scholarly journals Aquatic Competencies and Drowning Prevention in Children 2–4 Years: A Systematic Review

Safety ◽  
2020 ◽  
Vol 6 (2) ◽  
pp. 31 ◽  
Author(s):  
Danielle H. Taylor ◽  
Richard C. Franklin ◽  
Amy E. Peden
Keyword(s):  
English Language ◽  
Injury Severity ◽  
Age Groups ◽  
Skills Acquisition ◽  
Drowning Prevention ◽  
Age Related ◽  
Developmental Readiness ◽  
Increase Risk ◽  
Age Appropriate ◽  
The Relationship

Aquatic competencies have been proposed as a prevention strategy for children aged 2–4 years who are over-represented in drowning statistics. For this recommendation to be made, exploration of the connection between aquatic competencies and drowning is required. This review critically analyzed studies exploring aquatic competencies and their effect on drowning and/or injury severity in children 2–4 years. English language peer-reviewed literature up to 31 July 2019 was searched and the PRISMA process utilized. Data were extracted from twelve studies that fulfilled the inclusion criteria. Findings from this study included that aquatic competencies were not found to increase risk of drowning and demonstrated children aged 2–4 years are capable of developing age-appropriate aquatic competencies. Age-appropriate aquatic competencies extracted were propulsion/locomotion, flotation/buoyancy, water familiarization, submersion and water exits. The acquisition of these competencies holds benefit for the prevention of drowning. No evidence was found relating to injury severity. There was limited exploration of the relationship between aquatic competencies attainment and age-related developmental readiness. The review highlights the need for consistent measures of exposure, clarity around skills acquisition, better age-specific data (2 years vs. 3 years vs. 4 years), studies with larger sample sizes, further exploration of the dose–response relationship and consistent skill level testing across age groups. Further investigation is required to establish the efficacy of aquatic competencies as a drowning prevention intervention, as well as exploring the relationship between aquatic competencies and age-related developmental readiness. In conclusion, early evidence suggests aquatic competencies can help to reduce drowning.

scholarly journals Young Children's Exposure to and Ability to Eat Different Food Textures, as Reported by Parents (P11-119-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Sarah Smith-Simpson ◽  
Lisa Fries ◽  
Carolyn Ross
Keyword(s):  
Online Survey ◽  
Age Groups ◽  
Age Group ◽  
Older Children ◽  
Research Issues ◽  
Funding Sources ◽  
Food Texture ◽  
Age Related ◽  
Group Data ◽  
Age Appropriate

Abstract Objectives The objective was to identify the age at which parents expose their children to different food textures and how challenging the textures were for their child to eat. It was hypothesized that older children would be exposed to a wider variety of food textures and that parents would consider a larger proportion of these textures to be easy to eat. Methods Parents (n = 365) in Grand Rapids, MI, USA with a child aged 6–36 months completed an online survey. The survey had 37 questions, including 15 unique food texture categories with food examples (Table 1). Parents were asked how difficult each texture category was for their child to eat using a 5-point scale ranging from “Very Easy” to “Very Difficult”, plus an option for “My child hasn't tried this yet”. Children were divided into 5 age groups (6-8 months, 9–12 months, 13–18 months, 19–24 months, 25–36 months) for analysis. Across texture category and age group, data were analyzed using analysis of variance, with mean separation accomplished using Fisher's LSD (P < 0.05). Results A majority of children in the youngest age group (6-8 months) had only eaten foods described as creamy, dissolvable, or pureed. All of the texture categories had been served to a majority of 9–12 month-old children, except for “hard” and “tough meat”. By 18 months of age, a majority of children had tried all food texture categories except “hard”. Across all age groups, creamy, dissolvable, and puree were rated as easy and “tough meat” was rated as difficult. The other textures showed age-related differences, with parents of older children reporting the textures as easier to eat than those of younger children. Food textures were compared within the 9–12 and 13–18 month age groups, when most new food textures are introduced, and similar trends were observed. The easiest textures were creamy, dissolvable, puree and soft, followed by lumpy and juicy, then slippery, chewy, rubbery, and sticky. The most difficult textures were leafy, with skin, hard, tough meat and combination of textures. Conclusions When considering textures of the foods that comprise a well-balanced, healthy diet, many foods are difficult for children to eat. Preparing foods such as green vegetables specifically to have age-appropriate textures could improve consumption. Funding Sources Washington State Univ College of Agricultural, Human and Natural Resource Emerging Research Issues Grant.

