scholarly journals ASSESSING THE RELATIONSHIP BETWEEN SERUM IGF-1 AND ADIPOSITY BY AGE IN THE LONG LIFE FAMILY STUDY

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S257-S257
Author(s):  
Rehab A Sherlala ◽  
Candace M Kammerer ◽  
Allison L Kuipers ◽  
Mary K Wojczynski ◽  
Svetlana Ukraintseva ◽  
...  
Keyword(s):  
Family Study ◽  
Age Groups ◽  
Serum Levels ◽  
Total Sample ◽  
Age Cohorts ◽  
Age Related ◽  
Long Life ◽  
Using Data ◽  
Underlying Mechanisms ◽  
The Relationship

Abstract Serum levels of insulin-like growth factor 1 (IGF-1) and measures of adiposity, such as body mass index (BMI), are associated with susceptibility to age-related diseases. Previous reports of the relationship between IGF-1 and BMI ranged from positive to negative to no relationship, perhaps because previous reports studied different age cohorts. Using data on 4270 participants (aged 24-110 years) from the Long Life Family Study, we investigated the relationship between IGF-1 and BMI overall and by age groups. IGF-1 and BMI were positively correlated in the total sample (β=0.161, r2= 0.0038, p=1.8-05). However, further analyses revealed that the relationship between IGF-1 and BMI varied by age quartile: in the 1st quartile (24-58yo) the relationship was negative (β=−0.204, r2= 0.011, p=0.0008); in the 2nd quartile (59-66yo) the relationship was negative but non-significant (β=−0.069, r2= 0.0012, p=0.28); in the 3rd quartile (67-86yo) the relationship was positive but non-significant (β=0.106, r2= 0.002, p=0.13); and in the 4th quartile (87-110yo) the relationship was positive (β=0.388, r2= 0.019, p=1.2−05). This pattern did not differ by sex. We also detected a similar age-related pattern between IGF-1 and BMI using an independent dataset (NHANES III), comprising 2550 men and women aged 20-90 years. Our results may clarify some of the inconsistency in previous literature about the relationship between IGF-1 and BMI. Additional studies of IGF-1 and adiposity measures are needed to better understand the underlying mechanisms involved.

scholarly journals Relationship Between Serum IGF-1 and BMI Differs by Age

2020 ◽  
Author(s):  
Rehab A Sherlala ◽  
Candace M Kammerer ◽  
Allison L Kuipers ◽  
Mary K Wojczynski ◽  
Svetlana V Ukraintseva ◽  
...  
Keyword(s):  
Family Study ◽  
Age Groups ◽  
Serum Levels ◽  
The Third ◽  
Age Related ◽  
Long Life ◽  
Using Data ◽  
The Relationship ◽  
Nutritional Examination Survey ◽  
Related Pattern

Abstract Background Serum levels of insulin-like growth factor 1 (IGF-1) and body mass index (BMI) are both associated with susceptibility to age-related diseases. Reports on the correlation between them have been conflicting, with both positive to negative correlations reported. However, the age ranges of the participants varied widely among these studies. Methods Using data on 4241 participants (aged 24–110) from the Long Life Family Study, we investigated the relationship between IGF-1 and BMI by age groups using regression analysis. Results When stratified by age quartile, the relationship between IGF-1 and BMI varied: in the first quartile (Q1, 20–58 years) the relationship was negative (β = −0.2, p = .002); in Q2 (58–66 years) and Q3 (67–86 years) the relationship was negative (β = −0.07, β = −0.01, respectively) but nonsignificant; and in Q4 (87–110 years) the relationship was positive (β = 0.31, p = .0002). This pattern did not differ by sex. We observed a similar age-related pattern between IGF-1 and BMI among participants in the third National Health and Nutritional Examination Survey. Conclusions Our results that the relationship between IGF-1 and BMI differs by age may explain some of the inconsistency in reports about their relationship and encourage additional studies to understand the mechanisms underlying it.

scholarly journals Assessing the Relationship between Serum IGF-1 and BMI by Age in the Long Life Family Study

2020 ◽  
Author(s):  
Rehab A. Sherlala ◽  
Candace M. Kammerer ◽  
Allison L. Kuipers ◽  
Mary K. Wojczynski ◽  
Svetlana V. Ukraintseva ◽  
...  
Keyword(s):  
Family Study ◽  
Age Groups ◽  
Serum Levels ◽  
The Third ◽  
Age Related ◽  
Long Life ◽  
Using Data ◽  
The Relationship ◽  
Nutritional Examination Survey ◽  
Related Pattern

