scholarly journals Dry Powder Inhalers in the Digitalization Era: Current Status and Future Perspectives

Pharmaceutics ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1455
Author(s):  
Styliani Xiroudaki ◽  
Aurélie Schoubben ◽  
Stefano Giovagnoli ◽  
Dimitrios M. Rekkas
Keyword(s):  
Drug Carrier ◽  
Deep Understanding ◽  
Current Status ◽  
Dry Powder Inhalers ◽  
Theory Approach ◽  
Particle Engineering ◽  
Breathing Patterns ◽  
Dry Powder ◽  
Related Factors ◽  
Industrial Sectors

During the last decades, the term “drug delivery systems” (DDSs) has almost fully replaced previously used terms, such as “dosage forms”, in an attempt to emphasize the importance of the drug carrier in ensuring the claimed safety and effectiveness of the product. However, particularly in the case of delivery devices, the term “system”, which by definition implies a profound knowledge of each single part and their interactions, is not always fully justified when using the DDS term. Within this context, dry powder inhalers (DPIs), as systems to deliver drugs via inhalation to the lungs, require a deep understanding of the complex formulation–device–patient interplay. As of now and despite the progress made in particle engineering and devices design, DPIs’ clinical performance is limited by variable patients’ breathing patterns. To circumvent this pitfall, next-generation DPIs should ideally adapt to the different respiratory capacity of individuals across age, health conditions, and other related factors. In this context, the recent wave of digitalization in the health care and industrial sectors may drive DPI technology towards addressing a personalized device–formulation–patient liaison. In this review, evolving technologies are explored and analyzed to outline the progress made as well as the gaps to fill to align novel DPIs technologies with the systems theory approach.

scholarly journals Particle engineering of materials for oral inhalation by dry powder inhalers. II—Sodium cromoglicate

2011 ◽  
Vol 405 (1-2) ◽  
pp. 36-46 ◽  
Author(s):  
Lorraine M. Nolan ◽  
Jianhe Li ◽  
Lidia Tajber ◽  
Owen I. Corrigan ◽  
Anne Marie Healy
Keyword(s):  
Dry Powder Inhalers ◽  
Particle Engineering ◽  
Dry Powder ◽  
Oral Inhalation ◽  
Sodium Cromoglicate

Dry Powder Inhalers Are Commonly Misused

2007 ◽  
Vol 40 (23) ◽  
pp. 18
Author(s):  
PATRICE WENDLING
Keyword(s):  
Dry Powder Inhalers ◽  
Dry Powder

scholarly journals Current status and related factors of turnover intention of primary medical staff in Anhui Province, China: a cross-sectional study

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Guimei Chen ◽  
Lingzhi Sang ◽  
Jian Rong ◽  
Huosheng Yan ◽  
Hongzhang Liu ◽  
...  
Keyword(s):  
Social Support ◽  
Human Resources ◽  
Turnover Intention ◽  
Medical Staff ◽  
Psychological Capital ◽  
Pearson Correlation ◽  
Job Burnout ◽  
Current Status ◽  
Capital Social ◽  
Related Factors

Abstract Background The shortage of primary medical staff is an important issue in the management of health human resources, and it is also a problem that all countries in the world need to face together. Since 2009, China has implemented a new series of medical system reforms and the shortage and loss of primary medical staff have been alleviated accordingly. However, China has a large population and it is difficult to distribute health human resources evenly across regions. This study aimed to explore the current status of turnover intention and its relationship with psychological capital, social support, and job burnout, as well as how these factors influence turnover intention of primary medical staff in Anhui province, China. Methods Using structured questionnaires to collect data, including demographic characteristics, turnover intention, psychological capital, social support, and Chinese Maslach Burnout Inventory scale. A total of 1152 primary medical workers of Anhui were investigated. Data were analyzed by t-test, analysis of variance (ANOVA), Pearson correlation analysis, and multiple linear regression model. Results Total scores of turnover intention, psychological capital, social support, and job burnout of subjects were 14.15 ± 4.35, 100.09 ± 15.98, 64.93 ± 13.23 and 41.07 ± 9.437, respectively. Multiple linear regression showed the related factors of turnover intention were age, job position, work unit, and scores of job burnout. Pearson correlation showed psychological capital and social support were negatively correlated with turnover intention, while the score of job burnout was positively correlated with turnover intention. Conclusion The improvement of psychological capital and social support and the reduction of job burnout may play an important role in reducing turnover intention of primary medical staff. Primary medical managers should strengthen the humanistic care for primary medical staff, optimize the incentive mechanism, and improve internal management of medical institutions for stability.

scholarly journals Towards Deep Decarbonisation of Energy-Intensive Industries: A Review of Current Status, Technologies and Policies

