scholarly journals Doxycycline-Doped Polymeric Membranes Induced Growth, Differentiation and Expression of Antigenic Phenotype Markers of Osteoblasts

Polymers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1063
Author(s):  
Manuel Toledano-Osorio ◽  
Francisco J. Manzano-Moreno ◽  
Manuel Toledano ◽  
Antonio L. Medina-Castillo ◽  
Victor J. Costela-Ruiz ◽  
...  
Keyword(s):  
Composite Membranes ◽  
Polymeric Membranes ◽  
Potential Candidate ◽  
Polymeric Scaffold ◽  
Hla Dr ◽  
Proliferation And Differentiation ◽  
Physical Barriers ◽  
Antigenic Phenotype ◽  
Biomimetic Membrane ◽  
Phenotype Markers

Polymeric membranes are employed in guided bone regeneration (GBR) as physical barriers to facilitate bone in-growth. A bioactive and biomimetic membrane with the ability to participate in the healing and regeneration of the bone is necessary. The aim of the present study was to analyze how novel silicon dioxide composite membranes functionalized with zinc or doxycycline can modulate the osteoblasts’ proliferation, differentiation, and expression of selected antigenic markers related to immunomodulation. Nanostructured acrylate-based membranes were developed, blended with silica, and functionalized with zinc or doxycycline. They were subjected to MG63 osteoblast-like cells culturing. Proliferation was assessed by MTT-assay, differentiation by evaluating the alkaline phosphatase activity by a spectrophotometric method and antigenic phenotype was assessed by flow cytometry for selected markers. Mean comparisons were conducted by one-way ANOVA and Tukey tests (p < 0.05). The blending of silica nanoparticles in the tested non-resorbable polymeric scaffold improved the proliferation and differentiation of osteoblasts, but doxycycline doped scaffolds attained the best results. Osteoblasts cultured on doxycycline functionalized membranes presented higher expression of CD54, CD80, CD86, and HLA-DR, indicating a beneficial immunomodulation activity. Doxycycline doped membranes may be a potential candidate for use in GBR procedures in several challenging pathologies, including periodontal disease.

Removal of CO2 from High-Temperature Flue Gas by PDMS/IL composite membranes

2022 ◽  
Author(s):  
Mian Wu ◽  
Xuehua Li ◽  
Xiaobing Li
Keyword(s):  
High Temperature ◽  
Flue Gas ◽  
Membrane Separation ◽  
Composite Membranes ◽  
Economic Benefits ◽  
Polymeric Membranes ◽  
Separation Of Co2 ◽  
Thermal Stable

Membrane separation of CO2 from high-temperature flue gas has economic benefits. Thus, the development of thermal-stable polymeric membranes with efficient permselectivity is very crucial. In this work, we designed a...

scholarly journals The Role of New Inorganic Materials in Composite Membranes for Water Disinfection

Membranes ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 101 ◽  
Author(s):  
Roberto Castro-Muñoz
Keyword(s):  
Composite Membranes ◽  
Membrane Bioreactors ◽  
Polymeric Membranes ◽  
Inorganic Materials ◽  
Water Disinfection ◽  
Biologically Active ◽  
Separation Performance ◽  
Nanofiltration Membrane ◽  
Physical And Chemical

Today, there is an increasing interest in improving the physicochemical properties of polymeric membranes by merging the membranes with different inorganic materials. These so-called composite membranes have been implemented in different membrane-based technologies (e.g., microfiltration, ultrafiltration, nanofiltration, membrane bioreactors, among others) for water treatment and disinfection. This is because such inorganic materials (such as TiO2-, ZnO-, Ag-, and Cu-based nanoparticles, carbon-based materials, to mention just a few) can improve the separation performance of membranes and also some other properties, such as antifouling, mechanical, thermal, and physical and chemical stability. Moreover, such materials display specific biological activity towards viruses, bacteria, and protozoa, showing enhanced water disinfection properties. Therefore, the aim of this review is to collect the latest advances (in the last five years) in using composite membranes and new hybrid materials for water disinfection, paying particular emphasis on relevant results and new hydride composites together with their preparation protocols. Moreover, this review addresses the main mechanism of action of different conventional and novel inorganic materials toward biologically active matter.

scholarly journals Fabrication, Properties, Performances, and Separation Application of Polymeric Pervaporation Membranes: A Review

Polymers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1466 ◽  
Author(s):  
Luchen Wang ◽  
Yan Wang ◽  
Lianying Wu ◽  
Gang Wei
Keyword(s):  
Chemical Engineering ◽  
Environmental Science ◽  
Membrane Separation ◽  
Separation Efficiency ◽  
Low Cost ◽  
Composite Membranes ◽  
High Energy ◽  
Polymeric Membranes ◽  
Food Science ◽  
Preparation Methods

