scholarly journals Intact Fibrillated 3D-Printed Cellulose Macrofibrils/CaCO3 for Controlled Drug Delivery

Polymers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 1912
Author(s):  
Denesh Mohan ◽  
Zee Khai Teong ◽  
Mohd Shaiful Sajab ◽  
Nur Hidayatul Nazirah Kamarudin ◽  
Hatika Kaco
Keyword(s):  
Mechanical Properties ◽  
3D Printing ◽  
Three Dimensional ◽  
Volumetric Flow Rate ◽  
Homogeneous Distribution ◽  
Therapeutic Drug ◽  
Burst Release ◽  
Drug Release Profile ◽  
Precipitated Calcium Carbonate ◽  
Cellulose Fibrils

The tendency to use cellulose fibrils for direct ink writing (DIW) of three-dimensional (3D) printing has been growing extensively due to their advantageous mechanical properties. However, retaining cellulose in its fibrillated forms after the printing process has always been a challenge. In this study, cellulose macrofibrils (CMFs) from oil palm empty fruit bunch (OPEFB) fibers were partially dissolved for consistent viscosity needed for DIW 3D printing. The printed CMF structure obtained from optimized printing profiles (volumetric flow rate, Qv = 9.58 mm/s; print speed, v = 20 mm/s), exhibited excellent mechanical properties (tensile strength of 66 MPa, Young’s modulus of 2.16 GPa, and elongation of 8.76%). The remarkable structural and morphological effects of the intact cellulose fibrils show a homogeneous distribution with synthesized precipitated calcium carbonate (CaCO3) nanoparticles. The shear-aligned CMF/CaCO3 printed composite exhibited a sustained therapeutic drug release profile that can reduce rapid release that has adverse effects on healthy cells. In comparison with the initial burst release of 5-fluorouracil (5-FU) by CaCO3, the controlled release of 5-fluorouracil can be varied (48 to 75%) with the composition of CMF/CaCO3 allowing efficient release over time.

scholarly journals An Overview on the Rheology, Mechanical Properties, Durability, 3D Printing, and Microstructural Performance of Nanomaterials in Cementitious Composites

Materials ◽  
2021 ◽  
Vol 14 (11) ◽  
pp. 2950
Author(s):  
Hongwei Song ◽  
Xinle Li
Keyword(s):  
Mechanical Properties ◽  
3D Printing ◽  
Three Dimensional ◽  
Cementitious Materials ◽  
Research Area ◽  
Cementitious Composites ◽  
Split Tensile Strength ◽  
Contour Crafting ◽  
Wide Range ◽  
Active Research

The most active research area is nanotechnology in cementitious composites, which has a wide range of applications and has achieved popularity over the last three decades. Nanoparticles (NPs) have emerged as possible materials to be used in the field of civil engineering. Previous research has concentrated on evaluating the effect of different NPs in cementitious materials to alter material characteristics. In order to provide a broad understanding of how nanomaterials (NMs) can be used, this paper critically evaluates previous research on the influence of rheology, mechanical properties, durability, 3D printing, and microstructural performance on cementitious materials. The flow properties of fresh cementitious composites can be measured using rheology and slump. Mechanical properties such as compressive, flexural, and split tensile strength reveal hardened properties. The necessary tests for determining a NM’s durability in concrete are shrinkage, pore structure and porosity, and permeability. The advent of modern 3D printing technologies is suitable for structural printing, such as contour crafting and binder jetting. Three-dimensional (3D) printing has opened up new avenues for the building and construction industry to become more digital. Regardless of the material science, a range of problems must be tackled, including developing smart cementitious composites suitable for 3D structural printing. According to the scanning electron microscopy results, the addition of NMs to cementitious materials results in a denser and improved microstructure with more hydration products. This paper provides valuable information and details about the rheology, mechanical properties, durability, 3D printing, and microstructural performance of cementitious materials with NMs and encourages further research.

scholarly journals Extrusion Based 3D Printing of Sustainable Biocomposites from Biocarbon and Poly(trimethylene terephthalate)

