Greywater as an Alternative Solution for a Sustainable Management of Water Resources—A Review

In this paper, a comprehensive review on greywater is presented. Emphasis is given to the techniques used to treat and recover greywater, and special emphasis is placed on the risk of the existence of the novel coronavirus “SARS-CoV-2” in greywater and the possibility of its spread via the reuse of this water. In general, greywater is considered wastewater collected from domestic sources, with the exclusion of toilet water (which is considered as blackwater). Greywater represents 50 to 80% of the total volume of wastewater all over the world. This review provides various aspects related to greywater, such as origins, characteristics, and existing guidelines for greywater proper treatment and reuse. Several approaches and techniques have been developed to study the performance of different greywater treatment systems. These methods are critically discussed in this article. In the context of sustainable development, water management, and taking into account the scarcity of water resources, particularly in arid and semi-arid areas, the use of treated greywater is one of the alternatives methods that can reduce the burden of withdrawals from the resource. In addition, some successful examples of greywater valuation experiences in Tunisia were examined.

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COVID-19; Plague of the 21st Century; Situation Update

Asian Journal of Research in Infectious Diseases ◽

10.9734/ajrid/2020/v3i430132 ◽

2020 ◽

pp. 11-21

Author(s):

Mirza Zain Baig ◽

Zaitoon Zafar ◽

Abeer Aziz ◽

Umme Hani Abdullah

Keyword(s):

Global Economy ◽

Current Knowledge ◽

Social Stigma ◽

World Health ◽

The Novel ◽

Comprehensive Review ◽

The World ◽

Novel Coronavirus ◽

Health Organization ◽

Medical Infrastructure

The first known case of COVID-19 caused by the novel coronavirus now known as SARS-CoV-2 occurred in Wuhan, China in late December 2019. In a matter of a few months, it has spread globally to infect more than 500, 000 people and has caused more than 20,000 deaths. It was officially declared a pandemic on March 11, 2020, by the World Health Organization (WHO). To date, it has strained medical infrastructure, stagnated global economy and given rise to social stigma, fear, and racism. In this article, we provide a comprehensive review of our current knowledge and understanding of this new disease.

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A comprehensive review on COVID-19: What we know and how to treat against the novel coronavirus

E3S Web of Conferences ◽

10.1051/e3sconf/202129203091 ◽

2021 ◽

Vol 292 ◽

pp. 03091

Author(s):

Jiacheng Wang ◽

Xianhao Xu ◽

Zihan Xu

Keyword(s):

Vaccine Development ◽

Therapeutic Strategies ◽

Antiviral Drugs ◽

Extensive Study ◽

Passive Immunity ◽

The Novel ◽

Comprehensive Review ◽

Global Pandemic ◽

The World ◽

Novel Coronavirus

COVID-19 emerged in Wuhan, China, at the end of 2019 and then soon evolved into a global pandemic. The novel coronavirus inducing this pandemic is under extensive study held by researchers all over the world. We give out a comprehensive review of what we have known about this novel coronavirus, including the pathogenesis. Passive immunity, different strategies, and targets for vaccine development and antiviral drugs are introduced as therapeutic strategies. At last, many other properties of SARS-Cov-2 are discussed.

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Seasonal Water Crises and Social Dilemmas in Semi-Arid Areas of the Lake Zone of Tanzania

International Journal of Asian Social Science ◽

10.18488/journal.1.2018.85.213.226 ◽

2018 ◽

Vol 8 (5) ◽

pp. 213-226

Author(s):

L. M Laizer ◽

R.W Gibson ◽

E Lukonge

Keyword(s):

Water Management ◽

Water Resources ◽

Common Property ◽

Social Dilemmas ◽

Water Sources ◽

Arid Areas ◽

Informal Governance ◽

Economic Resource ◽

Lake Zone ◽

Semi Arid

The absence of formal institutions regulating water resources indicated a need to examine how informal governance works in semi-arid areas of the Lake Zone of Tanzania. Ostrom’s theory of common property resources was adapted to develop a questionnaire administered to 162 households using five different water sources (lake/dam, ponds near lake/dam, ponds, wells and waterholes) along with focus group discussions (6), key informant interviews (33) and field observations. The results indicated that communities do not have water management systems where water is abundant (lake/dam and ponds near these water sources). Conversely, where water is scarce (ponds, wells and water holes), communal water management occurs. However, such communal water governances are location specific and limited and, though they appear to function well at preventing water exhaustion, they fail to resolve the complex social dilemmas in that ecological system. Thus, most water resources are dominated by households with sound economic resource base, they take deliberate efforts to establish private wells in wetlands to intercept underground resources, raising issues of equity, contamination of underground water resources and human safety. Sandy river beds seemed to represent the worst ‘tragedy’ of unmanaged common resources, often being located in ‘no-man’s land’ between districts or regions, with uncontrolled competition resulting in enormous water holes dug by local resource users from both sides, and exhaustion by those with the deepest waterholes and access to engine-driven pumps. There are two water main crises: (1) too little is available to meet the current demand during an annual prolonged dry season (6-7 months) and (2) increasing social dilemmas on how to manage the little available. How external interventions could address these issues is discussed.

