scholarly journals Changes in Microbiota and Bacterial Protein Caseinolytic Peptidase B During Food Restriction in Mice: Relevance for the Onset and Perpetuation of Anorexia Nervosa

Nutrients ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 2514 ◽  
Author(s):  
Manon Dominique ◽  
Romain Legrand ◽  
Marie Galmiche ◽  
Saïda Azhar ◽  
Camille Deroissart ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Plasma Concentration ◽  
Associated Factors ◽  
Food Access ◽  
Food Restriction ◽  
Bacterial Protein ◽  
Limited Food ◽  
Access To Food ◽  
Colonic Content

Microbiota contributes to the regulation of eating behavior and might be implicated in the pathophysiology of anorexia nervosa. ClpB (Caseinolytic peptidase B) protein produced mainly by the Enterobacteriaceae family has been identified as a conformational mimetic of α-MSH, which could result in similar anorexigenic effects. The aim of this study was to highlight the role of the microbiome and the ClpB protein in deregulation and self-maintenance of anorexia pathology. Male C57Bl/6 mice were undergone to the ABA (Activity-Based Anorexia) protocol: after 5 days of acclimatization, both ABA and LFA (Limited Food Access) mice had progressively limited access to food until D17. At the end of protocol, the plasma ClpB concentration and Enterobacteriaceae DNA in colonic content were measured. As expected, dietary restriction induced lost weight in LFA and ABA mice. At D10, colonic permeability and plasma concentration of the ClpB protein were significantly increased in LFA and ABA mice vs. controls. At D17, plasma concentration of ClpB was increased in LFA and ABA mice and, it was correlated with proportion of Enterobacteriaceae in the faeces. These abnormally high ClpB concentrations and all associated factors, and therefore might contribute to the initiation and/or perpetuation of anorexia nervosa by interfering with satiety signaling.

scholarly journals Self-Starvation in the Rat: Running versus Eating

2007 ◽  
Vol 10 (2) ◽  
pp. 251-257 ◽  
Author(s):  
Robert A. Boakes
Keyword(s):  
Animal Model ◽  
Anorexia Nervosa ◽  
Ambient Temperature ◽  
Food Access ◽  
Activity Wheel ◽  
Aversion Learning ◽  
Food Aversion ◽  
Restricted Access ◽  
Unrestricted Access ◽  
Access To Food

Rats given the combination of unrestricted access to an activity wheel and restricted access to food can lose weight to the extent that they will die unless removed from these conditions. Although this has been known for forty years, why this happens has remained unclear. The phenomenon is paradoxical in that one might expect such rats to eat more as their weight decreases, but in fact they eat less than resting controls. This lecture first examines some of the factors than influence whether self-starvation will occur, such as age, time of food access, type of food and ambient temperature. It then compares competing explanations such as circadian adaptation, thermo-regulation and food aversion learning. As so often in psychology, it turns out that self-starvation results from a combination of many separate factors. The general implications of this research are examined, including whether it provides a useful animal model for human anorexia nervosa.

scholarly journals Failure to Find Altruistic Food Sharing in Rats

2021 ◽  
Vol 12 ◽  
Author(s):  
Haoran Wan ◽  
Cyrus Kirkman ◽  
Greg Jensen ◽  
Timothy D. Hackenberg
Keyword(s):  
Food Production ◽  
Food Access ◽  
Food Restriction ◽  
Food Motivation ◽  
Size Number ◽  
Production And Consumption ◽  
Food Size ◽  
Low Levels ◽  
Access To Food ◽  
Different Levels

