scholarly journals The Human Coronavirus Disease COVID-19: Its Origin, Characteristics, and Insights into Potential Drugs and Its Mechanisms

Pathogens ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 331 ◽  
Author(s):  
Lo’ai Alanagreh ◽  
Foad Alzoughool ◽  
Manar Atoum
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Genomic Structure ◽  
Genomic Analysis ◽  
Intermediate Hosts ◽  
Human Coronavirus ◽  
The World ◽  
Clinical Drugs

The emerging coronavirus disease (COVID-19) swept across the world, affecting more than 200 countries and territories. Genomic analysis suggests that the COVID-19 virus originated in bats and transmitted to humans through unknown intermediate hosts in the Wuhan seafood market, China, in December of 2019. This virus belongs to the Betacoronavirus group, the same group of the 2003 severe acute respiratory syndrome coronavirus (SARS-CoV), and for the similarity, it was named SARS-CoV-2. Given the lack of registered clinical therapies or vaccines, many physicians and scientists are investigating previously used clinical drugs for COVID-19 treatment. In this review, we aim to provide an overview of the CoVs origin, pathogenicity, and genomic structure, with a focus on SARS-CoV-2. Besides, we summarize the recently investigated drugs that constitute an option for COVID-19 treatment.

scholarly journals Severe acute respiratory syndrome (SARS) related coronavirus in bats

2021 ◽  
Vol 1 (1) ◽  
Author(s):  
Rong Geng ◽  
Peng Zhou
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Current Knowledge ◽  
Disease Outbreaks ◽  
First Century ◽  
Intermediate Hosts ◽  
Human Coronavirus ◽  
Transmission Potential ◽  
Disease Agent ◽  
And Control ◽  
Genomic Similarity

AbstractThree major human coronavirus disease outbreaks, severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS) and 2019 coronavirus disease (COVID-19), occurred in the twenty-first century and were caused by different coronaviruses (CoVs). All these viruses are considered to have originated from bats and transmitted to humans through intermediate hosts. SARS-CoV-1 and SARS-CoV-2, disease agent of COVID-19, shared around 80% genomic similarity, and thus belong to SARS-related CoVs. As a natural reservoir of viruses, bats harbor numerous other SARS-related CoVs that could potentially infect humans around the world, causing SARS or COVID-19 like outbreaks in the future. In this review, we summarized the current knowledge of CoVs on geographical distribution, genetic diversity, cross-species transmission potential and possible pathogenesis in humans, aiming for a better understanding of bat SARS-related CoVs in the context of prevention and control.

scholarly journals COVID-19 and Heart: From Clinical Features to Pharmacological Implications

2020 ◽  
Vol 9 (6) ◽  
pp. 1944 ◽  
Author(s):  
Vincenzo Russo ◽  
Roberta Bottino ◽  
Andreina Carbone ◽  
Anna Rago ◽  
Andrea Antonio Papa ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Disease Management ◽  
Severe Acute Respiratory Syndrome ◽  
Clinical Outcome ◽  
Hospital Admission ◽  
Clinical Features ◽  
Epidemiological Data ◽  
Human Coronavirus ◽  
Highly Pathogenic ◽  
The World

A highly pathogenic human coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been recently recognized in Wuhan, China, as the cause of the coronavirus disease 2019 (COVID-19) outbreak which has spread rapidly from China to other countries in the world, causing a pandemic with alarming morbidity and mortality. The emerging epidemiological data about COVID-19 patients suggest an association between cardiovascular diseases (CVD) and SARS-CoV-2 infection, in term of clinical features at hospital admission and prognosis for disease severity. The aim of our review is to describe the cardiological features of COVID-19 patients at admission, the acute cardiac presentation, the clinical outcome for patients with underlying CVD and the pharmacological implications for disease management.

scholarly journals Early detection of SARS-CoV-2 P.1 variant in Southern Brazil and reinfection of the same patient by P.2

