scholarly journals Betanodavirus and VER Disease: A 30-year Research Review

Pathogens ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 106 ◽  
Author(s):  
Isabel Bandín ◽  
Sandra Souto
Keyword(s):  
Marine Species ◽  
Diagnostic Methods ◽  
Control Measures ◽  
Research Review ◽  
Nervous Necrosis Virus ◽  
Marine Aquaculture ◽  
Virus Interaction ◽  
And Control ◽  
Viral Distribution ◽  
Viral Encephalopathy And Retinopathy

The outbreaks of viral encephalopathy and retinopathy (VER), caused by nervous necrosis virus (NNV), represent one of the main infectious threats for marine aquaculture worldwide. Since the first description of the disease at the end of the 1980s, a considerable amount of research has gone into understanding the mechanisms involved in fish infection, developing reliable diagnostic methods, and control measures, and several comprehensive reviews have been published to date. This review focuses on host–virus interaction and epidemiological aspects, comprising viral distribution and transmission as well as the continuously increasing host range (177 susceptible marine species and epizootic outbreaks reported in 62 of them), with special emphasis on genotypes and the effect of global warming on NNV infection, but also including the latest findings in the NNV life cycle and virulence as well as diagnostic methods and VER disease control.

scholarly journals The Diagnostic Challenges of Ovine Pulmonary Adenocarcinoma

Ruminants ◽  
2021 ◽  
Vol 1 (1) ◽  
pp. 58-71
Author(s):  
Hélder Quintas ◽  
Isabel Pires ◽  
Andreia Garcês ◽  
Justina Prada ◽  
Filipe Silva ◽  
...  
Keyword(s):  
Clinical Signs ◽  
Pulmonary Adenocarcinoma ◽  
Diagnostic Methods ◽  
Control Measures ◽  
Economic Losses ◽  
Ovine Pulmonary Adenocarcinoma ◽  
X Ray ◽  
Club Cells ◽  
Pulmonary Adenomatosis ◽  
And Control

Ovine pulmonary adenocarcinoma (OPA), also known as sheep pulmonary adenomatosis and jaagsiekte, is a contagious pulmonary tumor of sheep, characterized by neoplastic proliferation of type II pneumocyte and club cells. OPA is induced by the oncogenic activity of the envelope glycoprotein (Env) of exogenous jaagsiekte sheep retrovirus (JSRV). This disease is associated with significant economic losses in numerous sheep raising countries. The onset of suggestive clinical signs is often late, making difficult the early diagnosis of the disease and timely implementation of control measures on the affected farms. Further, the lack of diagnostic tests that can be performed routinely by veterinary clinicians to accurately assess infected animals (e.g., serological or others) means that the true prevalence at flock level is not known. Imaging diagnostic methods (e.g., ultrasound, X-ray and computed tomography) can be used to support the clinical diagnosis, even in pre-clinical stages in affected flocks. The diagnosis must be confirmed by PCR of nasal excretions or immunohistochemistry and PCR of tumor lesions. No vaccine for OPA has yet been developed. Thus, in this work, we review the main methods of diagnosis of OPA in order to support the clinician in the identification of the disease, avoid underdiagnosis and allow the implementation of suitable measures to prevent and control its spread.

scholarly journals Zoonotic Tuberculosis in Humans: Control, Surveillance, and the One Health Approach

2019 ◽  
Vol 41 (1) ◽  
pp. 130-144
Author(s):  
Rodrigo Macedo Couto ◽  
Otavio T Ranzani ◽  
Eliseu Alves Waldman
Keyword(s):  
Low Income ◽  
One Health ◽  
Control Strategies ◽  
Diagnostic Methods ◽  
Surveillance Data ◽  
Control Measures ◽  
Low Income Countries ◽  
Effective Control ◽  
Surveillance Systems ◽  
And Control

Abstract Zoonotic tuberculosis is a reemerging infectious disease in high-income countries and a neglected one in low- and middle-income countries. Despite major advances in its control as a result of milk pasteurization, its global burden is unknown, especially due the lack of surveillance data. Additionally, very little is known about control strategies. The purpose of this review was to contextualize the current knowledge about the epidemiology of zoonotic tuberculosis and to describe the available evidence regarding surveillance and control strategies in high-, middle-, and low-income countries. We conducted this review enriched by a One Health perspective, encompassing its inherent multifaceted characteristics. We found that the burden of zoonotic tuberculosis is likely to be underreported worldwide, with higher incidence in low-income countries, where the surveillance systems are even more fragile. Together with the lack of specific political commitment, surveillance data is affected by lack of a case definition and limitations of diagnostic methods. Control measures were dependent on risk factors and varied greatly between countries. This review supports the claim that a One Health approach is the most valuable concept to build capable surveillance systems, resulting in effective control measures. The disease characteristics and suggestions to implement surveillance and control programs are discussed.