scholarly journals ASSESSING THE RELATIONSHIP BETWEEN SERUM IGF-1 AND ADIPOSITY BY AGE IN THE LONG LIFE FAMILY STUDY

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S257-S257
Author(s):  
Rehab A Sherlala ◽  
Candace M Kammerer ◽  
Allison L Kuipers ◽  
Mary K Wojczynski ◽  
Svetlana Ukraintseva ◽  
...  
Keyword(s):  
Family Study ◽  
Age Groups ◽  
Serum Levels ◽  
Total Sample ◽  
Age Cohorts ◽  
Age Related ◽  
Long Life ◽  
Using Data ◽  
Underlying Mechanisms ◽  
The Relationship

Abstract Serum levels of insulin-like growth factor 1 (IGF-1) and measures of adiposity, such as body mass index (BMI), are associated with susceptibility to age-related diseases. Previous reports of the relationship between IGF-1 and BMI ranged from positive to negative to no relationship, perhaps because previous reports studied different age cohorts. Using data on 4270 participants (aged 24-110 years) from the Long Life Family Study, we investigated the relationship between IGF-1 and BMI overall and by age groups. IGF-1 and BMI were positively correlated in the total sample (β=0.161, r2= 0.0038, p=1.8-05). However, further analyses revealed that the relationship between IGF-1 and BMI varied by age quartile: in the 1st quartile (24-58yo) the relationship was negative (β=−0.204, r2= 0.011, p=0.0008); in the 2nd quartile (59-66yo) the relationship was negative but non-significant (β=−0.069, r2= 0.0012, p=0.28); in the 3rd quartile (67-86yo) the relationship was positive but non-significant (β=0.106, r2= 0.002, p=0.13); and in the 4th quartile (87-110yo) the relationship was positive (β=0.388, r2= 0.019, p=1.2−05). This pattern did not differ by sex. We also detected a similar age-related pattern between IGF-1 and BMI using an independent dataset (NHANES III), comprising 2550 men and women aged 20-90 years. Our results may clarify some of the inconsistency in previous literature about the relationship between IGF-1 and BMI. Additional studies of IGF-1 and adiposity measures are needed to better understand the underlying mechanisms involved.

scholarly journals Relationship Between Serum IGF-1 and BMI Differs by Age

2020 ◽  
Author(s):  
Rehab A Sherlala ◽  
Candace M Kammerer ◽  
Allison L Kuipers ◽  
Mary K Wojczynski ◽  
Svetlana V Ukraintseva ◽  
...  
Keyword(s):  
Family Study ◽  
Age Groups ◽  
Serum Levels ◽  
The Third ◽  
Age Related ◽  
Long Life ◽  
Using Data ◽  
The Relationship ◽  
Nutritional Examination Survey ◽  
Related Pattern

Abstract Background Serum levels of insulin-like growth factor 1 (IGF-1) and body mass index (BMI) are both associated with susceptibility to age-related diseases. Reports on the correlation between them have been conflicting, with both positive to negative correlations reported. However, the age ranges of the participants varied widely among these studies. Methods Using data on 4241 participants (aged 24–110) from the Long Life Family Study, we investigated the relationship between IGF-1 and BMI by age groups using regression analysis. Results When stratified by age quartile, the relationship between IGF-1 and BMI varied: in the first quartile (Q1, 20–58 years) the relationship was negative (β = −0.2, p = .002); in Q2 (58–66 years) and Q3 (67–86 years) the relationship was negative (β = −0.07, β = −0.01, respectively) but nonsignificant; and in Q4 (87–110 years) the relationship was positive (β = 0.31, p = .0002). This pattern did not differ by sex. We observed a similar age-related pattern between IGF-1 and BMI among participants in the third National Health and Nutritional Examination Survey. Conclusions Our results that the relationship between IGF-1 and BMI differs by age may explain some of the inconsistency in reports about their relationship and encourage additional studies to understand the mechanisms underlying it.

scholarly journals Age-Related Changes in the 25-Hydroxyvitamin D Versus Parathyroid Hormone Relationship Suggest a Different Reason Why Older Adults Require More Vitamin D

2003 ◽  
Vol 88 (1) ◽  
pp. 185-191 ◽  
Author(s):  
Reinhold Vieth ◽  
Yasmin Ladak ◽  
Paul G. Walfish
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Secondary Hyperparathyroidism ◽  
Age Groups ◽  
The Elderly ◽  
Age Group ◽  
Hydroxyvitamin D ◽  
Age Related ◽  
25 Hydroxyvitamin D ◽  
The Relationship

