The Sun’s Vitamin in Adult Patients Affected by Prader–Willi Syndrome

Prader–Willi syndrome (PWS) is a genetic disorder characterized by hyperphagia with progressive, severe obesity, and an increased risk of obesity-related comorbidities in adult life. Although low dietary vitamin D intake and low 25-hydroxy vitamin D (25OHD) levels are commonly reported in PWS in the context of bone metabolism, the association of low 25OHD levels with fat mass has not been extensively evaluated in PWS adults. The aims of this study were to investigate the following in PWS adults: (1) 25OHD levels and the dietary vitamin D intake; (2) associations among 25OHD levels with anthropometric measurements and fat mass; (3) specific cut-off values for body mass index (BMI) and fat mass predictive of the 25OHD levels. In this cross-sectional, single-center study we enrolled 30 participants, 15 PWS adults (age 19–41 years and 40% males) and 15 control subjects matched by age, sex, and BMI from the same geographical area (latitude 40° 49’ N; elevation 17 m). Fat mass was assessed using a bioelectrical impedance analysis (BIA) phase-sensitive system. The 25OHD levels were determined by a direct competitive chemiluminescence immunoassay. Dietary vitamin D intake data was collected by three-day food records. The 25OHD levels in the PWS adults were constantly lower across all categories of BMI and fat mass compared with their obese counterpart. The 25OHD levels were negatively associated with BMI (p = 0.04), waist circumference (p = 0.03), fat mass (p = 0.04), and dietary vitamin D intake (p < 0.001). During multiple regression analysis, dietary vitamin D intake was entered at the first step (p < 0.001), thus explaining 84% of 25OHD level variability. The threshold values of BMI and fat mass predicting the lowest decrease in the 25OHD levels were found at BMI ≥ 42 kg/m2 (p = 0.01) and fat mass ≥ 42 Kg (p = 0.003). In conclusion, our data indicate that: (i) 25OHD levels and dietary vitamin D intake were lower in PWS adults than in the control, independent of body fat differences; (ii) 25OHD levels were inversely associated with BMI, waist circumference, and fat mass, but low dietary vitamin D intake was the major determinant of low vitamin D status in these patients; (iii) sample-specific cut-off values of BMI and fat mass might help to predict risks of the lowest 25OHD level decreases in PWS adults. The presence of trained nutritionists in the integrated care teams of PWS adults is strongly suggested in order to provide an accurate nutritional assessment and tailored vitamin D supplementations.

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Dietary vitamin D intake and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition: the EPIC-InterAct study

European Journal of Clinical Nutrition ◽

10.1038/ejcn.2013.235 ◽

2013 ◽

Vol 68 (2) ◽

pp. 196-202 ◽

Cited By ~ 10

Author(s):

S Abbas ◽

J Linseisen ◽

S Rohrmann ◽

J W J Beulens ◽

B Buijsse ◽

...

Keyword(s):

Type 2 Diabetes ◽

Vitamin D ◽

Dietary Vitamin ◽

Vitamin D Intake ◽

Dietary Vitamin D ◽

Prospective Investigation

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Association of vitamin D with incident glaucoma: findings from the Women’s Health Initiative

Journal of Investigative Medicine ◽

10.1136/jim-2020-001645 ◽

2021 ◽

pp. jim-2020-001645

Author(s):

Laura D Carbone ◽

Karen Johnson ◽

Joseph C Larson ◽

Fridtjof Thomas ◽

Jean Wactawski-Wende ◽

...

Keyword(s):

Vitamin D ◽

Women's Health ◽

Postmenopausal Women ◽

Serum Levels ◽

Dietary Vitamin ◽

Health Initiative ◽

Vitamin D Intake ◽

Vitamin D Supplements ◽

Dietary Vitamin D ◽

The Women’S Health Initiative

The relationship between vitamin D and glaucoma is controversial. The objective of this study was to examine women from the Women’s Health Initiative (WHI) to determine if there is an association between vitamin D and incident glaucoma in postmenopausal women. We examined the association between dietary vitamin D intake, vitamin D supplements and serum 25 hydroxyvitamin D (25(OH)D) levels and the risk of developing glaucoma. 143,389 postmenopausal women from the WHI including a subset with serum 25(OH) D measurements were examined to determine the association of dietary, supplemental and serum levels of vitamin D to the development of glaucoma. Dietary intakes of vitamin D, use of vitamin D supplements and serum levels of 25(OH) D were predictors examined for the main outcome of incident glaucoma. In multivariable models adjusted for demographic, clinical variables and medication use, dietary vitamin D, vitamin D supplements, total vitamin D intake (diet plus supplements) and serum 25 (OH) D measurements were not significantly associated with incident glaucoma. In the CaD placebo-controlled intervention clinical trial, there was also no association in the active intervention arm with glaucoma. We conclude that dietary vitamin D intake, supplements and serum levels are not significantly related to the risk of developing glaucoma in postmenopausal women.

