scholarly journals An Assessment of Risk Factors for Insufficient Levels of Vitamin D during Early Infancy

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1068
Author(s):  
Keith T. S. Tung ◽  
Rosa S. Wong ◽  
Hing Wai Tsang ◽  
Bianca N. K. Chan ◽  
Siew Yan Wong ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Risk Model ◽  
Early Stage ◽  
Cumulative Risk ◽  
Vitamin D Insufficiency ◽  
Increased Risk ◽  
Cumulative Risk Model ◽  
History Of ◽  
Guidelines And Recommendations

Recent evidence suggests that breastfeeding may increase the risk of vitamin D deficiency in offspring. However, it is unclear whether increased risk results from breastfeeding alone, or whether it is associated together with other risk factors. This study surveyed 208 infant–mother dyads recruited by stratified random sampling in different districts of Hong Kong. Mothers were asked to complete a questionnaire on their demographics, history of risk behavior, and feeding practices. Peripheral blood samples were collected from infants to determine their vitamin D status. Among all infant participants, 70 were vitamin D insufficient or deficient. Being breastfed, being a girl, having a multiparous mother, and the use of sun cream were found to be the strongest risk factors for vitamin D insufficiency during infancy (all p < 0.05), after mutual adjustment. The cumulative risk model displayed a dose–response pattern between the number of risk factors and the risk of vitamin D insufficiency during this period. Our findings indicate the risk profile of infants with insufficient vitamin D. Guidelines and recommendations on healthy diet and lifestyle should be provided to mothers during the early stage of pregnancy to increase the likelihood of adequate levels of vitamin D in their offspring.

Risk Factors for Suicide Attempts Among African American Women Experiencing Recent Intimate Partner Violence

2002 ◽  
Vol 17 (3) ◽  
pp. 283-295 ◽  
Author(s):  
Martie P. Thompson ◽  
Nadine J. Kaslow ◽  
J. B. Kingree
Keyword(s):  
Risk Factors ◽  
African American ◽  
Suicide Attempt ◽  
African American Women ◽  
Suicide Attempts ◽  
Risk Model ◽  
Cumulative Risk ◽  
American Women ◽  
Cumulative Risk Model ◽  
Risk Factors For Suicide

The purposes of this study were to identify risk factors for suicide attempts among 200 African American abused women (100 attempters, 100 nonattempters) and to test a cumulative risk model to determine if a woman’s likelihood of making a suicide attempt increased as the number of risk factors increased. Results revealed that attempters were significantly more likely than nonattempters to report high levels of depressive symptoms, hopelessness, drug abuse, and childhood abuse and neglect. Results from the cumulative risk model revealed a linear association between the number of risk factors and the odds of making a suicide attempt. Compared to women with no risk factors, women with two risk factors, women with three risk factors, and women with four to five risk factors were 10, 25, and 107 times, respectively, more likely to attempt suicide. The identification of risk variables highlights the importance of designing interventions to address these factors in order to reduce the risk of suicidal behavior in abused, African American women.

Media Violence and Other Aggression Risk Factors in Seven Nations

2017 ◽  
Vol 43 (7) ◽  
pp. 986-998 ◽  
Author(s):  
Craig A. Anderson ◽  
Kanae Suzuki ◽  
Edward L. Swing ◽  
Christopher L. Groves ◽  
Douglas A. Gentile ◽  
...  
Keyword(s):  
Risk Factors ◽  
Protective Factors ◽  
Risk Model ◽  
Cumulative Risk ◽  
Risk And Protective Factors ◽  
The United States ◽  
Media Violence ◽  
Individual Risk ◽  
Cumulative Risk Model ◽  
The Media

Cultural generality versus specificity of media violence effects on aggression was examined in seven countries (Australia, China, Croatia, Germany, Japan, Romania, the United States). Participants reported aggressive behaviors, media use habits, and several other known risk and protective factors for aggression. Across nations, exposure to violent screen media was positively associated with aggression. This effect was partially mediated by aggressive cognitions and empathy. The media violence effect on aggression remained significant even after statistically controlling a number of relevant risk and protective factors (e.g., abusive parenting, peer delinquency), and was similar in magnitude to effects of other risk factors. In support of the cumulative risk model, joint effects of different risk factors on aggressive behavior in each culture were larger than effects of any individual risk factor.

scholarly journals A Cumulative Risk Model of Child Physical Maltreatment Potential: Findings From a Community-Based Study

2015 ◽  
Vol 33 (8) ◽  
pp. 1287-1305 ◽  
Author(s):  
Diogo Lamela ◽  
Bárbara Figueiredo
Keyword(s):  
Risk Factors ◽  
Risk Model ◽  
Trigger Point ◽  
Risk Index ◽  
Cumulative Risk ◽  
Cumulative Effect ◽  
Self Report ◽  
Risk Indicators ◽  
Cumulative Risk Model ◽  
Physical Maltreatment

