scholarly journals Relationship Between Serum IGF-1 and BMI Differs by Age

2020 ◽  
Author(s):  
Rehab A Sherlala ◽  
Candace M Kammerer ◽  
Allison L Kuipers ◽  
Mary K Wojczynski ◽  
Svetlana V Ukraintseva ◽  
...  
Keyword(s):  
Family Study ◽  
Age Groups ◽  
Serum Levels ◽  
The Third ◽  
Age Related ◽  
Long Life ◽  
Using Data ◽  
The Relationship ◽  
Nutritional Examination Survey ◽  
Related Pattern

Abstract Background Serum levels of insulin-like growth factor 1 (IGF-1) and body mass index (BMI) are both associated with susceptibility to age-related diseases. Reports on the correlation between them have been conflicting, with both positive to negative correlations reported. However, the age ranges of the participants varied widely among these studies. Methods Using data on 4241 participants (aged 24–110) from the Long Life Family Study, we investigated the relationship between IGF-1 and BMI by age groups using regression analysis. Results When stratified by age quartile, the relationship between IGF-1 and BMI varied: in the first quartile (Q1, 20–58 years) the relationship was negative (β = −0.2, p = .002); in Q2 (58–66 years) and Q3 (67–86 years) the relationship was negative (β = −0.07, β = −0.01, respectively) but nonsignificant; and in Q4 (87–110 years) the relationship was positive (β = 0.31, p = .0002). This pattern did not differ by sex. We observed a similar age-related pattern between IGF-1 and BMI among participants in the third National Health and Nutritional Examination Survey. Conclusions Our results that the relationship between IGF-1 and BMI differs by age may explain some of the inconsistency in reports about their relationship and encourage additional studies to understand the mechanisms underlying it.

scholarly journals Assessing the Relationship between Serum IGF-1 and BMI by Age in the Long Life Family Study

2020 ◽  
Author(s):  
Rehab A. Sherlala ◽  
Candace M. Kammerer ◽  
Allison L. Kuipers ◽  
Mary K. Wojczynski ◽  
Svetlana V. Ukraintseva ◽  
...  
Keyword(s):  
Family Study ◽  
Age Groups ◽  
Serum Levels ◽  
The Third ◽  
Age Related ◽  
Long Life ◽  
Using Data ◽  
The Relationship ◽  
Nutritional Examination Survey ◽  
Related Pattern

AbstractBackgroundSerum levels of insulin-like growth factor 1 (IGF-1) and body mass index (BMI) are both associated with susceptibility to age-related diseases. Reports on the correlation between them have been conflicting, with both positive to negative correlations reported. However, the age ranges of the participants varied widely among these studies.MethodsUsing data on 4,241 participants (aged 24–110) from the Long Life Family Study, we investigated the relationship between IGF-1 and BMI by age groups using regression analysis.ResultsWhen stratified by age quartile, the correlation between IGF-1 and BMI varied: in the 1st quartile (Q1, 24 y–58 y) the correlation was negative (r = −0.1, P = 0.0008); in Q2 (59 y– 66 y) it was negative (r = −0.035) but non-significant; in Q3 (67 y–86 y) it was positive (r = 0.045) but non-significant; and in Q4 (87 y–110 y) the correlation was positive (r = 0.14, P < 0.0001). This pattern did not differ by sex. We observed a similar age-related pattern between IGF-1 and BMI among participants in the third National Health and Nutritional Examination Survey.ConclusionsOur results, that the relationship between IGF-1 and BMI differs by age, may explain some of the inconsistency in reports about their relationship and encourage additional studies to understand the mechanisms underlying it.

scholarly journals ASSESSING THE RELATIONSHIP BETWEEN SERUM IGF-1 AND ADIPOSITY BY AGE IN THE LONG LIFE FAMILY STUDY

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S257-S257
Author(s):  
Rehab A Sherlala ◽  
Candace M Kammerer ◽  
Allison L Kuipers ◽  
Mary K Wojczynski ◽  
Svetlana Ukraintseva ◽  
...  
Keyword(s):  
Family Study ◽  
Age Groups ◽  
Serum Levels ◽  
Total Sample ◽  
Age Cohorts ◽  
Age Related ◽  
Long Life ◽  
Using Data ◽  
Underlying Mechanisms ◽  
The Relationship

