fructan–containing snack bars on the human gut microbiota in low dietary fiber consumers in a randomized crossover trial

2020 ◽  
Vol 111 (6) ◽  
pp. 1286-1296 ◽  
Author(s):  
Raylene A Reimer ◽  
Adriana Soto-Vaca ◽  
Alissa C Nicolucci ◽  
Shyamchand Mayengbam ◽  
Heekuk Park ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Dietary Fiber ◽  
Low Dose ◽  
Healthy Adults ◽  
Control Group ◽  
Fiber Intake ◽  
Moderate Dose ◽  
Double Blind ◽  
Dietary Fiber Intake ◽  
Gi Symptoms

Abstract Background The low intake of dietary fiber compared to recommended amounts has been referred to as the dietary fiber gap. The addition of fiber to snack foods could favorably alter gut microbiota and help individuals meet intake recommendations. Objectives Our objective was to examine the effect of low- and moderate-dose fiber-containing snack bars, comprising mainly chicory root inulin-type fructans (ITF), on gut microbiota in healthy adults with habitual low dietary fiber intake using 16S ribosomal RNA–based approaches. Methods In 2 separate 4-wk, placebo-controlled, double-blind, crossover trials, 50 healthy adults with low dietary fiber intake were randomly assigned to receive isocaloric snack bars of either moderate-dose fiber (7 g/d) or control in Trial 1 (n = 25) or low-dose fiber (3 g/d) or control in Trial 2 (n = 25), with 4-wk washout periods. Fecal microbiota composition and inferred function, fecal SCFA concentration, gastrointestinal (GI) symptoms, dietary intake, and quality of life were measured. Results Compared with the control group, the moderate-dose group showed significant differences across multiple microbial taxa, most notably an increased relative abundance of the Bifidobacterium genus from (mean ± SEM) 5.3% ± 5.9% to 18.7% ± 15.0%. With low-dose ITF, significant increases in Bifidobacterium were no longer present after correction for multiple comparisons but targeted analysis with qPCR showed a significant increase in Bifidobacterium. Predictive functional profiling identified changes in predicted function after intake of the moderate- but not the low-dose bar. Fecal SCFAs were affected by time but not treatment. There were no between-group differences in GI symptoms. Importantly, fiber intake increased significantly with the moderate- and low-dose bars. Conclusions In healthy adults, adding 3 or 7 g ITF to snack bars increased Bifidobacterium, a beneficial member of the gut microbial community. The addition of ITF to food products could help reduce the dietary fiber gap prevalent in modern life. This trial was registered at clinicaltrials.gov as NCT03042494.

scholarly journals Nutritional Bar with Potato-Based Resistant Starch Attenuated Post-Prandial Glucose and Insulin Response in Healthy Adults

Foods ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. 1679
Author(s):  
Vishnupriya Gourineni ◽  
Maria L. Stewart ◽  
Meredith L. Wilcox ◽  
Kevin C. Maki
Keyword(s):  
Resistant Starch ◽  
Area Under Curve ◽  
Insulin Response ◽  
Healthy Adults ◽  
Double Blind ◽  
Total Dietary Fiber ◽  
High Fiber ◽  
Naturally Occurring ◽  
Capillary Glucose ◽  
Physiological Benefits

Resistant starch is a non-digestible starch fraction and is classified as fiber. Beyond naturally occurring fiber sources, starches can be modified to resist digestion, increase their fiber content and provide physiological benefits. The current study examined acute postprandial glycemic responses of VERSAFIBE™ 1490 resistant starch type-4, containing 90% total dietary fiber (TDF, AOAC (Association of Official Analytical Collaboration International) 991.43 method). In a double-blind, randomized, placebo-controlled, cross-over study, healthy adults (n = 38) consumed a nutritional bar containing either control (2 g), medium (21 g) or high (30 g) fiber. The test bars were matched with control for available carbohydrates, fat and protein. Venous glucose, insulin, and capillary glucose were measured. Mean ± SEM capillary glucose incremental area-under-curve (iAUC0)-120 min in min*mmol/L was lower (p < 0.005) for both fiber bars (136.2 ± 9.2 and 137.0 ± 10.4 for the medium and high fiber bars, respectively) compared to the control bar (174.9 ± 13.5). Mean venous insulin iAUC0-120 min in min*pmol/L was also lower for medium (8096.3 ± 894.5) and high fiber (7533.8 ± 932.9) bars, respectively, compared to the control bar (11871.6 ± 1123.9, p < 0.001). Peak capillary glucose and venous insulin concentrations were also significantly reduced (p < 0.001) after consumption of both fiber bars compared to the control bar. The results of this study suggest that nutritional bars containing potato based RS4 fiber reduced post-consumption glycemic and insulinemic responses when consumed by generally healthy adults.

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