Previous studies have identified the predictive risk factors of child physical maltreatment (CPM). However, a significant number of these studies assessed risk factors in isolation. The cumulative risk hypothesis postulates that health problems are caused by the accumulation of risk factors, independently of the presence or absence of specific risk indicators. Few studies examined the effect of cumulative risk on CPM potential. This study aimed to test two concurrent models of cumulative risk of CPM potential by investigating whether CPM potential was better predicted by a threshold cumulative risk model or a linear cumulative risk model. Data from the National Representative Study of Psychosocial Context of Child Abuse and Neglect in Portugal were used. Parents of school-age children ( N = 796) answered to self-report measures regarding sociodemographic variables, history of child maltreatment, psychological distress, and CPM potential. A cumulative risk index was computed, comprising 10 dichotomized risk factors. Evidence for a threshold cumulative effect was found. Additional bivariate logistic regressions revealed that the odds for high-potential CPM were dramatically higher for those parents with six or more risk factors when compared with parents with any one risk factor. By testing and confirming a threshold cumulative effect on CPM potential, it was possible to find a “trigger point” from which a dramatic increase in child physical maltreatment potential occurs.

Social and family risk factors for infant development at one year: An application of the cumulative risk model

1998 ◽  
Vol 19 (1) ◽  
pp. 85-96 ◽  
Author(s):  
Stephen R. Hooper ◽  
Margaret R. Burchinal ◽  
Joanne Erwick Roberts ◽  
Susan Zeisel ◽  
Eloise C. Neebe
Keyword(s):  
Risk Factors ◽  
Infant Development ◽  
Risk Model ◽  
Cumulative Risk ◽  
Family Risk Factors ◽  
Family Risk ◽  
Cumulative Risk Model ◽  
One Year

scholarly journals Risk Factors Related to Acute Respiratory Distress Syndrome and Death in Patients with COVID-19: A Retrospective Cohort Study in Wuhan, China

2020 ◽  
Author(s):  
Jing Wang ◽  
Lu Wang ◽  
Meng Jin ◽  
Zequn Lu ◽  
Jun Xiao ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Prediction Model ◽  
Distress Syndrome ◽  
Immune Cell ◽  
Risk Model ◽  
Early Stage ◽  
Increased Risk

Abstract Background: The COVID-19 pandemic has been considered as the great threat to global public health. We aimed to clarify the risk factors associated with the development of acute respiratory distress syndrome (ARDS) and progression from ARDS to death and construct a risk prediction model.Methods: In this single-centered, retrospective, and observational study, 796 COVID-19 patients developed ARDS and 735 COVID-19 patients without ARDS were matched by propensity score at an approximate ratio of 1:1 based on age, sex and comorbidities. Demographic data, symptoms, radiological findings, laboratory examinations, and clinical outcomes were compared between with or without ARDS. Univariable and multivariable logistic regression models were applied to explore the risk factors for development of ARDS and progression from ARDS to death and establish a comprehensive risk model. Results: Higher SOFA, qSOFA, APACHE II and SIRS scores, elevated inflammatory cytokines, dysregulated multi-organ damage biomarkers, decreased immune cell subsets were associated with higher proportion of death (34.17% vs 1.22%; P<0.001) and increased risk odds of death (OR=57.216, 95%CI=28.373-115.378; P<0.001) in COVID-19 patients with ARDS. In addition to previous reported risk factors related to ARDS development and death, such as neutrophils, IL-6, D-Dimer, leukocytes and platelet, we identified elevated TNF-α (OR=1.146, 95%CI=1.100-1.194; P<0.001), CK-MB (OR=1.350, 95%CI=1.180-1.545; P<0.001), declined ALB (OR=0.834, 95%CI=0.799-0.872; P<0.001), CD8+ T cells (OR=0.983, 95%CI=0.976-0.990; P<0.001) and CD3-CD19+ B cells (OR=0.992, 95%CI=0.988-0.997; P=0.003) as novel risk factors. Most importantly, the predictive accuracy of the combined model integrating four score systems and these risk factors demonstrated highest among all models for the development of ARDS (AUC= 0.904) and the progression from ARDS to death (AUC= 0.959).Conclusion: COVID-19 patients with ARDS were more likely to develop into death. The potential risk factors and the comprehensive prediction model could be helpful to identify patients developed ARDS with poor prognosis at an early stage, which might help physicians to formulate a timely therapeutic strategy.

scholarly journals Risk factors related to acute respiratory distress syndrome and death in patients with COVID-19: a retrospective cohort study in Wuhan, China

