scholarly journals Is Macronutrients Intake a Challenge for Cardiometabolic Risk in Obese Adolescents?

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1785
Author(s):  
Sara Vizzuso ◽  
Matilde Amatruda ◽  
Alberico Del Torto ◽  
Enza D’Auria ◽  
Giulio Ippolito ◽  
...  
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Regression Analysis ◽  
Multiple Regression Analysis ◽  
Multiple Regression ◽  
Cardiometabolic Risk ◽  
Z Score ◽  
Obese Adolescents ◽  
Saturated Fats ◽  
Age And Sex

(1) Background: Pediatric obesity is an emerging public health issue, mainly related to western diet. A cross-sectional study was conducted to explore the association between macronutrients intake and cardiometabolic risk factors in obese adolescents. (2) Methods: Ninety-three Italian obese adolescents were recruited; anthropometric parameters, body composition, glucose and lipid metabolism profiles were measured. Macronutrients intake was estimated by a software-assisted analysis of a 120-item frequency questionnaire. The association between macronutrients and cardiometabolic risk factors was assessed by bivariate correlation, and multiple regression analysis was used to adjust for confounders such as age and sex. (3) Results: By multiple regression analysis, we found that higher energy and lower carbohydrate intakes predicted higher body mass index (BMI) z-score, p = 0.005, and higher saturated fats intake and higher age predicted higher HOmeostasis Model Assessment of insulin resistance (HOMA-IR) and lower QUantitative Insulin-sensitivity ChecK (QUICK) index, p = 0.001. In addition, a saturated fats intake <7% was associated with normal HOMA-IR, and a higher total fats intake predicted a higher HOMA of percent β-cell function (HOMA-β), p = 0.011. (4) Conclusions: Higher energy intake and lower carbohydrate dietary intake predicted higher BMI z-score after adjustment for age and sex. Higher total and saturated fats dietary intakes predicted insulin resistance, even after adjustment for confounding factors. A dietary pattern including appropriate high-quality carbohydrate and reduced saturated fat intakes could result in reduced cardiometabolic risk in obese adolescents.

scholarly journals The Effects of Different Exercise Modalities in the Treatment of Cardiometabolic Risk Factors in Obese Adolescents with Sedentary Behavior—A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Children ◽  
2021 ◽  
Vol 8 (11) ◽  
pp. 1062
Author(s):  
Daxin Li ◽  
Ping Chen
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
High Risk ◽  
Sedentary Behavior ◽  
Cardiometabolic Risk ◽  
Meta Analysis ◽  
Cardiometabolic Risk Factors ◽  
Controlled Trials ◽  
Obese Adolescents ◽  
Randomized Controlled

Purpose: Obesity has become increasingly prevalent in adolescents due to unhealthy diet habits, sedentary behavior and a lack of physical activities. This study aims to assess the effects of different exercise modalities in the treatment of cardiometabolic risk factors (CRF) in obese adolescents with sedentary behavior. Methods: A systematic search was conducted using databases (PubMed, Embase, Cochrane library, Web of Science, CNKI and VIP database) from the earliest available date to August 2021. Nineteen randomized controlled trials (RCTs) with 704 participants were included. The included studies were evaluated for methodological quality by the Cochrane bias risk assessment tool, and a statistical analysis was performed by the Review Manage 5.3 and Stata 15.1 software. Results: The results of the meta-analysis showed that exercise could significantly improve obese adolescents’ body mass index (BMI) (MD = −1.99, 95% CI: −2.81 to −1.17, p < 0.00001), low density liptein cholesterol (LDL-C) (SMD = −0.98, 95% CI: −1.58 to −0.37, p = 0.002), triglyceride (TG) (SMD = −0.93, 95% CI: −1.72 to −0.14, p = 0.02), total cholesterol (TC) (SMD = −1.00, 95% CI: −1.73 to −0.26, p = 0.008), peak oxygen uptake (VO2peak) (MD = 3.27, 95% CI: 1.52 to 5.02, p = 0.0003) and homeostatic model assessment insulin resistance (HOMA-IR) (SMD = −2.07, 95% CI: −3.3 to −0.84, p = 0.001). However, there was no statistically significant difference in high-density liptein cholesterol (HDL-C) (SMD = 0.40, 95% CI: −0.28 to 1.08, p = 0.25). Conclusion: Exercise can effectively improve cardiometabolic risk factors in obese adolescents with sedentary behavior. For obese adolescents who want to lose weight and improve cardiorespiratory fitness, combined aerobic and resistance training and high-intensity interval training are optimal choices. For obese adolescents with high blood lipids, aerobic training can be regarded as a primary exercise modality to reduce the high risk of cardiovascular diseases; For obese adolescents with insulin resistance, combined aerobic and resistance training can be considered to reduce the high risk of diabetes. It is hoped that more high-quality studies will further expand the meta-analysis results and demonstrate the optimal exercise frequency and treatment intensity of cardiometabolic risk factors in obese adolescents with sedentary behavior in the future.