Abstract Serum levels of insulin-like growth factor 1 (IGF-1) and measures of adiposity, such as body mass index (BMI), are associated with susceptibility to age-related diseases. Previous reports of the relationship between IGF-1 and BMI ranged from positive to negative to no relationship, perhaps because previous reports studied different age cohorts. Using data on 4270 participants (aged 24-110 years) from the Long Life Family Study, we investigated the relationship between IGF-1 and BMI overall and by age groups. IGF-1 and BMI were positively correlated in the total sample (β=0.161, r2= 0.0038, p=1.8-05). However, further analyses revealed that the relationship between IGF-1 and BMI varied by age quartile: in the 1st quartile (24-58yo) the relationship was negative (β=−0.204, r2= 0.011, p=0.0008); in the 2nd quartile (59-66yo) the relationship was negative but non-significant (β=−0.069, r2= 0.0012, p=0.28); in the 3rd quartile (67-86yo) the relationship was positive but non-significant (β=0.106, r2= 0.002, p=0.13); and in the 4th quartile (87-110yo) the relationship was positive (β=0.388, r2= 0.019, p=1.2−05). This pattern did not differ by sex. We also detected a similar age-related pattern between IGF-1 and BMI using an independent dataset (NHANES III), comprising 2550 men and women aged 20-90 years. Our results may clarify some of the inconsistency in previous literature about the relationship between IGF-1 and BMI. Additional studies of IGF-1 and adiposity measures are needed to better understand the underlying mechanisms involved.

scholarly journals Five reasons COVID-19 is less severe in younger age groups

2020 ◽  
Author(s):  
Paul W Turke
Keyword(s):  
Life History ◽  
Life History Theory ◽  
Age Of Onset ◽  
Age Groups ◽  
Medical Community ◽  
System Function ◽  
The Third ◽  
Immune System Function ◽  
Age Related ◽  
Younger Age

Abstract The severity of COVID-19 is age-related, with the advantage going to younger age groups. Five reasons are presented. The first two are well-known, are being actively researched by the broader medical community, and therefore are discussed only briefly here. The third, fourth, and fifth reasons derive from evolutionary life history theory, and potentially fill gaps in current understanding of why and how young and old age groups respond differently to infection with SARS-CoV-2. Age of onset of generalized somatic aging, and the timing of its progression, are identified as important causes of these disparities, as are specific antagonistic pleiotropic tradeoffs in immune system function.

scholarly journals Airline Financial Distress and Customer Satisfaction

2011 ◽  
Vol 48 (1) ◽  
Author(s):  
Dina Ribbink ◽  
Christian Hofer ◽  
Martin Dresner
Keyword(s):  
Customer Service ◽  
Airline Industry ◽  
Financial Distress ◽  
Service Levels ◽  
The Third ◽  
Time Performance ◽  
Using Data ◽  
Relationship Of ◽  
The Impact ◽  
The Relationship

An investigation is conducted on the effect of financial distress on customer service levels in the U.S. airline industry. Using data from the first quarter of 1998 to the third quarter of 2006, we employ a seemingly unrelated regressions (SUR) model to analyze the impact of financial distress on three measures of customer service. We find that higher financial distress is associated with better on-time performance of airlines and fewer lost bags. The relationship of airline financial distress to the number of bumped customers, however, is insignificant.

scholarly journals Evaluation of the Relationship between the Level of DHEA-S and Sex Hormones in Some Infertile Iraqi Men

2021 ◽  
Vol 8 (5) ◽  
pp. 130-136
Author(s):  
Khaled S. Abd ◽  
Adnan F. AL-Azzawie
Keyword(s):  
Sex Hormones ◽  
Seminal Fluid ◽  
Age Groups ◽  
Serum Levels ◽  
Dehydroepiandrosterone Sulfate ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Infertile Men ◽  
The Relationship