2021 ◽  
Author(s):  
Jing Wang ◽  
Lu Wang ◽  
Meng Jin ◽  
Zequn Lu ◽  
Yao Li ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Prediction Model ◽  
Distress Syndrome ◽  
Immune Cell ◽  
Risk Model ◽  
Early Stage ◽  
Increased Risk

Abstract Background:The COVID-19 pandemic has been considered a great threat to global public health. We aimed to clarify the risk factors associated with the development of acute respiratory distress syndrome (ARDS) and progression from ARDS to death and construct a risk prediction model.Methods:In this single-centered, retrospective, and observational study, 796 COVID-19 patients developed ARDS and 735 COVID-19 patients without ARDS were matched by propensity score at an approximate ratio of 1:1 based on age, sex and comorbidities. Demographic data, symptoms, radiological findings, laboratory examinations, and clinical outcomes were compared between those with or without ARDS. Univariable and multivariable logistic regression models were applied to explore the risk factors for development of ARDS and progression from ARDS to death and establish a comprehensive risk model. Results:Higher SOFA, qSOFA, APACHE II and SIRS scores, elevated inflammatory cytokines, dysregulated multi-organ damage biomarkers, decreased immune cell subsets were associated with higher proportion of death (34.17% vs 1.22%; P<0.001) and increased risk odds of death (OR=57.216, 95%CI=28.373-115.378; P<0.001) in COVID-19 patients with ARDS. In addition to previous reported risk factors related to ARDS development and death, such as neutrophils, IL-6, D-Dimer, leukocytes and platelet, we identified elevated TNF-α (OR=1.146, 95%CI=1.100-1.194; P<0.001), CK-MB (OR=1.350, 95%CI=1.180-1.545; P<0.001), declined ALB (OR=0.834, 95%CI=0.799-0.872; P<0.001), CD8+ T cells (OR=0.983, 95%CI=0.976-0.990; P<0.001) and CD3-CD19+ B cells (OR=0.992, 95%CI=0.988-0.997; P=0.003) as novel risk factors. Most importantly, the predictive accuracy of the combined model integrating four score systems and these risk factors demonstrated highest among all models for the development of ARDS (AUC= 0.904) and the progression from ARDS to death (AUC= 0.959).Conclusion:COVID-19 patients with ARDS were more likely to develop into death. The potential risk factors and the comprehensive prediction model could be helpful to identify patients that are at risk of developing ARDS with poor prognosis at an early stage, which might help physicians to formulate a timely therapeutic strategy.

scholarly journals The possibility of early diagnostics of atrial fibrillation in patients with high risk of it’s development

2018 ◽  
Vol 22 (2) ◽  
pp. 14-18
Author(s):  
Ksenia S. Devyashina ◽  
Ksenia G. Oganyan ◽  
Stella M. Panchoyan ◽  
Yulia A. Yakovleva ◽  
Elena V. Frolova
Keyword(s):  
Risk Factors ◽  
Atrial Fibrillation ◽  
Arterial Hypertension ◽  
Early Stage ◽  
Thromboembolic Complications ◽  
Early Diagnostics ◽  
Additional Equipment ◽  
Increased Risk ◽  
History Of ◽  
Rhythm Disorder

Atrial fibrillation (AF) is the most common rhythm disorder. The consequences of undiagnosed AF are an increased risk of developing of heart failure and thromboembolic complications. The article is devoted to study of the possibility of using the medical device MyDiagnostick 1001R® in clinical practice for patients with the risk of AF development for early stage diagnosis. Methods. A group of subjects included 30 patients who did not have a history of AF, but who had the risk factors for its development — arterial hypertension, diabetes, obesity, ischemic heart disease (IHD). The average age of participants was 65.9 ± 12.1 years. A questionnaire containing 16 questions was developed to identify the risk factors of AF development. Results. From 30 participants 80% had arterial hypertension, 43.3% diabetes, 3.3% were obese, 50% suffered from IHD, 16.6% had stroke in anamnesis and 23.3% were smokers. All patients had a combination of risk factors. As a result, with the help of MyDiagnostick 1001R® 26.7% (8 patients) of the group was discovered to have AF episodes. For all participants recommendations for further examination and treatment were given. Conclusions. MyDiagnostick 1001R® is a simple device that does not require additional equipment, and allows to identify previously undiagnosed AF within 24 hours for subsequent diagnosis. It allows us to recommend this device for screening of patients with AF risk factors.