Vitamin D requirements are thought to vary with age, but there is little comparative evidence for this. One goal in establishing a vitamin D requirement is to avoid secondary hyperparathyroidism. We studied 1741 euthyroid, thyroid clinic outpatients without evidence of calcium abnormalities, ranging in age from 19 to 97 yr, whose serum and urine had been analyzed for calcium, vitamin D, and parathyroid status. We found no effect of age on the 25-hydroxyvitamin D [25(OH)D] concentration associated with specific vitamin D intakes, and there was no relationship between 25(OH)D and 1,25hydroxyvitamin D [1,25(OH)2D]. In every age group, serum 1,25(OH)2D declined with increasing creatinine (P &lt; 0.001). What changed with age included creatinine, which correlated with 25(OH)D (r = 0.146, P &lt; 0.001) only in the youngest age group (19–50 yr) but not in the older age groups (P &gt; 0.1). Creatinine did not correlate with PTH in the youngest age group, but the relationship became significant as age increased (e.g. for the elderly, r = 0.365, P &lt; 0.001). Linear regression of log PTH vs. log 25(OH)D agreed with the natural shape of the relationship observed with scatterplot smoothing, and this showed no plateau in PTH as 25(OH)D increased. We compared PTH concentrations among age groups, based on 20 nmol/liter increments in 25(OH)D. Mean PTH in adults older than 70 yr was consistently higher than in adults younger than 50 yr (P &lt; 0.05 by ANOVA and Dunnett’s t test). PTH levels of the elderly who had 25(OH)D concentrations greater than 100 nmol/liter matched PTH of younger adults having 25(OH)D concentrations near 70 nmol/liter. This study shows that all age groups exhibit a high prevalence of 25(OH)D insufficiency and secondary hyperparathyroidism. Older adults are just as efficient in maintaining 25(OH)D, but they need more vitamin D to produce the higher 25(OH)D concentrations required to overcome the hyperparathyroidism associated with their diminishing renal function.

scholarly journals The relationship between asthma and suicidal behaviours: a systematic literature review

2015 ◽  
Vol 46 (1) ◽  
pp. 96-106 ◽  
Author(s):  
Emma Barker ◽  
Kairi Kõlves ◽  
Diego De Leo
Keyword(s):  
Literature Review ◽  
Systematic Literature Review ◽  
English Language ◽  
Age Groups ◽  
Suicide Mortality ◽  
Original Research ◽  
Time Period ◽  
The Usa ◽  
Potential Link ◽  
The Relationship

Asthma is a highly prevalent chronic condition worldwide, and is particularly common in younger people compared to other chronic conditions. Asthma can result in a number of symptoms that are detrimental to the quality of life of sufferers. The aim of the present systematic literature review was to analyse the existing literature on the relationship between asthma and fatal and nonfatal suicidal behaviours.Articles were retrieved from Scopus, PubMed, ProQuest and Web of Knowledge. We searched for the terms (suicid* OR self-harm) AND (asthma* OR “bronchial hyperreactivity”) published in English-language peer-reviewed journals between 1990 and December 2014. Original research papers providing empirical evidence about the potential link between asthma and suicidal behaviours were included.The initial search identified 746 articles. Specific limiting criteria reduced the number of articles to the 19 articles that were finally included in the systematic review.The review found a potential link between asthma and suicide mortality, ideation and attempts across the age groups. Limitations of the review include the restriction to English-language papers published within the chosen time period, the limited number of papers involving suicide mortality, and the fact that the majority of papers originated from the USA.

Relationship between vasopressin and renal concentrating ability in aging rats

1992 ◽  
Vol 262 (5) ◽  
pp. R826-R833 ◽  
Author(s):  
G. Geelen ◽  
B. Corman
Keyword(s):  
Plasma Concentration ◽  
Urinary Excretion ◽  
Arginine Vasopressin ◽  
Age Groups ◽  
Urine Osmolality ◽  
Similar Increase ◽  
Aging Rats ◽  
Inappropriate Secretion ◽  
Age Related ◽  
The Relationship