This study aims to evaluate serum levels of the Dehydroepiandrosterone sulfate (DHEA-S) and its relationship with some sex hormones such as Follicle stimulating hormone (FSH), Luteinizing hormone (LH), prolactin and testosterone hormone and the infertility type in some infertile Iraqi men. Blood and seminal fluid samples from (60) idiopathic male infertile and (60) healthful individuals as a control group aged (18 to 60 year) were collected from private clinics. Serum hormones (DHEA-S, FSH, LH, prolactin and testosterone) were measurement using Enzyme Linked Immunosorbent Assay (ELISA). The levels of DHEA-S, FSH, LH and prolactin are significantly higher (P≤0.01) expect of the testosterone level was significantly decreased (P≤ 0.01) in the infertile men as compared with control group. High significant differences (P≤0.01) were recorded when comparing the hormonal levels (DHEA-S, FSH, LH, prolactin and testosterone) according to the age groups. There are significant differences (P≤ 0.01) in levels of (DHEA-S, FSH, LH, prolactin and testosterone) in the infertility period.  Smoker infertile men have high levels (P≤ 0.05) in the DHEA-S and LH while have low levels in the prolactin hormones compared with control. Patients with family history have shown significant differences (P≤0.05) in the levels of DHEA-S, FSH, LH and prolactin. In conclusion, this study revealed significantly increase in the DHEA-S levels in the infertile men and negative correlation between DHEA-S and FSH. Therefore, DHEA-S has important role in the diagnosis and follow up of the male infertility.

scholarly journals O32 Ontogeny of human kidney OCT2 expression across the paediatric age range

2019 ◽  
Vol 104 (6) ◽  
pp. e14.2-e14
Author(s):  
N Smeets ◽  
B van Groen ◽  
J Pertijs ◽  
M Wilmer ◽  
B Smeets ◽  
...  
Keyword(s):  
Organic Cation ◽  
Basolateral Membrane ◽  
Age Groups ◽  
Kidney Tissue ◽  
Human Kidney ◽  
Organic Cation Transporter ◽  
Age Related ◽  
Paediatric Age ◽  
Organic Cation Transporter 2 ◽  
Related Pattern

BackgroundIn adults, the organic cation transporter 2 (protein name OCT2, gene name SLC22A2) is localised in the kidney proximal tubules where it mediates organic cation secretion. Hence, the transporter plays a role in the disposition and excretion of several drugs and drug-drug interactions. To better understand the disposition of OCT2 substrate drugs in children, we studied OCT2 localisation and expression in paediatric kidney tissue.MethodsThe expression of OCT2 was visualised in tissue using immunohistochemical staining. Tissues were derived post-mortem from children aged 0 -14 years. Gestational age varied between 24 and 40 weeks. Intensity of the staining at the basolateral membrane was scored by two individual observers using three categories; negative, detectible and high. Agreement between two observers was determined using Cohen’s kappa.Results44 kidney samples (n=17 neonates, n=17 infants, n=7 children, n=3 adolescent) were analysed and scored. There was substantial agreement between two judgements with a kappa of 0.773 (p< 0.005). No age related pattern was observed in the expression of OCT2. Even in the youngest age group, the expression of OCT2 was clearly visible.ConclusionThe kidney expression of OCT2 did not show an age-related pattern. In all age groups, expression levels were similar and OCT2 was properly localised at the basolateral membrane. These findings suggest that, with increasing age, OCT2 will not influence the renal excretion of its substrates.Disclosure(s)Nothing to disclose

scholarly journals Age-Related Changes in the 25-Hydroxyvitamin D Versus Parathyroid Hormone Relationship Suggest a Different Reason Why Older Adults Require More Vitamin D

2003 ◽  
Vol 88 (1) ◽  
pp. 185-191 ◽  
Author(s):  
Reinhold Vieth ◽  
Yasmin Ladak ◽  
Paul G. Walfish
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Secondary Hyperparathyroidism ◽  
Age Groups ◽  
The Elderly ◽  
Age Group ◽  
Hydroxyvitamin D ◽  
Age Related ◽  
25 Hydroxyvitamin D ◽  
The Relationship