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4164
Author(s):  
Elizabeth Diederichs ◽  
Maisyn Picard ◽  
Boon Peng Chang ◽  
Manjusri Misra ◽  
Amar Mohanty
Keyword(s):  
Mechanical Properties ◽  
3D Printing ◽  
Surface Finish ◽  
Three Dimensional ◽  
Morphological Properties ◽  
Great Promise ◽  
Structural Components ◽  
Computer Aided ◽  
Trimethylene Terephthalate ◽  
Optimal Quantity

Three-dimensional (3D) printing manufactures intricate computer aided designs without time and resource spent for mold creation. The rapid growth of this industry has led to its extensive use in the automotive, biomedical, and electrical industries. In this work, biobased poly(trimethylene terephthalate) (PTT) blends were combined with pyrolyzed biomass to create sustainable and novel printing materials. The Miscanthus biocarbon (BC), generated from pyrolysis at 650 °C, was combined with an optimized PTT blend at 5 and 10 wt % to generate filaments for extrusion 3D printing. Samples were printed and analyzed according to their thermal, mechanical, and morphological properties. Although there were no significant differences seen in the mechanical properties between the two BC composites, the optimal quantity of BC was 5 wt % based upon dimensional stability, ease of printing, and surface finish. These printable materials show great promise for implementation into customizable, non-structural components in the electrical and automotive industries.

scholarly journals Exceptional Mechanical Properties and Heat Resistance of Photocurable Bismaleimide Ink for 3D Printing

Materials ◽  
2021 ◽  
Vol 14 (7) ◽  
pp. 1708
Author(s):  
Wenqiang Hua ◽  
Qilang Lin ◽  
Bo Qu ◽  
Yanyu Zheng ◽  
Xiaoying Liu ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
3D Printing ◽  
Heat Resistance ◽  
Three Dimensional ◽  
Mechanical And Thermal Properties ◽  
Amino Group ◽  
Building Models ◽  
Fast Processing ◽  
Forming Precision ◽  
Complex Structural

Photosensitive resins used in three-dimensional (3D) printing are characterized by high forming precision and fast processing speed; however, they often possess poor mechanical properties and heat resistance. In this study, we report a photocurable bismaleimide ink with excellent comprehensive performance for stereolithography (SLA) 3D printing. First, the main chain of bismaleimide with an amino group (BDM) was synthesized, and then, the glycidyl methacrylate was grafted to the amino group to obtain the bismaleimide oligomer with an unsaturated double bond. The oligomers were combined with reaction diluents and photo-initiators to form photocurable inks that can be used for SLA 3D printing. The viscosity and curing behavior of the inks were studied, and the mechanical properties and heat resistance were tested. The tensile strength of 3D-printed samples based on BDM inks could reach 72.6 MPa (166% of that of commercial inks), glass transition temperature could reach 155 °C (205% of that of commercial inks), and energy storage modulus was 3625 MPa at 35 °C (327% of that of commercial inks). The maximum values of T-5%, T-50%, and Tmax of the 3D samples printed by BDM inks reached 351.5, 449.6, and 451.9 °C, respectively. These photocured BDM inks can be used to produce complex structural components and models with excellent mechanical and thermal properties, such as car parts, building models, and pipes.

scholarly journals Parameters Affecting the Mechanical Properties of Three-Dimensional (3D) Printed Carbon Fiber-Reinforced Polylactide Composites

Polymers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 2456
Author(s):  
Demei Lee ◽  
Guan-Yu Wu
Keyword(s):  
Mechanical Properties ◽  
Carbon Fiber ◽  
3D Printing ◽  
Three Dimensional ◽  
Fused Deposition Modelling ◽  
Layer By Layer ◽  
Fused Deposition ◽  
Bed Temperature ◽  
3D Printed ◽  
The Impact

Three-dimensional (3D) printing is a manufacturing technology which creates three-dimensional objects layer-by-layer or drop-by-drop with minimal material waste. Despite the fact that 3D printing is a versatile and adaptable process and has advantages in establishing complex and net-shaped structures over conventional manufacturing methods, the challenge remains in identifying the optimal parameters for the 3D printing process. This study investigated the influence of processing parameters on the mechanical properties of Fused Deposition Modelling (FDM)-printed carbon fiber-filled polylactide (CFR-PLA) composites by employing an orthogonal array model. After printing, the tensile and impact strengths of the printed composites were measured, and the effects of different parameters on these strengths were examined. The experimental results indicate that 3D-printed CFR-PLA showed a rougher surface morphology than virgin PLA. For the variables selected in this analysis, bed temperature was identified as the most influential parameter on the tensile strength of CFR-PLA-printed parts, while bed temperature and print orientation were the key parameters affecting the impact strengths of printed composites. The 45° orientation printed parts also showed superior mechanical strengths than the 90° printed parts.