AbstractBackgroundSerum levels of insulin-like growth factor 1 (IGF-1) and body mass index (BMI) are both associated with susceptibility to age-related diseases. Reports on the correlation between them have been conflicting, with both positive to negative correlations reported. However, the age ranges of the participants varied widely among these studies.MethodsUsing data on 4,241 participants (aged 24–110) from the Long Life Family Study, we investigated the relationship between IGF-1 and BMI by age groups using regression analysis.ResultsWhen stratified by age quartile, the correlation between IGF-1 and BMI varied: in the 1st quartile (Q1, 24 y–58 y) the correlation was negative (r = −0.1, P = 0.0008); in Q2 (59 y– 66 y) it was negative (r = −0.035) but non-significant; in Q3 (67 y–86 y) it was positive (r = 0.045) but non-significant; and in Q4 (87 y–110 y) the correlation was positive (r = 0.14, P < 0.0001). This pattern did not differ by sex. We observed a similar age-related pattern between IGF-1 and BMI among participants in the third National Health and Nutritional Examination Survey.ConclusionsOur results, that the relationship between IGF-1 and BMI differs by age, may explain some of the inconsistency in reports about their relationship and encourage additional studies to understand the mechanisms underlying it.

scholarly journals IGF-1 Haploinsufficiency Causes Age-Related Chronic Cochlear Inflammation and Increases Noise-Induced Hearing Loss

Cells ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1686
Author(s):  
Adelaida M. Celaya ◽  
Lourdes Rodríguez-de la Rosa ◽  
Jose M. Bermúdez-Muñoz ◽  
José M. Zubeldia ◽  
Carlos Romá-Mateo ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Inflammatory Cytokines ◽  
Noise Exposure ◽  
Sensorineural Deafness ◽  
Serum Levels ◽  
Genetic Syndromes ◽  
Expression Ratio ◽  
Postnatal Maturation ◽  
Age Related ◽  
Underlying Mechanisms

Insulin-like growth factor 1 (IGF-1) deficiency is an ultrarare syndromic human sensorineural deafness. Accordingly, IGF-1 is essential for the postnatal maturation of the cochlea and the correct wiring of hearing in mice. Less severe decreases in human IGF-1 levels have been associated with other hearing loss rare genetic syndromes, as well as with age-related hearing loss (ARHL). However, the underlying mechanisms linking IGF-1 haploinsufficiency with auditory pathology and ARHL have not been studied. Igf1-heterozygous mice express less Igf1 transcription and have 40% lower IGF-1 serum levels than wild-type mice. Along with ageing, IGF-1 levels decreased concomitantly with the increased expression of inflammatory cytokines, Tgfb1 and Il1b, but there was no associated hearing loss. However, noise exposure of these mice caused increased injury to sensory hair cells and irreversible hearing loss. Concomitantly, there was a significant alteration in the expression ratio of pro- and anti-inflammatory cytokines in Igf1+/− mice. Unbalanced inflammation led to the activation of the stress kinase JNK and the failure to activate AKT. Our data show that IGF-1 haploinsufficiency causes a chronic subclinical proinflammatory age-associated state and, consequently, greater susceptibility to stressors. This work provides the molecular bases to further understand hearing disorders linked to IGF-1 deficiency.

scholarly journals Evaluation of the Relationship between the Level of DHEA-S and Sex Hormones in Some Infertile Iraqi Men

2021 ◽  
Vol 8 (5) ◽  
pp. 130-136
Author(s):  
Khaled S. Abd ◽  
Adnan F. AL-Azzawie
Keyword(s):  
Sex Hormones ◽  
Seminal Fluid ◽  
Age Groups ◽  
Serum Levels ◽  
Dehydroepiandrosterone Sulfate ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Infertile Men ◽  
The Relationship