Prior research has found that one rat will release a second rat from a restraint in the presence of food, thereby allowing that second rat access to food. Such behavior, clearly beneficial to the second rat and costly to the first, has been interpreted as altruistic. Because clear demonstrations of altruism in rats are rare, such findings deserve a careful look. The present study aimed to replicate this finding, but with more systematic methods to examine whether, and under what conditions, a rat might share food with its cagemate partner. Rats were given repeated choices between high-valued food (sucrose pellets) and 30-s social access to a familiar rat, with the (a) food size (number of food pellets per response), and (b) food motivation (extra-session access to food) varied across conditions. Rats responded consistently for both food and social interaction, but at different levels and with different sensitivity to the food-access manipulations. Food production and consumption was high when food motivation was also high (food restriction) but substantially lower when food motivation was low (unlimited food access). Social release occurred at moderate levels, unaffected by the food-based manipulations. When food was abundant and food motivation low, the rats chose food and social options about equally often, but sharing (food left unconsumed prior to social release) occurred at low levels across sessions and conditions. Even under conditions of low food motivation, sharing occurred on only 1% of the sharing opportunities. The results are therefore inconsistent with claims in the literature that rats are altruistically motivated to share food with other rats.

scholarly journals Differential effects of fasting vs food restriction on liver thyroid hormone metabolism in male rats

2014 ◽  
Vol 224 (1) ◽  
pp. 25-35 ◽  
Author(s):  
E M de Vries ◽  
H C van Beeren ◽  
M T Ackermans ◽  
A Kalsbeek ◽  
E Fliers ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Food Intake ◽  
Caloric Restriction ◽  
Food Restriction ◽  
Male Rats ◽  
Hormone Metabolism ◽  
Thyroid Hormone Metabolism ◽  
Limited Food ◽  
Fasted Rats

A variety of illnesses that leads to profound changes in the hypothalamus–pituitary–thyroid (HPT) are axis collectively known as the nonthyroidal illness syndrome (NTIS). NTIS is characterized by decreased tri-iodothyronine (T3) and thyroxine (T4) and inappropriately low TSH serum concentrations, as well as altered hepatic thyroid hormone (TH) metabolism. Spontaneous caloric restriction often occurs during illness and may contribute to NTIS, but it is currently unknown to what extent. The role of diminished food intake is often studied using experimental fasting models, but partial food restriction might be a more physiologically relevant model. In this comparative study, we characterized hepatic TH metabolism in two models for caloric restriction: 36 h of complete fasting and 21 days of 50% food restriction. Both fasting and food restriction decreased serum T4concentration, while after 36-h fasting serum T3also decreased. Fasting decreased hepatic T3but not T4concentrations, while food restriction decreased both hepatic T3and T4concentrations. Fasting and food restriction both induced an upregulation of liver D3 expression and activity, D1 was not affected. A differential effect was seen inMct10mRNA expression, which was upregulated in the fasted rats but not in food-restricted rats. Other metabolic pathways of TH, such as sulfation and UDP-glucuronidation, were also differentially affected. The changes in hepatic TH concentrations were reflected by the expression of T3-responsive genesFasandSpot14only in the 36-h fasted rats. In conclusion, limited food intake induced marked changes in hepatic TH metabolism, which are likely to contribute to the changes observed during NTIS.

Effects of limited food intake on the obese-hyperglycemic syndrome

1976 ◽  
Vol 230 (6) ◽  
pp. 1474-1479 ◽  
Author(s):  
PU Dubuc
Keyword(s):  
Insulin Sensitivity ◽  
Food Intake ◽  
Recent Work ◽  
Lean Body Mass ◽  
Food Restriction ◽  
Somatic Growth ◽  
Immunoreactive Insulin ◽  
Limited Food ◽  
Reduced Rate ◽  
Access To Food

In ob/ob mice a 12-wk period of food restriction led to a reduced rate of somatic growth and a decreased lean body mass, along with small but reliable reductions in systemic immunoreactive insulin levels and evidence of increased insulin sensitivity. However, no effects of limited access to food were noted on the basal hyperglycemia, the elevated percent carcass lipid, or on the significantly higher levels of serum corticoids that occur in obese animals. These data indicate that hyperphagia alone is not responsible for the maintenance of many of the commonly reported characteristics of the obese-hyperglycemic syndrome, but do not exclude the contribution of factors secondary to the quantity of ingested food. Additionally, the present data lend support to recent work suggesting that chronic hyperinsulinemia or an elevated set point of total carcass lipid may be instrumental in the development of this syndrome.