Immunohistochemical evaluation is not prognostic for recurrence in fully staged high-risk endometrial cancer

2002 ◽  
Vol 12 (3) ◽  
pp. 286-289 ◽  
Author(s):  
J Fanning ◽  
S Brown ◽  
G Phibbs ◽  
T Kramer ◽  
A Zaher
Keyword(s):  
Risk Factors ◽  
Regression Analysis ◽  
Endometrial Cancer ◽  
High Risk ◽  
Multiple Regression Analysis ◽  
Multiple Regression ◽  
Tumor Recurrence ◽  
Prognostic Significance ◽  
Medical Illness ◽  
Stage Iiic

Abstract.Fanning J, Brown S, Phibbs G, Kramer T, Zaher A. Immunohistochemical evaluation is not prognostic for recurrence in fully staged high-risk endometrial cancer.The objective of this study was to determine the prognostic significance of common immunohistochemical pathologic risk factors in fully staged high-risk endometrial cancers. Sixty-two of 265 consecutive endometrioid adenocarcinomas were considered high risk for recurrence because of deep myometrial invasion and poor differentiation (stage IC, G3), cervical metastasis (stage II), ovarian metastasis (stage IIIA) or lymph node metastasis (stage IIIC). All patients underwent complete surgical staging with bilateral pelvic and aortic lymphadenectomy. Expression of estrogen receptors, progesterone receptors, p53, HER-2/neu, c-myc, bcl-2, FVIII, and Ki-67 were analyzed by immunohistochemistry using commercially available monoclonal antibodies. A general linear model multiple regression analysis was used to determine if any of the immunostains, along with grade or stage, were predictors of recurrence. Mean age was 68 years and mean weight 188 pounds. Sixty-eight percent of patients had associated medical illness. The majority of tumors were poorly differentiated (44%) and were stage IIIC (29%). Mean follow-up was 4.3 years. Fourteen patients (22%) developed tumor recurrence. Using multiple regression analysis, none of the immunostains were predictive for recurrence (P = 0.19-.96). Only stage and grade were predictive of tumor recurrence (P = 0.04, .02). We conclude that in completely staged high risk endometrial cancer, commonly used immunohistochemical risk factors are not predictive for recurrence.

scholarly journals The state of periodontum and cardiovascular risk factors in adolescents with high blood pressure

2019 ◽  
Vol 8 (4) ◽  
Author(s):  
Anna V. Pogodina ◽  
Larisa R. Kolesnikova ◽  
Olga V. Valyavskaya ◽  
Liliya V. Zurbanova ◽  
Lyubov V. Rychkova
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Regression Analysis ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Multiple Regression Analysis ◽  
Multiple Regression ◽  
High Blood Pressure ◽  
Oral Hygiene ◽  
The Other

Objective — To establish significant associations between periodontium status, circadian blood pressure (BP) profile and cardiovascular risk factors in adolescents with high BP. Material and Methods — The cross-sectional study involved 113 adolescents (78 boys) aged 10 to 17 years, with a BP level (during repeated office measurements) of ≥95 percentile for age, height and sex, or ≥140/90 mmHg in adolescents older than 16 years. All adolescents were subjected to 24-hour blood pressure monitoring, anthropometric measurements, laboratory blood tests (lipids, uric acid, alanine aminotransferase, aspartate aminotransferase, fasting glucose), echocardiography (left ventricular myocardial mass index, relative wall thickness), assessment of the stage of puberty, dental examination (complex periodontal index (CPI), oral hygiene index). The association between the periodontium status and cardiovascular risk factors was assessed using univariant and multiple regression analysis, adjusted by sex, age, Tanner stage, body mass index, and oral hygiene index. Results — Clinical features of periodontitis were found in 32.7% of adolescents. Multiple regression analysis showed the presence of significant associations of CPI with the levels of systolic, mean and pulse BP during 24 hours (β=0.42, р=0.0001; β=0.31, р=0.003 and β=0.26, р=0.018, respectively), diastolic BP in the daytime (β=0.23, р=0.019), as well as the indices of load with high systolic BP within 24 hours (β=0.42, р=0.0001) and diastolic BP in the daytime (β=0.25, р=0.006). None of the other cardiovascular risk factors showed meaningful relationships with periodontium status in the multivariate analysis. Conclusion — The relationship between periodontium status and blood pressure level exists already in adolescence. That may, on the one hand, justify assessment of periodontium status and (if necessary) timely implementation of prophylactic measures in adolescents with high blood pressure and, on the other hand, recommend BP assessment in adolescents with diagnosed periodontitis.

