scholarly journals Potential Relevance of Bioactive Peptides in Sports Nutrition

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 3997
Author(s):  
Daniel König ◽  
Jan Kohl ◽  
Simon Jerger ◽  
Christoph Centner
Keyword(s):  
Bioactive Peptides ◽  
Positive Impact ◽  
Proteolytic Enzymes ◽  
Sports Nutrition ◽  
Biologically Active ◽  
Rehabilitation Process ◽  
Practical Applications ◽  
Active Peptides ◽  
Health Related ◽  
Positive Effect

Bioactive peptides are physiologically active peptides mostly derived from proteins following gastrointestinal digestion, fermentation or hydrolysis by proteolytic enzymes. It has been shown that bioactive peptides can be resorbed in their intact form and have repeatedly been shown to have a positive effect on health-related parameters such as hypertension, dyslipoproteinemia, inflammation and oxidative stress. In recent years, there has been increasing evidence that biologically active peptides could also play an important role in sports nutrition. Current studies have shown that bioactive peptides could have a positive impact on changes in body composition and muscular performance, reduce muscle damage following exercise and induce beneficial adaptions within the connective tissue. In the following overview, potential mechanisms as well as possible limitations regarding the sports-related effect of bioactive peptides and their potential mechanisms are presented and discussed. In addition, practical applications will be discussed on how bioactive peptides can be integrated into a nutritional approach in sports to enhance athletic performance as well as prevent injuries and improve the rehabilitation process.

PERSPECTIVES OF BIOINFORMATICS FOR RESEARCHING FOOD BIOACTIVE PEPTIDES USING IN SILICO INSTRUMENTS

2020 ◽  
Author(s):  
К.А. РЯЗАНЦЕВА ◽  
Е.Ю. АГАРКОВА
Keyword(s):  
In Silico ◽  
Bioactive Peptides ◽  
Rapid Development ◽  
Biologically Active ◽  
Food Proteins ◽  
Active Peptides ◽  
Biologically Active Peptides ◽  
Speed Up ◽  
Bioinformatic Approaches

В статье приведен обзор основных классических подходов к производству биологически активных пептидов (БП) и способы их идентификации. Показано, что традиционно используемые способы получения и анализа БП требуют значительных временных и материальных затрат, что ограничивает подробные исследования и оперативную разработку БП. Новые биоинформационные подходы in silico, используемые для идентификации, характеристики, разработки биоактивных механизмов и производства БП из пищевых белков, могут упростить получение и исследование БП, что позволит ускорить разработку функциональных продуктов с использованием БП. The article describes the main classical approaches to the production of biologically active peptides and methods for their identification. It has been shown that the traditionally used methods of obtaining and analyzing bioactive peptides (BP) are not only very costly, but also require a significant amount of time, which limits detailed research and rapid development of BP. New bioinformatic approaches in silico used for identification, characterization, development of bioactive mechanisms and production of BP from food proteins can simplify the production and study of biologically active peptides, which will speed up the development of functional products using BP.

Health Implications of Bioactive Peptides: A Review

2018 ◽  
Vol 88 (5-6) ◽  
pp. 319-343 ◽  
Author(s):  
Elham Nourmohammadi ◽  
Alireza Sadeghi Mahoonak
Keyword(s):  
Food Habits ◽  
Bioactive Peptides ◽  
Biologically Active ◽  
Health Claims ◽  
Novel Foods ◽  
Active Peptides ◽  
Synthetic Drugs ◽  
Anti Cancer ◽  
Biologically Active Peptides ◽  
Mineral Binding

Abstract. Today, due to immobility, improper food habits, and changes in lifestyle, communities are faced with an increase in health problems such as blood pressure, cholesterol, diabetes, and thrombosis. Bioactive peptides are considered as being the main products of protein hydrolysis which exert high effects on the nervous, immune, and gastrointestinal systems. Unlike synthetic drugs, bioactive peptides have no side effects and this advantage has qualified them as an alternative to such drugs. Due to the above-mentioned properties, this paper focuses on the study of health-improving attributes of bioactive peptides such as anti-oxidative, anti-hypertensive, immunomodulatory, anti-microbial, anti-allergenic, opioid, anti-thrombotic, mineral-binding, anti-inflammatory, hypocholesterolemic, and anti-cancer effects. We also discuss the formation of bioactive peptides during fermentation, the main restrictions on the use of bioactive peptides and their applications in the field of functional foods. In general, food-derived biologically active peptides play an important role in human health and may be used in the development of novel foods with certain health claims.

