scholarly journals Particle Engineering of Chitosan and Kaolin Composite as a Novel Tablet Excipient by Nanoparticles Formation and Co-Processing

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1844
Author(s):  
Chonwipa Yarangsee ◽  
Phanphen Wattanaarsakit ◽  
Jakkapan Sirithunyalug ◽  
Phuriwat Leesawat
Keyword(s):  
Physical Properties ◽  
Spray Drying ◽  
Chitosan Nanoparticles ◽  
Direct Compression ◽  
Spray Dryer ◽  
Particle Engineering ◽  
Successful Development ◽  
Feed Formulation ◽  
The Individual ◽  
Tablet Hardness

Chitosan is not a common excipient for direct compression due to poor flowability and inadequate compressibility. Co-processing of chitosan and kaolin is a challenging method to overcome the limitations of the individual excipients. The purpose of the present study was to develop co-processed chitosan–kaolin by the spray drying technique (rotary atomizer spray dryer) and to characterize the excipient properties. The formation of chitosan nanoparticles was the major factor for desirable tablet hardness. The ratio of chitosan/tripolyphosphate of 10:1 and 20:1 had a significant effect on hardness. The successful development of co-processed chitosan–kaolin as a novel tablet excipient was obtained from a feed formulation composed of chitosan and kaolin at a ratio of 55:45 and the optimum chitosan/tripolyphosphate ratio of 20:1. Co-processing altered the physical properties of co-processed chitosan–kaolin in such a way that it enhanced the flowability and tableting performance compared to the physical mixture.

scholarly journals Effect of Drying Temperature of Small Scale Spray Dryer on Physical Properties of Coffee Powder

2020 ◽  
Vol 28 (4) ◽  
Author(s):  
Joko Nugroho Wahyu Karyadi ◽  
Dwi Ayuni ◽  
Tsania Ayu Rohani ◽  
Devi Yuni Susanti
Keyword(s):  
Moisture Content ◽  
Physical Properties ◽  
Spray Drying ◽  
Product Yield ◽  
Feed Solution ◽  
Small Scale ◽  
Inlet Temperature ◽  
Spray Dryer ◽  
Drying Process ◽  
High Product Yield

Nowadays, coffee has become one of the most favorable commodities for beverages, flavoring as well as for cosmetic industries. In Indonesia, coffee becomes more popular, especially among youngsters. In this study, the spray drying process was evaluated, giving the potential of how simple spray dryer can help local farmers of Indonesia to produce their coffee powders. One small scale of spray dryer was constructed with the total dimensions of 2.85 x 0.64 for length x width, with a height of 2.32 m. The spray dryer was equipped with a digital thermo regulator, the pneumatic nozzle system, and 4 finned heaters with the power of 2700 watt for each. The spray drying constructed was revealed to be able to produce coffee powders with fine quality. The inlet temperature of the drying chamber, as well as the initial Brix content of feed solution, were proven to affect the physical properties of powder produced such as moisture content, product yield, and solubility. The final moisture content of powders was ranged from 3 - 7% db, with the high product yield of the drying process, which could reach up to 70%.

scholarly journals Spray Drying for Direct Compression of Pharmaceuticals

Processes ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 267
Author(s):  
Nizar Al-Zoubi ◽  
Shadi Gharaibeh ◽  
Ahmad Aljaberi ◽  
Ioannis Nikolakakis
Keyword(s):  
Spray Drying ◽  
High Speed ◽  
Cost Effective ◽  
Effective Drug ◽  
Direct Compression ◽  
Active Pharmaceutical Ingredients ◽  
Particle Engineering ◽  
Flow Properties ◽  
Pharmaceutical Ingredients ◽  
Drug Manufacturing

Tableting by direct compression (DC) is one of the simplest and most cost-effective drug manufacturing approaches. However, most active pharmaceutical ingredients (APIs) and excipients lack the compression and flow properties required to meet the needs of high-speed industrial tablet presses. Therefore, the majority of DC APIs and excipients are modified via processing/co-processing particle engineering techniques to boost their properties. Spray drying is one of the most commonly employed techniques to prepare DC grades of APIs and excipients with prominent advantages. This review aims to present an overview of the commercially marketed and investigationally-prepared DC APIs and excipients produced by spray drying.