scholarly journals Failure to Find Altruistic Food Sharing in Rats

2020 ◽  
Author(s):  
Haoran Wan ◽  
Cyrus Kirkman ◽  
Greg Jensen ◽  
Timothy D Hackenberg
Keyword(s):  
Food Production ◽  
Food Access ◽  
Food Restriction ◽  
Food Motivation ◽  
Size Number ◽  
Production And Consumption ◽  
Food Size ◽  
Low Levels ◽  
Access To Food ◽  
Different Levels

Prior research has found that one rat will release a second rat from restraint in the presence of food, thereby allowing that second rat access to food. Such behavior, clearly beneficial to the second rat and costly to the first, has been interpreted as altruistic. Because clear demonstrations of altruism in rats are rare, such findings deserve a careful look. The present study aimed to replicate this finding, but with more systematic methods to examine whether, and under what conditions, a rat might share food with its cagemate partner. Rats were given repeated choices between high-valued food (sucrose pellets) and 30-s social access to a familiar rat, with the (a) food size (number of food pellets per response), and (b) food motivation (extra-session access to food) varied across conditions. Rats responded consistently for both food and social interaction, but at different levels and with different sensitivity to the food-access manipulations. Food production and consumption was high when food motivation was also high (food restriction) but substantially lower when food motivation was low (unlimited food access). Social release occurred at moderate levels, unaffected by the food-based manipulations. When food was abundant and food motivation low, the rats chose food and social options about equally often, but sharing (food left unconsumed prior to social release) occurred at low levels across sessions and conditions. Even under conditions of low food motivation, sharing occurred on only 1% of the sharing opportunities. The results are therefore inconsistent with claims in the literature that rats are altruistically motivated to share food with other rats.

Social Rank and Food Access in Red Deer Stags

Behaviour ◽  
1980 ◽  
Vol 74 (3-4) ◽  
pp. 294-309 ◽  
Author(s):  
Michael C. Appleby
Keyword(s):  
Cervus Elaphus ◽  
Food Access ◽  
Red Deer ◽  
Social Rank ◽  
Selective Advantage ◽  
High Rank ◽  
Behaviour Pattern ◽  
Feeding Site ◽  
Limited Food ◽  
Access To Food

AbstractThe behaviour of a free-living group of male red deer (Cervus elaphus L.) on the Isle of Rhum, Scotland, was studied throughout the year to investigate the relations between social dominance and food access. The study is based on the collection of agonistic interactions between members of the study group outside the rutting season. Analysis of these confirmed that dyadic dominance relationships summate to a very clear agonistic hierarchy, while seasonal changes in frequency and type of interactions suggested that rank in the hierarchy may affect access to food through direct feeding interference. This would constitute a selective advantage of the acquisition of high rank. A behaviour pattern in which a stag displaces a subordinate and takes over his feeding-site is proposed as a mechanism of direct feeding interference. It occurs throughout the year, but with a frequency closely related to changes in food availability and quality. The proportion of such interactions that an individual wins is related to his rank, so advantages gained from this behaviour would primarily benefit high-ranking stags. These are likely to consist of improved body condition and winter survival. The importance of high rank in obtaining access to limited food was supported by the results of a simple experiment providing a small area of fertilized grass. Most of the grazing in the area was due to the highest-ranking stag present at any time.

Thyroid hormone-catecholamine interrelationships during exposure to cold

1981 ◽  
Vol 97 (1) ◽  
pp. 91-97 ◽  
Author(s):  
H. Storm ◽  
C. van Hardeveld ◽  
A. A. H. Kassenaar
Keyword(s):  
Nervous System ◽  
Plasma Concentration ◽  
Thyroid Hormone ◽  
Sympathetic Nervous System ◽  
Plasma Levels ◽  
Surgical Procedure ◽  
Exposure To Cold ◽  
Basal Plasma ◽  
Sympathetic Nervous