scholarly journals A review of dengue diagnostics and implications for surveillance and control

2019 ◽  
Vol 113 (11) ◽  
pp. 653-660 ◽  
Author(s):  
Nader Raafat ◽  
Stuart D Blacksell ◽  
Richard J Maude
Keyword(s):  
Disease Surveillance ◽  
Dengue Infection ◽  
Signs And Symptoms ◽  
Diagnostic Methods ◽  
Control Measures ◽  
Polymerase Chain ◽  
Dengue Diagnostics ◽  
Dengue Control ◽  
Age Range ◽  
And Control

Abstract Dengue is the world’s most common arboviral infection, with almost 4 billion people estimated to be living at risk of dengue infection. A recently introduced vaccine is currently recommended only for seropositive individuals in a restricted age range determined by transmission intensity. With no effective dengue vaccine for the general population or any antiviral therapy, dengue control continues to rely heavily on vector control measures. Early and accurate diagnosis is important for guiding appropriate management and for disease surveillance to guide prompt dengue control interventions. However, major uncertainties exist in dengue diagnosis and this has important implications for all three. Dengue can be diagnosed clinically against predefined lists of signs and symptoms and by detection of dengue-specific antibodies, non-structural 1 antigen or viral RNA by reverse transcriptase–polymerase chain reaction. All of these methods have their limitations. This review aims to describe and quantify the advantages, uncertainties and variability of the various diagnostic methods used for dengue and discuss their implications and applications for dengue surveillance and control.

Ectoparasites in sheep

Livestock ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 286-289
Author(s):  
Valentina Busin
Keyword(s):  
Future Development ◽  
Genetic Selection ◽  
Clinical Signs ◽  
Geographical Location ◽  
Diagnostic Methods ◽  
Control Measures ◽  
Negative Effects ◽  
The Uk ◽  
And Control

Ectoparasites in sheep have significant effects on both welfare and production and their importance varies in relation to the geographical location and the system of production. This article focuses on the main ectoparasites and their related diseases within the UK, covering clinical signs, diagnostic methods and the treatment and control measures available. To conclude, future development in the areas of vaccine, biotechnologies and genetic selection are addressed to improve the control and reduce the negative effects of ectoparasites.

scholarly journals Differential Nervous Necrosis Virus (NNV) Replication in Five Putative Susceptible Cell Lines

Pathogens ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 1565
Author(s):  
Yulema Valero ◽  
Carmen López-Vázquez ◽  
Sandra Souto ◽  
José G. Olveira ◽  
Alberto Cuesta ◽  
...  
Keyword(s):  
Cell Line ◽  
Cell Lines ◽  
Control Measures ◽  
Effective Control ◽  
Fish Cell ◽  
Nervous Necrosis Virus ◽  
Necrosis Virus ◽  
Susceptible Cell ◽  
Viral Encephalopathy And Retinopathy

Viral encephalopathy and retinopathy caused by nervous necrosis virus (NNV), is one of the most threatening viral diseases affecting marine fish worldwide. In vitro propagation of NNV strains is essential for the design of effective control measures. In the present study we analysed both the susceptibility and the permissiveness of five fish cell lines (E-11, GF-1, SAF-1, DLB-1, and SaB-1) to three NNV strains (one RGNNV, one SJNNV, and one reassortant RGNNV/SJNNV). E-11 and DLB-1 were demonstrated to be highly susceptible to NNV strains, with average adsorption efficiency (AE) values higher than 90%. SAF-1 also showed high susceptibility (AE 88%), whereas GF-1 can be regarded as moderately susceptible (AE around 50%). On the contrary, SaB-1 can be considered a poorly susceptible cell line (AE values below 20%). E-11 and GF-1 cell lines provided the highest production rates for RGNNV and RG/SJ (around 103) and both cell lines can be regarded as fully permissive for these viral types. However, the SJNNV production rate in GF-1 was only 17.8 and therefore this cell line should be considered semi-permissive for this genotype. In SAF-1 cells, moderate viral replication was recorded but differences in intracellular and extracellular production suggest that viral progeny was not efficiently released. In DLB-1 and SaB-1 the final viral titres obtained in E-11 were lower than those of the inoculum. However, RNA1 synthesis values seem to indicate that RGNNV replication in DLB-1 and SAF-1 could have been underestimated, probably due to a poor adaptation of the virus grown in these cell lines to E-11. Based on all these results, E-11 seems to be the most appropriate cell for in vitro culture of RGNNV, SJNNV, and reassortant strains.