scholarly journals Effects of Cellulose Nanocrystal and Inorganic Nanofillers on the Morphological and Mechanical Properties of Digital Light Processing (DLP) 3D-Printed Photopolymer Composites

2021 ◽  
Vol 11 (15) ◽  
pp. 6835
Author(s):  
Sang-U Bae ◽  
Birm-June Kim
Keyword(s):  
Mechanical Properties ◽  
3D Printing ◽  
Mechanical Strength ◽  
Stress Transfer ◽  
Cellulose Nanocrystal ◽  
Morphological Properties ◽  
Precipitated Calcium Carbonate ◽  
Digital Light Processing ◽  
3D Printed ◽  
Cellulose Nanomaterials

Photopolymer composites filled with cellulose nanocrystal (CNC) and/or inorganic nanofillers were fabricated by using digital light processing (DLP) 3D printing. To investigate the effects of different CNC lyophilization concentrations and behaviors of CNC particles in the photopolymer composites, morphological and mechanical properties were analyzed. CNC loading levels affected the morphological and mechanical properties of the filled composites. Better CNC dispersion was seen at a lower lyophilization concentration, and the highest mechanical strength was observed in the 0.25 wt% CNC-filled composite. Furthermore, nano-precipitated calcium carbonate (nano-PCC) and nanoclay were added to photocurable resins, and then the effect of inorganic nanofillers on the morphological and mechanical properties of the composites were evaluated. By analyzing the morphological properties, the stress transfer mechanism of nano-PCC and nanoclay in the photopolymer composites was identified and related models were presented. These supported the improved mechanical strength of the composites filled with CNC, nano-PCC, and nanoclay. This study suggested a new approach using wood-derived cellulose nanomaterials and inorganic nanofillers as effective fillers for DLP 3D printing.

scholarly journals INVESTIGATION ON THE MECHANICAL, THERMAL, BIO-DEGRADATION, AND BIO-COMPATIBILITY PROPERTIES OF POLY (LACTIC ACID) / POLY (ETHYLENE GLYCOL) BLEND

2021 ◽  
Vol 22 (1) ◽  
pp. 223-233
Author(s):  
Zohreh Zarinkolah ◽  
Hamed Bagheri ◽  
Saman Hosseinkhani ◽  
Maryam Nikkhah
Keyword(s):  
Mechanical Properties ◽  
Drug Release ◽  
Drug Loading ◽  
Poly Lactic Acid ◽  
Burst Release ◽  
Mechanical And Thermal Properties ◽  
Cytotoxicity Test ◽  
Test Results ◽  
Drug Release Profile ◽  
Absorbable Sutures

