Modification of Glial Attachment by Surface Nanostructuring of SU-8 Thin Films

Various methods are currently under development to enhance the biocompatibility of neural electrodes and to minimize the reactive gliosis around the implant surface. As cells in their native microenvironment interact with 3D nanoscale topographies of the extracellular matrix, physical modification of implant surfaces may provide an alternative solution to the negative tissue response by imitating the structure of the extracellular matrix, and therefore affecting the attachment and behavior of neurons and glial cells. The attachment of primary mouse astrocytes on nanostructured SU8 polymer surfaces fabricated by e-beam lithography was investigated in our study. We found that attachment of primary mouse astrocytes on silicon-SU8 surfaces is strongly influenced by the surface topography.

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Relationship between structure, surface topography and tribo-mechanical behavior of Ti-N thin films elaborated at different N2 flow rates

Thin Solid Films ◽

10.1016/j.tsf.2021.138598 ◽

2021 ◽

Vol 724 ◽

pp. 138598

Author(s):

Linda AISSANI ◽

Akram ALHUSSEIN ◽

Abdelhak AYAD ◽

Corinne NOUVEAU ◽

Elia ZGHEIB ◽

...

Keyword(s):

Thin Films ◽

Mechanical Behavior ◽

Surface Topography ◽

Flow Rates ◽

Structure Surface

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Characterisation of ‘wet’ polymer surfaces for tissue engineering applications: Are flat surfaces a suitable model for complex structures?

e-Polymers ◽

10.1515/epoly.2005.5.1.92 ◽

2005 ◽

Vol 5 (1) ◽

Cited By ~ 3

Author(s):

Laleh Safinia ◽

Jonny J. Blaker ◽

Véronique Maquet ◽

Aldo R. Boccaccini ◽

Athanassios Mantalaris ◽

...

Keyword(s):

Thin Films ◽

Tissue Engineering ◽

Pore Wall ◽

Polymer Surfaces ◽

Suitable Model ◽

Tissue Engineering Scaffolds ◽

3D Structures ◽

Flat Surfaces ◽

Point Test ◽

Highly Porous

AbstractTissue engineering scaffolds are 3D constructs that simulate the growth environment in vivo. The present work aims to address the question of whether thin films, i.e., flat surfaces, are a suitable model for more complex 3D structures? With this in mind a complete study of the morphology and surface chemistry of poly(D,Llactide) (PDLLA) substrates, fabricated into two different structures, is presented. The polymer structures studied include a 3D, porous, foam-like scaffold prepared by the thermally induced phase separation (TIPS) method and flat polymer thin films made by solvent casting. Based on the maximum bubble point test, a new method to assess the wettability of wet pore wall surfaces inside highly porous 3D structures was developed and tested. The maximum pore diameter determined using the maximum bubble point test for the total wetting liquids was confirmed through image analysis of scanning electron micrographs. The method allows the determination of the contact angle between the wet pore wall and a contacting liquid. The captive bubble method was employed to characterise the wettability of flat polymer films in contact with water. Both structures were further characterised using zeta- (ζ-) potential measurements to assess the surface chemistry of the polymer. The results demonstrate that PDLLA contains acidic functional groups and is hydrophobic. In order to evaluate the sensitivity of the test methods, the polymer surfaces were modified by protein adsorption using fibronectin and collagen. ζ-Potential and wettability measurements show that proteins indeed adsorb on virgin PDLLA surfaces. Protein adsorption causes the wettability of the PDLLA for water to improve. Our results strongly indicate that flat surfaces are not a suitable model for surfaces in complex 3D structures such as highly porous tissue engineering scaffolds. Such scaffolds must be characterised as a 3D system.

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Impact of implant surface topography: a clinical study with a mean functional loading time of 85 months

Clinical Oral Implants Research ◽

10.1111/j.1600-0501.2012.02498.x ◽

2012 ◽

pp. n/a-n/a ◽

Cited By ~ 2

Author(s):

Christoph Arnhart ◽

Gabriella Dvorak ◽

Caroline Trefil ◽

Christian Huber ◽

Georg Watzek ◽

...

