Effects of Different Exercise Conditions on Antioxidant Potential and Mental Assessment

Exercise increases oxidative stress, leading the body to strengthen its antioxidant defenses, thus reducing the incidence of major diseases. As these associations are relatively unclear for ordinary levels of exercise for reduced stress, this study evaluated the effects of different exercise conditions on diacron-reactive oxygen metabolites (d-ROMs), biological antioxidant potential (BAP), and subjective mood. Forty-nine students (22.4 ± 2.6 years) were assessed using the Profile of Mood States (POMS) before and after exercising for 60 min. Participants were divided into two groups: Group A engaged in compulsory sports and Group B in freely chosen sports. d-ROMs and BAP were measured, and their modified ratio was calculated as an index of antioxidant potential. Physiological evaluation showed significant improvements in BAP and the BAP/d-ROMs ratio, irrespective of exercise condition (p < 0.001, p < 0.01). Comparison between the exercise conditions revealed a significant difference in the modified ratio (p < 0.02). In mood assessment, scores on emotion-related scales without vigor improved significantly under both exercise conditions (p < 0.001). Mental changes were evident after exercise, and potential antioxidant capacity was higher in freely chosen sports (p < 0.03). Assessment of antioxidant status before and after exercise may provide an objective index of mental and physical conditioning.

Download Full-text

The influence of osteopathic correction on the rate of various rhythms of the body

Russian Osteopathic Journal ◽

10.32885/2220-0975-2019-1-2-64-71 ◽

2019 ◽

pp. 64-71 ◽

Cited By ~ 1

Author(s):

A. E. Chernikova ◽

Yu. P. Potekhina

Keyword(s):

Heart Rate ◽

Respiratory Rate ◽

Age Groups ◽

Biomechanical Properties ◽

Dispersion Analysis ◽

The Body ◽

Body Tissues ◽

Age Related ◽

Significant Difference ◽

Before And After

Introduction. An osteopathic examination determines the rate, the amplitude and the strength of the main rhythms (cardiac, respiratory and cranial). However, there are relatively few studies in the available literature dedicated to the influence of osteopathic correction (OC) on the characteristics of these rhythms.Goal of research — to study the influence of OC on the rate characteristics of various rhythms of the human body.Materials and methods. 88 adult osteopathic patients aged from 18 to 81 years were examined, among them 30 men and 58 women. All patients received general osteopathic examination. The rate of the cranial rhythm (RCR), respiratory rate (RR) heart rate (HR), the mobility of the nervous processes (MNP) and the connective tissue mobility (CTM) were assessed before and after the OC session.Results. Since age varied greatly in the examined group, a correlation analysis of age-related changes of the assessed rhythms was carried out. Only the CTM correlated with age (r=–0,28; p<0,05) in a statistically significant way. The rank dispersion analysis of Kruskal–Wallis also showed statistically significant difference in this indicator in different age groups (p=0,043). With the increase of years, the CTM decreases gradually. After the OC, the CTM, increased in a statistically significant way (p<0,0001). The RCR varied from 5 to 12 cycles/min in the examined group, which corresponded to the norm. After the OC, the RCR has increased in a statistically significant way (p<0,0001), the MNP has also increased (p<0,0001). The initial heart rate in the subjects varied from 56 to 94 beats/min, and in 15 % it exceeded the norm. After the OC the heart rate corresponded to the norm in all patients. The heart rate and the respiratory rate significantly decreased after the OC (р<0,0001).Conclusion. The described biorhythm changes after the OC session may be indicative of the improvement of the nervous regulation, of the normalization of the autonomic balance, of the improvement of the biomechanical properties of body tissues and of the increase of their mobility. The assessed parameters can be measured quickly without any additional equipment and can be used in order to study the results of the OC.

Download Full-text

Comparison of montelukast and mometasone furoate in the prevention of recurrent nasal polyps

Therapeutic Advances in Respiratory Disease ◽

10.1177/1753465811427577 ◽

2011 ◽

Vol 6 (1) ◽

pp. 5-10 ◽

Cited By ~ 21

Author(s):

Erkan Vuralkan ◽

Cem Saka ◽

Istemihan Akin ◽

Sema Hucumenoglu ◽

Binnur Uzmez Unal ◽

...