The relationship between arginine vasopressin (AVP) secretion and the age-related change in renal concentrating ability was studied in 10-, 20-, and 30-mo-old conscious rats. In control condition, urine osmolality (Uosmol) was 2,358 +/- 99, 1,919 +/- 87, and 1,135 +/- 173 mosmol/kgH2O (mean +/- SE) and the corresponding plasma AVP concentration 3.1 +/- 1.2, 2.8 +/- 0.7, and 3.3 +/- 0.7 pg/ml at 10, 20, and 30 mo. Urinary AVP excretion and AVP content in the hypothalamus were comparable in the 3 age groups, while the basal AVP pituitary content was significantly higher at 10 than at 20 or 30 mo. Three days of dehydration induced 1) a similar increase in plasma concentration and urinary excretion of AVP in the 3 groups, even though the maximal Uosmol reached by the oldest animals was significantly reduced (3,988 +/- 218, 3,652 +/- 273, and 2,826 +/- 197 mosmol/kgH2O at 10, 20, and 30 mo, respectively) and 2) a similar AVP depletion of the pituitary at 10, 20, and 30 mo and an increase of the AVP content in the hypothalamus at 10 mo but not at 20 and 30 mo. These results suggest that the decrease in renal concentrating ability reported in aging rats is not due to an inappropriate secretion of AVP along the hypothalamo-neurohypophysial axis but is rather related to an impaired responsiveness of the kidney to the antidiuretic hormone.

scholarly journals Age-Related Changes in Neural Networks Supporting Complex Visual and Social Processing in Adolescence

2019 ◽  
Author(s):  
Yulia Lerner ◽  
K. Suzanne Scherf ◽  
Mikhail Katkov ◽  
Uri Hasson ◽  
Marlene Behrmann
Keyword(s):  
Neural Development ◽  
Age Groups ◽  
Critical Question ◽  
Fine Grained ◽  
Age Related ◽  
Brain Responses ◽  
Adolescent Groups ◽  
Age Appropriate ◽  
Almost All ◽  
The Brain

AbstractDespite our differences, there is much about the natural visual world that almost all observers apparently perceive in common. This coherence across observers is evidenced by the finding that, across adults, approximately 30% of the brain is activated in a consistent fashion in response to viewing naturalistic input. The critical question addressed here is how does this consistency emerge and is this pattern of coherence apparent from early in development or does it evolve with time and/or experience? We focused our investigation at a key developmental juncture that might bridge the child and adult patterns, namely, the period of adolescence. We acquired fMRI BOLD data evoked by an 11-minute age-appropriate movie in younger (age 9-14 years) and older adolescents (age 15-19 years) and in adults. Using an intra-subject correlation approach, we characterized the consistency of the neural response within-individual (across two separate runs of the movie), and then, using an inter-subject correlation approach, evaluated the similarity of the response profile within individuals of the same age group and between age-groups. In primary sensory areas (A1+, V1) the response profiles in both groups of adolescents were highly similar to those of the adults, suggesting that these areas are functionally mature at earlier stages of the development. In contrast, some other regions exhibited higher within-age correlations in the adolescent groups than in the adult group. Last, we evaluated the brain responses across the whole cortex and identified the different patterns of maturation as reflected in different inter-subject correlations across the age groups. Together, these findings provide a fine-grained characterization of functional neural development. The approach offers the potential for careful tracking of the development of widespread cortical networks that support the emerging stereotypical responses to naturalistic visual and social stimuli and has important implications for future studies of cortical development.

scholarly journals Anticoagulant Effects of Dabigatran in Paediatric Patients Compared with Adults: Combined Data from Three Paediatric Clinical Trials

2018 ◽  
Vol 118 (09) ◽  
pp. 1625-1636 ◽  
Author(s):  
Hugo Maas ◽  
Savion Gropper ◽  
Fenglei Huang ◽  
Joachim Stangier ◽  
Igor Tartakovsky ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Dabigatran Etexilate ◽  
Age Groups ◽  
Graphical Analysis ◽  
Physiological Age ◽  
Thrombin Time ◽  
Clotting Time ◽  
Age Related ◽  
Coagulation Assay ◽  
The Relationship

Background Physiological age-related changes in the haemostatic and coagulation systems result in differing anticoagulant assay responses to standard anticoagulants. Therefore, we investigated the response of anticoagulant assays to dabigatran etexilate (DE) in children compared with adults. Objective This article assesses the relationship between plasma dabigatran concentration and coagulation assay results across age groups in children and adults. Patients and Methods Data from three clinical trials in which children received DE following standard of care for venous thromboembolism were compared with data from adult clinical trials. The effects of dabigatran concentration on diluted thrombin time (dTT), ecarin clotting time (ECT) and activated partial thromboplastin time (aPTT) were analysed graphically and with modelling. Results The concentration–dTT relationships were consistent in children across all ages and adults in the graphical analysis. For ECT and aPTT, relationships based on ratios over baseline were similar across all ages; absolute clotting times showed that the same exposure resulted in longer clotting times in some of the children aged < 1 year versus adults. Modelling showed concentration–clotting time relationships for all three assays were largely comparable between adults and children, except in those aged < 2 months, in whom there was a slight upward shift in ECT and aPTT relative to adults. Conclusion Results suggest that developmental haemostatic changes will have little impact on response to DE. However, further paediatric clinical trials assessing the relationship between coagulation assay responses and clinical outcomes will be needed to confirm this finding.