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High Prevalence of Vitamin D Inadequacy During Late Postpartum in Canadian Mothers

Current Developments in Nutrition ◽

10.1093/cdn/nzab046_087 ◽

2021 ◽

Vol 5 (Supplement_2) ◽

pp. 790-790

Author(s):

Sarah Montgomery ◽

Angella Lee ◽

Nasime Sarbar ◽

Deborah Zibrik ◽

Yvonne Lamers

Keyword(s):

Vitamin D ◽

British Columbia ◽

Dietary Intake ◽

Dietary Vitamin ◽

Nutrient Deficiencies ◽

Cross Sectional ◽

Convenience Sample ◽

Vitamin D Intake ◽

Pregnancy And Postpartum ◽

Dietary Vitamin D

Abstract Objectives To assess maternal dietary intake and adequacy at postpartum and to determine whether lifestyle characteristics and breastfeeding status are related to nutrient intakes. Methods We analyzed cross-sectional data from a convenience sample of 129 mothers at 18-mo postpartum, whose families were enrolled into a randomized toddler intervention trial, in the Lower Mainland, British Columbia, Canada. The Canadian Diet History Questionnaire II (C-DHQ II) was used to estimate usual dietary intake in the mothers during the preceding 12 months (i.e., between 6- to 18-mo postpartum). Implausible energy intakes were defined as <600 kcal/day or >3500 kcals/day, and excluded from analysis. Demographic and lifestyle characteristic data about the pregnancy and postpartum time period were collected using a questionnaire. Results Maternal mean (SD) age at birth was 33.5 (4.0) years and most women were of European (46%) or Asian (38%) ethnicity, and had Bachelor's degree or higher education (70%). About 75%, 88%, and 89% did not meet their dietary requirements (i.e., intake below the EAR) for fiber, potassium, and vitamin D intakes, from food only, respectively. Considering total dietary intake from food and supplements, the prevalence of dietary vitamin D inadequacy was 25%. Women of European ethnicity had higher vitamin D intake (median (IQR) in mg/1000kcal/day: 19.5 (7.26,101)) compared to Asian women (10.8 (3.87, 21.1); P < 0.05). Dietary vitamin D intake was higher in breastfeeding (i.e., providing breastmilk as primary milk source, i.e., ³2 times/day, to their 18-mo old toddlers) compared to non- or occasionally breastfeeding mothers (20.0 (10.5, 61.1) versus 14.9 (4.28, 26.7) mg/1000kcal/day; P < 0.05). Conclusions While most Canadian mothers in this sample met the EARs for most nutrients, the prevalence of dietary inadequacy was very high for vitamin D, potassium, and fiber. Some population groups may be especially at risk of developing nutrient deficiencies in this period of life characterized by postpartum recovery and transition; targeted public health strategies may be needed to address these deficiencies. Funding Sources This study is supported by The University of British Columbia, and the British Columbia Children's Hospital Research Institute, Canada, and is funded by Société des Produits Nestlé S.A.

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Dietary vitamin D intake, cardiovascular disease and cardiometabolic risk factors: a sex‐based analysis from the ATTICA cohort study

Journal of Human Nutrition and Dietetics ◽

10.1111/jhn.12748 ◽

2020 ◽

Vol 33 (5) ◽

pp. 708-717

Author(s):

M. Kouvari ◽

D. B. Panagiotakos ◽

C. Chrysohoou ◽

M. Yannakoulia ◽

E. N. Georgousopoulou ◽

...

Keyword(s):

Risk Factors ◽

Cardiovascular Disease ◽

Vitamin D ◽

Cohort Study ◽

Cardiometabolic Risk ◽

Cardiometabolic Risk Factors ◽

Dietary Vitamin ◽

Vitamin D Intake ◽

Dietary Vitamin D

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Association Between Vitamin D and Hyperuricemia Among Adults in the United States

Frontiers in Nutrition ◽

10.3389/fnut.2020.592777 ◽

2020 ◽

Vol 7 ◽

Author(s):

Yi-Ying Zhang ◽

Hong-Bin Qiu ◽

Jin-Wei Tian

Keyword(s):