Keyword(s):

Recurrence Rate ◽

Nasal Spray ◽

Peripheral Blood ◽

Nasal Polyposis ◽

Mometasone Furoate ◽

Significant Difference ◽

Before And After ◽

Group A ◽

Group B ◽

Snot 22

Background: The aim of our study was to compare the effects of montelukast and mometasone furoate nasal spray on the postoperative course of patients with nasal polyposis. Patients and methods: Fifty patients diagnosed with nasal polyposis between March 2006 and August 2007 were included in the study. All patients underwent bilateral endoscopic sphenoethmoidectomy and were randomized postoperatively into two groups. Group A ( n = 25) received 10 mg montelukast per day and group B ( n = 25) received 400 µg mometasone furoate nasal spray twice daily. All patients were followed up for 6 months. Sino-Nasal Outcome Test (SNOT)-22 scores, polyp grades, computerized tomography (CT) scores (Lund–Mackay), eosinophils in peripheral blood and polyp tissue were evaluated before and after surgery. Results: There was a significant reduction in SNOT-22 scores in both groups throughout the study period. There was a significant difference in the recurrence rate between both groups with a marginal advantage of mometasone furoate nasal spray. Eosinophils in peripheral blood were found to be effective on the recurrence rate ( p < 0.05). Conclusions: In conclusion, both drugs seem to have a complementary action and further studies are needed to determine which patients should receive which treatment.

Download Full-text

Differences in triglyceride levels before and after whey protein intervention in field workers exposed and unexposed to arsenic

JURNAL GIZI INDONESIA ◽

10.14710/jgi.9.2.166-171 ◽

2021 ◽

Vol 9 (2) ◽

pp. 166-171

Author(s):

Eka Putri Rahmadhani ◽

Ani Margawati ◽

Apoina Kartini

Keyword(s):

Whey Protein ◽

Dairy Products ◽

Metabolic Disorders ◽

Fat Metabolism ◽

Exposed Group ◽

The Body ◽

Unexposed Group ◽

Significant Difference ◽

Before And After ◽

Field Workers

Background: A work environment that is exposed to heavy metals, such as a coal mining environment, can change fat metabolism in the body. Changes in fat metabolism will lead to cardiovascular disease. Consumption of dairy products, e.g. whey protein, can reduce the risk of metabolic disorders and cardiovascular disease.Objectives: To test and analyze the differences in triglyceride levels before and after whey protein intervention to field workers with different working conditions.Materials and Methods: This experimental research with pretest and posttest was conducted on field workers at PT Bukit Asam Tbk. Tarahan Port Unit, Lampung as an Arsenic exposed group and PTPN VII Way Berulu Business Unit as an Arsenic unexposed group. Both groups received 24 grams of whey protein daily for 28 days. The triglyceride levels before and after the intervention were measured by laboratory analysis using the enzymatic calorimetry method. The data were analyzed using independent t-test, Mann Whitney test, and Wilcoxon test.Results: The average triglyceride levels increased by 50.48 ± 98.09 mg/dL in the exposed group and 16.78 ± 67.67 mg/dL in the unexposed group. There was a significant difference in triglyceride levels before and after the whey protein intervention in the two groups.Conclusions: The whey protein intervention increased the triglyceride level in the exposed group and decreased it in the unexposed group.

Download Full-text

PRE AND POSTPRANDIAL THERMOGRAPHIC PROFILE OF GREEN IGUANAS (IGUANA IGUANA)

Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca Veterinary Medicine ◽

10.15835/buasvmcn-vm:12345 ◽

2016 ◽

Vol 73 (2) ◽

pp. 425

Author(s):

Simona Rusu ◽

Zdenek Knotek ◽

Radu Lacatus ◽

Ionel Papuc

Keyword(s):