scholarly journals WHO essential medicines for children 2011–2019: age-appropriateness of enteral formulations

2021 ◽  
pp. archdischild-2021-321831
Author(s):  
Ebiowei Samuel F Orubu ◽  
Jennifer Duncan ◽  
Catherine Tuleu ◽  
Mark A Turner ◽  
Anthony Nunn
Keyword(s):  
Age Groups ◽  
Essential Medicine ◽  
Access To Medicines ◽  
Essential Medicines ◽  
Older Children ◽  
Efficacy Evaluation ◽  
7Th Edition ◽  
Age Related ◽  
Age Appropriate ◽  
Medicines For Children

IntroductionThe WHO Essential Medicine List for children (EMLc) is used for promoting access to medicines. The age-appropriateness of enteral (oral and rectal) formulations for children depend on their adaptability/flexibility to allow age-related or weight-related doses to be administered/prescribed and the child’s ability to swallow, as appropriate. There is scant information on the age-appropriateness of essential enteral medicines for children.ObjectiveTo evaluate the age-appropriateness of enteral essential medicines.Materials and methodsAge-appropriateness of all enteral formulations indicated and recommended in the EMLc 3rd to 7th (2011–2019) editions were determined by assessing swallowability and/or dose adaptability for children under 12 years, stratified into five age groups.ResultsEnteral formulations in the EMLc were more age-appropriate for older children aged 6–11 years than for younger children. In the 3rd edition, for older children, 77%, n=342, of formulations were age-appropriate. For younger children, age-appropriateness decreased with age group: 34% in those aged 3–5 years, 30% in those aged 1–2 years, 22% among those aged 28 days to 11 months and 15% in those aged 0–27 days. Overall, similar proportions were found for the 7th edition. In contrast, the majority of medicines in the 7th list were age-appropriate in targeted diseases like HIV and tuberculosis.ConclusionMost recommended enteral essential medicines in EMLc 2011 and 2019 were not age-appropriate for children <6 years. Medicines which are not age-appropriate must be manipulated before administration, leading to potential issues of safety and efficacy. Evaluation of the age-appropriateness of formulations for medicines to be included in EMLc could improve access to better medicines for children in the future.

scholarly journals Study of Cataract in Relation to Axial Length and Refractivity of the Eye

1970 ◽  
Vol 12 (3) ◽  
pp. 130-134
Author(s):  
Surabhi Sharma ◽  
Satyaswarup Tripathy ◽  
Syed Ali Raza Rizvi
Keyword(s):  
Refractive Error ◽  
Axial Length ◽  
Age Groups ◽  
Nuclear Cataract ◽  
Spherical Equivalent ◽  
Posterior Subcapsular Cataract ◽  
Age Related ◽  
Different Types ◽  
The Relationship ◽  
Axial Myopia

Aim: To ascertain the association between different types and densities of age-related cataract with axial length and refractive state of the eye.Methods: This prospective observational institute-based study enrolled 462 eyes of 450 patients aged 40 years or older. Eyes were classified as myopic (axial length, >25 mm), emmetropic (axial length, 21-25 mm), and hypermetropic (axial length, <21 mm). Refractive error was defined as myopia (spherical equivalent, <-0.5 D) and hypermetropia (spherical equivalent, >+0.5 D). Cataract was categorised as nuclear, cortical, or posterior subcapsular. Nuclear density was measured based on the Emery and Little Classification after slit-lamp biomicroscopy. Student t test for unpaired samples and Fisher and Yates tables were used to analyse statistical significance.Results: Emmetropia was the most common condition (417 eyes). The most common cataract combination was nuclear with posterior subcapsular (n = 198; 44%). In the axial myopia group, nuclear cataract was thecommonest type, alone or in combination with other types (n = 33; 100%). Most eyes had refractive error of 0 to -5 D. The grade of nuclear cataract increased with increasing age (n = 48 for grade IV nuclear cataract in the 70 to 79 years age group). In all age groups, a higher grade of nuclear sclerosis was significantly associated with axial length (t = 2.2; p < 0.05). The relationship was also significant for posterior subcapsular cataract (t = 2.7; p < 0.05).Conclusions: Nuclear cataract leads to a myopic shift in refraction. In otherwise healthy eyes, there is a gradual hypermetropic shift. The prevalence and grade of nuclear cataract increases with age. Longer axial length is associated with a higher grade of nuclear and posterior subcapsular cataract.

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