Vitamin D requirements are thought to vary with age, but there is little comparative evidence for this. One goal in establishing a vitamin D requirement is to avoid secondary hyperparathyroidism. We studied 1741 euthyroid, thyroid clinic outpatients without evidence of calcium abnormalities, ranging in age from 19 to 97 yr, whose serum and urine had been analyzed for calcium, vitamin D, and parathyroid status. We found no effect of age on the 25-hydroxyvitamin D [25(OH)D] concentration associated with specific vitamin D intakes, and there was no relationship between 25(OH)D and 1,25hydroxyvitamin D [1,25(OH)2D]. In every age group, serum 1,25(OH)2D declined with increasing creatinine (P &lt; 0.001). What changed with age included creatinine, which correlated with 25(OH)D (r = 0.146, P &lt; 0.001) only in the youngest age group (19–50 yr) but not in the older age groups (P &gt; 0.1). Creatinine did not correlate with PTH in the youngest age group, but the relationship became significant as age increased (e.g. for the elderly, r = 0.365, P &lt; 0.001). Linear regression of log PTH vs. log 25(OH)D agreed with the natural shape of the relationship observed with scatterplot smoothing, and this showed no plateau in PTH as 25(OH)D increased. We compared PTH concentrations among age groups, based on 20 nmol/liter increments in 25(OH)D. Mean PTH in adults older than 70 yr was consistently higher than in adults younger than 50 yr (P &lt; 0.05 by ANOVA and Dunnett’s t test). PTH levels of the elderly who had 25(OH)D concentrations greater than 100 nmol/liter matched PTH of younger adults having 25(OH)D concentrations near 70 nmol/liter. This study shows that all age groups exhibit a high prevalence of 25(OH)D insufficiency and secondary hyperparathyroidism. Older adults are just as efficient in maintaining 25(OH)D, but they need more vitamin D to produce the higher 25(OH)D concentrations required to overcome the hyperparathyroidism associated with their diminishing renal function.

Age-related topography of renal vascular-ization of the goats of anglo-nubian breed

2020 ◽  
Vol 1 ◽  
pp. 100-104
Author(s):  
K.O. Maslenitcyn ◽  
◽  
M.V. Shchipakin ◽  
Keyword(s):  
Left Kidney ◽  
Age Groups ◽  
Renal Arteries ◽  
Goat Breed ◽  
The Third ◽  
Age Related ◽  
One Year ◽  
The Right ◽  
Renal Vascular ◽  
Newborn Animals

The basis for the study was cadaver material from animals obtained during slaughter from the "Gzhelskoe Podvorye", Moscow region. Four age groups were formed. The first group included newborn animals. The sec-ond group included animals of one month. The third group included young animals of five or six months. The fourth group consist-ed of goats, starting from one year old. The age of the animals was determined according to the data obtained from monitor cards. A total of twenty heads were examined. Based on our research, primarily we established that the change in the topography of the right and left kidney in Anglo-Nubian goats exists mainly because of the displacement of the caudal end of the kidney cranially at a dis-tance equal to the length of one or two verte-brae. In both kidneys, the anterior or cranial end does not have a pronounced displace-ment. Studying kidney syntopia in goats, we found confirmation that the caudal hollow vein together with the abdominal aorta lie dorsally from the kidneys, while the rumen sac is located laterocranially from the left kidney, when it overflows, a slight change in the topography of the kidney can be visual-ized, and parts of the duodenum are located laterocranially. The data we have established confirm the similarity of the Anglo-Nubian breed of goats with goats of other breeds. By studying the vascularization of the kidneys in the Anglo-Nubian goat breed, we con-firmed that the renal blood supply is pro-duced by two renal arteries, each of which is directed to the corresponding kidney "L2-L3". We also found that the severe increase in the diameter of the renal arteries occurs in these animals from 1 to 6 months.