Heat Transfer ◽

Body Temperature ◽

Temperature Difference ◽

The Body ◽

Significant Difference ◽

Before And After ◽

Significant Temperature ◽

Green Iguanas ◽

The Right ◽

Head Temperature

Abstract The body temperature of 10 clinically healthy green iguanas (Iguana iguana) was measured using a thermographic camera (FLIR E6, Flir Systems Sweden) before and after the food was offered. For each animal there were performed a total of 6 measurements (3 before feeding and 3 after the food was offered). The purpose of this experiment was to observe the thermographic pattern of the body before and after the feeding, since herbivore reptiles tend to bask after the feeding to increase the body temperature that will help them afterwards digest the food. The animals were housed in individual vivariums with every animal having a basking spot available. The pictures were taken outside the vivarium in an adjacent room. The animals were handled with gloves and transported in a cardboard box in order to avoid heat transfer between the handler and the iguana that would have produced thermal artefacts. Each individual was placed on a table on a styrofoam slate, again, to avoid the heat transfer between the table and the animal`s body. For each animal a total of 4 pictures were taken (up, front, left and right). The pictures were analysed with the FLIR Tools program that is provided by the manufacturer and 3 temperatures were taken into consideration (the head temperature, body temperature on the right side and body temperature on the left side). The temperatures were compared between them and with the temperature of the vivariums that consisted of the average between the temperature in 3 different spots (basking spot, the feeding bowl site and the coldest spot) measured with an infrared thermometer GM300 (Benetech, China). The temperature of the body was dependent on the vivarium temperature and it was a significant temperature difference between the measurements before the feeding and after the feeding. Also we discovered a significant difference between the head temperature and the body temperature on the left side before the feeding that disappeared after the animals ate. There was also a significant difference between the temperature on right side and on left side of the animals both before and after the feeding. No significant temperature difference was observed between the head and the right side of the body neither before nor after the feeding.

Download Full-text

PREVALENCE OF HEPATIC STEATOSIS AMONG CHILDREN AND ADOLESCENTS WITH CYSTIC FIBROSIS AND ITS ASSOCIATION WITH NUTRITIONAL STATUS

Revista Paulista de Pediatria ◽

10.1590/1984-0462/;2019;37;4;00007 ◽

2019 ◽

Vol 37 (4) ◽

pp. 435-441

Author(s):

Amanda Oliva Gobato ◽

Ana Carolina Junqueira Vasques ◽

Antonio Fernando Ribeiro ◽

Roberto Massao Yamada ◽

Gabriel Hessel

Keyword(s):

Cystic Fibrosis ◽

Nutritional Status ◽

Children And Adolescents ◽

Hepatic Steatosis ◽

Statistical Tests ◽

The Body ◽

Significant Difference ◽

Group A ◽

The Mean ◽

Group B

ABSTRACT Objective: To determine the prevalence of hepatic steatosis (HS) in children and adolescents with cystic fibrosis (CF) and associate it with nutritional status. Methods: Cross-sectional study with children and adolescents with CF diagnosis. Weight and height were used to calculate the body mass index (BMI) and subsequent classification of the nutritional status. The midarm circumference (MAC), triceps skinfold thickness (TSF) and midarm muscle circumference (MAMC) were used to evaluate body composition. Abdominal ultrasonography was performed for diagnosis of HS. The statistical tests used were Student’s t test, Mann-Whitney test and chi-square test with significance level of 5%. Results: 50 patients with CF were evaluated, 18 (36%) were diagnosed with HS (Group A) and 32 (64%) without HS (Group B). The mean age of Group A was 13,2±4,9 years old and Group B 11,7±4,9; for BMI, the value for Group A was 18,0±4,1 and Group B was 15,7±3,8; the TSF of Group A was 8,4±3,5 mm and Group B was 7,0±2,5 mm. For these variables, there was no significant difference between the groups. The mean of MAC and MAMC differed significantly between the groups, being higher in the HS group, with p values of 0,047 and 0,043. Conclusions: The frequency of HS in patients with CF is high and it is not related to malnutrition, according to the parameters of BMI, TSF and MAMC. The values of MAC and MAMC indicated a greater reserve of muscle mass in patients with HS.

Download Full-text

Effect of supplemented dietary protein on certain haematological values and meat yield characteristics of broiler birds

Bangladesh Journal of Veterinary Medicine ◽

10.3329/bjvm.v2i2.2543 ◽

1970 ◽

Vol 2 (2) ◽

pp. 121-123 ◽

Cited By ~ 1

Author(s):

MS Alam ◽

N Ahmad ◽

MA Miah ◽

R Islam

Keyword(s):