High Prevalence of Metabolic Syndrome and of Insulin Resistance in Psoriatic Arthritis is Associated with the Severity of Underlying Disease

2014 ◽  
Vol 41 (7) ◽  
pp. 1357-1365 ◽  
Author(s):  
Muhammad Haroon ◽  
Phil Gallagher ◽  
Eric Heffernan ◽  
Oliver FitzGerald
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Regression Analysis ◽  
Psoriatic Arthritis ◽  
Multiple Regression Analysis ◽  
Multiple Regression ◽  
Age Of Onset ◽  
Tumor Necrosis Factor Inhibitor ◽  
Underlying Disease ◽  
Model Assessment

Objective.To investigate the prevalence of metabolic syndrome (MetS) and of insulin resistance (IR) in an ethnically homogeneous cohort of established psoriatic arthritis (PsA), and to identify clinical associations of MetS and IR in patients with PsA.Methods.A cohort of 283 patients with PsA all meeting ClASsification for Psoriatic ARthritis (CASPAR) criteria was included. All underwent detailed skin and rheumatologic assessments, along with cardiovascular risk factor evaluation. IR was defined as an elevated homeostasis model assessment (HOMA-IR) value of > 2.5. Severe PsA was defined as the presence of 1 or more of the PsA-related radiographic damage features (peripheral joint erosions, osteolysis, sacroiliitis), and PsA requiring tumor necrosis factor inhibitor therapy.Results.The demographic and clinical characteristics of the cohort were mean age 54.6 ± 12 years, 52% female, mean PsA duration 19 ± 9 years. MetS was present in 44% of the studied patients (n = 283). On multiple regression analysis, a significant association of MetS was noted with more severe PsA (OR 4.47, p < 0.001), higher smoking pack-years (OR 1.03, p = 0.02), and worse EQ-5D scores (OR 1.28, p = 0.02). Data on IR were available for 263 patients, and among them, the mean HOMA-IR was 1.43 ± 1.09. Forty-one patients (16%) had IR. On multiple regression analysis, a significant association of IR was noted with more severe PsA (OR 3.49, p = 0.03), later psoriasis age of onset (OR 1.07, p = 0.001), and higher body mass index (OR 1.22, p < 0.001).Conclusion.Among patients with PsA, MetS and IR are highly prevalent, and are independently associated with the severity of underlying PsA.

scholarly journals DISIPLIN K3 MELALUI PEMAKAIAN ALAT PELINDUNG DIRI (APD) DI LABORATORIUM KIMIA PT SUCOFINDO

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Tatan Sukwika ◽  
Susan Endah Kartikasari
Keyword(s):  
Regression Analysis ◽  
Multiple Regression Analysis ◽  
Multiple Regression ◽  
Occupational Safety ◽  
Occupational Safety And Health ◽  
Hazardous Chemicals ◽  
Chemical Laboratory ◽  
Safety And Health ◽  
Simultaneous Influence ◽  
Age And Sex

Chemical laboratories are environments where a wide variety of analytical activities are associated with hazardous chemicals that can have negative implications for occupational safety and health (OSH). The research objective is to analyze the level of discipline based on knowledge, attitudes and commitment to carry out OSH by PT Sucofindo employees in the chemical laboratory. The method used is crosstab analysis and multiple regression analysis. The results of the crosstab analysis showed that there was an influence between age and sex, but there was no effect of working time on the use of PPE. The multiple regression results show that there is a simultaneous influence on the four variables mentioned above with OSH behavior. As for partially, there is an influence between knowledge, PPE facilities and supervision on OSH behaviour there is no influence on supervision. It is recommended that a refresher and outreach should be done regarding the use of PPE, providing PPE equipment needed and supervising the use of PPE at least once time a month in a chemical laboratory.

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