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Comparative docking of SARS-CoV-2 receptors antagonists from repurposing drugs

10.26434/chemrxiv.12044538.v4 ◽

2020 ◽

Author(s):

Micael Davi Lima de Oliveira ◽

Kelson Mota Teixeira de Oliveira

Keyword(s):

World Health Organisation ◽

World Health ◽

Lung Cells ◽

The Novel ◽

High Modulation ◽

Main Protease ◽

The World ◽

Novel Coronavirus ◽

Viral Receptors ◽

Theoretical Results

According to the World Health Organisation, until 16 June, 2020, the number of confirmed and notified cases of COVID-19 has already exceeded 7.9 million with approximately 434 thousand deaths worldwide. This research aimed to find repurposing antagonists, that may inhibit the activity of the main protease (Mpro) of the SARS-CoV-2 virus, as well as partially modulate the ACE2 receptors largely found in lung cells, and reduce viral replication by inhibiting Nsp12 RNA polymerase. Docking molecular simulations were performed among a total of 60 structures, most of all, published in the literature against the novel coronavirus. The theoretical results indicated that, in comparative terms, paritaprevir, ivermectin, ledipasvir, and simeprevir, are among the most theoretical promising drugs in remission of symptoms from the disease. Furthermore, also corroborate indinavir to the high modulation in viral receptors. The second group of promising drugs includes remdesivir and azithromycin. The repurposing drugs HCQ and chloroquine were not effective in comparative terms to other drugs, as monotherapies, against SARS-CoV-2 infection.

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Association and treatment of diabetes in patients affected by Covid-19

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v11ispl1.3591 ◽

2020 ◽

Vol 11 (SPL1) ◽

pp. 1198-1201

Author(s):

Syed Yasir Afaque

Keyword(s):

Diabetes Mellitus ◽

Prognostic Value ◽

Heart Diseases ◽

The Novel ◽

The World ◽

Treatment Of Diabetes ◽

Coronavirus Infection ◽

Composite Outcomes ◽

Novel Coronavirus ◽

The Impact

In December 2019, a unique coronavirus infection, SARS-CoV-2, was first identified in the province of Wuhan in China. Since then, it spread rapidly all over the world and has been responsible for a large number of morbidity and mortality among humans. According to a latest study, Diabetes mellitus, heart diseases, Hypertension etc. are being considered important risk factors for the development of this infection and is also associated with unfavorable outcomes in these patients. There is little evidence concerning the trail back of these patients possibly because of a small number of participants and people who experienced primary composite outcomes (such as admission in the ICU, usage of machine-driven ventilation or even fatality of these patients). Until now, there are no academic findings that have proven independent prognostic value of diabetes on death in the novel Coronavirus patients. However, there are several conjectures linking Diabetes with the impact as well as progression of COVID-19 in these patients. The aim of this review is to acknowledge about the association amongst Diabetes and the novel Coronavirus and the result of the infection in such patients.

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Collaboration platforms in water management

Water Practice & Technology ◽

10.2166/wpt.2011.062 ◽

2011 ◽

Vol 6 (3) ◽

Author(s):

C. E. Hidaka ◽

H. R. Kolar ◽

R. P. Williams ◽

P. G. Hartswick ◽

S. B. Foong

Keyword(s):

Water Management ◽

Information Technology ◽

Water Resources ◽

Data Sources ◽

Effective Management ◽

Holistic View ◽

The World ◽

Technical Architecture ◽

Multiple Levels ◽

Collaboration Platforms

In many parts of the world, management of water resources and infrastructures is fragmented between agencies at multiple levels – state, provincial, and local – and sometimes between functions within individual agencies. Consequently it is often impossible to take a holistic view of the issues at hand to enable effective management of the resource or infrastructure – either because of the overhead of managing the coordination required, and/or because of politics between the different stakeholders. In their work for IBM, the authors created a concept of an information technology (IT)-enabled “collaboration platform” that integrates different water data sources with IT tools to enable multiple entities to maintain and share a “common operating picture.” This greatly assists with coordination and reduces politics to manageable levels. In this paper, the authors describe the collaboration platform and its benefits by reference to examples of such platforms in use, and propose a reference technical architecture for creating collaboration platforms.