Body Weight ◽

Dietary Protein ◽

Body Weight Gain ◽

The Body ◽

Meat Yield ◽

Haematological Values ◽

Significant Difference ◽

The Mean ◽

Group B ◽

Different Levels

The effect of different levels of supplemented dietary protein on body weight, certain haematological values and meat yield characteristics in 20 "Shaver Star Bro" broilers was studied during the period from 02 March to 12 April 2002. The broilers were randomly assigned to four equal groups (A to D) each consisting of 5 birds. Group A was considered as control, fed only with commercial ration and other three groups were treated with extra dietary protein supplement @ 5%, 10% and 15% as group B, C and D respectively. Increased body weight was recorded in group B and the body weight decreases as the level of protein increased from 5% to 10% and 15% and the decrease was linear. No differences in haematological values were observed among the groups but the TEC varied significantly (p < 0.05). The mean weight of breast meat, drum stick meat varied significantly (p < 0.01). The shank weight varied significantly (p < 0.05) but there was no significant difference among the mean weight of thigh meat and wing meat corresponding to the different levels of supplemented dietary protein. It can be concluded that 5% supplemented dietary protein with commercial ration gives better result in respect to body weight gain, haematological values and meat yield characteristics.Key words: dietary protein; haematological values; meat yield; broiler birdsdoi: 10.3329/bjvm.v2i2.2543Bangl. J. Vet. Med. (2004). 2 (2): 121-123

Download Full-text

Effect of Esophageal Endoscopic Submucosal Dissection on Motility and Symptoms: A Prospective Study

Gastroenterology Research and Practice ◽

10.1155/2018/3735473 ◽

2018 ◽

Vol 2018 ◽

pp. 1-10

Author(s):

Tsutomu Takeda ◽

Kenshi Matsumoto ◽

Akihito Nagahara ◽

Hiroyuki Komori ◽

Yoichi Akazawa ◽

...

Keyword(s):

Endoscopic Submucosal Dissection ◽

Symptom Score ◽

Esophageal Motility ◽

High Resolution Manometry ◽

Submucosal Dissection ◽

Significant Difference ◽

Before And After ◽

Group A ◽

Integrated Relaxation Pressure ◽

Group B

Background.Endoscopic submucosal dissection (ESD) of esophageal tumors can cause stenosis, yet the effect of esophageal ESD on motility remains unclarified. This study aimed to compare esophageal motility and symptoms, before and after ESD, using high-resolution manometry (HRM) and symptom scoring.Methods.Twenty-eight patients with 35 cT1a cancers were prospectively enrolled between December 2014 and February 2016. Pre- and post-ESD symptom score and HRM were recorded. Based on circumferential resection (CR), patients were divided into group A (n=17, <2/3 CR) or B (n=11, 2/3 CR or greater). HRM parameters evaluated were distal contractile integral (DCI), contractile front velocity (CFV), intrabolus pressure, integrated relaxation pressure, distal latency, and peristaltic breaks.Results.Symptom scores worsened after ESD in 8/11 patients in group B, and 0/17 patients in group A. There was no significant difference in any HRM parameter after ESD in the whole study group but mean DCI tended to increase (p=0.07). In group B, DCI increased significantly after ESD (p=0.04), and CFV tended to decrease after ESD (p=0.08).Conclusions.DCI tended to increase after esophageal ESD. ESD affected the symptom score and esophageal motility in cases with 2/3 CR or greater. This trial is registered withUMIN000015829.

Download Full-text

Stress responses of transportation on red tilapia which given feed containing chromium

Jurnal Akuakultur Indonesia ◽

10.19027/jai.17.1.16-25 ◽

2018 ◽

Vol 17 (1) ◽

pp. 16 ◽

Cited By ~ 1

Author(s):

Rakhmawati, Rakhmawati ◽

Muhammad Agus Suprayudi ◽

Mia Setiawati ◽

Widanarni, Widanarni ◽

Muhammad Zairin Junior ◽

...

