scholarly journals Hydrogels Based on Alginates and Carboxymethyl Cellulose with Modulated Drug Release—An Experimental and Theoretical Study

Polymers ◽  
2021 ◽  
Vol 13 (24) ◽  
pp. 4461
Author(s):  
Cătălina Anișoara Peptu ◽  
Elena Simona Băcăiță ◽  
Corina-Lenuta Savin (Logigan) ◽  
Marian Luțcanu ◽  
Maricel Agop
Keyword(s):  
Drug Delivery ◽  
Carboxymethyl Cellulose ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Relativity Theory ◽  
Release Process ◽  
Hemostatic Activity ◽  
Swelling Capacity ◽  
Drug Efficiency ◽  
Capacity Loading

New hydrogels films crosslinked with epichlorohydrin were prepared based on alginates and carboxymethyl cellulose with properties that recommend them as potential drug delivery systems (e.g., biocompatibility, low toxicity, non-immunogenicity, hemostatic activity and the ability to absorb large amounts of water). The characterization of their structural, morphological, swelling capacity, loading/release and drug efficiency traits proved that these new hydrogels are promising materials for controlled drug delivery systems. Further, a new theoretical model, in the framework of Scale Relativity Theory, was built with to offer insights on the release process at the microscopic level and to simplify the analysis of the release process.

Synthesis and in vitro Evaluation of Tamoxifen-Loaded Gelatin as Effective Nanocomplex in Drug Delivery Systems

2020 ◽  
Vol 19 (05) ◽  
pp. 2050002
Author(s):  
Nasrin Faramarzi ◽  
Javad Mohammadnejad ◽  
Hanieh Jafary ◽  
Asghar Narmani ◽  
Mojtaba Koosha ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cell Death ◽  
Cancer Treatment ◽  
Drug Delivery Systems ◽  
Drug Loading ◽  
Delivery Systems ◽  
Gelatin Nanoparticles ◽  
Drug Efficiency ◽  
Mcf 7

Recently, using gelatin nanoparticles as a biocompatible carrier in drug delivery systems is growing up. Drug delivery is one of the most common applications of nanoparticles in cancer treatment in order to optimize the drug efficiency. In this study, gelatin nanoparticles were firstly synthesized and loaded with tamoxifen that subsequently characterized by SEM, TGA and FT-IR analyses. The approximate drug loading efficiency was calculated about 17.43% for tamoxifen-loaded gelatin (TG). Then, the effect of TG on apoptosis induction and cytotoxicity of MCF-7 cell line was evaluated and compared with flow cytometry and MTT assay. The MTT results showed that tamoxifen and TG nanoparticles could inhibit the proliferation of MCF-7 cells in a dose-responsive manner, with an IC[Formula: see text] of IC[Formula: see text] of 200 [Formula: see text]g/mL and 50 [Formula: see text]g/mL after 24[Formula: see text]h and 48[Formula: see text]h, respectively. Moreover, from flow cytometric results, it can be suggested that TG nanoparticles are more potent in inducing apoptosis and cell death through programmed cell death. Actually, TG nanoparticles primarily increased the early apoptotic cells during the 24-h incubation period Our results revealed that tamoxifen-loaded gelatin nanoparticles are more potent than tamoxifen alone. These findings support the use of tamoxifen-loaded gelatin nanoparticles in target-specific therapy for cancer treatment.

scholarly journals Drug Delivery Based on Stimuli-Responsive Injectable Hydrogels for Breast Cancer Therapy: A Review

Gels ◽  
2022 ◽  
Vol 8 (1) ◽  
pp. 45
Author(s):  
Hai Xin ◽  
Sina Naficy
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Side Effects ◽  
Drug Delivery Systems ◽  
Structural Integrity ◽  
Delivery Systems ◽  
Cancer Therapies ◽  
Stimuli Responsive ◽  
Injectable Hydrogels ◽  
Drug Efficiency

Breast cancer is the most common and biggest health threat for women. There is an urgent need to develop novel breast cancer therapies to overcome the shortcomings of conventional surgery and chemotherapy, which include poor drug efficiency, damage to normal tissues, and increased side effects. Drug delivery systems based on injectable hydrogels have recently gained remarkable attention, as they offer encouraging solutions for localized, targeted, and controlled drug release to the tumor site. Such systems have great potential for improving drug efficiency and reducing the side effects caused by long-term exposure to chemotherapy. The present review aims to provide a critical analysis of the latest developments in the application of drug delivery systems using stimuli-responsive injectable hydrogels for breast cancer treatment. The focus is on discussing how such hydrogel systems enhance treatment efficacy and incorporate multiple breast cancer therapies into one system, in response to multiple stimuli, including temperature, pH, photo-, magnetic field, and glutathione. The present work also features a brief outline of the recent progress in the use of tough hydrogels. As the breast undergoes significant physical stress and movement during sporting and daily activities, it is important for drug delivery hydrogels to have sufficient mechanical toughness to maintain structural integrity for a desired period of time.

Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

1985 ◽  
Vol 43 ◽  
pp. 710-711
Author(s):  
G.E. Visscher ◽  
R. L. Robison ◽  
G. J. Argentieri
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Gastrocnemius Muscle ◽  
Degradation Process ◽  
Delivery Systems ◽  
Tissue Reaction ◽  
Electron Microscopic ◽  
Tissue Samples ◽  
Injectable Polymer ◽  
Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

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