Abstract. Basal plasma levels for adrenalin (A), noradrenalin (NA), l-triiodothyronine (T3), and l-thyroxine (T4) were determined in rats with a chronically inserted catheter. The experiments described in this report were started 3 days after the surgical procedure when T3 and T4 levels had returned to normal. Basal levels for the catecholamines were reached already 4 h after the operation. The T3/T4 ratio in plasma was significantly increased after 3, 7, and 14 days in rats kept at 4°C and the same holds for the iodide in the 24-h urine after 7 and 14 days at 4°C. The venous NA plasma concentration was increased 6- to 12-fold during the same period of exposure to cold, whereas the A concentration remained at the basal level. During infusion of NA at 23°C the T3/T4 ratio in plasma was significantly increased after 7 days compared to pair-fed controls, and the same holds for the iodide excretion in the 24-h urine. This paper presents further evidence for a role of the sympathetic nervous system on T4 metabolism in rats at resting conditions.

Interpersonal Psychotherapy for the Treatment of Eating Disorders

2010 ◽  
pp. 347-372 ◽  
Author(s):  
Marian Tanofsky-Kraff ◽  
Denise E. Wilfley
Keyword(s):  
Anorexia Nervosa ◽  
Clinical Care ◽  
Interpersonal Psychotherapy ◽  
Future Research ◽  
Cognitive Behavior ◽  
Research Directions ◽  
Routine Clinical Care ◽  
Interpersonal Factors ◽  
Future Research Directions

Interpersonal psychotherapy (IPT) is a focused, time-limited treatment that targets interpersonal problem(s) associated with the onset and/or maintenance of EDs. IPT is supported by substantial empirical evidence documenting the role of interpersonal factors in the onset and maintenance of EDs. IPT is a viable alternative to cognitive behavior therapy for the treatment of bulimia nervosa and binge eating disorder. The effectiveness of IPT for the treatment of anorexia nervosa requires further investigation. The utility of IPT for the prevention of obesity is currently being explored. Future research directions include enhancing the delivery of IPT for EDs, increasing the availability of IPT in routine clinical care settings, exploring IPT adolescent and parent–child adaptations, and developing IPT for the prevention of eating and weight-related problems that may promote full-syndrome EDs or obesity.

scholarly journals Evaluation of the Effectiveness of Brazilian Community Restaurants for the Dimension of Low-Income People Access to Food

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2671
Author(s):  
Mateus Santana Sousa ◽  
Camila Silveira Silva Teixeira ◽  
Jamacy Costa Souza ◽  
Priscila Ribas de Farias Costa ◽  
Renata Puppin Zandonadi ◽  
...  
Keyword(s):  
Low Income ◽  
Formal Education ◽  
Average Energy ◽  
Secondary Data ◽  
Target Population ◽  
Service Capacity ◽  
The Public ◽  
The Government ◽  
Access To Food

This study aimed to evaluate the effectiveness of community restaurants (CRs), managed by the Government of the State of Bahia/Brazil, for the dimension of access to food. The study used secondary data obtained from the public opinion survey Profile of users of community restaurants in Salvador. The nutritional information was accessed through the analysis of CRs’ menus. Adequate effectiveness of access to food was considered when the CR served meals to 50% to 70% of the users considered the target audience (individuals served by the two CRs located in the city of Salvador/Bahia/Brazil). The participants (n = 1464; 778 as low-income individuals) were adult CR users from Salvador/Brazil. Most of the respondents were male, 40 to 54 years old, not white, had up to 9 years of formal education, without a partner, and living in the municipality of Salvador. The evaluated CRs are effective in serving 53.1% of the target population in their total service capacity. Meal provision only reached an estimated 0.7% of the socially vulnerable community in the district. The average energy value of the meal served by the CR units was 853.05 kcal/meal, with a mean energy density composition classified as average (1.15 kcal/g). The effectiveness of the evaluated community restaurants showed that these instruments were minimally effective in promoting access to food for the low-income population within their total daily service capacity, and the current quantity of these facilities was insufficient. However, these instruments stand out in the fundamental role of promoting the daily distribution of meals to the Brazilian population with the highest social vulnerability levels.

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