Keyword(s):

Blood Glucose ◽

Stress Responses ◽

Plasma Cortisol ◽

Enzyme Concentration ◽

The Body ◽

Red Tilapia ◽

Significant Difference ◽

Before And After ◽

Negative Effect ◽

Keywords Stress

ABSTRACTThis study was conducted to evaluate stress responses of transportation on red tilapia Oreochromis sp. which given feed containing chromium. Three isonitrogenous and isocaloric experimental feeds were prepared, these diets were control (without chromium), CrPic 1 mg/kg, and CrYst 2 mg/kg supplementation in feed, all group were arranged triplicate. Satiation feeding was done three times a day. After a 60-day feeding experiment, the experimental fishes were fasted and distributed in polyethylene bags (N=60 fish/bag) containing 3 L of water, subjected to condition of transport simulation for 13 hours. Survival rate, levels of plasma cortisol, blood glucose, superoxide dismutase (SOD), and malondialdehyde (MDA) enzyme were observed at before transportation, after transportation, one day, and two days after transportation. The result showed that chromium supplementation reduced the levels of plasma cortisol before and after transportation, one day, and two days after transportation. Also, it decreased blood glucose compared with control significantly before transportation and one day after transportation. The SOD enzyme concentration increased significantly after fish was fed with feed containing chromium for 30 days, while the MDA enzyme concentration increased significantly after two days of transportation. However, there was no significant difference in the survival of red tilapia between treatments. The best result was obtained in the treatment of fish which fed with feed containing chromium. CrPic supplementation 1 mg/kg and CrYst 2 mg/kg increased the body resistance in red tilapia by decreasing the negative effect of stress while transportation. Keywords: stress, transportation, red tilapia, chromium ABSTRAKPenelitian dilakukan untuk mengevaluasi respons stres transportasi ikan nila merah Oreochromis sp. yang diberikan pakan yang mengandung kromium. Pada penelitian ini digunakan tiga jenis pakan, terdiri atas pakan tanpa suplementasi kromium (kontrol), pakan bersuplementasi kromium pikolinat (CrPic 1 mg/kg), dan kromium yeast (CrYst 2 mg/kg), semua perlakuan diulang sebanyak tiga ulangan. Pemberian pakan sebanyak tiga kali sehari dan dilakukan secara at satiation. Setelah 30 hari pemeliharaan, ikan uji dipuasakan dan didistribusikan dalam plastik polietilen (N=60 ekor ikan/kantong plastik) yang berisi 3 L air, dilakukan dengan simulasi transportasi selama 13 jam. Parameter yang diamati pada penelitian ini adalah kelangsungan hidup, kortisol, glukosa darah, enzim superoksida dismustase (SOD), dan malondialdehida (MDA) saat sebelum transportasi, sesaat setelah transportasi, sehari, dan dua hari setelah transportasi. Hasil yang didapatkan adalah suplementasi kromium menurunkan konsentrasi kortisol secara signifikan sebelum transportasi, sesaat, sehari, dan dua hari setelah transportasi. Suplementasi kromium menurunkan glukosa darah secara signifikan pada saat sebelum transportasi dan sehari setelah transportasi. Konsentrasi enzim SOD meningkat secara signifikan setelah pemberian pakan bersuplementasi kromium selama 30 hari, sedangkan konsentrasi enzim MDA meningkat secara signifikan setelah dua hari transportasi pada ikan yang diberi pakan bersuplementasi kromium. Namun, tidak ada perbedaan yang signifikan pada kelangsungan hidup ikan nila merah antarperlakuan. Hasil terbaik diperoleh pada perlakuan ikan dengan suplementasi kromium. Suplementasi 1 mg/kg CrPic dan 2 mg/kg CrYst dapat meningkatkan daya tahan tubuh pada budidaya ikan nila merah dengan menurunkan pengaruh negatif stres akibat transportasi. Kata kunci: stres, transportasi, nila merah, kromium

Download Full-text

Efficacy of Korean Medicine Combination Treatment on Recurrent Neck Pain After Medical Procedures: A Retrospective Study

Journal of Acupuncture Research ◽

10.13045/jar.2020.00262 ◽

2021 ◽

Vol 38 (1) ◽

pp. 32-40

Author(s):

Hyo-Seung Huh ◽

Wu-Jin Jeong ◽

Ki-Tae Park ◽

Sun-Ho Lee ◽

Sun-A Kim ◽

...