This study aims to evaluate serum levels of the Dehydroepiandrosterone sulfate (DHEA-S) and its relationship with some sex hormones such as Follicle stimulating hormone (FSH), Luteinizing hormone (LH), prolactin and testosterone hormone and the infertility type in some infertile Iraqi men. Blood and seminal fluid samples from (60) idiopathic male infertile and (60) healthful individuals as a control group aged (18 to 60 year) were collected from private clinics. Serum hormones (DHEA-S, FSH, LH, prolactin and testosterone) were measurement using Enzyme Linked Immunosorbent Assay (ELISA). The levels of DHEA-S, FSH, LH and prolactin are significantly higher (P≤0.01) expect of the testosterone level was significantly decreased (P≤ 0.01) in the infertile men as compared with control group. High significant differences (P≤0.01) were recorded when comparing the hormonal levels (DHEA-S, FSH, LH, prolactin and testosterone) according to the age groups. There are significant differences (P≤ 0.01) in levels of (DHEA-S, FSH, LH, prolactin and testosterone) in the infertility period.  Smoker infertile men have high levels (P≤ 0.05) in the DHEA-S and LH while have low levels in the prolactin hormones compared with control. Patients with family history have shown significant differences (P≤0.05) in the levels of DHEA-S, FSH, LH and prolactin. In conclusion, this study revealed significantly increase in the DHEA-S levels in the infertile men and negative correlation between DHEA-S and FSH. Therefore, DHEA-S has important role in the diagnosis and follow up of the male infertility.

scholarly journals Age-Related Changes in the 25-Hydroxyvitamin D Versus Parathyroid Hormone Relationship Suggest a Different Reason Why Older Adults Require More Vitamin D

2003 ◽  
Vol 88 (1) ◽  
pp. 185-191 ◽  
Author(s):  
Reinhold Vieth ◽  
Yasmin Ladak ◽  
Paul G. Walfish
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Secondary Hyperparathyroidism ◽  
Age Groups ◽  
The Elderly ◽  
Age Group ◽  
Hydroxyvitamin D ◽  
Age Related ◽  
25 Hydroxyvitamin D ◽  
The Relationship

Vitamin D requirements are thought to vary with age, but there is little comparative evidence for this. One goal in establishing a vitamin D requirement is to avoid secondary hyperparathyroidism. We studied 1741 euthyroid, thyroid clinic outpatients without evidence of calcium abnormalities, ranging in age from 19 to 97 yr, whose serum and urine had been analyzed for calcium, vitamin D, and parathyroid status. We found no effect of age on the 25-hydroxyvitamin D [25(OH)D] concentration associated with specific vitamin D intakes, and there was no relationship between 25(OH)D and 1,25hydroxyvitamin D [1,25(OH)2D]. In every age group, serum 1,25(OH)2D declined with increasing creatinine (P &lt; 0.001). What changed with age included creatinine, which correlated with 25(OH)D (r = 0.146, P &lt; 0.001) only in the youngest age group (19–50 yr) but not in the older age groups (P &gt; 0.1). Creatinine did not correlate with PTH in the youngest age group, but the relationship became significant as age increased (e.g. for the elderly, r = 0.365, P &lt; 0.001). Linear regression of log PTH vs. log 25(OH)D agreed with the natural shape of the relationship observed with scatterplot smoothing, and this showed no plateau in PTH as 25(OH)D increased. We compared PTH concentrations among age groups, based on 20 nmol/liter increments in 25(OH)D. Mean PTH in adults older than 70 yr was consistently higher than in adults younger than 50 yr (P &lt; 0.05 by ANOVA and Dunnett’s t test). PTH levels of the elderly who had 25(OH)D concentrations greater than 100 nmol/liter matched PTH of younger adults having 25(OH)D concentrations near 70 nmol/liter. This study shows that all age groups exhibit a high prevalence of 25(OH)D insufficiency and secondary hyperparathyroidism. Older adults are just as efficient in maintaining 25(OH)D, but they need more vitamin D to produce the higher 25(OH)D concentrations required to overcome the hyperparathyroidism associated with their diminishing renal function.

TSH-regulation and goitrogenesis in severe iodine deficiency

1983 ◽  
Vol 103 (1) ◽  
pp. 21-27 ◽  
Author(s):  
H. Bachtarzi ◽  
M. Benmiloud
Keyword(s):  
Iodine Deficiency ◽  
Age Groups ◽  
Serum Levels ◽  
Endemic Goitre ◽  
Age Related ◽  
Gradual Development ◽  
Tsh Regulation ◽  
Group A ◽  
Goitre Prevalence ◽  
Group B