2021 ◽  
Author(s):  
Mariana Soares da Silva ◽  
Meriane Demoliner ◽  
Alana Witt Hansen ◽  
Juliana Schons Gularte ◽  
Flávio Silveira ◽  
...  
Keyword(s):  
Early Detection ◽  
Severe Acute Respiratory Syndrome ◽  
Primary Infection ◽  
Genomic Analysis ◽  
First Episode ◽  
Southern Brazil ◽  
The World ◽  
Early Case ◽  
Northern Brazil ◽  
Multiple Variants

Abstract Multiple variants of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are constantly reported across the world. B.1.1.28 lineage has been evolving in Brazil since February 2020 and originated P.1 (VOC) and P.2 (VOI). Here we describe an early case of P.1 primary infection in Southern Brazil in late November 2020, soon after the emergence of the variant in Manaus, Northern Brazil. The same patient suffered a reinfection case by another B1.1.28 variant, namely P.2, in March, 2021. Genomic analysis showed genetically significant differences between the viruses recovered in both infections. P.1 lineage at the first episode and P.2 at the reinfection. We also have investigated the circulation of P.1 in the same region by differential RT-qPCR, showing that this was an isolated case of P.1 at the time of detection, whereas the variant disseminated and became prominent from late January 2021 to the end of March 2021.

scholarly journals Structure, transmission, diagnostic symptoms, host and entry mechanism of covid-19: A review

Coronaviruses ◽  
2020 ◽  
Vol 01 ◽  
Author(s):  
Prashant Swapnil ◽  
Mukesh Meena ◽  
Tansukh Barupal ◽  
Yashwant Sompura ◽  
Deepa Hada
Keyword(s):  
Clinical Trials ◽  
Severe Acute Respiratory Syndrome ◽  
Antiviral Drug ◽  
Genomic Analysis ◽  
Clinical Recovery ◽  
Human Contact ◽  
The World ◽  
Diagnostic Symptoms ◽  
Viral Outbreak ◽  
Entry Mechanism

Abstract:: In Wuhan, China, a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been reported and caused coronavirus disease 19 (COVID-19). The infection of coronavirus is pathogenic and highly transmittable which spread quickly around the world by human to human contact. Through genomic analysis it has been revealed that primary reservoir of SARSCoV-2 are bats due to having severe acute respiratory syndrome-like (SARS-like) viruses phylogenetically. The viral infection rapidly transmitted by human to human contact but the intermediate source of their origin and transfer is not known. Till date, any clinically approved vaccine or antiviral drug is not prepared against COVID-19. However, researchers and scientist have been evaluated some broad-spectrum of antiviral drugs against COVID-19 through clinical trials and found satisfactory clinical recovery. This review summarise the comparative analysis of the emergence and pathogenicity of COVID-19, severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV). This review also focused to development of effective vaccines or antidrug and also focused on an approach to practice therapeutic combinations to fight with this viral outbreak.

scholarly journals First Description of a Multisystemic and Lethal SARS-CoV-2 Variant of Concern P.1 (Gamma) Infection in a FeLV-Positive Cat: New Concerns Regarding Viral Re-emergence and Adaption to Pets

2021 ◽  
Author(s):  
Rodrigo Lima Carneiro ◽  
Jessica Pires Farias ◽  
Josilene Ramos Pinheiro ◽  
Jackson Farias ◽  
Andre Carloto Vielmo ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Leukemia Virus ◽  
Fatal Case ◽  
Genomic Analysis ◽  
High Load ◽  
Feline Leukemia Virus ◽  
Intermediate Hosts ◽  
Species Barrier ◽  
Pathological Analysis ◽  
New Hosts

Abstract Background: Coronaviruses are recognized for their ability to cross the species barrier and infect new hosts. The coronavirus disease 2019 (COVID-19) is caused by the new coronavirus SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2). It remains unclear whether other animals, including pets, are crucial in the spread and maintenance of COVID-19 worldwide. Methods: In this study, we analysed the first fatal case of a SARS-CoV-2 and FeLV (Feline leukemia virus) co-infection of an eight-year-old male cat. We carried out a clinical evaluation, pathological analysis, and viral genomic analysis. Results: As main results, we observed an animal presenting severe acute respiratory syndrome and lesions in several organs, which led to animal’s death. The causative agent was confirmed to be SARS-CoV-2, variant of concern P.1 (Gamma). The virus presented a pattern of mutations potentially associated with feline infection. In addition, the virus was detected by RT-qPCR in the spleen, liver, heart, lungs, trachea, intestines and kidneys, indicating a multisystemic viral infection. The virus was found in a high load in the trachea, suggesting a capacity of transmitting the virus. Conclusion: Our data show that felines, such as FeLV-positive cats, are susceptible to SARS-CoV-2 infection, and may be intermediate hosts in this pandemic.