Vitamin D ◽

Uric Acid ◽

Serum Uric Acid ◽

The United States ◽

Dietary Vitamin ◽

Multivariable Logistic Regression Analysis ◽

Total Vitamin ◽

Vitamin D Intake ◽

Supplemental Vitamin ◽

Dietary Vitamin D

Background: Serum uric acid can act as a risk factor for cardiovascular disease (CVD) and as antioxidant defense. Vitamin D deficiency can activate the parathyroid to induce the release of parathyroid hormone, which was thought to increase serum uric acid level, and low vitamin D status may also be associated with risk of CVD. No known studies have explored the association between serum 25(OH) D, vitamin D intake, and HU for the American population.Methods: We extracted 15,723 US adults aged 20–85 years from the National Health and Nutrition Examination Survey (NHANES) in 2007–2014. All dietary intakes were evaluated through 24-h dietary recalls. Multivariable logistic regression analysis was performed to examine the associations after adjustment for confounders.Results: Compared to the lowest quintile (Q1), for males, adjusted odds ratios (ORs) of HU in Q2 to Q4 of serum 25(OH) D levels were 0.78 (95% CI, 0.65–0.93), 0.97 (0.81–1.16), and 0.72 (0.60–0.88); ORs in Q2–Q5 of total vitamin D intake were 0.83 (0.69–0.98), 0.69 (0.58–0.83), 0.66 (0.55–0.79), and 0.59 (0.48–0.71), respectively. In females, OR was 0.80 (0.66–0.97) of serum 25(OH) D for Q3, and ORs in Q5 of total vitamin D intake were 0.80 (0.65–0.98).Conclusions: Our findings indicated that the serum 25(OH) D intakes of dietary vitamin D, supplemental vitamin D, and total vitamin D were inversely associated with HU in males. In females, a lower risk of HU with higher serum 25(OH) D, dietary vitamin D, and total vitamin D intake was found, but with no association between supplemental vitamin D intake and the risk of HU.

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Dietary vitamin D intake, 25-hydroxyvitamin D3 levels and premenstrual syndrome in a college-aged population

The Journal of Steroid Biochemistry and Molecular Biology ◽

10.1016/j.jsbmb.2010.03.076 ◽

2010 ◽

Vol 121 (1-2) ◽

pp. 434-437 ◽

Cited By ~ 31

Author(s):

Elizabeth R. Bertone-Johnson ◽

Patricia O. Chocano-Bedoya ◽

Sofija E. Zagarins ◽

Ann E. Micka ◽

Alayne G. Ronnenberg

Keyword(s):

Vitamin D ◽

Premenstrual Syndrome ◽

Dietary Vitamin ◽

Aged Population ◽

Vitamin D Intake ◽

Dietary Vitamin D

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Dietary Vitamin D Intake Among High-Risk Adolescents With Insulin Dependent Diabetes

The Diabetes Educator ◽

10.1177/0145721711398534 ◽

2011 ◽

Vol 37 (2) ◽

pp. 222-226 ◽

Cited By ~ 4

Author(s):

Heather C. Janisse ◽

Nedim Cakan ◽

Deborah Ellis ◽

Kathryn Brogan

Keyword(s):

Vitamin D ◽

High Risk ◽

Insulin Dependent Diabetes ◽

Dietary Vitamin ◽

Vitamin D Intake ◽

Insulin Dependent ◽

Dietary Vitamin D

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A Narrative Review of The Role of Foods as Dietary Sources of Vitamin D of Ethnic Minority Populations with Darker Skin: The Underestimated Challenge

Nutrients ◽

10.3390/nu11010081 ◽

2019 ◽

Vol 11 (1) ◽

pp. 81 ◽

Cited By ~ 5

Author(s):

Jing Guo ◽

Julie A. Lovegrove ◽

David I. Givens

Keyword(s):

Vitamin D ◽

Ethnic Minority ◽

Ultraviolet B ◽

Dietary Vitamin ◽

Minority Populations ◽

Vitamin D Status ◽

Vitamin D Intake ◽

Ethnic Minority Populations ◽

Dietary Vitamin D ◽

Lower Vitamin

In recent years, vitamin D deficiency has attracted attention worldwide. Especially many ethnic minority populations are considered at high-risk of vitamin D deficiency, owing to a lesser ability to synthesis vitamin D from sunlight (ultraviolet B), due to the skin pigment melanin and/or reduced skin exposure due to coverage required by religious and cultural restrictions. Therefore, vitamin D intake from dietary sources has become increasingly important for many ethnic minority populations to achieve adequate vitamin D status compared with the majority of the population. The aim of the study was critically evaluate the vitamin D intake and vitamin D status of the ethnic minority populations with darker skin, and also vitamin D absorption from supplements and ultraviolet B. Pubmed, Embaase and Scopus were searched for articles published up to October 2018. The available evidence showed ethnic minority populations generally have a lower vitamin D status than the majority populations. The main contributory food sources for dietary vitamin D intake were different for ethnic minority populations and majority populations, due to vary dietary patterns. Future strategies to increase dietary vitamin D intake by food fortification or biofortification needs to be explored, not only for the majority population but more specifically for ethnic minority populations who are generally of lower vitamin D status.

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