Abstract. Since goitre prevalence increases sharply during the first two decades of life, age-related changes in the adaptation of the thyroid to iodine deficiency may occur. In order to study this, we have measured serum levels of TSH, T4 and T3 in 247 subjects (age range 5 to 60 years) living in an endemic goitre area of North Algeria (group A) and in 64 control subjects living in the non-iodine deficient city of Algiers (group B). TRH tests were also performed in 88 subjects from the goitrous area and in 30 controls. Patients from group A had significantly higher serum TSH and T3 and lower serum T4 than those from group B. Analysis of group A by age groups revealed significantly higher TSH concentrations in the 2–9 years group and a moderate but significant decrease in the group from 50–59 years. No significant changes were demonstrated for T4 and T3. In the goitrous area, the response of TSH to TRH was exaggerated and prolonged. ΔTSH20 was inversely correlated with age. The different age groups showed a significantly progressive and continuous decrease of ΔTSH20, ΔTSH60, ΔTSH120 from age 10–19 to age 50–59 years. Our findings thus show a sharp increase of TSH during the first decades of life, which coincides with the phase of maximal growth of the thyroid gland. These results suggest that TSH plays a definite role in the genesis of endemic goitre. The subsequent progressive decrease of TSH secretion and reserve, with unchanged T4 and T3, imply a gradual development of autonomous activity in longstanding multinodular goitre.

scholarly journals Age and Lateral Sleep Position: A Pilot Study

2009 ◽  
Author(s):  
Susan Gordon ◽  
Petra Buettner
Keyword(s):  
Pilot Study ◽  
Research University ◽  
Age Groups ◽  
Elderly Person ◽  
South Australia ◽  
The Elderly ◽  
Total Sample ◽  
Lateral Position ◽  
Sleep Position ◽  
Age Related

Purpose: Previous research, undertaken using a Super 8 camera and non-continuous data, has reported that with increasing age, people are more likely to sleep in the right lateral position. It has been postulated that this is due to age related alterations in cardiovascular function. This pilot study was undertaken to determine if collection and analysis of continuous sleep data was a feasible method for further investigation of this topic and to determine the sample size required for an adequately powered study. Increased understanding of age related changes in sleep position may provide valuable information to improve sleep quality and nursing care of the elderly person. Method: Research at the Centre for Sleep Research, University of South Australia, investigated the association between age and sleep position. Infra-red illumination and video cameras recorded the sleep patterns of 12 subjects for two nights. Videos were examined and the amount of time spent in each sleep position was calculated in seconds. Results: In a one-way analysis of variance, sample sizes of 19, 19, and, 19 are necessary from the three age groups whose means are to be compared. The expected means are 20, 25 and 45 for the three age groups respectively. The total sample of 57 subjects achieves 82% power to detect differences among the means versus the alternative of equal means using an F test with a 0.05 significance level.Conclusions: The results of this pilot study support further investigation of the relationship between age and lateral sleep position preference, and particularly the physiological parameters which may underpin the adoption of different sleep positions with increasing age. The described method is appropriate and modifications are suggested to further improve future studies.

PENDELEGASIAN TUGAS KEPALA RUANGAN MENURUT PERSEPSI PERAWAT PELAKSANA DAPAT MENINGKATKAN KEPUASAN KERJA

2017 ◽  
Vol 11 (3) ◽  
pp. 194
Author(s):  
ISNA OVARI ◽  
Setyowati Setyowati ◽  
Yasmi Yasmi
Keyword(s):  
Random Sampling ◽  
Negative Attitude ◽  
Simple Random Sampling ◽  
Total Sample ◽  
P Value ◽  
Nurse Satisfaction ◽  
Chi Square ◽  
Primary Function ◽  
Using Data ◽  
The Relationship