COVID-19

2022 ◽  
pp. 1-16
Author(s):  
Soraia El Baz ◽  
My Abdelmonaim El Hidan ◽  
Nadia Zouhairi ◽  
Abdelmohcine Aimrane ◽  
Redouane Chatoui ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Current Knowledge ◽  
Virus Disease ◽  
Case Fatality ◽  
Unknown Etiology ◽  
Human Coronavirus ◽  
Corona Virus ◽  
The World ◽  
Human Coronaviruses

Since December 2019, a pneumonia outbreak with unknown etiology occurred in Wuhan, China. Later, the pathogen was identified as novel human coronavirus and named as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The disease was named corona virus disease 2019 (COVID-19) and caused a pandemic. As of 23 June 2020, the global COVID-19 pandemic has battered the world. More than 1.5 million people have died with over 80 million people confirmed infected. This outbreak is spreading in approximately 216 countries and regions as of 22 July 2020. Comparing the three human coronavirus, SARS and MERS have significantly higher case fatality rates than COVID-19, but COVID-19 is more infectious and spreads more easily among people. Therefore, in this chapter, the authors summarize the most fatal pandemic in recorded history. Also, they collected all information about the current knowledge about COVID-19 pandemic including similarity and differences with other human coronaviruses.

scholarly journals Early detection of SARS-CoV-2 P.1 variant in Southern Brazil and reinfection of the same patient by P.2

2021 ◽  
Author(s):  
Mariana Soares da Silva ◽  
Meriane Demoliner ◽  
Alana Witt Hansen ◽  
Juliana Schons Gularte ◽  
Flávio Silveira ◽  
...  
Keyword(s):  
Early Detection ◽  
Severe Acute Respiratory Syndrome ◽  
Primary Infection ◽  
Genomic Analysis ◽  
First Episode ◽  
Southern Brazil ◽  
The World ◽  
Early Case ◽  
Northern Brazil ◽  
Multiple Variants

Abstract Multiple variants of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are constantly reported across the world. B.1.1.28 lineage has been evolving in Brazil since February 2020 and originated P.1 (VOC) and P.2 (VOI). Here we describe an early case of P.1 primary infection in Southern Brazil in late November 2020, soon after the emergence of the variant in Manaus, Northern Brazil. The same patient suffered a reinfection case by another B1.1.28 variant, namely P.2, in March, 2021. Genomic analysis showed genetically significant differences between the viruses recovered in both infections. P.1 lineage at the first episode and P.2 at the reinfection. We also have investigated the circulation of P.1 in the same region by differential RT-qPCR, showing that this was an isolated case of P.1 at the time of detection, whereas the variant disseminated and became prominent from late January 2021 to the end of March 2021.

The relevance of dietetic approach of Ayurveda from the perspective of COVID-19 pandemic

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 748-752
Author(s):  
Swapnali Khabade ◽  
Bharat Rathi ◽  
Renu Rathi
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Healthy Person ◽  
World Health ◽  
Physical And Mental Health ◽  
Leading Role ◽  
Global Pandemic ◽  
The People ◽  
The World ◽  
Health Organization ◽  
The Individual

A novel, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causes severe acute respiratory syndrome and spread globally from Wuhan, China. In March 2020 the World Health Organization declared the SARS-Cov-2 virus as a COVID- 19, a global pandemic. This pandemic happened to be followed by some restrictions, and specially lockdown playing the leading role for the people to get disassociated with their personal and social schedules. And now the food is the most necessary thing to take care of. It seems the new challenge for the individual is self-isolation to maintain themselves on the health basis and fight against the pandemic situation by boosting their immunity. Food organised by proper diet may maintain the physical and mental health of the individual. Ayurveda aims to promote and preserve the health, strength and the longevity of the healthy person and to cure the disease by properly channelling with and without Ahara. In Ayurveda, diet (Ahara) is considered as one of the critical pillars of life, and Langhana plays an important role too. This article will review the relevance of dietetic approach described in Ayurveda with and without food (Asthavidhi visheshaytana & Lanhgan) during COVID-19 like a pandemic.