Therapeutic options in male osteoporosis

2013 ◽  
Vol 22 (04) ◽  
pp. 271-276 ◽  
Author(s):  
P. Farahmand ◽  
J. D. Ringe
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Public Health Problem ◽  
Male Osteoporosis ◽  
Individual Risk ◽  
Modes Of Action ◽  
Increased Risk ◽  
Study Results ◽  
Long Term Treatment ◽  
Male Patients

SummaryOsteoporosis in men is increasingly recognized as an important public health problem but affected patients are still under-diagnosed and -treated. As in women the diagnostic and therapeutic strategy has to be adapted to the individual case. In the practical management it is very important to detect possible causes of secondary osteoporosis, to explain the possibilities of basic therapy counteracting individual risk factors and communicate that osteoporosis is a chronic disease and adherence to a long-term treatment is crucial. In established severe osteoporosis a careful analgesic therapy is important to avoid further bone loss related to immobility. In elderly men with increased risk of falling insufficient Vitamin D supply or impaired activation of Vitamin D due to renal insufficiency must be taken into consideration. Specific medications available today for the treatment of male osteoporosis comprise among antiresorptive drugs the bis phosphonates alendronate, risedronate and zoledronic acid. Denosumab, the first biological therapy is approved for men with androgen deprivation therapy for prostate cancer. An important advantage of this potent antiresorptive drug is the increased adherence due to the comfortable application by sixmonthly subcutaneous injections. Study results from the 2-year multi-center randomized controlled ADAMO-Study will very soon allow the use of denosumab in all types of male osteoporosis. Teriparatide, the 34 N-terminal amino acid sequence of parathyroid hormone was approved for men with osteoporosis as an anabolic agent based on proven efficacy by different studies. Among drugs with other modes of action the D-hormone pro-drug alfacalcidol can be used in men alone or in combination with the advantage of pleiotropic effects on calcium absorption, parathyroids, bone and muscle. Recently also Strontium-ranelate was approved for male patients with the limitation to exclude men with clinical relevant cardiovascular risk factors. In general the possibilities to treat male osteoporosis have considerably improved during recent years. Today there is a choice of a spectrum of drugs from mild to strong potency with different modes of action on bone turnover to design strategies for individual male patients.

scholarly journals Patients with SLE have higher risk of cardiovascular events and mortality in comparison with controls with the same levels of traditional risk factors and intima-media measures, which is related to accumulated disease damage and antiphospholipid syndrome: a case–control study over 10 years

2021 ◽  
Vol 8 (1) ◽  
pp. e000454
Author(s):  
Sofia Ajeganova ◽  
Ingiäld Hafström ◽  
Johan Frostegård
Keyword(s):  
Risk Factors ◽  
Antiphospholipid Syndrome ◽  
Carotid Plaque ◽  
Adverse Outcome ◽  
Density Lipoprotein ◽  
Index Score ◽  
Baseline Body Mass Index ◽  
Systemic Lupus ◽  
Increased Risk ◽  
History Of

ObjectiveSLE is a strong risk factor for premature cardiovascular (CV) disease and mortality. We investigated which factors could explain poor prognosis in SLE compared with controls.MethodsPatients with SLE and population controls without history of clinical CV events who performed carotid ultrasound examination were recruited for this study. The outcome was incident CV event and death. Event-free survival rates were compared using Kaplan-Meier curves. Relative HR (95% CI) was used to estimate risk of outcome.ResultsPatients (n=99, 87% female), aged 47 (13) years and with a disease duration of 12 (9) years, had mild disease at inclusion, Systemic Lupus Erythematosus Diseases Activity Index score of 3 (1–6) and Systemic Lupus International Collaborating Clinics (SLICC) Damage Index score of 0 (0–1). The controls (n=109, 91% female) were 49 (12) years old. Baseline carotid intima-media thickness (cIMT) did not differ between the groups, but plaques were more prevalent in patients (p=0.068). During 10.1 (9.8-10.2) years, 12 patients and 4 controls reached the outcome (p=0.022). Compared with the controls, the risk of the adverse outcome in patients increased threefold to fourfold taking into account age, gender, history of smoking and diabetes, family history of CV, baseline body mass index, waist circumference, C reactive protein, total cholesterol, high-density lipoprotein, low-density lipoprotein, dyslipidaemia, cIMT and presence of carotid plaque. In patients, higher SLICC score and SLE-antiphospholipid syndrome (SLE-APS) were associated with increased risk of the adverse outcome, with respective HRs of 1.66 (95% CI 1.20 to 2.28) and 9.08 (95% CI 2.71 to 30.5), as was cIMT with an HR of 1.006 (95% CI 1.002 to 1.01). The combination of SLICC and SLE-APS with cIMT significantly improved prediction of the adverse outcome (p<0.001).ConclusionIn patients with mild SLE of more than 10 years duration, there is a threefold to fourfold increased risk of CV events and death compared with persons who do not have SLE with similar pattern of traditional CV risk factors, cIMT and presence of carotid plaque. SLICC, SLE-APS and subclinical atherosclerosis may indicate a group at risk of worse outcome in SLE.

Sign in / Sign up

Export Citation Format

Share Document