scholarly journals Binder Jet 3D Printing of Compound LEV-PN Dispersible Tablets: An Innovative Approach for Fabricating Drug Systems with Multicompartmental Structures

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1780
Author(s):  
Xiaoxuan Hong ◽  
Xiaolu Han ◽  
Xianfu Li ◽  
Jiale Li ◽  
Zengming Wang ◽  
...  
Keyword(s):  
3D Printing ◽  
Three Dimensional ◽  
Drug Dose ◽  
Solid Dosage Forms ◽  
Precise Control ◽  
Solid Dosage ◽  
Application Potential ◽  
Dispersible Tablets ◽  
Coffee Ring Effect ◽  
Printing Ink

Three-dimensional (3D) printing is an emerging technology that has high application potential for individualized medicines and complex solid dosage forms. This study is designed to explore binder jet 3D printing (BJ-3DP) for the development of high-precision and repeatable compound levetiracetam-pyridoxine hydrochloride (LEV-PN) multicompartmental structure dispersible tablets. PN was dissolved in printing ink directly and accurately jetted into the middle, nested layer of the tablet, and precise control of the drug dose was achieved through the design of printing layers. With modification of the drying method, the “coffee ring” effect caused by drug migration during the curing and molding of the tablets was overcome. Furthermore, 3D topography showed that the tablets have a promising surface morphology. Scanning electron microscopy and porosity results indicated that the tablets have a loose interior and tight exterior, which would ensure good mechanical properties while enabling the tablet to disintegrate quickly in the mouth and achieve rapid release of the two drugs. This study used BJ-3DP technology to prepare personalized multicompartmental structures of drug systems and provides a basis for the development of complex preparations.

scholarly journals Additive Manufacturing of Oral Tablets: Technologies, Materials and Printed Tablets

Pharmaceutics ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 156
Author(s):  
Alperen Abaci ◽  
Christina Gedeon ◽  
Anna Kuna ◽  
Murat Guvendiren
Keyword(s):  
Additive Manufacturing ◽  
3D Printing ◽  
Three Dimensional ◽  
Pharmaceutical Formulations ◽  
Dosage Forms ◽  
High Complexity ◽  
Solid Dosage Forms ◽  
Detailed Review ◽  
Solid Dosage ◽  
Materials Used

Additive manufacturing (AM), also known as three-dimensional (3D) printing, enables fabrication of custom-designed and personalized 3D constructs with high complexity in shape and composition. AM has a strong potential to fabricate oral tablets with enhanced customization and complexity as compared to tablets manufactured using conventional approaches. Despite these advantages, AM has not yet become the mainstream manufacturing approach for fabrication of oral solid dosage forms mainly due to limitations of AM technologies and lack of diverse printable drug formulations. In this review, AM of oral tablets are summarized with respect to AM technology. A detailed review of AM methods and materials used for the AM of oral tablets is presented. This article also reviews the challenges in AM of pharmaceutical formulations and potential strategies to overcome these challenges.

3D Printing Technology in Pharmaceutical Dosage forms: Advantages and Challenges

2021 ◽  
Vol 22 ◽  
Author(s):  
Prasanna Kumar Desu ◽  
Balaji Maddiboyina ◽  
Vanitha K. ◽  
GSN Koteswara Rao ◽  
Anusha R. ◽  
...  
Keyword(s):  
3D Printing ◽  
Low Cost ◽  
Three Dimensional ◽  
Dosage Forms ◽  
Solid Dosage Forms ◽  
Printing Technology ◽  
Pharmaceutical Dosage Forms ◽  
3D Printing Technology ◽  
Solid Dosage ◽  
Personalized Medicines

Three Dimensional (3D) Printing is a promising method for quick prototyping and manufacturing of any material. It is similar to photocopy or printing, where the new materials are formed on layers (3D) like its mother component. Following its growth and advancement in the 1980s, its application in pharmaceuticals is still limited. It has become one of the most innovative and influential tools serving as a technology of precise manufacturing of developed dosage forms from the last decade. The potential of 3D printing to produce drugs for precise measurement customized to specific patients' needs has shown the possibility of developing personalized medicines to novel dosage forms. The breakthrough allows the clear perception of the dosage structures on different shapes, sizes, and surfaces challenging to deliver using Designed conditions. There are different difficulties related to the correct utilization of 3D imprinting in the pharmaceutical Part, which ought to be defeated to abuse the extent of this technology. Recent advancements in the field of 3D printing technology used in the pharmaceutical industry mainly focused on different techniques for the fabrication of different dosage forms. The Food and Drug Administration's (FDA) recent approval of the first 3D prescription highlights possibilities for 3D printing innovation in the pharmaceutical drug supply field. This analysis assesses 3D printing advancement possibilities, particularly in the area of custom prescriptions. This technology can be regarded as the future of demand-produced, low-cost solid dosage forms, and helps minimize side effects due to overdose.