Optimization of Microcrystalline Cellulose PH 101, Lactose, and Kollidon® K 30 To Obtain Co-Processed Excipient Through Spray Drying

2017 ◽  
Vol 7 (2) ◽  
Author(s):  
Kusuma P. ◽  
Syukri Y ◽  
Sholehuddin F. ◽  
Fazzri N. ◽  
Romdhonah . ◽  
...  
Keyword(s):  
Spray Drying ◽  
Microcrystalline Cellulose ◽  
Chemical Change ◽  
Direct Compression ◽  
Flow Properties ◽  
Scanning Calorimetry ◽  
Compression Process ◽  
Infrared Spectrophotometer ◽  
Physical Mixtures ◽  
Spray Dried

The most efficient tablet processing method is direct compression. For this method, the filler-binder can be made by coprocessing via spray drying method. The purpose of this study was to investigate the effect of spray dried co-processing on microcrystalline cellulose (MCC) PH 101, lactose and Kollidon® K 30 as well as to define the optimum proportions. Spray dried MCC PH 101, lactose, and Kollidon® K 30 were varied in 13 different mixture design proportions to obtain compact, free-flowing filler-binder co-processed excipients (CPE). Compactibility and flow properties became the key parameters to determine the optimum proportions of CPE that would be compared to their physical mixtures. The result showed that the optimum proportion of CPE had better compactibility and flow properties than the physical mixtures. The optimum CPE, consisting of only MCC PH 101 and Kollidon® K 30 without lactose, that were characterized using infrared spectrophotometer, differential scanning calorimetry (DSC), X-ray diffraction (XRD), and scanning electron microscope (SEM) indicated no chemical change therein. Therefore, this study showed that spray dried MCC PH 101, lactose and Kollidon® K 30 could be one of the filler-binder alternatives for direct compression process.

Spray Drying of Serratia marcescens in the Jet Spray Dryer

1977 ◽  
Vol 16 (1) ◽  
pp. 12-18 ◽  
Author(s):  
E. W. Comings ◽  
Harry Higa ◽  
J. E. Myers ◽  
Henry Koffler ◽  
H. A. McLain
Keyword(s):  
Serratia Marcescens ◽  
Spray Drying ◽  
Spray Dryer

Spray Drying Performance of a Laboratory Spray Dryer for Tomato Powder Preparation

2003 ◽  
Vol 21 (7) ◽  
pp. 1273-1289 ◽  
Author(s):  
Athanasia M. Goula ◽  
Konstantinos G. Adamopoulos
Keyword(s):  
Spray Drying ◽  
Spray Dryer ◽  
Powder Preparation ◽  
Tomato Powder

Effect of spray-drying process on physical properties of sodium chloride/maltodextrin complexes

2015 ◽  
Vol 277 ◽  
pp. 141-146 ◽  
Author(s):  
Hyung-Yong Cho ◽  
Byeongsoo Kim ◽  
Ji-Yeon Chun ◽  
Mi-Jung Choi
Keyword(s):  
Sodium Chloride ◽  
Physical Properties ◽  
Spray Drying ◽  
Drying Process

scholarly journals Effect of Spray Dryer Scale Size on the Properties of Dried Beetroot Juice

Molecules ◽  
2021 ◽  
Vol 26 (21) ◽  
pp. 6700
Author(s):  
Jolanta Gawałek
Keyword(s):  
Spray Drying ◽  
Industrial Process ◽  
Laboratory Scale ◽  
Industrial Scale ◽  
Process Conditions ◽  
Spray Dryer ◽  
Beetroot Juice ◽  
Centrifugal Atomization ◽  
Drying Conditions ◽  
Drying Efficiency

Experiments detailing the spray drying of fruit and vegetable juices are necessary at the experimental scale in order to determine the optimum drying conditions and to select the most appropriate carriers and solution formulations for drying on the industrial scale. In this study, the spray-drying process of beetroot juice concentrate on a maltodextrin carrier was analyzed at different dryer scales: mini-laboratory (ML), semi-technical (ST), small industrial (SI), and large industrial (LI). Selected physicochemical properties of the beetroot powders that were obtained (size and microstructure of the powder particles, loose and tapped bulk density, powder flowability, moisture, water activity, violet betalain, and polyphenol content) and their drying efficiencies were determined. Spray drying with the same process parameters but at a larger scale makes it possible to obtain beetroot powders with a larger particle size, better flowability, a color that is more shifted towards red and blue, and a higher retention of violet betalain pigments and polyphenols. As the size of the spray dryer increases, the efficiency of the process expressed in powder yield also increases. To obtain a drying efficiency >90% on an industrial scale, process conditions should be selected to obtain an efficiency of a min. of 50% at the laboratory scale or 80% at the semi-technical scale. Designing the industrial process for spray dryers with a centrifugal atomization system is definitely more effective at the semi-technical scale with the same atomization system than it is at laboratory scale with a two-fluid nozzle.

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