A Review of Bioactive Peptides: Chemical Modification, Structural Characterization and Therapeutic Applications

2020 ◽  
Vol 16 (12) ◽  
pp. 1687-1718
Author(s):  
Huiwen Hou ◽  
Juan Wang ◽  
Jie Wang ◽  
Wen Tang ◽  
Abdul Sami Shaikh ◽  
...  
Keyword(s):  
Half Life ◽  
Bioactive Peptides ◽  
Structural Characteristics ◽  
The Body ◽  
Biologically Active ◽  
Bioactive Peptide ◽  
Protein Drugs ◽  
Active Peptides ◽  
Biologically Active Peptides ◽  
Further Development

In recent years, the development and applications of protein drugs have attracted extensive attention from researchers. However, the shortcomings of protein drugs also limit their further development. Therefore, bioactive peptides isolated or simulated from protein polymers have broad application prospects in food, medicine, biotechnology, and other industries. Such peptides have a molecular weight distribution between 180 and 1000 Da. As a small molecule substance, bioactive peptide is usually degraded by various enzymes in the organism and have a short half-life. At the same time, such substances have poor stability and are difficult to produce and store. Therefore, these active peptides may be modified through phosphorylation, glycosylation, and acylation. Compared with other protein drugs, the modified active peptides are more easily absorbed by the body, have longer half-life, stronger targeting, and fewer side effects in addition to higher bioavailability. In the light of their functions, bioactive peptide can be divided into antimicrobial, anti-tumour, anti-angiogenic, antioxidant, anti-fatigue, and anti-hypertensive peptides. This article mainly focuses on the introduction of several promising biologically active peptides functioning as antimicrobial, anti-tumour, antiangiogenic, and antioxidant peptides from the three aspects modification, structural characteristics and mechanism of action.

Biofunctional properties of milk protein derived bioactive peptides -A review

2015 ◽  
Vol 34 (4) ◽  
Author(s):  
Prasad Patil ◽  
Akanksha Wadehra ◽  
Varsha Garg ◽  
Kanchan Munjal ◽  
Sudhir Kumar Tomar ◽  
...  
Keyword(s):  
Milk Protein ◽  
Bioactive Peptides ◽  
Therapeutic Potential ◽  
Proteolytic Enzymes ◽  
Biological Activities ◽  
Milk Proteins ◽  
Physiological Effect ◽  
Amino Acid Sequences ◽  
The Body ◽  
Biologically Active

Milk has long been acknowledged as a source of macro- and micro nutrients. Presently, several identified biologically active substances from milk and their derivatives has attracted much attention from the scientific community. These bioactive compounds confer many health benefits that might support disease prevention. Worldwide, there is an increasing interest in the therapeutic potential of bioactive peptides which collectively present a cornucopia of bioactivities for utilization in humans. Bioactive peptides are hydrolysates with specific amino acid sequences that exert a positive physiological effect on the body. Most of the biological activities are encrypted within the primary sequence of the native protein and can be released during digestion by proteolytic enzymes in the gastrointestinal tract or during fermentation and food processing. Milk protein is an important source of bioactive peptides which may contribute to regulate the nervous, gastrointestinal, and cardiovascular systems as well as the immune system. Milk protein derived bioactive peptides are shown to have antihypertensive, antimicrobial, immunomodulatory, antioxidative and mineral-binding properties. Bioactive peptides derived from milk proteins are of particular interest to the food industry due to the potential functional and physiological roles that they exhibit.

scholarly journals Current Trends of Bioactive Peptides—New Sources and Therapeutic Effect

Foods ◽  
2020 ◽  
Vol 9 (7) ◽  
pp. 846 ◽  
Author(s):  
Anna Jakubczyk ◽  
Monika Karaś ◽  
Kamila Rybczyńska-Tkaczyk ◽  
Ewelina Zielińska ◽  
Damian Zieliński
Keyword(s):  
Bioactive Peptides ◽  
Current Knowledge ◽  
Antimicrobial Properties ◽  
Biologically Active ◽  
Active Peptides ◽  
Current Trends ◽  
Bioactive Properties ◽  
Biologically Active Peptides ◽  
Alternative Sources ◽  
Different Sources

Generally, bioactive peptides are natural compounds of food or part of protein that are inactive in the precursor molecule. However, they may be active after hydrolysis and can be transported to the active site. Biologically active peptides can also be synthesized chemically and characterized. Peptides have many properties, including antihypertensive, antioxidant, antimicrobial, anticoagulant, and chelating effects. They are also responsible for the taste of food or for the inhibition of enzymes involved in the development of diseases. The scientific literature has described many peptides with bioactive properties obtained from different sources. Information about the structure, origin, and properties of peptides can also be found in many databases. This review will describe peptides inhibiting the development of current diseases, peptides with antimicrobial properties, and new alternative sources of peptides based on the current knowledge and documentation of their bioactivity. All these issues are part of modern research on peptides and their use in current health or technological problems in food production.