Absorbable sutures are widely used in surgery. In addition to acceptable mechanical properties, the surgical sutures should exhibit favorable degradability properties. In this research, the mechanical and thermal properties, hydrophilicity, biodegradability, pH changes, and drug release profile of polylactic acid (PLA) and polyethylene glycol (PEG) alloy were examined to fabricate absorbable sutures. The test results for the mechanical properties showed that the strength of the PLA/PEG alloy decreased with increasing PEG content, leading to an increase in elongation. The differential thermal analysis indicated that the resulting material was above its glass transition temperature (Tg) at ambient temperature and was thus flexible enough. According to the degradation test results, the alloys were degraded similar to the commercial sample. Furthermore, the pH measurements revealed that the degradation of the alloy had no significant effect on the pH of the environment. Bupivacaine hydrochloride was incorporated into a certain amount of PLA and PEG, and the drug release rate was then measured. The sample provided a suitable substrate for burst release. Moreover, the cytotoxicity test was carried out to evaluate the biocompatibility properties of the PLA/PEG alloy and it was found that this alloy is biocompatible and the biocompatibility of the material decreases with increasing drug loading. ABSTRAK: Sutur boleh serap telah digunakan dalam pembedahan secara meluas. Tambahan kepada sifat-sifat mekanikal ini, sutur pembedahan perlu memiliki ciri-ciri kebolehurain yang dikehendaki. Dalam kajian ini, sifat-sifat mekanikal dan terma, kehidrofilikan, kebolehuraian, perubahan pH, dan profil penguraian ubat asid polilaktik (PLA) dan aloi polietilena glikol (PEG) telah dikaji bagi mencipta sutur boleh serap. Hasil kajian mendapati sifat-sifat mekanikal menunjukkan kekuatan PLA/PEG aloi berkurangan dengan penambahan level PEG, menyebabkan bertambahnya pemanjangan. Analisis pembezaan terma menunjukkan hasil bahan adalah melepasi suhu perubahan gelas (Tg) pada suhu sekitar dan oleh itu sangat lentur. Berdasarkan hasil kajian degradasi, aloi ini telah digradasi seperti sampel komersial. Tambahan lagi, ukuran pH menunjukkan degradasi aloi ini tidak menunjukkan kesan langsung pada pH persekitaran. Bupivacaine hidroklorida dimasukkan ke dalam PLA dan PEG, dan kadar ubat dibebaskan kemudiannya diukur. Sampel substrat yang bersesuian disediakan bagi pelepas letus. Tambahan, ujian Kesitotoksikan telah dijalankan bagi menilai ciri-ciri keserasian-bio aloi PLA/PEG dan didapati aloi ini serasi-bio dan keserasian-bio bahan berkurangan dengan penambahan beban ubat.

A novel 3D-printable hydrogel with high mechanical strength and shape memory properties

2019 ◽  
Vol 7 (47) ◽  
pp. 14913-14922 ◽  
Author(s):  
Qiang Zhou ◽  
Kaixiang Yang ◽  
Jiaqing He ◽  
Haiyang Yang ◽  
Xingyuan Zhang
Keyword(s):  
Mechanical Properties ◽  
3D Printing ◽  
Mechanical Strength ◽  
Shape Memory ◽  
Three Dimensional ◽  
High Mechanical Strength ◽  
Shape Memory Properties ◽  
Potential Applications

The three-dimensional (3D)-printing of hydrogels with excellent mechanical properties has attracted extensive attention owing to their potential applications in many fields.

DLP 3D printing of Dexamethasoneincorporated PEGDA-based photopolymers: compressive properties and drug release

2020 ◽  
Vol 6 (3) ◽  
pp. 406-409
Author(s):  
Robert Mau ◽  
Thomas Reske ◽  
Thomas Eickner ◽  
Niels Grabow ◽  
Hermann Seitz
Keyword(s):  
Mechanical Properties ◽  
3D Printing ◽  
Drug Release ◽  
Drug Loading ◽  
Patient Specific ◽  
Burst Release ◽  
Compressive Properties ◽  
Drug Load ◽  
Polyethylene Glycol Diacrylate ◽  
3D Printed

AbstractPhotopolymerizing, high-resolution 3D printing methods such as Stereolithography (SLA) or Digital Light Processing (DLP) are very promising for the manufacturing of drug-incorporated, patient specific implants. However, a drug-load may be limited by adequately solubility of the active pharmaceutical ingredient (API) in the photopolymer. Furthermore, a drug-load may affect the mechanical properties of the material negatively. Here, we investigate the DLP 3D printing of drugincorporated photopolymers. Polyethylene glycol diacrylate (PEGDA, Mn = 700 g/mol) is used as matrix polymer and Dexamethasone (DEX) is used for drug-loading (10 g/L and 20 g/L). Compressive properties, drug release and drug stability of 3D printed test samples were analyzed. DEX was found to be sparingly soluble in the PEGDA-based photopolymer. Not all drug particles can be dissolved at a concentration of 20 g/L and a slurry-like suspension is formed. Drug-incorporated photopolymers of 10 g/L (solution) and 20 g/L (suspension) were processed successfully via DLP. The higher the drug-load, the lower the compressive strength. Mechanical properties can be improved via a post-curing in a UV light curing box. Drug-incorporated 3D printed test samples show burst-release of DEX. The post-curing process does not affect drug release. DEX degrades in 3D-printed test samples significantly (~ 30 %) over a several days time period.