TSH-regulation and goitrogenesis in severe iodine deficiency

1983 ◽  
Vol 103 (1) ◽  
pp. 21-27 ◽  
Author(s):  
H. Bachtarzi ◽  
M. Benmiloud
Keyword(s):  
Iodine Deficiency ◽  
Age Groups ◽  
Serum Levels ◽  
Endemic Goitre ◽  
Age Related ◽  
Gradual Development ◽  
Tsh Regulation ◽  
Group A ◽  
Goitre Prevalence ◽  
Group B

Abstract. Since goitre prevalence increases sharply during the first two decades of life, age-related changes in the adaptation of the thyroid to iodine deficiency may occur. In order to study this, we have measured serum levels of TSH, T4 and T3 in 247 subjects (age range 5 to 60 years) living in an endemic goitre area of North Algeria (group A) and in 64 control subjects living in the non-iodine deficient city of Algiers (group B). TRH tests were also performed in 88 subjects from the goitrous area and in 30 controls. Patients from group A had significantly higher serum TSH and T3 and lower serum T4 than those from group B. Analysis of group A by age groups revealed significantly higher TSH concentrations in the 2–9 years group and a moderate but significant decrease in the group from 50–59 years. No significant changes were demonstrated for T4 and T3. In the goitrous area, the response of TSH to TRH was exaggerated and prolonged. ΔTSH20 was inversely correlated with age. The different age groups showed a significantly progressive and continuous decrease of ΔTSH20, ΔTSH60, ΔTSH120 from age 10–19 to age 50–59 years. Our findings thus show a sharp increase of TSH during the first decades of life, which coincides with the phase of maximal growth of the thyroid gland. These results suggest that TSH plays a definite role in the genesis of endemic goitre. The subsequent progressive decrease of TSH secretion and reserve, with unchanged T4 and T3, imply a gradual development of autonomous activity in longstanding multinodular goitre.

scholarly journals THE RELATIONSHIP BETWEEN AGE GROUPS AND KNOWLEDGE AND UNDERSTANDING OF COVID-19 VACCINE

2021 ◽  
Vol 9 (08) ◽  
pp. 482-48/6
Author(s):  
Laphatrada Sakunee ◽  
◽  
Nakamon Khorprasert ◽  
Nitit Noumtong ◽  
Tanyaporn Tangguay ◽  
...  
Keyword(s):  
Consumption Rate ◽  
Age Groups ◽  
Cross Sectional Survey ◽  
Online Questionnaire ◽  
Cross Sectional ◽  
Factors Affecting ◽  
Vaccine Candidates ◽  
The Third ◽  
Preventative Measures ◽  
The Relationship

Coronavirus disease 2019 (COVID-19) is still an ongoing issue in the New Normal world. As COVID-19 is a human-to-human transmission disease, the viruses spread widely, and many people got infected. There are several preventative measures used to protect an individual from this situation, including vaccination. Thus, more vaccine candidates have been provided to generate a specific immune response against the disease-causing agent, and are prepared. Additionally, not all vaccine candidates are suitable for each individual. The main purposes of this study were to evaluate and determine the knowledge and understanding of the COVID-19 vaccines and the relationship between age groups and Thai citizens. To test whether the two aforementioned variables correlate, we conducted a cross-sectional survey through an online platform, Google form. Four hundred and Ten participants completed the survey. To determine the correlation, we used Statistical Product and Service Solution version 22.0 (SPSS) for data analysis. Pearsons correlation test revealed that there is no significant correlation between age groups and knowledge and understanding of COVID-19 vaccines. Although we did not find any correlation, we think that there may be other factors affecting peoples knowledge about the COVID-19 vaccines such as the sudden awareness due to the new pandemic outbreak and the straightforwardness of our online questionnaire. Since most people are now facing the third ripple of COVID-19 crisis, there might be a higher consumption rate of COVID-19 vaccine news and the majority of seniors (aged above 60) tend to reject answering the online questionnaire which significantly reduced our sample size.

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