<p><strong><em>Abstract</em></strong><em>: Nurses executive showing negative attitude towards their job signify unsatisfied with their job. One of the factors that will influence nurse satisfaction work implementing the room is the head of exercising the functions of an organizing in inpatient rooms .This study attempts to captures the relationship between the primary function of the organizing the head of the room with satisfaction work implementing nurse. The total sample 61 nurses implementing , taken with simple techniques proportional random sampling , using data analyzed test chi square. The research results show a significant relation exists between the primary function of the organizing the head of the room with nurse satisfaction work in the perception of implementing nurse, p value = 0,037, α = 0.05, a variable whose a dominant influence work nurse satisfaction is the delegation of implementing duty, p value = 0,002, α = 0.05.  The interpretation of it is the delegation of duty able to increase work nurse satisfaction implementing. Ward’s chief</em><em> important to give the delegation of duty to nurses implementing satisfaction nurse to work can increase  </em><strong><em></em></strong></p><p><strong><em>Keywords</em></strong><em>: </em><em>Nurse’s’satisfaction, </em><em>The delegation of duty, </em><em>Ward’s chief</em><strong> </strong></p><p><strong><br /></strong></p><p><strong>Abstrak</strong> : Perawat pelaksana  yang menampilkan sikap negatif terhadap pekerjaan menandakan ketidakpuasannya dalam bekerja. Salah satu faktor yang bisa mempengaruhi kepuasan kerja perawat pelaksana adalah Kepala Ruangan yang melaksanakan fungsi pengorganisasian di ruang rawat inap. Penelitian ini bertujuan untuk menggambarkan hubungan antara pelaksanaan fungsi pengorganisasian Kepala Ruangan dengan kepuasan  kerja perawat pelaksana. Jumlah sampel 61 orang perawat pelaksana, diambil dengan teknik <em>proportional simple random sampling, </em>data dianalisis menggunakan uji <em>Chi Square</em>. Hasil penelitian menunjukkan ada hubungan yang signifikan antara pelaksanaan fungsi pengorganisasian Kepala Ruangan dengan kepuasan kerja perawat menurut persepsi perawat pelaksana, nilai p = 0,037, α =. 0,05, variabel  yang dominan mempengaruhi kepuasan kerja perawat pelaksana adalah pendelegasian tugas, nilai p = 0,002, 0,05. Maknanya adalah pendelegasian tugas dapat meningkatkan kepuasan kerja perawat pelaksana. Simpulannya Kepala Ruangan penting untuk memberikan pendelegasian tugas kepada perawat pelaksana agar kepuasan kerja perawat bisa meningkat. </p><p><strong>Kata kunci : </strong>Kepuasan kerja, Kepala Ruangan, Pendelegasian Tugas</p>

A MATHEMATICAL FRAMEWORK EXHIBITING THE EMERGENCE OF DYNAMIC EXPANSION OF TASK REPERTOIRE IN PHEIDOLE DENTATA

2016 ◽  
Vol 24 (02n03) ◽  
pp. 217-235 ◽  
Author(s):  
JASON M. GRAHAM ◽  
IVAN L. SIMPSON-KENT ◽  
MARC A. SEID
Keyword(s):  
Mathematical Modeling ◽  
Age Groups ◽  
Theoretical Work ◽  
Clear Understanding ◽  
Mathematical Framework ◽  
Modeling Framework ◽  
Age Related ◽  
Pheidole Dentata ◽  
Underlying Mechanisms ◽  
Theoretical Results

The division of labor (DOL) and task allocation (TA) among groups of ants living in a colony is thought to be highly efficient, and key to the robust survival of a colony. A great deal of experimental and theoretical work has been done toward gaining a clear understanding of the evolution of, and underlying mechanisms of these phenomena. Much of this research has utilized mathematical modeling. Here we continue this tradition by developing a mathematical model for a particular aspect of TA, known as age-related repertoire expansion, that has been observed in the minor workers of the ant species Pheidole dentata. In fact, we present a relatively broad mathematical modeling framework based on the dynamics of the frequency with which members of specific age groups carry out distinct tasks. We apply our modeling approach to a specific TA scenario, and compare our theoretical results with experimental data. It is observed that the model predicts perceived behavior, and provides a possible explanation for the aforementioned experimental results.

Socioeconomic Status and the Frequency of Anger across the Life Course

2003 ◽  
Vol 46 (2) ◽  
pp. 207-222 ◽  
Author(s):  
Scott Schieman
Keyword(s):  
General Social Survey ◽  
Age Groups ◽  
Negative Relationship ◽  
Economic Conditions ◽  
Social Survey ◽  
Financial Conditions ◽  
Using Data ◽  
The Life Course ◽  
The Relationship ◽  
Different Levels

Previous studies suggest that older people report less anger. However, little is known about the relationship between age and the frequency of anger among individuals with different levels of education and economic circumstances. Using data from the 1996 General Social Survey ( N = 1,442), I examine the effects of age on anger across levels of education and objective and subjective economic conditions. A significant and positive age × education interaction suggests that the negative relationship between age and the frequency of anger is stronger at lower levels of education. Adjustment for social roles and economic conditions fails to account for the age × education interaction effect. In addition, differences in anger between individuals who reported worsening financial conditions and those who reported that their finances improved or stayed the same are greatest among the youngest age groups, and the gap decreases at successively older age levels. I discuss the ways that these results contradict recent findings of SES-based age differences in depressive emotions and physical health status.

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