Knowledge and Awareness of Dengue Fever

2018 ◽  
pp. 219-222
Author(s):  
Y. Arockia Suganthi ◽  
Chitra K. ◽  
J. Magelin Mary
Keyword(s):  
Dengue Fever ◽  
Prevention And Control ◽  
Control Measures ◽  
Infection Transmission ◽  
Standard Guideline ◽  
The World ◽  
Different Types ◽  
Prevention And Control Measures ◽  
Dengue Prevention ◽  
And Control

Dengue fever is a painful mosquito-borne infection caused by different types of virus in various localities of the world. There is no particular medicine or vaccine to treat person suffering from dengue fever. Dengue viruses are transmitted by the bite of female Aedes (Ae) mosquitoes. Dengue fever viruses are mainly transmitted by Aedes which can be active in tropical or subtropical climates. Aedes Aegypti is the key step to avoid infection transmission to save millions of people in all over the world. This paper provides a standard guideline in the planning of dengue prevention and control measures. At the same time gives the priorities including clinical management and hospitalized dengue patients have to address essentially.

The Prospects and Risks Connected with Increasing the Level of Self-Organisation in Students

2020 ◽  
pp. 75-81
Author(s):  
Svetlana Alexandrovna Kosareva ◽  
Keyword(s):  
Higher Education ◽  
Professional Competence ◽  
Initial Level ◽  
Education Institution ◽  
Diagnostic Methods ◽  
Study Guide ◽  
Learning Approaches ◽  
Control Groups ◽  
Self Organisation ◽  
And Control

The paper describes the method for increasing the level of self-organisation in students which has been developed by the author. It also contains the method testing results and presents the prospects and risks teachers could face while applying the method in a higher education institution. The purpose of this study is to find out the prospects and risks of applying the method for increasing the level of self-organisation in students and to determine the ways of reducing the risks. Methodology. The author points out the learning approaches which were the basis of developing the method and describes diagnostic methods for determining students’ self-organisation levels. The work focused on increasing each student’s initial level consists of a theoretical and a practical part and includes project activities on creating a study guide. The results of the study. The method developed proved to be effective. It was established by diagnosing the final level of self-organisation in students in the experimental and control groups. The paper considers the advantages of the method among which there is universal character, flexibility, improvements to teacher’s and students’ professional competence, etc. At the same time it is necessary to be aware of the risks due to the increased amount of teacher’s work and the fact that students’ work within the project tends to be monotonous. In conclusion, the prospects of the method for increasing the level of self-organisation in students are related to its advantages and the final results of the work. The risks of its use can be reduced with the help of the measures proposed in the paper.

The Mediterranean Action Plan: A Regional Approach to Pollution Control

1986 ◽  
Vol 18 (9) ◽  
pp. 197-205
Author(s):  
Lj Jeftié ◽  
L. J. Saliba
Keyword(s):  
Mediterranean Sea ◽  
Action Plan ◽  
Control Measures ◽  
Industrial Wastes ◽  
Pollution Monitoring ◽  
Environmental Preservation ◽  
Agricultural Pesticides ◽  
The Mediterranean ◽  
A Prospective Study ◽  
And Control

Increasing concern over the deterioration of the Mediterranean sea as a result of increasing pollution by untreated sewage and industrial wastes, agricultural pesticides and fertilizers and oil discharges, led to a series of meetings between 1970 and 1974, and finally to the UNEP-sponsored Mediterranean Action Plan, adopted by governments of the region in 1975 and ongoing since that time. The legal component of the Plan includes a framework Convention and four protocols; the environmental assessment component (the MED POL programme) consists of national pollution monitoring programmes, and research projects conducted by Mediterranean institutions; the environmental management component consists of the Blue Plan (a prospective study combining socio-economic development with environmental preservation) and the Priority Actions Programme (a series of sub-region sectoral projects in defined areas). The Plan has been financed by Mediterranean States since 1979, and is managed by UNEP with the cooperation of other competent UN Agencies. During the last ten years, activities undertaken have improved knowledge of the state of pollution of the Mediterranean sea, and facilitated joint regional action in the form of preventive and control measures.

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