Energies ◽  
2021 ◽  
Vol 14 (9) ◽  
pp. 2408
Author(s):  
Anissa Nurdiawati ◽  
Frauke Urban
Keyword(s):  
Technological Development ◽  
Steel Production ◽  
Political Support ◽  
Current Status ◽  
Low Carbon ◽  
Price Support ◽  
Reference Case ◽  
Technological Trajectories ◽  
Industrial Sectors ◽  
Energy Intensive Industries

Industries account for about 30% of total final energy consumption worldwide and about 20% of global CO2 emissions. While transitions towards renewable energy have occurred in many parts of the world in the energy sectors, the industrial sectors have been lagging behind. Decarbonising the energy-intensive industrial sectors is however important for mitigating emissions leading to climate change. This paper analyses various technological trajectories and key policies for decarbonising energy-intensive industries: steel, mining and minerals, cement, pulp and paper and refinery. Electrification, fuel switching to low carbon fuels together with technological breakthroughs such as fossil-free steel production and CCS are required to bring emissions from energy-intensive industry down to net-zero. A long-term credible carbon price, support for technological development in various parts of the innovation chain, policies for creating markets for low-carbon materials and the right condition for electrification and increased use of biofuels will be essential for a successful transition towards carbon neutrality. The study focuses on Sweden as a reference case, as it is one of the most advanced countries in the decarbonisation of industries. The paper concludes that it may be technically feasible to deep decarbonise energy-intensive industries by 2045, given financial and political support.

scholarly journals In-Depth Comparison of Dry Particle Coating Processes Used in DPI Particle Engineering

Pharmaceutics ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 580
Author(s):  
Nicholas Bungert ◽  
Mirjam Kobler ◽  
Regina Scherließ
Keyword(s):  
Drug Carrier ◽  
Magnesium Stearate ◽  
High Shear ◽  
Particle Engineering ◽  
Dry Powder Inhalation ◽  
Particle Coating ◽  
Lower Drug ◽  
Dry Particle Coating ◽  
Coarse Model ◽  
Carrier Systems

High-shear mixer coatings as well as mechanofusion processes are used in the particle-engineering of dry powder inhalation carrier systems. The aim of coating the carrier particle is usually to decrease carrier–drug adhesion. This study comprises the in-depth comparison of two established dry particle coating options. Both processes were conducted with and without a model additive (magnesium stearate). In doing so, changes in the behaviour of the processed particles can be traced back to either the process or the additive. It can be stated that the coarse model carrier showed no significant changes when processed without additives. By coating the particles with magnesium stearate, the surface energy decreased significantly. This leads to a significant enhancement of the aerodynamic performance of the respective carrier-based blends. Comparing the engineered carriers with each other, the high-shear mixer coating shows significant benefits, namely, lower drug–carrier adhesion and the higher efficiency of the coating process.

Countering Threats

2014 ◽  
Vol 4 (2) ◽  
pp. 35-45
Author(s):  
Margarita Jaitner
Keyword(s):  
Social Media ◽  
Law Enforcement ◽  
Ad Hoc ◽  
Physical Violence ◽  
Deep Understanding ◽  
Current Status ◽  
Mobile Web ◽  
Use Of Social Media ◽  
Legal Frameworks ◽  
High Level

The increased adoption of social media has presented security and law enforcement authorities with significant new challenges. For example, the Swedish Security Service (SÄPO) asserts that a large proportion of radicalization takes place in open fora online. Still, approaches to contain social media-driven challenges to security, particularly in democratic societies, remain little explored. Nonetheless, this type of knowledge may become relevant in European countries in the near future: Amongst other factors, the challenging economic situation has resulted in increased public discontent leading to emergence or manifestation of groups that seek to challenge the existing policies by almost any means. Use of social media multiplies the number of vectors that need law enforcement attention. First, a high level of social media adaption allows groups to reach and attract a wider audience. Unlike previously, many groups today consist of a large but very loosely connected network. This lack of cohesion can present a challenge for authorities, to identify emerging key actors and assess threat levels. Second, a high level of mobile web penetration has allowed groups to ad-hoc organize, amend plans and redirect physical activities. Third, the tool social media is as not exclusive to potential perpetrators of unlawful action, but is as well available to law enforcement authorities. Yet, efficient utilization of social media requires a deep understanding of its nature and a well-crafted, comprehensive approach. Acknowledging the broad functionality of social media, as well as its current status in the society, this article describes a model process for security authorities and law enforcement work with social media in general and security services work in particular. The process is cyclic and largely modular. It provides a set of goals and tasks for each stage of a potential event, rather than fixed activities. This allows authorities to adapt the process to individual legal frameworks and organization setups. The approach behind the process is holistic where social media is regarded as both source and destination of information. Ultimately, the process aims at efficiently and effectively mitigating the risk of virtual and physical violence.

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