Keyword(s):

Clinical Study ◽

Surface Topography ◽

Implant Surface ◽

Functional Loading

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A Study on the Effect of Process Parameters on Surface Topography of Al Thin Films on Various Substrates Using AFM

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.383-390.903 ◽

2011 ◽

Vol 383-390 ◽

pp. 903-908

Author(s):

S. Shanmugan ◽

D. Mutharasu ◽

Z. Hassan ◽

H. Abu. Hassan

Keyword(s):

Thin Films ◽

Surface Topography ◽

Flow Rate ◽

Gas Flow ◽

Process Conditions ◽

Gas Flow Rate ◽

Glass Substrates ◽

Sputtering Power ◽

Large Particles ◽

Ar Gas

Al thin films were prepared over different substrates at various process conditions using DC sputtering. The surface topography of all prepared films was examined using AFM technique. Very smooth, uniform and dense surface were observed for Al films coated over Glass substrates. The observed particle size was nano scale (20 -70 nm) for Glass substrates. Sputtering power showed immense effect on surface roughness with respective to Ar gas flow rate. Noticeable change on surface with large particles was observed in Copper substrates at various sputtering power and gas flow rate.

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Growth, structure, surface topography and magnetic properties of GdMnO3multiferroic epitaxial thin films

EPJ Web of Conferences ◽

10.1051/epjconf/20134015014 ◽

2013 ◽

Vol 40 ◽

pp. 15014 ◽

Cited By ~ 2

Author(s):

N. Andreev ◽

V. Chichkov ◽

T. Sviridova ◽

N. Tabachkova ◽

A. Volodin ◽

...

Keyword(s):

Thin Films ◽

Magnetic Properties ◽

Surface Topography ◽

Epitaxial Thin Films ◽

Growth Structure ◽

Structure Surface

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Positronium Formation as a Probe of Polymer Surfaces and Thin Films

Physical Review Letters ◽

10.1103/physrevlett.74.4947 ◽

1995 ◽

Vol 74 (24) ◽

pp. 4947-4950 ◽

Cited By ~ 101

Author(s):

L. Xie ◽

G. B. DeMaggio ◽

W. E. Frieze ◽

J. DeVries ◽

D. W. Gidley ◽

...

Keyword(s):

Thin Films ◽

Polymer Surfaces ◽

Positronium Formation

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Effect of Etchant Concentration on the Optical Properties and Surface Topography of MoO3 Selective Solar Absorber Thin Films - CORRIGENDUM

MRS Advances ◽

10.1557/adv.2020.278 ◽

2020 ◽

Vol 5 (43) ◽

pp. 2249-2249

Author(s):

R. Akoba ◽

G. G. Welegergs ◽

M. Luleka ◽

J Sackey ◽

N Nauman ◽

...

Keyword(s):

Thin Films ◽

Optical Properties ◽

Surface Topography ◽

Solar Absorber

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The Extracellular Matrix: An Accomplice in Gastric Cancer Development and Progression

Cells ◽

10.3390/cells9020394 ◽

2020 ◽

Vol 9 (2) ◽

pp. 394 ◽

Cited By ~ 3

Author(s):

Ana Margarida Moreira ◽

Joana Pereira ◽

Soraia Melo ◽

Maria Sofia Fernandes ◽

Patrícia Carneiro ◽

...

Keyword(s):

Gastric Cancer ◽

Extracellular Matrix ◽

Expression Patterns ◽

Predictive Biomarkers ◽

Gastric Epithelium ◽

Comprehensive Overview ◽

Diagnostic Biomarkers ◽

Malignant Lesions ◽

And Behavior ◽

Disease Stages

The extracellular matrix (ECM) is a dynamic and highly organized tissue structure, providing support and maintaining normal epithelial architecture. In the last decade, increasing evidence has emerged demonstrating that alterations in ECM composition and assembly strongly affect cellular function and behavior. Even though the detailed mechanisms underlying cell-ECM crosstalk are yet to unravel, it is well established that ECM deregulation accompanies the development of many pathological conditions, such as gastric cancer. Notably, gastric cancer remains a worldwide concern, representing the third most frequent cause of cancer-associated deaths. Despite increased surveillance protocols, patients are usually diagnosed at advanced disease stages, urging the identification of novel diagnostic biomarkers and efficient therapeutic strategies. In this review, we provide a comprehensive overview regarding expression patterns of ECM components and cognate receptors described in normal gastric epithelium, pre-malignant lesions, and gastric carcinomas. Important insights are also discussed for the use of ECM-associated molecules as predictive biomarkers of the disease or as potential targets in gastric cancer.

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