Membrane separation technologies have attracted great attentions in chemical engineering, food science, analytical science, and environmental science. Compared to traditional membrane separation techniques like reverse osmosis (RO), ultrafiltration (UF), electrodialysis (ED) and others, pervaporation (PV)-based membrane separation shows not only mutual advantages such as small floor area, simplicity, and flexibility, but also unique characteristics including low cost as well as high energy and separation efficiency. Recently, different polymer, ceramic and composite membranes have shown promising separation applications through the PV-based techniques. To show the importance of PV for membrane separation applications, we present recent advances in the fabrication, properties and performances of polymeric membranes for PV separation of various chemicals in petrochemical, desalination, medicine, food, environmental protection, and other industrial fields. To promote the easy understanding of readers, the preparation methods and the PV separation mechanisms of various polymer membranes are introduced and discussed in detail. This work will be helpful for developing novel functional polymer-based membranes and facile techniques to promote the applications of PV techniques in different fields.

One-pot cross-linked copolymerization for the construction of robust antifouling and antibacterial composite membranes

2015 ◽  
Vol 3 (20) ◽  
pp. 4170-4180 ◽  
Author(s):  
Chong Cheng ◽  
Ai He ◽  
Chuanxiong Nie ◽  
Yi Xia ◽  
Chao He ◽  
...  
Keyword(s):  
Composite Membranes ◽  
Polymeric Membranes ◽  
One Pot ◽  
Functional Monomers ◽  
Highly Efficient ◽  
Universal Protocol

This study reports a highly efficient, convenient and universal protocol for the fabrication of robust antifouling and antibacterial polymeric membranes via one-pot cross-linked copolymerization of functional monomers.

scholarly journals Ultra-selective defect-free interfacially polymerized molecular sieve thin-film composite membranes for H2 purification

2018 ◽  
Vol 6 (1) ◽  
pp. 30-35 ◽  
Author(s):  
Z. Ali ◽  
F. Pacheco ◽  
E. Litwiller ◽  
Y. Wang ◽  
Y. Han ◽  
...  
Keyword(s):  
Thin Film ◽  
Molecular Sieve ◽  
State Of The Art ◽  
Composite Membranes ◽  
Polymeric Membranes ◽  
Mixed Gas ◽  
Film Composite ◽  
Thin Film Composite

Ultrathin, defect-free thin-film polyamide composite membranes developed for H2/CO2 separation exhibit mixed-gas performance far exceeding all state-of-the-art polymeric membranes.

Zirconium Hydrogen Phosphate/Sulfonated Poly(arylyene ether)s Composite Membrane for Direct Methanol Fuel Cells

2014 ◽  
Vol 971-973 ◽  
pp. 224-227
Author(s):  
Ai Hua Tian ◽  
Dong Hui Shen
Keyword(s):  
Fuel Cells ◽  
Composite Membrane ◽  
Direct Methanol Fuel Cells ◽  
Composite Membranes ◽  
Unit Cell ◽  
Potential Candidate ◽  
Hydrogen Phosphate ◽  
Direct Methanol ◽  
Methanol Fuel Cells ◽  
Sulfonated Poly

Zirconium hydrogen phosphate / sulfonated poly (arylyene ether) s composite membranes has been prepared and evaluated by the unit cell test for direct methanol fuel cell (DMFC) applications. The comparison between the performances of zirconium hydrogen phosphate/ sulfonated poly (arylyene ether) s composite membranes and Nafion 115 shows that the unit cell performance with composite membrane was superior to that of Nafion, which makes zirconium hydrogen phosphate/ sulfonated poly (arylyene ether) s composite membrane a potential candidate for direct methanol fuel cells.

scholarly journals Implication of a New Molecule IK in CD34+ Hematopoietic Progenitor Cell Proliferation and Differentiation

Blood ◽  
1997 ◽  
Vol 89 (10) ◽  
pp. 3615-3623 ◽  
Author(s):  
Liang-Xian Cao ◽  
Marie-Caroline Le Bousse-Kerdilès ◽  
Denis Clay ◽  
Sergey Oshevski ◽  
Claude Jasmin ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Growth Factor ◽  
Antisense Oligonucleotide ◽  
Hematopoietic Progenitor Cell ◽  
Antisense Oligodeoxynucleotide ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord ◽  
Cell Proliferation And Differentiation ◽  
Hla Dr ◽  
Proliferation And Differentiation