Extrusion-based 3D printing of oral solid dosage forms: Material requirements and equipment dependencies

2021 ◽  
Vol 598 ◽  
pp. 120361 ◽  
Author(s):  
S. Henry ◽  
A. Samaro ◽  
F.H. Marchesini ◽  
B. Shaqour ◽  
J. Macedo ◽  
...  
Keyword(s):  
3D Printing ◽  
Dosage Forms ◽  
Solid Dosage Forms ◽  
Solid Dosage ◽  
Material Requirements

3 D printing technology and experimental study of chitosan gel using atomized solidification liquid-assisted extrusion molding

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Yangwei Wang ◽  
Peilun Lv ◽  
Jian Li ◽  
Liying Yu ◽  
Guodong Yuan ◽  
...  
Keyword(s):  
3D Printing ◽  
Three Dimensional ◽  
Theoretical Research ◽  
Error Sources ◽  
Printing Technology ◽  
Content Type ◽  
Printing Ink ◽  
Printing Parameters ◽  
Chitosan Gel ◽  
Printing Method

Purpose This paper aims to propose a suitable atomizing solidification chitosan (CS) gel liquid extrusion molding technology for the three dimensional (3D) printing method, and experiments verify the feasibility of this method. Design/methodology/approach This paper mainly uses experimental means, combined with theoretical research. The preparation method, solidification forming method and 3D printing method of CS gel solution were studied. The CS gel printing mechanism and printing error sources are analyzed on the basis of the CS gel ink printing results, printing performance with different ratios of components by constructing a gel print prototype, experiments evaluating the CS gel printing technology and the effects of the process parameters on the scaffold formation. Findings CS printing ink was prepared; the optimal formula was found; the 3 D printing experiment of CS was completed; the optimal printing parameters were obtained; and the reliability of the forming prototype, printing ink and gel printing process was verified, which allowed for the possibility to apply the 3 D printing technology to the manufacturing of a CS gel structure. Originality/value This study can provide theoretical and technical support for the potential application of CS 3 D printed gels in tissue engineering.

Testing Procedures on Materials to Formulate the Ink for 3D Printing

2020 ◽  
Vol 2674 (2) ◽  
pp. 21-32 ◽  
Author(s):  
Malo Charrier ◽  
Claudiane Ouellet-Plamondon
Keyword(s):  
3D Printing ◽  
Yield Stress ◽  
Three Dimensional ◽  
Testing Procedure ◽  
Full Potential ◽  
Cement Pastes ◽  
Slump Test ◽  
Testing Procedures ◽  
Transportation Sector ◽  
Printing Ink

Three-dimensional (3D) printing has been used in various fields to tackle applications difficult for conventional manufacturing. To realize the full potential of this technology in the transportation sector, it is imperative to identify suitable tests and mixtures for printing “inks” made of mortar. In this study, several conventional and non-conventional tests on mortars and cement pastes were conducted. This work highlights the correlation between the results of slump test and the deformation test that indicates the comportment of the mixture under a stack of printed layers. Moreover, a strong connection between yield stress and mini-slump is observed, demonstrating a simplification of the testing procedure, and a link between the mortar and the cement paste is developed. In the printing ink design phase, this association enables the prediction of flowability. The yield stress and the final radius of the mini-slump tests were very well correlated for the admixture tested. The use of the mini-slump test simplifies the testing procedure and allows for quicker formulations of admixtures in the printing ink.

scholarly journals Recent Cell Printing Systems for Tissue Engineering

2017 ◽  
Vol 3 (1) ◽  
Author(s):  
Hyeongjin Lee ◽  
YoungWon Koo ◽  
Miji Yeo ◽  
SuHon Kim ◽  
Geun Hyung Kim
Keyword(s):  
Tissue Engineering ◽  
Growth Factors ◽  
3D Printing ◽  
Cell Damage ◽  
Three Dimensional ◽  
Human Tissues ◽  
Printing Process ◽  
Cell Printing ◽  
3D Space ◽  
Printing Ink

 Three-dimensional (3D) printing in tissue engineering has been studied for the bio mimicry of the structures of human tissues and organs. Now it is being applied to 3D cell printing, which can position cells and biomaterials, such as growth factors, at desired positions in the 3D space. However, there are some challenges of 3D cell printing, such as cell damage during the printing process and the inability to produce a porous 3D shape owing to the embedding of cells in the hydrogel-based printing ink, which should be biocompatible, biodegradable, and non-toxic, etc. Therefore, researchers have been studying ways to balance or enhance the post-print cell viability and the print-ability of 3D cell printing technologies by accommodating several mechanical, electrical, and chemical based systems. In this mini-review, several common 3D cell printing methods and their modified applications are introduced for overcoming deficiencies of the cell printing process.