Bioactive peptides from egg: a review

2015 ◽  
Vol 45 (2) ◽  
pp. 190-212 ◽  
Author(s):  
Z. F. Bhat ◽  
Sunil Kumar ◽  
Hina Fayaz Bhat
Keyword(s):  
Bioactive Peptides ◽  
Antioxidant Activities ◽  
Positive Impact ◽  
Antimicrobial Properties ◽  
Specific Protein ◽  
Biologically Active ◽  
Content Type ◽  
Treatment And Prevention

Purpose – The aim of the article was to focus on various peptides identified in the egg and their probable application as novel ingredients in the development of functional food products. Bioactive peptides of egg origin have attracted increasing interest as one of the prominent candidates for development of various health-promoting functional and designer foods. Design/methodology/approach – Traditionally known as a source of highly valuable proteins in human nutrition, eggs are nowadays also considered as an important source of many bioactive peptides which may find wide application in medicine and food production. These specific protein fragments from egg proteins which, above and beyond their nutritional capabilities, have a positive impact on the body’s function or condition by affecting the digestive, endocrine, cardiovascular, immune and nervous systems, and may ultimately influence health. Findings – Several peptides that are released in vitro or in vivo from egg proteins have been attributed to different health effects, including antihypertensive effects, antimicrobial properties, antioxidant activities, anticancer activity, immunomodulating activity, antiadhesive properties and enhancement of nutrient absorption and/or bioavailability. Extensive research has been undertaken to identify and characterize these biologically active peptides of egg origin which has changed the image of egg as a new source of biologically active ingredients for the development of functional foods with specific benefits for human health and treatment and prevention of diseases. Originality/value – The paper mainly describes the above-stated properties of bioactive peptides derived from egg proteins.

scholarly journals An exploration of bioactive peptides: My collaboration with Ervin G. Erdös

2018 ◽  
Vol 293 (21) ◽  
pp. 7907-7915 ◽  
Author(s):  
Rajko Igić
Keyword(s):  
Bioactive Peptides ◽  
Research Direction ◽  
The United States ◽  
Biologically Active ◽  
Active Peptides ◽  
Biologically Active Peptides ◽  
High Regard ◽  
Personal Qualities ◽  
New Research ◽  
Historical Sketch

This paper provides a brief historical sketch of the science of biologically active peptides. It also offers the story of how Ervin G. Erdös, a pioneer in the study of metabolism of various peptides, influenced me through collaborations that span many years. I worked in Dr. Erdös's research laboratories in Oklahoma City, Dallas, and Chicago, and we shared research interests through visits across the Atlantic between the former Yugoslavia and the United States. Among other findings, we discovered angiotensin-converting enzyme in the retina, which opened up a new research direction for many scientists interested in serious ocular diseases. This tribute to my mentor paints a portrait of a man who, in addition to his dedication to science and his seminal discoveries about the metabolism of peptides, took the time to invest in training many young scientists. His fine personal qualities explain why all of those who worked with him hold him in such high regard.

scholarly journals Aquatic Exercise to Treat Pregnancy Related Issues in Pregnant Women: A Systematic Review

2020 ◽  
Vol 6 (2) ◽  
pp. 391-400
Author(s):  
Asif Ali ◽  
Muhammad Azam ◽  
Zargham ul Hassan Askry
Keyword(s):  
Pregnant Women ◽  
Psychological Factors ◽  
Positive Impact ◽  
Labor Pain ◽  
Assessment Procedure ◽  
Sleep Health ◽  
Beneficial Effects ◽  
Physical Problems ◽  
Health Related ◽  
Positive Effect

Background: Wide ranges of physiological changes occur as a result of pregnancy in women that, in certain cases, may cause variety of psychological and physical problems in pregnant women.  Aquatic exercises believed to be safe for pregnant women and believed to foster positive effect on psychophysical health. Current health care setting and nursing emphasizes on evidence based approaches when developing and implementing interventions to address health related issues of pregnant women. Purpose: This review sought to synthesize qualitatively the existing research evidences concerning association between aquatic exercises and psychophysical problems in pregnant women. Methods: A 1989 records were yielded as result of conducting a systematic search in nine research data bases. After undergoing rigorous screening and assessment procedure of eligibility, and quality appraisal, a total of seventeen research articles were ultimately selected to include in this review. Result: Out of seventeen admissible studies, ten studies found that aquatic exercises exerts positive impact to decreases variety of physical discomforts such as fatigue, pelvic pain, labor pain, and edema. The remaining seven studies presented beneficial effects of aquatic exercises for psychological factors such as body image, stress, depression, feelings, mood, distress, and anxiety in pregnant women. Moreover, among the seventeen studies, only two studies showed effectiveness of aquatic exercises to manage body weight and two studies found improvement in sleep during pregnancy.    Conclusion: This review found some evidence in support of the efficacy of aquatic exercises to reduce physical discomfort and improve psychological factors in pregnant women. More studies essential to reach stronger conclusion. The existing evidence concerning effectiveness of this intervention for weight management and sleep health during pregnancy is insufficient.