Keyword(s):

Cervical Spine ◽

Neck Pain ◽

Combination Treatment ◽

Medical Procedures ◽

Korean Medicine ◽

Significant Difference ◽

Before And After ◽

Group A ◽

Group B ◽

Admission Group

Background: The aim of this study was to evaluate the efficacy of Korean medicine combination treatment on recurrent neck pain after medical procedures.Methods: This retrospective study included 158 inpatients of the Daejeon Jaseng Hospital of Korean Medicine who were diagnosed with “Cervical disc disorder with radiculopathy (M50.1)” between December 14th, 2017 and May 29th, 2019. The patients were assigned to 1 of 2 groups based on whether they received medical procedures on the cervical spine at least once. Korean medicine combination treatment was evaluated using EuroQol-5 dimensions index (EQ-5D), numeric rating scale (NRS), and neck disability index (NDI) scores.Results: Before and after treatment, the patients who received medical procedures on the cervical spine at least once before admission (Group A) showed a statistically significant difference in the NDI and NRS scores but not in the EQ-5D scores. This was similar to the patients who had not received medical procedures on the cervical spine before admission (Group B) they showed a statistically significant difference in the NDI and NRS scores but not in the EQ-5D scores. When comparing the results of Group A and Group B before and after treatment, no statistically significant differences were observed in the EQ-5D, NDI, and NRS scores.Conclusion: Korean medicine combination treatment improves the neck functional disability of patients who suffer from recurrent neck pain despite patients having undergone medical procedures.

Download Full-text

KADAR KLORIDA SERUM PADA LATIHAN FISIK INTENSITAS RINGAN MAHASISWA FAKULTAS KEDOKTERAN UNIVERSITAS SAM RATULANGI

Jurnal e-Biomedik ◽

10.35790/ebm.2.1.2014.3709 ◽

2014 ◽

Vol 2 (1) ◽

Author(s):

Gina Irene Ishak

Keyword(s):

Light Intensity ◽

Physical Exercise ◽

Chloride Ion ◽

The Body ◽

Wilcoxon Test ◽

Purposive Sampling ◽

Serum Chloride ◽

Significant Difference ◽

Before And After ◽

Rate Maximum

Abstract: Physical exercise stimulates sweat from inside the body to transfer the heat out of it. Sweat consists of both water and electrolytes, including chloride ion, so if the excretion of water and electrolytes is not corrected can disturb the body’s homeostasis and health. This study aimed to determine the differencesof serum chloride levels before and after light intensity physical exercise. This study was a pre - experimental with one group pretest – posttest design. There were 30 respondents obtained by using purposive sampling method. The respondents did a brisk walk on a treadmill at 50-63 % heart rate maximum intensity for 30 minutes. Blood was taken before and after the exercise in order to examine the levels of serum chloride. The results of this study were processed by using Wilcoxon test. Averagely, the level of serum chloride before exercise was 106,23 ± 2,208 mmol/L, and 106,90 ± 1,9 mmol/L after exercise. Statistical test result showed p = 0,007. It is concluded that there is a significant difference on the levels of serum chloride before and after light intensity exercise in the students of Medical Faculty Sam Ratulangi University. Keywords: Serum Chloride, Exercise , Light Intensity. Abstrak: Latihan fisik memicu pengeluaran keringat untuk memindahkan panas dari dalam tubuh ke lingkungan. Keringat terdiri dari air dan elektrolit, termasuk ion klorida, sehingga jika elektrolit dan air yang keluar dari tubuh tidak dikoreksi dapat menganggu homeostasis tubuh dan kesehatan. Penelitian ini bertujuan untuk mengetahui perbedaan kadar klorida serum sebelum dan sesudah latihan fisik intensitas ringan. Penelitian ini merupakan penelitian pre-eksperimental dengan pendekatan one group pretest-posttest design. Sebanyak 30 responden yang diambil menggunakan metode purposive sampling, melakukan jalan cepat diatas treadmill dengan intensitas 50-63% denyut jantung maksimum selama 30 menit. Pengambilan darah dilakukan sebelum dan sesudah latihan guna pemeriksaan kadar klorida serum. Hasil penelitian diolah menggunakan uji Wilcoxon. Hasil menunjukkan rerata kadar klorida sebelum latihan 106,23±2,208 mmol/L dan 106,90 ± 1,9 mmol/L setelah latihan. Hasil uji statistik menunjukkan p=0,007. Disimpulkan bahwa terdapat perbedaan yang signifikan kadar klorida serum sebelum dan sesudah latihan fisik intensitas ringan pada mahasiswa Fakultas Kedokteran Universitas Sam Ratulangi. Kata kunci: Klorida Serum, Latihan Fisik, Intensitas Ringan.

Download Full-text