Plasma therapy a possible hope to fight against COVID-19

2020 ◽  
Author(s):  
Ravikant Piyush ◽  
Aroni Chatterjee ◽  
Shashikant Ray
Keyword(s):  
Middle East ◽  
Severe Acute Respiratory Syndrome ◽  
Viral Disease ◽  
Plasma Therapy ◽  
Therapeutic Drugs ◽  
Wild Fire ◽  
The World ◽  
Short Span ◽  
Game Changer

The world is currently going through a disastrous event and a catastrophic upheaval caused by the coronavirus disease 2019 (COVID-19). The pandemic has resulted in loss of more than 150000 deaths across the globe. Originating from China and spreading across all continents within a short span of time, it has become a matter of international emergency. Different agencies are adopting diverse approaches to stop and spread of this viral disease but still now nothing confirmatory has come up. Due to lack of vaccines and proper therapeutic drugs, the disease is still spreading like wild fire without control. An Old but very promising method- the convalescent plasma therapy could be the key therapy to stop this pandemic. This method has already proven its mettle on several occasions previously and has been found to be effective in curing the pandemics induced by Ebola, severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV). The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) belongs to the same group of β-Coronavirus that has resulted in the above diseases. Therefore, the role of plasma therapy is being explored for treatment of this disease. In this review, we have mainly focused on the role of convalescent plasma therapy and why its use should be promoted in fight against COVID-19, as it could turn out to be a game changer.

scholarly journals Deepening of In Silico Evaluation of SARS-CoV-2 Detection RT-qPCR Assays in the Context of New Variants

Genes ◽  
2021 ◽  
Vol 12 (4) ◽  
pp. 565
Author(s):  
Mathieu Gand ◽  
Kevin Vanneste ◽  
Isabelle Thomas ◽  
Steven Van Gucht ◽  
Arnaud Capron ◽  
...  
Keyword(s):  
Performance Evaluation ◽  
Severe Acute Respiratory Syndrome ◽  
In Silico ◽  
The Other ◽  
Viral Rna ◽  
Potential Threat ◽  
The World

For 1 year now, the world is undergoing a coronavirus disease-2019 (COVID-19) pandemic due to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The most widely used method for COVID-19 diagnosis is the detection of viral RNA by RT-qPCR with a specific set of primers and probe. It is important to frequently evaluate the performance of these tests and this can be done first by an in silico approach. Previously, we reported some mismatches between the oligonucleotides of publicly available RT-qPCR assays and SARS-CoV-2 genomes collected from GISAID and NCBI, potentially impacting proper detection of the virus. In the present study, 11 primers and probe sets investigated during the first study were evaluated again with 84,305 new SARS-CoV-2 unique genomes collected between June 2020 and January 2021. The lower inclusivity of the China CDC assay targeting the gene N has continued to decrease with new mismatches detected, whereas the other evaluated assays kept their inclusivity above 99%. Additionally, some mutations specific to new SARS-CoV-2 variants of concern were found to be located in oligonucleotide annealing sites. This might impact the strategy to be considered for future SARS-CoV-2 testing. Given the potential threat of the new variants, it is crucial to assess if they can still be correctly targeted by the primers and probes of the RT-qPCR assays. Our study highlights that considering the evolution of the virus and the emergence of new variants, an in silico (re-)evaluation should be performed on a regular basis. Ideally, this should be done for all the RT-qPCR assays employed for SARS-CoV-2 detection, including also commercial tests, although the primer and probe sequences used in these kits are rarely disclosed, which impedes independent performance evaluation.

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