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Synthetic and semi-synthetic drugs as promising therapeutic option for the treatment of COVID-19

Mini-Reviews in Medicinal Chemistry ◽

10.2174/1389557520666201204162103 ◽

2020 ◽

Vol 20 ◽

Author(s):

Ekta Shirbhate ◽

Preeti Patel ◽

Vijay K Patel ◽

Ravichandran Veerasamy ◽

Prabodh C Sharma ◽

...

Keyword(s):

Therapeutic Option ◽

Antiviral Treatment ◽

The Novel ◽

Clinical Experiences ◽

Synthetic Compounds ◽

Synthetic Drugs ◽

Global Pandemic ◽

The World ◽

Novel Coronavirus

: The novel coronavirus disease-19 (COVID-19), a global pandemic that emerged from Wuhan, China has today travelled all around the world, so far 216 countries or territories with 21,732,472 people infected and 770,866 deaths globally (as per WHO COVID-19 update dated August 18, 2020). Continuous efforts are being made to repurpose the existing drugs and develop vaccines for combating this infection. Despite, to date, no certified antiviral treatment or vaccine prevails. Although, few candidates have displayed their efficacy in in vitro studies and are being repurposed for COVID-19 treatment. This article summarizes synthetic and semi-synthetic compounds displaying potent activity in their clinical experiences or studies against COVID-19 and also focuses on mode of action of drugs being repositioned against COVID-19.

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An outline of SARS-CoV-2 pathogenesis and the complement cascade of immune system

Bulletin of the National Research Centre ◽

10.1186/s42269-021-00582-2 ◽

2021 ◽

Vol 45 (1) ◽

Author(s):

Padmalochan Hembram

Keyword(s):

Immune System ◽

Dark Side ◽

Main Body ◽

The Novel ◽

Transmission Chain ◽

The World ◽

Therapeutic Molecules ◽

Rapid Transmission ◽

Novel Coronavirus ◽

Near Future

Abstract Background Coronavirus disease 19 is a viral infection caused by a novel coronavirus, SARS-CoV-2. It was first notified in Wuhan, China, is now spread into numerous part of the world. Thus, the world needs urgent support and encouragement to develop a vaccine or antiviral treatments to combat the atrocious outbreak. Main body of the abstract The origin of this virus is yet unknown; however, rapid transmission from human-to-human “Anthroponosis” has widely confirmed. The world is witnessing a continuous hike in SARS-CoV-2 infection. In light of the outbreak of coronavirus disease 19, we have aimed to highlight the basic and vital information about the novel coronavirus. We provide an overview of SARS-CoV-2 transmission, timeline and its pathophysiological properties which would be an aid for the development of therapeutic molecules and antiviral drugs. Immune system plays a crucial role in virus infection in order to control but may have dark side when becomes uncontrollable. The host and SARS-CoV-2 interaction describe how the virus exploits host machinery and how overactive host immune response can cause disease severity also addressed in this review. Short conclusion Safe and effective vaccines may be the game-changing tools, but in the near future wearing mask, washing hands at regular intervals, avoiding crowed, maintaining physical distancing and hygienic surrounding, must be good practices to reduce and break the transmission chain. Still, research is ongoing not only on how vaccines protect against disease, but also against infection and transmission.

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COVID-19 Vaccination: From Interesting Agent to the Patient

Vaccines ◽

10.3390/vaccines9020120 ◽

2021 ◽

Vol 9 (2) ◽

pp. 120

Author(s):

Anis Daou

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Gastrointestinal Tract ◽

Circulatory System ◽

The Novel ◽

Lead Compound ◽

Fda Approval ◽

The World ◽

The Central Nervous System ◽

Novel Coronavirus

The vaccination for the novel Coronavirus (COVID-19) is undergoing its final stages of analysis and testing. It is an impressive feat under the circumstances that we are on the verge of a potential breakthrough vaccination. This will help reduce the stress for millions of people around the globe, helping to restore worldwide normalcy. In this review, the analysis looks into how the new branch of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) came into the forefront of the world like a pandemic. This review will break down the details of what COVID-19 is, the viral family it belongs to and its background of how this family of viruses alters bodily functions by attacking vital human respiratory organs, the circulatory system, the central nervous system and the gastrointestinal tract. This review also looks at the process a new drug analogue undergoes, from (i) being a promising lead compound to (ii) being released into the market, from the drug development and discovery stage right through to FDA approval and aftermarket research. This review also addresses viable reasoning as to why the SARS-CoV-2 vaccine may have taken much less time than normal in order for it to be released for use.

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