Abstract HLA-DR is one of the markers associated with hematopoietic cell differentiation, since expression of this molecule is modulated throughout hematopoiesis. We have previously described and cloned the gene encoding factor IK, which inhibits both interferon gamma (IFN-γ)-induced and constitutive HLA-DR expression. The current study demonstrates that IK gene transcripts are present in CD34+ cells purified from human umbilical cord blood. IK expression increased and was therefore inversely correlated with the gradual loss of HLA-DR during growth factor–induced CD34+ cell proliferation and differentiation. To study the possible role of IK in hematopoiesis, antisense probes were used. IK expression was specifically inhibited by an antisense oligodeoxynucleotide containing two phosphorothioate internucleotide linkages at each of the 3′ and 5′ ends and corresponding to the initiation site of IK mRNA. A control oligonucleotide was also tested in parallel. A specific decrease of IK transcripts was correlated with an increase of HLA-DR antigen expression level. In colony-forming assays, IK antisense oligonucleotide inhibited colony formation by multilineage early erythroid and granulomonocytic CD34+ progenitors. The mean colony size was decreased 70% by IK antisense oligonucleotide in comparison to controls. These results provide evidence that the IK molecule participates in the regulation of HLA-DR expression on hematopoietic cells and plays a role in growth factor–dependent CD34+ cell proliferation and differentiation by modulating HLA-DR expression.

scholarly journals JNK1 Induces Notch1 Expression to Regulate Genes Governing Photoreceptor Production

Cells ◽  
2019 ◽  
Vol 8 (9) ◽  
pp. 970
Author(s):  
Pan ◽  
Hu ◽  
Wang ◽  
Zhou ◽  
Zhang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Transcriptional Factor ◽  
Negative Regulator ◽  
Potential Candidate ◽  
Wild Type ◽  
Cell Proliferation And Differentiation ◽  
Proliferation And Differentiation ◽  
Factor Expression ◽  
Ophthalmic Diseases ◽  
Essential Function

c-Jun N-terminal kinases (JNKs) regulate cell proliferation and differentiation via phosphorylating such transcription factors as c-Jun. The function of JNKs in retinogenesis remains to be elucidated. Here, we report that knocking out Jnk1, but not Jnk2, increased the number of photoreceptors, thus enhancing the electroretinogram (ERG) responses. Intriguingly, Notch1, a well-established negative regulator of photoreceptor genesis, was significantly attenuated in Jnk1 knockout (KO) mice compared to wild-type mice. Mechanistically, light specifically activated JNK1 to phosphorylate c-Jun, which in turn induced Notch1 transcription. The identified JNK1–c-Jun–Notch1 axis strongly inhibited photoreceptor-related transcriptional factor expression and ultimately impaired photoreceptor opsin expression. Our study uncovered an essential function of JNK1 in retinogenesis, revealing JNK1 as a potential candidate for targeting ophthalmic diseases.

Synthesis and physiochemical performances of PVC-sodium polyacrylate and PVC-sodium polyacrylate-graphite composite polymer membrane

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Abdul Hamid ◽  
Muhammad Khan ◽  
Fakhar Hussain ◽  
Amir Zada ◽  
Tiehu Li ◽  
...  
Keyword(s):  
Ion Exchange ◽  
Water Uptake ◽  
Composite Membranes ◽  
Type A ◽  
Exchange Capacity ◽  
Proton Exchange ◽  
Polymeric Membranes ◽  
Sodium Polyacrylate ◽  
Ion Exchange Capacity ◽  
Graphite Composite

Abstract Three types (type-A, B, and C) of composite polymeric membranes (CPMs) based on poly vinyl chloride (PVC) and different fillers (sodium polyacrylate and sodium polyacrylate-graphite) soaked in water and 0.5 N HCl were prepared using solvent casting method. Different physicochemical parameters such as microscopic surface study, water uptake, perpendicular swelling, density, porosity (ε), ion exchange capacity, and conductivity of the as the prepared CPMs were evaluated. Interestingly, type-A CPM cast with filler-A has greater values of the above parameters except density and ionic conductivity than those of type-B and C CPMs. The water uptake of type-A, B and C composite membranes was respectively in the range of 220.42–534.70, 59.64–41.65, and 15.94–2.62%. Ion exchange capacity of type-A, B and C CPMs was in the range of 3.669 × 107–2.156 × 107, 5.948 × 107–1.258 × 107, and 1.454 × 107–1.201 × 107 m.eq.g−1 respectively while the conductivity order was type-A < B < C. These types of CPMs may be helpful in many applications including proton exchange membranes, fuel cell like devices, as sensors for different metals, gas purification, water treatment, and battery separators.

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