scholarly journals Computational screening of microalgae and cyanobacteria RuBisCO as potential precursor for bioactive peptides

2017 ◽  
Author(s):  
Gurudeeban Selvaraj ◽  
Satyavani Kaliamurthi ◽  
Zeynep Elibol Cakmak ◽  
Turgay Cakmak
Keyword(s):  
Bioactive Peptides ◽  
Proteolytic Enzymes ◽  
Chlorella Pyrenoidosa ◽  
Biologically Active ◽  
Proteinase K ◽  
Peptide Fragments ◽  
Bisphosphate Carboxylase ◽  
Computational Screening ◽  
Active Fragments ◽  
Chaetoceros Calcitrans

Ribulose-1,5-bisphosphate carboxylase/oxygense (RuBisCO) is present in plants and autotrophic organisms like microalgae. The aim of this study was to perform an in silico evaluation of RuBisCo protein in microalgae and cyanobacteria as potential precursors of bioactive peptides, as well as to determine whether such peptides can be released by selected proteolytic enzymes. Fourteen RuBioCo sequences of microalgae and cyanobacteria were analysed by using the BIOPEP server amd database. The biological activity, enzyme action and calculation of active peptide tools were used to determine the frequency of occurrence of fragments, proteolysis, and the frequency of release of fragments with given activity by selected enzymes. The physio-chemical parameters of the selected sequences were performed with Protpram tool. Amongst the RuBisCo proteins of selected algae, Chaetoceros. calcitrans exhibits the best prospect as a source of DPP-IV inhibiting peptides, Chlorella pyrenoidosa for ACE inhibitor and Aphanizomenon flos-aquae for antioxidative, activating ubiquitin, and antiamnestic activities. High number of bioactive fragments in Aphanizomenon flos-aquae, Dunaliella salina, Chlorella pyrenoidosa, and Chlorella vulgaris are associated with a high content of glycine and proline amino acids that are most rich in biologically active fragments. Papain and Proteinase K, an enzyme with wide specificity, can release considerably more biologically active fragments than bromealin and chymotrpsin. These findings will contribute towards consumption of microalgal and cyanobacterial RuBisCO as alternative sources of bioactive peptide fragments based nutraceuticals for human.

Bovine Meat Proteins as Potential Precursors of Biologically Active Peptides - a Computational Study based on the BIOPEP Database

2011 ◽  
Vol 17 (1) ◽  
pp. 39-45 ◽  
Author(s):  
P. Minkiewicz ◽  
J. Dziuba ◽  
J. Michalska
Keyword(s):  
Proteolytic Enzymes ◽  
Computational Study ◽  
Angiotensin Converting Enzyme Inhibitors ◽  
Biologically Active ◽  
Proteinase K ◽  
Converting Enzyme Inhibitors ◽  
Active Peptides ◽  
Biologically Active Peptides ◽  
Meat Proteins ◽  
Active Fragments

The aim of the present study was to perform an in silico evaluation of bovine meat proteins as potential precursors of biologically active peptides, as well as to determine whether such peptides can be released by selected proteolytic enzymes. The sequences of 19 bovine meat proteins were processed using the BIOPEP database and program. The profiles of potential biological activity of protein fragments were determined and the following parameters were calculated: the frequency of occurrence of fragments with given activity (A), the frequency of release of fragments with given activity by selected enzymes (AE), and the relative frequency of release of fragments with given activity by selected enzymes (W). Among the examined proteins, collagen and elastin appear to be the richest potential source of bioactive peptides, in particular of angiotensin-converting enzyme inhibitors, antithrombotic fragments, inhibitors of dipeptidyl peptidase IV and peptides regulating gastric mucosal activity. The high number of bioactive fragments in collagen and elastin is associated with a high content of glycine and proline, amino acids that are most abundant in biologically active fragments. Of the two investigated proteolytic enzymes, Proteinase K — an enzyme with broad specificity (e.g., against peptide bonds formed by the carboxyl groups of proline) can release considerably more biologically active fragments than Proteinase P1 — an enzyme with narrow specificity, not including proline residues.

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