Printability assessment of psyllium husk (isabgol)/gelatin blends using rheological and mechanical properties

2020 ◽  
pp. 088532822097947
Author(s):  
Piyush Sunil Agarwal ◽  
Suruchi Poddar ◽  
Neelima Varshney ◽  
Ajay Kumar Sahi ◽  
Kiran Yellappa Vajanthri ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
3D Printing ◽  
Storage Modulus ◽  
Loss Tangent ◽  
Loss Modulus ◽  
Three Dimensional ◽  
Elastic Behavior ◽  
Flow Index ◽  
Plastic Behavior ◽  
Psyllium Husk

The primary goal of this study is to highlight the rheological and mechanical properties of a new blend composed of naturally-derived hydrogel materials- psyllium husk (PH) and gelatin (G) for its potential use in three-dimensional (3D) printing technology. The mixtures were prepared at various weight ratios of 100PH, 75PH + 25G and 50PH + 50G. A suitable selection of the printable ink was made based on the preliminary screening steps of manual filament drop test and layer stacking by 3D printing. Printing of the common features such as hexagon and square grids helped evaluating shape fidelity of the chosen ink. Although 50PH + 50G blend was found meeting most of the criteria for an ideal 3D printable ink, rheological and mechanical characterizations have been performed for all the ratios of polymeric blends. This study documents the correlation between various factors of rheology that should be taken into account while categorizing any biomaterial as a printable ink. Yield stress was measured as 18.59 ± 4.21 Pa, 268.74 ± 13.56 Pa and 109.16 ± 9.85 Pa for 50PH + 50G, 75PH + 25G and 100PH, respectively. Similarly, consistency index (K) and flow index (n) were calculated using the power law equation and found as 49.303 ± 4.17, 530.59 ± 10.92, 291.82 ± 10.53 and 0.275 ± 0.04, 0.05 ± 0.005, 0.284 ± 0.04 for 50PH + 50G, 75PH + 25G and 100PH, respectively. The loss modulus (G″) was observed dominating over storage modulus (G′) for 50PH + 50G, that depicts its liquid-like property; whereas storage modulus (G′) was found dominating in case of 75PH + 25G and 100PH, indicating their solid-like characteristics. In addition, the loss tangent value (tan δ) of 50PH + 50G was observed exceeding unity (1.05), supporting its plastic behavior, unlike 75PH + 25G (0.5) and 100PH (0.33) whose loss tangent values were estimated less than unity revealing their elastic behavior. Also, 50PH + 50G was found to have the highest mechanical strength amongst the three blends with a Young’s modulus of 9.170 ± 0.0881 kPa.

Fabrication, characterization, and application of polyester/wood flour composites

2017 ◽  
Vol 37 (7) ◽  
pp. 689-698 ◽  
Author(s):  
Chin-San Wu ◽  
Hsin-Tzu Liao
Keyword(s):  
Mechanical Properties ◽  
Antibacterial Activity ◽  
Thermal Properties ◽  
Composite Materials ◽  
3D Printing ◽  
Maleic Anhydride ◽  
Water Resistance ◽  
Wood Flour ◽  
Three Dimensional ◽  
Ester Formation

Abstract The mechanical properties, thermal properties, antibacterial activity, and fabrication of three-dimensional (3D) printing strips of composite materials containing polyhydroxyalkanoate (PHA) and wood flour (WF) were evaluated. Maleic anhydride (MA)-grafted PHA (PHA-g-MA) and WF were used to enhance the desired characteristics of these composites. The PHA-g-MA/WF composites had better mechanical properties than the PHA/WF composites did. This effect was attributed to a greater compatibility between the grafted polyester and WF. Additionally, the PHA-g-MA/WF composites provided higher quality 3D printing strips and were more easily processed because of ester formation. The water resistance of the PHA-g-MA/WF composite was greater than that of PHA/WF. Moreover, WF enhanced the antibacterial activity of the composites. Composites of PHA-g-MA or PHA containing WF had better antibacterial activity.

Sign in / Sign up

Export Citation Format

Share Document