Fabrication of nanocellulose/PEGDA hydrogel by 3D printing

2018 ◽  
Vol 24 (8) ◽  
pp. 1265-1271 ◽  
Author(s):  
Aimin Tang ◽  
Qinwen Wang ◽  
Shan Zhao ◽  
Wangyu Liu
Keyword(s):  
Additive Manufacturing ◽  
3D Printing ◽  
3D Structure ◽  
Three Dimensional ◽  
Aqueous Dispersion ◽  
Compression Modulus ◽  
Content Type ◽  
Precise Control ◽  
Light Curing ◽  
Equilibrium Swelling Ratio

Purpose Nanocellulose is characterised by favourable biocompatibility, degradability, nanostructure effect, high modulus and high tensile strength and has been widely applied in various fields. The current research in the field of new nanocellulose materials mainly focuses on the hydrogel, aerogel and the tissue engineering scaffold. All of these are three-dimensional (3D) porous materials, but conventional manufacturing technology fails to realise precise control. Therefore, the method of preparing structural materials using 3D printing and adopting the nanocellulose as the 3D printing material has been proposed. Then, how to realise 3D printing of nanocellulose is the problem that should be solved. Design/methodology/approach By adding the photosensitive component polyethyleneglycol diacrylate (PEGDA) in the aqueous dispersion system of nanocellulose, the nanocellulose was endowed with photosensitivity. Then, nanocellulose/PEGDA hydrogels were prepared by the additive manufacturing of nanocellulose through light curing. Findings The results showed that the nanocellulose/PEGDA hydrogels had a uniform shape and a controllable structure. The nanocellulose supported the scaffold structure in the hydrogels. Prepared with 1.8 per cent nanocellulose through 40 s of light curing, the nanocellulose/PEGDA hydrogels had a maximum compression modulus of 0.91 MPa. The equilibrium swelling ratio of the nanocellulose/PEGDA hydrogel prepared with 1.8 per cent nanocellulose was 13.56, which increased by 44 per cent compared with that of the PEGDA hydrogel without nanocellulose. Originality/value The paper proposed a method for rapidly prototyping the nanocellulose with expected properties, which provided a theoretical basis and technological reference for the 3D additive manufacturing of nanocellulose 3D structure materials with a controlled accurate architecture.

A COMPARATIVE QUALITATIVE STUDY OF DISPERSIBLE TABLETS OF THREE DIFFERENT COMMERCIAL BRANDS

2019 ◽  
Vol 8 (5) ◽  
Author(s):  
Ankita Kishore ◽  
Pradeep Kashyap ◽  
Devender Sharma ◽  
Ranjan Kumar Singh
Keyword(s):  
Acetylsalicylic Acid ◽  
Water Absorption ◽  
Dosage Forms ◽  
Solid Dosage Forms ◽  
Disintegration Time ◽  
Old Patients ◽  
Solid Dosage ◽  
Absorption Ratio ◽  
Wetting Time ◽  
Dispersible Tablets

Dispersible tablets are uncoated or film-coated tablets meant to be spread in water before administration giving a unvaried dispersion. Pediatric and old patients face complications in swallowing the conventional tablets. So according to the need dispersible tablets have been developed which combine the benefits of liquid dosage forms and solid dosage forms. The dispersible tablets allow dispersion in water prior to administration. In present study we have compared three brands of different dispersible tablets. The objective of the study was to find out the best dosage form based on the post compression parameters of dispersible tablets and to develop a co-relation among these parameters. Three brands of dispersible tablets had been selected i.e. Acetylsalicylic acid, Cefixime & Paracetamol tablets and they have been compared on the basis of different parameters of dispersible tablets like uniformity of weight, friability testing, hardness, wetting time, wetting volume, water absorption ratio, dispersion time, disintegration time, uniformity of dispersion. Acetylsalicylic acid & Cefixime complies all the parameters except friability test, while Paracetamol tablets complies all the tests except it was showing more hardness compared to other two brands due to which it’s properties like wetting time, wetting volume, water absorption ratio, dispersion time, disintegration time was lower than other two. So after overall comparison Cefixime was found to be the best in comparison to other two brands. Keywords: Dispersible tablets, paracetamol, cefixime, acetylsalicylic acid, comparison, post compression parameters.

scholarly journals APPLICATION OF 3D PRINTING IN INNOVATED DRUG DELIVERY: A REVIEW

2021 ◽  
pp. 77-86
Author(s):  
ZAINAB EASSA JASSIM
Keyword(s):  
3D Printing ◽  
Fused Deposition Modeling ◽  
Selective Laser Sintering ◽  
Solid Dosage Forms ◽  
Drug Products ◽  
Solid Dosage ◽  
Fused Deposition ◽  
Deposition Modeling ◽  
3D Printed ◽  
Medical Materials

Increasing requests for modified and personalized pharmaceutics and medical materials makes the implementation of additive manufacturing increased rapidly in recent years. 3D printing has been involved numerous advantages in case of reduction in waste, flexibility in the design, and minimizing the high cost of intended products for bulk production of. Several of 3D printing technologies have been developed to fabricate novel solid dosage forms, including selective laser sintering, binder deposition, stereolithography, inkjet printing, extrusion-based printing, and fused deposition modeling. The selection of 3D printing techniques depends on their compatibility with the printed drug products. This review intent to provide a perspective on the incentives and possible applications of 3D printed pharmaceuticals, besides a practical viewpoint on how 3D printing could be included across the pharmaceutical field.

Sign in / Sign up

Export Citation Format

Share Document